GediPNet logo

CRK (CRK proto-oncogene, adaptor protein)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1398
Gene nameGene Name - the full gene name approved by the HGNC.
CRK proto-oncogene, adaptor protein
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CRK
SynonymsGene synonyms aliases
CRKII, p38
ChromosomeChromosome number
17
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytop
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002993 hsa-miR-126-3p Luciferase reporter assay 18602365
MIRT002993 hsa-miR-126-3p Luciferase reporter assay, Western blot 18602365
MIRT002993 hsa-miR-126-3p qRT-PCR 18602365
MIRT002993 hsa-miR-126-3p Review 19935707
MIRT002993 hsa-miR-126-3p Luciferase reporter assay 18602365
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000186 Process Activation of MAPKK activity TAS
GO:0001764 Process Neuron migration IEA
GO:0001784 Function Phosphotyrosine residue binding IPI 20624904
GO:0001878 Process Response to yeast IEA
GO:0005159 Function Insulin-like growth factor receptor binding IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P46108
Protein name Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Protein function Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. ; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates atta
PDB 1JU5 , 2DVJ , 2EYV , 2EYW , 2EYX , 2EYY , 2EYZ , 2MS4 , 5UL6 , 6ATV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00017 SH2
13 104
SH2 domain
Domain
PF00018 SH3_1
138 184
SH3 domain
Domain
PF07653 SH3_2
239 294
Variant SH3 domain
Domain
Sequence
Sequence length 304
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  MAPK signaling pathway
ErbB signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
Efferocytosis
Focal adhesion
Fc gamma R-mediated phagocytosis
Neurotrophin signaling pathway
Regulation of actin cytoskeleton
Insulin signaling pathway
Growth hormone synthesis, secretion and action
Bacterial invasion of epithelial cells
Shigellosis
Yersinia infection
Human cytomegalovirus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
MicroRNAs in cancer
Renal cell carcinoma
Chronic myeloid leukemia
  ARMS-mediated activation
Downstream signal transduction
Regulation of actin dynamics for phagocytic cup formation
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
MET receptor recycling
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Myocardial ischemia Myocardial Ischemia 16214533

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412