TAF1L (TATA-box binding protein associated factor 1 like)

Gene

• Entrez ID: 138474
• Gene name: TATA-box binding protein associated factor 1 like
• Gene symbol: TAF1L
• Synonyms: TAF(II)210, TAF2A2
• Chromosome: 9
• Chromosome location: 9p21.1
• Summary: This locus is intronless, and apparently arose in the primate lineage from retrotransposition of the transcript from the multi-exon TAF1 locus on the X chromosome. The gene is expressed in male germ cells, and the product has been shown to function interc

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1409274	hsa-miR-1228	CLIP-seq
MIRT1409275	hsa-miR-3135b	CLIP-seq
MIRT1409276	hsa-miR-3652	CLIP-seq
MIRT1409277	hsa-miR-4430	CLIP-seq
MIRT1409278	hsa-miR-4438	CLIP-seq
MIRT1409279	hsa-miR-4450	CLIP-seq
MIRT1409280	hsa-miR-4667-5p	CLIP-seq
MIRT1409281	hsa-miR-4700-5p	CLIP-seq
MIRT1409282	hsa-miR-5095	CLIP-seq
MIRT1409283	hsa-miR-637	CLIP-seq
MIRT1409284	hsa-miR-767-5p	CLIP-seq
MIRT1921390	hsa-miR-1280	CLIP-seq
MIRT1921391	hsa-miR-1302	CLIP-seq
MIRT1921392	hsa-miR-4286	CLIP-seq
MIRT1921393	hsa-miR-4287	CLIP-seq
MIRT1921394	hsa-miR-4298	CLIP-seq
MIRT1921395	hsa-miR-4469	CLIP-seq
MIRT1921396	hsa-miR-4685-3p	CLIP-seq
MIRT2122742	hsa-miR-3680	CLIP-seq
MIRT2122743	hsa-miR-4695-3p	CLIP-seq
MIRT2122744	hsa-miR-4772-3p	CLIP-seq
MIRT2122745	hsa-miR-498	CLIP-seq
MIRT1409275	hsa-miR-3135b	CLIP-seq
MIRT2345113	hsa-miR-3155	CLIP-seq
MIRT2345114	hsa-miR-3155b	CLIP-seq
MIRT1409276	hsa-miR-3652	CLIP-seq
MIRT2122742	hsa-miR-3680	CLIP-seq
MIRT2345115	hsa-miR-4268	CLIP-seq
MIRT1409277	hsa-miR-4430	CLIP-seq
MIRT2345116	hsa-miR-4464	CLIP-seq
MIRT2345117	hsa-miR-4506	CLIP-seq
MIRT2345118	hsa-miR-450b-3p	CLIP-seq
MIRT2345119	hsa-miR-4691-5p	CLIP-seq
MIRT2122743	hsa-miR-4695-3p	CLIP-seq
MIRT2345120	hsa-miR-4713-3p	CLIP-seq
MIRT2345121	hsa-miR-4748	CLIP-seq
MIRT2345122	hsa-miR-4772-5p	CLIP-seq
MIRT2345123	hsa-miR-484	CLIP-seq
MIRT2345124	hsa-miR-638	CLIP-seq
MIRT2345125	hsa-miR-769-3p	CLIP-seq
MIRT1409274	hsa-miR-1228	CLIP-seq
MIRT2461067	hsa-miR-1976	CLIP-seq
MIRT2461068	hsa-miR-3157-5p	CLIP-seq
MIRT2461069	hsa-miR-370	CLIP-seq
MIRT2461070	hsa-miR-3977	CLIP-seq
MIRT2461071	hsa-miR-4279	CLIP-seq
MIRT1409278	hsa-miR-4438	CLIP-seq
MIRT1409279	hsa-miR-4450	CLIP-seq
MIRT2461072	hsa-miR-4532	CLIP-seq
MIRT2461073	hsa-miR-4794	CLIP-seq
MIRT2122745	hsa-miR-498	CLIP-seq
MIRT1409282	hsa-miR-5095	CLIP-seq
MIRT1409284	hsa-miR-767-5p	CLIP-seq
MIRT1409274	hsa-miR-1228	CLIP-seq
MIRT2461067	hsa-miR-1976	CLIP-seq
MIRT2638175	hsa-miR-3149	CLIP-seq
MIRT2461069	hsa-miR-370	CLIP-seq
MIRT2461070	hsa-miR-3977	CLIP-seq
MIRT2638176	hsa-miR-411	CLIP-seq
MIRT2461071	hsa-miR-4279	CLIP-seq
MIRT1409278	hsa-miR-4438	CLIP-seq
MIRT1409279	hsa-miR-4450	CLIP-seq
MIRT2461072	hsa-miR-4532	CLIP-seq
MIRT2638177	hsa-miR-4735-5p	CLIP-seq
MIRT2638178	hsa-miR-4775	CLIP-seq
MIRT2461073	hsa-miR-4794	CLIP-seq
MIRT2122745	hsa-miR-498	CLIP-seq
MIRT1409282	hsa-miR-5095	CLIP-seq
MIRT2638179	hsa-miR-590-3p	CLIP-seq
MIRT1409284	hsa-miR-767-5p	CLIP-seq
MIRT1409274	hsa-miR-1228	CLIP-seq
MIRT2461067	hsa-miR-1976	CLIP-seq
MIRT2638175	hsa-miR-3149	CLIP-seq
MIRT2461069	hsa-miR-370	CLIP-seq
MIRT2461070	hsa-miR-3977	CLIP-seq
MIRT2461071	hsa-miR-4279	CLIP-seq
MIRT1409278	hsa-miR-4438	CLIP-seq
MIRT1409279	hsa-miR-4450	CLIP-seq
MIRT2461072	hsa-miR-4532	CLIP-seq
MIRT2638177	hsa-miR-4735-5p	CLIP-seq
MIRT2638178	hsa-miR-4775	CLIP-seq
MIRT2461073	hsa-miR-4794	CLIP-seq
MIRT2122745	hsa-miR-498	CLIP-seq
MIRT1409282	hsa-miR-5095	CLIP-seq
MIRT2638179	hsa-miR-590-3p	CLIP-seq
MIRT1409284	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0004402	Function	Histone acetyltransferase activity	ISS	12217962
GO:0004674	Function	Protein serine/threonine kinase activity	ISS	12217962
GO:0005575	Component	Cellular_component	ND
GO:0005654	Component	Nucleoplasm	TAS
GO:0005669	Component	Transcription factor TFIID complex	IBA	21873635
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	12217962
GO:0006366	Process	Transcription by RNA polymerase II	TAS
GO:0006367	Process	Transcription initiation from RNA polymerase II promoter	TAS
GO:0006468	Process	Protein phosphorylation	IEA
GO:0007140	Process	Male meiotic nuclear division	IEP	12217962
GO:0016251	Function	RNA polymerase II general transcription initiation factor activity	IBA	21873635
GO:0016573	Process	Histone acetylation	IEA
GO:0017025	Function	TBP-class protein binding	IBA	21873635
GO:0017025	Function	TBP-class protein binding	IPI	12217962
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	12217962
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	IBA	21873635
GO:0070577	Function	Lysine-acetylated histone binding	IDA	22464331
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS

