CRMP1 (collapsin response mediator protein 1)

Gene

• Entrez ID: 1400
• Gene name: Collapsin response mediator protein 1
• Gene symbol: CRMP1
• Synonyms: CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3
• Chromosome: 4
• Chromosome location: 4p16.2
• Summary: This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collaps

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT569829	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT569828	hsa-miR-151a-5p	PAR-CLIP	20371350
MIRT569827	hsa-miR-151b	PAR-CLIP	20371350
MIRT569826	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT569825	hsa-miR-4784	PAR-CLIP	20371350
MIRT569824	hsa-miR-4434	PAR-CLIP	20371350
MIRT569823	hsa-miR-4516	PAR-CLIP	20371350
MIRT569822	hsa-miR-5703	PAR-CLIP	20371350
MIRT569821	hsa-miR-765	PAR-CLIP	20371350
MIRT569819	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT569820	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT569818	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT569817	hsa-miR-5698	PAR-CLIP	20371350
MIRT569816	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT569815	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT569814	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT569829	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT569828	hsa-miR-151a-5p	PAR-CLIP	20371350
MIRT569827	hsa-miR-151b	PAR-CLIP	20371350
MIRT569826	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT569825	hsa-miR-4784	PAR-CLIP	20371350
MIRT569824	hsa-miR-4434	PAR-CLIP	20371350
MIRT569823	hsa-miR-4516	PAR-CLIP	20371350
MIRT569822	hsa-miR-5703	PAR-CLIP	20371350
MIRT569821	hsa-miR-765	PAR-CLIP	20371350
MIRT569819	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT569820	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT569818	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT569817	hsa-miR-5698	PAR-CLIP	20371350
MIRT569816	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT569815	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT569814	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT910372	hsa-miR-1208	CLIP-seq
MIRT910373	hsa-miR-1265	CLIP-seq
MIRT910374	hsa-miR-141	CLIP-seq
MIRT910375	hsa-miR-1909	CLIP-seq
MIRT910376	hsa-miR-1972	CLIP-seq
MIRT910377	hsa-miR-200a	CLIP-seq
MIRT910378	hsa-miR-30a	CLIP-seq
MIRT910379	hsa-miR-30b	CLIP-seq
