ADAMTS14 (ADAM metallopeptidase with thrombospondin type 1 motif 14)

Gene

• Entrez ID: 140766
• Gene name: ADAM metallopeptidase with thrombospondin type 1 motif 14
• Gene symbol: ADAMTS14
• Synonyms: -
• Chromosome: 10
• Chromosome location: 10q22.1
• Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT496781	hsa-miR-4667-5p	PAR-CLIP	22291592
MIRT496780	hsa-miR-4700-5p	PAR-CLIP	22291592
MIRT496779	hsa-miR-8089	PAR-CLIP	22291592
MIRT496778	hsa-miR-637	PAR-CLIP	22291592
MIRT496777	hsa-miR-7155-5p	PAR-CLIP	22291592
MIRT496776	hsa-miR-3184-5p	PAR-CLIP	22291592
MIRT496775	hsa-miR-423-5p	PAR-CLIP	22291592
MIRT496774	hsa-miR-3926	PAR-CLIP	22291592
MIRT496773	hsa-miR-6731-5p	PAR-CLIP	22291592
MIRT496772	hsa-miR-8085	PAR-CLIP	22291592
MIRT496771	hsa-miR-3175	PAR-CLIP	22291592
MIRT496770	hsa-miR-1343-5p	PAR-CLIP	22291592
MIRT496769	hsa-miR-939-5p	PAR-CLIP	22291592
MIRT496768	hsa-miR-6825-5p	PAR-CLIP	22291592
MIRT496767	hsa-miR-6762-5p	PAR-CLIP	22291592
MIRT496766	hsa-miR-6845-5p	PAR-CLIP	22291592
MIRT496765	hsa-miR-4314	PAR-CLIP	22291592
MIRT496764	hsa-miR-3150a-3p	PAR-CLIP	22291592
MIRT496763	hsa-miR-6763-5p	PAR-CLIP	22291592
MIRT496781	hsa-miR-4667-5p	PAR-CLIP	22291592
MIRT496780	hsa-miR-4700-5p	PAR-CLIP	22291592
MIRT496779	hsa-miR-8089	PAR-CLIP	22291592
MIRT496778	hsa-miR-637	PAR-CLIP	22291592
MIRT496777	hsa-miR-7155-5p	PAR-CLIP	22291592
MIRT496776	hsa-miR-3184-5p	PAR-CLIP	22291592
MIRT496775	hsa-miR-423-5p	PAR-CLIP	22291592
MIRT496774	hsa-miR-3926	PAR-CLIP	22291592
MIRT496773	hsa-miR-6731-5p	PAR-CLIP	22291592
MIRT496772	hsa-miR-8085	PAR-CLIP	22291592
MIRT496771	hsa-miR-3175	PAR-CLIP	22291592
MIRT496770	hsa-miR-1343-5p	PAR-CLIP	22291592
MIRT496769	hsa-miR-939-5p	PAR-CLIP	22291592
MIRT496768	hsa-miR-6825-5p	PAR-CLIP	22291592
MIRT496767	hsa-miR-6762-5p	PAR-CLIP	22291592
MIRT496766	hsa-miR-6845-5p	PAR-CLIP	22291592
MIRT496765	hsa-miR-4314	PAR-CLIP	22291592
MIRT496764	hsa-miR-3150a-3p	PAR-CLIP	22291592
MIRT496763	hsa-miR-6763-5p	PAR-CLIP	22291592
MIRT766370	hsa-let-7a	CLIP-seq
MIRT766371	hsa-let-7b	CLIP-seq
MIRT766372	hsa-let-7c	CLIP-seq
MIRT766373	hsa-let-7d	CLIP-seq
MIRT766374	hsa-let-7e	CLIP-seq
MIRT766375	hsa-let-7f	CLIP-seq
MIRT766376	hsa-let-7g	CLIP-seq
MIRT766377	hsa-let-7i	CLIP-seq
MIRT766378	hsa-miR-202	CLIP-seq
MIRT766379	hsa-miR-2277-3p	CLIP-seq
MIRT766380	hsa-miR-3660	CLIP-seq
MIRT766381	hsa-miR-4458	CLIP-seq
MIRT766382	hsa-miR-4500	CLIP-seq
MIRT766383	hsa-miR-4514	CLIP-seq
MIRT766384	hsa-miR-4526	CLIP-seq
MIRT766385	hsa-miR-4663	CLIP-seq
MIRT766386	hsa-miR-4692	CLIP-seq
MIRT766387	hsa-miR-4732-3p	CLIP-seq
MIRT766388	hsa-miR-486-3p	CLIP-seq
MIRT766389	hsa-miR-628-5p	CLIP-seq
MIRT766390	hsa-miR-940	CLIP-seq
MIRT766391	hsa-miR-98	CLIP-seq
MIRT766392	hsa-miR-218	CLIP-seq
MIRT766393	hsa-miR-3646	CLIP-seq
MIRT766394	hsa-miR-3662	CLIP-seq
MIRT766395	hsa-miR-4327	CLIP-seq
MIRT766396	hsa-miR-636	CLIP-seq
MIRT1925783	hsa-miR-1262	CLIP-seq
MIRT1925784	hsa-miR-3065-3p	CLIP-seq
MIRT1925785	hsa-miR-3120-3p	CLIP-seq
MIRT1925786	hsa-miR-3659	CLIP-seq
MIRT1925787	hsa-miR-4658	CLIP-seq
MIRT1925788	hsa-miR-4701-3p	CLIP-seq
MIRT1925789	hsa-miR-574-5p	CLIP-seq
MIRT1925790	hsa-miR-600	CLIP-seq
MIRT1925791	hsa-miR-938	CLIP-seq
MIRT2167123	hsa-miR-1972	CLIP-seq
MIRT2167124	hsa-miR-29a	CLIP-seq
MIRT2167125	hsa-miR-29b	CLIP-seq
MIRT2167126	hsa-miR-29c	CLIP-seq
MIRT1925784	hsa-miR-3065-3p	CLIP-seq
MIRT2167127	hsa-miR-338-3p	CLIP-seq
MIRT2167128	hsa-miR-4286	CLIP-seq
MIRT2167129	hsa-miR-4530	CLIP-seq
MIRT2167130	hsa-miR-4733-3p	CLIP-seq
MIRT2167131	hsa-miR-508-5p	CLIP-seq
MIRT2167132	hsa-miR-766	CLIP-seq
MIRT2383889	hsa-miR-1289	CLIP-seq
MIRT2383890	hsa-miR-2115	CLIP-seq
MIRT2383891	hsa-miR-3198	CLIP-seq
MIRT2383892	hsa-miR-3607-3p	CLIP-seq
MIRT2383893	hsa-miR-3686	CLIP-seq
MIRT2383894	hsa-miR-4294	CLIP-seq
MIRT2383895	hsa-miR-4309	CLIP-seq
MIRT2383896	hsa-miR-4487	CLIP-seq
MIRT766388	hsa-miR-486-3p	CLIP-seq
MIRT2383897	hsa-miR-516b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA	21873635
GO:0005576	Component	Extracellular region	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0030198	Process	Extracellular matrix organization	IBA	21873635
GO:0030199	Process	Collagen fibril organization	IEA
GO:0030574	Process	Collagen catabolic process	IEA
GO:0031012	Component	Extracellular matrix	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 607506
• HGNC: 14899
• e!Ensembl: ENSG00000138316

