UNC5D (unc-5 netrin receptor D)

Gene

• Entrez ID: 137970
• Gene name: Unc-5 netrin receptor D
• Gene symbol: UNC5D
• Synonyms: PRO34692, Unc5h4
• Chromosome: 8
• Chromosome location: 8p12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022228	hsa-miR-124-3p	Microarray	18668037
MIRT651857	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT651856	hsa-miR-4328	HITS-CLIP	23824327
MIRT651855	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT651854	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT651853	hsa-miR-548aw	HITS-CLIP	23824327
MIRT651852	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT651851	hsa-miR-527	HITS-CLIP	23824327
MIRT651850	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT651849	hsa-miR-507	HITS-CLIP	23824327
MIRT651848	hsa-miR-557	HITS-CLIP	23824327
MIRT651847	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT651857	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT651856	hsa-miR-4328	HITS-CLIP	23824327
MIRT651855	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT651854	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT651853	hsa-miR-548aw	HITS-CLIP	23824327
MIRT651852	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT651851	hsa-miR-527	HITS-CLIP	23824327
MIRT651850	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT651849	hsa-miR-507	HITS-CLIP	23824327
MIRT651848	hsa-miR-557	HITS-CLIP	23824327
MIRT651847	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT1475579	hsa-miR-1200	CLIP-seq
MIRT1475580	hsa-miR-1266	CLIP-seq
MIRT1475581	hsa-miR-1322	CLIP-seq
MIRT1475582	hsa-miR-182	CLIP-seq
MIRT1475583	hsa-miR-3140-5p	CLIP-seq
MIRT1475584	hsa-miR-3148	CLIP-seq
MIRT1475585	hsa-miR-3154	CLIP-seq
MIRT1475586	hsa-miR-3163	CLIP-seq
MIRT1475587	hsa-miR-325	CLIP-seq
MIRT1475588	hsa-miR-365	CLIP-seq
MIRT1475589	hsa-miR-3660	CLIP-seq
MIRT1475590	hsa-miR-3664-3p	CLIP-seq
MIRT1475591	hsa-miR-374a	CLIP-seq
MIRT1475592	hsa-miR-374b	CLIP-seq
MIRT1475593	hsa-miR-3913-3p	CLIP-seq
MIRT1475594	hsa-miR-3921	CLIP-seq
MIRT1475595	hsa-miR-3942-3p	CLIP-seq
MIRT1475596	hsa-miR-421	CLIP-seq
MIRT1475597	hsa-miR-4276	CLIP-seq
MIRT1475598	hsa-miR-4282	CLIP-seq
MIRT1475599	hsa-miR-4470	CLIP-seq
MIRT1475600	hsa-miR-4493	CLIP-seq
MIRT1475601	hsa-miR-4518	CLIP-seq
MIRT1475602	hsa-miR-4526	CLIP-seq
MIRT1475603	hsa-miR-4641	CLIP-seq
MIRT1475604	hsa-miR-4653-5p	CLIP-seq
MIRT1475605	hsa-miR-4659a-3p	CLIP-seq
MIRT1475606	hsa-miR-4659b-3p	CLIP-seq
MIRT1475607	hsa-miR-4695-3p	CLIP-seq
MIRT1475608	hsa-miR-4709-5p	CLIP-seq
MIRT1475609	hsa-miR-4714-5p	CLIP-seq
MIRT1475610	hsa-miR-4797-5p	CLIP-seq
MIRT1475611	hsa-miR-489	CLIP-seq
MIRT1475612	hsa-miR-499-3p	CLIP-seq
MIRT1475613	hsa-miR-499a-3p	CLIP-seq
MIRT1475614	hsa-miR-516a-3p	CLIP-seq
MIRT1475615	hsa-miR-548a-5p	CLIP-seq
MIRT1475616	hsa-miR-548ab	CLIP-seq
MIRT1475617	hsa-miR-548ak	CLIP-seq
MIRT1475618	hsa-miR-548b-5p	CLIP-seq
MIRT1475619	hsa-miR-548c-5p	CLIP-seq
MIRT1475620	hsa-miR-548d-5p	CLIP-seq
MIRT1475621	hsa-miR-548h	CLIP-seq
MIRT1475622	hsa-miR-548i	CLIP-seq
MIRT1475623	hsa-miR-548j	CLIP-seq
MIRT1475624	hsa-miR-548n	CLIP-seq
MIRT1475625	hsa-miR-548w	CLIP-seq
MIRT1475626	hsa-miR-548y	CLIP-seq
MIRT1475627	hsa-miR-559	CLIP-seq
MIRT1475628	hsa-miR-628-3p	CLIP-seq
MIRT1475629	hsa-miR-769-5p	CLIP-seq
MIRT1475630	hsa-miR-873	CLIP-seq
MIRT1555343	hsa-miR-3124-3p	CLIP-seq
MIRT1555344	hsa-miR-4422	CLIP-seq
MIRT1555345	hsa-miR-4757-5p	CLIP-seq
MIRT1475579	hsa-miR-1200	CLIP-seq
MIRT2143339	hsa-miR-1252	CLIP-seq
MIRT1475581	hsa-miR-1322	CLIP-seq
MIRT2143340	hsa-miR-3074-5p	CLIP-seq
MIRT2143341	hsa-miR-330-3p	CLIP-seq
MIRT2143342	hsa-miR-3646	CLIP-seq
MIRT2143343	hsa-miR-3929	CLIP-seq