MIRT910380	hsa-miR-30c	CLIP-seq
MIRT910381	hsa-miR-30d	CLIP-seq
MIRT910382	hsa-miR-30e	CLIP-seq
MIRT910383	hsa-miR-3190	CLIP-seq
MIRT910384	hsa-miR-3202	CLIP-seq
MIRT910385	hsa-miR-3660	CLIP-seq
MIRT910386	hsa-miR-412	CLIP-seq
MIRT910387	hsa-miR-4256	CLIP-seq
MIRT910388	hsa-miR-4420	CLIP-seq
MIRT910389	hsa-miR-4475	CLIP-seq
MIRT910390	hsa-miR-4491	CLIP-seq
MIRT910391	hsa-miR-4526	CLIP-seq
MIRT910392	hsa-miR-4533	CLIP-seq
MIRT910393	hsa-miR-4650-5p	CLIP-seq
MIRT910394	hsa-miR-4657	CLIP-seq
MIRT910395	hsa-miR-4688	CLIP-seq
MIRT910396	hsa-miR-4717-5p	CLIP-seq
MIRT910397	hsa-miR-4762-3p	CLIP-seq
MIRT910398	hsa-miR-4764-5p	CLIP-seq
MIRT910399	hsa-miR-4795-5p	CLIP-seq
MIRT910400	hsa-miR-486-3p	CLIP-seq
MIRT910401	hsa-miR-510	CLIP-seq
MIRT910402	hsa-miR-642b	CLIP-seq
MIRT1969889	hsa-miR-4318	CLIP-seq
MIRT910385	hsa-miR-3660	CLIP-seq
MIRT910386	hsa-miR-412	CLIP-seq
MIRT910391	hsa-miR-4526	CLIP-seq
MIRT910373	hsa-miR-1265	CLIP-seq
MIRT2447658	hsa-miR-130a	CLIP-seq
MIRT2447659	hsa-miR-130b	CLIP-seq
MIRT2447660	hsa-miR-139-5p	CLIP-seq
MIRT2447661	hsa-miR-153	CLIP-seq
MIRT910375	hsa-miR-1909	CLIP-seq
MIRT910376	hsa-miR-1972	CLIP-seq
MIRT2447662	hsa-miR-19a	CLIP-seq
MIRT2447663	hsa-miR-19b	CLIP-seq
MIRT2447664	hsa-miR-2276	CLIP-seq
MIRT2447665	hsa-miR-301a	CLIP-seq
MIRT2447666	hsa-miR-301b	CLIP-seq
MIRT2447667	hsa-miR-3126-5p	CLIP-seq
MIRT2447668	hsa-miR-331-3p	CLIP-seq
MIRT2447669	hsa-miR-3605-5p	CLIP-seq
MIRT2447670	hsa-miR-3666	CLIP-seq
MIRT2447671	hsa-miR-3943	CLIP-seq
MIRT2447672	hsa-miR-4257	CLIP-seq
MIRT2447673	hsa-miR-4295	CLIP-seq
MIRT2447674	hsa-miR-448	CLIP-seq
MIRT910390	hsa-miR-4491	CLIP-seq
MIRT2447675	hsa-miR-454	CLIP-seq
MIRT910393	hsa-miR-4650-5p	CLIP-seq
MIRT910394	hsa-miR-4657	CLIP-seq
MIRT2447676	hsa-miR-4671-3p	CLIP-seq
MIRT910395	hsa-miR-4688	CLIP-seq
MIRT2447677	hsa-miR-4690-3p	CLIP-seq
MIRT2447678	hsa-miR-4708-3p	CLIP-seq
MIRT2447679	hsa-miR-4711-5p	CLIP-seq
MIRT2447680	hsa-miR-4714-3p	CLIP-seq
MIRT910396	hsa-miR-4717-5p	CLIP-seq
MIRT2447681	hsa-miR-4722-3p	CLIP-seq
MIRT910398	hsa-miR-4764-5p	CLIP-seq
MIRT2447682	hsa-miR-4769-3p	CLIP-seq
MIRT2447683	hsa-miR-4772-3p	CLIP-seq
MIRT2447684	hsa-miR-4773	CLIP-seq
MIRT910400	hsa-miR-486-3p	CLIP-seq
MIRT2447685	hsa-miR-499a-5p	CLIP-seq
MIRT910401	hsa-miR-510	CLIP-seq
MIRT910402	hsa-miR-642b	CLIP-seq