Other IDs

• MIM: 607798
• HGNC: 18056
• e!Ensembl: ENSG00000122728

Protein

• UniProt ID: Q8IZX4
• Protein name: Transcription initiation factor TFIID subunit 1-like (TAF(II)210) (TBP-associated factor 1-like) (TBP-associated factor 210 kDa) (Transcription initiation factor TFIID 210 kDa subunit)
• Protein function: May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.
• PDB: 3HMH, 5IGL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09247	TBP-binding	22 → 85	TATA box-binding protein binding	Domain
  PF12157	DUF3591	584 → 1047	Protein of unknown function (DUF3591)	Family
  PF15288	zf-CCHC_6	1280 → 1319	Zinc knuckle	Domain
  PF00439	Bromodomain	1408 → 1491	Bromodomain	Domain
  PF00439	Bromodomain	1530 → 1614	Bromodomain	Domain

• Sequence:

  MRPGCDLLLRAAATVTAAIMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDDE
  CKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDES
  QRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSES
  GEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDAT
  KLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKKHRELIQEEQIQEVECS
  VESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVAEW
  RYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLADEN
  FLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLDDD
  KPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEEAT
  SNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQGLR
  GTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPLLK
  HIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIK
  NYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPETD
  FLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDR
  PRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAKVS
  PEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAA
  MKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLSLK
  NAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQER
  YKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSREW
  EEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEYVR
  CETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQEKE
  KLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQEE
  ELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVGTT
  VHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKII
  TRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKL
  KEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYY
  KMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICY
  QTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTSRD
  ASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGG
  DGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDV
  GYGGIRPKQPFMLQHASGEHKDGHGK

• Sequence length: 1826

Pathways

KEGG:

Basal transcription factors

Reactome:

RNA Polymerase II Pre-transcription Events
Regulation of TP53 Activity through Phosphorylation
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Glioblastoma	Glioblastoma Multiforme	rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888
Lung carcinoma	Small cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		29610475