Protein

• UniProt ID: Q8WXS8
• Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAM-TS 14) (ADAM-TS14) (ADAMTS-14) (EC 3.4.24.-)
• Protein function: Has aminoprocollagen type I processing activity in the absence of ADAMTS2 (PubMed:11741898). Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity (PubMed:11741898). Cleaves lysyl oxid
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01562	Pep_M12B_propep	39 → 207	Reprolysin family propeptide	Family
  PF01421	Reprolysin	259 → 460	Reprolysin (M12B) family zinc metalloprotease	Domain
  PF17771	ADAM_CR_2	472 → 541	ADAM cysteine-rich domain	Domain
  PF00090	TSP_1	556 → 606	Thrombospondin type 1 domain	Domain
  PF05986	ADAM_spacer1	714 → 829	ADAM-TS Spacer 1	Family
  PF19030	TSP1_ADAMTS	851 → 906		Domain
  PF19030	TSP1_ADAMTS	911 → 968		Domain
  PF19030	TSP1_ADAMTS	972 → 1021		Domain

• Sequence:

  MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGP
  AAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLR
  LRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRT
  DSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLV
  GDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESL
  GVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLT
  RQDFGPSGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETS
  LGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDE
  QCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC
  IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQV
  CNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVF
  MNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTL
  GKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTA
  MGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNN
  VLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRR
  CNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEAR
  RPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPA
  CGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYC
  SIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGS
  EDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTPVPE
  DKGQPGEDLRHPGTSLPAASPVT

• Sequence length: 1223

Pathways

Reactome:

Collagen biosynthesis and modifying enzymes
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	22694930