MIRT2447686	hsa-miR-802	CLIP-seq
MIRT2447687	hsa-miR-942	CLIP-seq
MIRT2447667	hsa-miR-3126-5p	CLIP-seq
MIRT2447672	hsa-miR-4257	CLIP-seq
MIRT910373	hsa-miR-1265	CLIP-seq
MIRT2447658	hsa-miR-130a	CLIP-seq
MIRT2447659	hsa-miR-130b	CLIP-seq
MIRT2447664	hsa-miR-2276	CLIP-seq
MIRT2447665	hsa-miR-301a	CLIP-seq
MIRT2447666	hsa-miR-301b	CLIP-seq
MIRT2447668	hsa-miR-331-3p	CLIP-seq
MIRT2509137	hsa-miR-342-3p	CLIP-seq
MIRT2447669	hsa-miR-3605-5p	CLIP-seq
MIRT2447670	hsa-miR-3666	CLIP-seq
MIRT2447673	hsa-miR-4295	CLIP-seq
MIRT910390	hsa-miR-4491	CLIP-seq
MIRT2447675	hsa-miR-454	CLIP-seq
MIRT910394	hsa-miR-4657	CLIP-seq
MIRT2447676	hsa-miR-4671-3p	CLIP-seq
MIRT2509138	hsa-miR-4695-3p	CLIP-seq
MIRT2447678	hsa-miR-4708-3p	CLIP-seq
MIRT2447680	hsa-miR-4714-3p	CLIP-seq
MIRT2447681	hsa-miR-4722-3p	CLIP-seq
MIRT910398	hsa-miR-4764-5p	CLIP-seq
MIRT2447682	hsa-miR-4769-3p	CLIP-seq
MIRT2447683	hsa-miR-4772-3p	CLIP-seq
MIRT2509139	hsa-miR-513a-5p	CLIP-seq
MIRT2509140	hsa-miR-552	CLIP-seq
MIRT910402	hsa-miR-642b	CLIP-seq
MIRT2447687	hsa-miR-942	CLIP-seq
MIRT910373	hsa-miR-1265	CLIP-seq
MIRT2447658	hsa-miR-130a	CLIP-seq
MIRT2447659	hsa-miR-130b	CLIP-seq
MIRT910375	hsa-miR-1909	CLIP-seq
MIRT910376	hsa-miR-1972	CLIP-seq
MIRT2447664	hsa-miR-2276	CLIP-seq
MIRT2447665	hsa-miR-301a	CLIP-seq
MIRT2447666	hsa-miR-301b	CLIP-seq
MIRT2447667	hsa-miR-3126-5p	CLIP-seq
MIRT2447668	hsa-miR-331-3p	CLIP-seq
MIRT2447669	hsa-miR-3605-5p	CLIP-seq
MIRT2447670	hsa-miR-3666	CLIP-seq
MIRT2447671	hsa-miR-3943	CLIP-seq
MIRT2447672	hsa-miR-4257	CLIP-seq
MIRT2447673	hsa-miR-4295	CLIP-seq
MIRT910390	hsa-miR-4491	CLIP-seq
MIRT2447675	hsa-miR-454	CLIP-seq
MIRT910393	hsa-miR-4650-5p	CLIP-seq
MIRT910394	hsa-miR-4657	CLIP-seq
MIRT2447676	hsa-miR-4671-3p	CLIP-seq
MIRT910395	hsa-miR-4688	CLIP-seq
MIRT2447677	hsa-miR-4690-3p	CLIP-seq
MIRT2447678	hsa-miR-4708-3p	CLIP-seq
MIRT2447680	hsa-miR-4714-3p	CLIP-seq
MIRT910396	hsa-miR-4717-5p	CLIP-seq
MIRT2447681	hsa-miR-4722-3p	CLIP-seq
MIRT910398	hsa-miR-4764-5p	CLIP-seq
MIRT2447682	hsa-miR-4769-3p	CLIP-seq
MIRT2447683	hsa-miR-4772-3p	CLIP-seq
MIRT910400	hsa-miR-486-3p	CLIP-seq
MIRT910401	hsa-miR-510	CLIP-seq
MIRT910402	hsa-miR-642b	CLIP-seq
MIRT2447687	hsa-miR-942	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CEBPA	Unknown	18524846
NFKB1	Unknown	18782567
SP1	Unknown	18524846

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IEA
GO:0004157	Function	Dihydropyrimidinase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	15383276, 16169070, 21900206, 24722188, 25416956, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	8973361
GO:0006208	Process	Pyrimidine nucleobase catabolic process	IBA	21873635
GO:0007399	Process	Nervous system development	TAS	8973361
GO:0007411	Process	Axon guidance	IEA
GO:0010977	Process	Negative regulation of neuron projection development	IGI	25358863
GO:0030426	Component	Growth cone	IEA
GO:0030496	Component	Midbody	IDA	19799413
GO:0031005	Function	Filamin binding	IPI	25358863
GO:0042802	Function	Identical protein binding	IPI	24722188, 25416956
GO:0043204	Component	Perikaryon	IEA
GO:1904530	Process	Negative regulation of actin filament binding	IDA	25358863
GO:1904530	Process	Negative regulation of actin filament binding	IMP	25358863

Other IDs

• MIM: 602462
• HGNC: 2365
• e!Ensembl: ENSG00000072832

Protein

• UniProt ID: Q14194
• Protein name: Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3)
• Protein function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissocia
• PDB: 4B3Z
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01979	Amidohydro_1	64 → 453	Amidohydrolase family	Domain

• Sequence:

  MSYQGKKSIPHITSDRLLIKGGRIINDDQSLYADVYLEDGLIKQIGENLIVPGGVKTIEA
  NGRMVIPGGIDVNTYLQKPSQGMTAADDFFQGTRAALVGGTTMIIDHVVPEPGSSLLTSF
  EKWHEAADTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDVYQMSDSQ
  LYEAFTFLKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAI
  TIAGRINCPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAAA
  FVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEE
  RMTVVWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKLKTI
  TAKSHKSAVEYNIFEGMECHGSPLVVISQGKIVFEDGNINVNKGMGRFIPRKAFPEHLYQ
  RVKIRNKVFGLQGVSRGMYDGPVYEVPATPKYATPAPSAKSSPSKHQPPPIRNLHQSNFS
  LSGAQIDDNNPRRTGHRIVAPPGGRSNITSLG

• Sequence length: 572

Pathways

Reactome:

CRMPs in Sema3A signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Ellis-van creveld syndrome	Ellis-Van Creveld Syndrome	rs1265421045, rs137852924, rs137852925, rs137852926, rs137852927, rs794726665, rs121908424, rs121908425, rs587776619, rs121908426, rs794726666, rs1302074641, rs146538906, rs751356206, rs886037764, rs886037763, rs548681312, rs200300612, rs150814290, rs146475474, rs965707319, rs767913372, rs1553815019, rs376133710, rs769864196, rs761707323, rs748523193, rs755381180, rs765269619, rs1553891936, rs759106605, rs1017946059, rs1553876034, rs1553812417, rs1424976594, rs1553865346, rs1553876870, rs753581033, rs760066386, rs1553833239, rs767072839, rs777505711, rs1553849894, rs1553855074, rs1553855151, rs1485152854, rs1553871764, rs1553871866, rs527255616, rs1553873138, rs760607210, rs1169539647, rs770918273, rs762947212, rs1553837446, rs1553811863, rs1307502841, rs1553851870, rs781096099, rs1553818428, rs1447633595, rs749251178, rs769799880, rs992326794, rs1431987950, rs1553836169, rs772840335, rs1553867117, rs1553873969, rs909612975, rs1262933856, rs755789146, rs1553889992, rs773019082, rs1553892090, rs1305301849, rs1553850677, rs1553895755, rs778793911, rs1553851462, rs760382778, rs1007534611, rs73198165, rs1553855127, rs1490912913, rs1430962566, rs1553857801, rs1159758018, rs1553840713, rs763363403, rs1553857995, rs1294715119, rs1553871792, rs1236566474, rs1553852469, rs1214848359, rs1420414097, rs1221185345, rs1300178432, rs1477102573, rs1553876813, rs764397417, rs1553857828, rs1553891368, rs1363547577, rs1553867138, rs779915989, rs1553886849, rs753014919, rs779275317, rs1553894457, rs1553895776, rs1437174284, rs777852863, rs762795511, rs1577638781, rs1722451930, rs758841632, rs767400887	29068549, 23220543, 17024374, 10700184, 29321360, 20184732, 19810119
Polydactyly	Polydactyly	rs1583729398, rs121917709, rs1583734240, rs121917714, rs397507422, rs398122899, rs587776959, rs386833752, rs1057518698, rs1060499558, rs755938967, rs1375768446, rs1309855392, rs1565601979, rs748321474, rs368652620, rs1562587032, rs760694987
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22798627

Unknown
Disease name	Disease term	dbSNP ID	References
Majewski syndrome	Majewski Syndrome
Micrognathism	Micrognathism
Social anhedonia	Social Anhedonia		22798627
Syndactyly of the toes	Syndactyly of the toes
Thoracic hypoplasia	Thoracic hypoplasia
Vertical talus	Vertical Talus
Weyers acrofacial dysostosis	Weyers acrofacial dysostosis		23220543, 29068549, 17024374, 10700184