MIRT2143344	hsa-miR-4325	CLIP-seq
MIRT2143345	hsa-miR-4419b	CLIP-seq
MIRT1555344	hsa-miR-4422	CLIP-seq
MIRT2143346	hsa-miR-4438	CLIP-seq
MIRT2143347	hsa-miR-4478	CLIP-seq
MIRT2143348	hsa-miR-4490	CLIP-seq
MIRT2143349	hsa-miR-4666-5p	CLIP-seq
MIRT2143350	hsa-miR-4793-3p	CLIP-seq
MIRT2143351	hsa-miR-548p	CLIP-seq
MIRT2143352	hsa-miR-548u	CLIP-seq
MIRT2143353	hsa-miR-607	CLIP-seq
MIRT2363591	hsa-miR-1290	CLIP-seq
MIRT2363592	hsa-miR-3127-5p	CLIP-seq
MIRT2143341	hsa-miR-330-3p	CLIP-seq
MIRT2363593	hsa-miR-3616-5p	CLIP-seq
MIRT2363594	hsa-miR-3647-5p	CLIP-seq
MIRT2363595	hsa-miR-3655	CLIP-seq
MIRT2363596	hsa-miR-3940-5p	CLIP-seq
MIRT2363597	hsa-miR-4270	CLIP-seq
MIRT2143344	hsa-miR-4325	CLIP-seq
MIRT1555344	hsa-miR-4422	CLIP-seq
MIRT2363598	hsa-miR-4436a	CLIP-seq
MIRT2363599	hsa-miR-4441	CLIP-seq
MIRT2363600	hsa-miR-4474-5p	CLIP-seq
MIRT2363601	hsa-miR-4506	CLIP-seq
MIRT2363602	hsa-miR-4507	CLIP-seq
MIRT1475610	hsa-miR-4797-5p	CLIP-seq
MIRT2363603	hsa-miR-485-3p	CLIP-seq
MIRT2363604	hsa-miR-513a-5p	CLIP-seq
MIRT2363605	hsa-miR-573	CLIP-seq
MIRT2143353	hsa-miR-607	CLIP-seq
MIRT2363606	hsa-miR-653	CLIP-seq
MIRT2143341	hsa-miR-330-3p	CLIP-seq
MIRT2143344	hsa-miR-4325	CLIP-seq
MIRT1555344	hsa-miR-4422	CLIP-seq
MIRT2143353	hsa-miR-607	CLIP-seq
MIRT1475588	hsa-miR-365	CLIP-seq
MIRT2462933	hsa-miR-4290	CLIP-seq
MIRT2462934	hsa-miR-4667-3p	CLIP-seq
MIRT2462935	hsa-miR-4799-5p	CLIP-seq
MIRT1475588	hsa-miR-365	CLIP-seq
MIRT2462933	hsa-miR-4290	CLIP-seq
MIRT2462934	hsa-miR-4667-3p	CLIP-seq
MIRT2462935	hsa-miR-4799-5p	CLIP-seq
MIRT1475588	hsa-miR-365	CLIP-seq
MIRT2462933	hsa-miR-4290	CLIP-seq
MIRT2462934	hsa-miR-4667-3p	CLIP-seq
MIRT2462935	hsa-miR-4799-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005042	Function	Netrin receptor activity	IBA	21873635
GO:0005886	Component	Plasma membrane	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0007411	Process	Axon guidance	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0038007	Process	Netrin-activated signaling pathway	IEA
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IDA	26235030

Other IDs

• MIM: 616466
• HGNC: 18634
• e!Ensembl: ENSG00000156687

Protein

• UniProt ID: Q6UXZ4
• Protein name: Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D)
• Protein function: Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07679	I-set	159 → 249	Immunoglobulin I-set domain	Domain
  PF00090	TSP_1	256 → 306	Thrombospondin type 1 domain	Domain
  PF00090	TSP_1	312 → 359	Thrombospondin type 1 domain	Domain
  PF00791	ZU5	543 → 639	ZU5 domain	Family
  PF17217	UPA	687 → 826	UPA domain	Domain
  PF00531	Death	858 → 936	Death domain	Domain

• Sequence:

  MGRAAATAGGGGGARRWLPWLGLCFWAAGTAAARGTDNGEALPESIPSAPGTLPHFIEEP
  DDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINVTR
  QQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHC
  RPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKR
  RSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKIT
  CTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCI
  LDKKPLHEIKPQSIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSAL
  TGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSD
  IKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRT
  ELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLS
  PEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCL
  LDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAF
  QEVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWC
  SNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDS
  TFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAV
  ILNLWEARHQHDGDLDSLACALEEIGRTHTKLSNISESQLDEADFNYSRQNGL

• Sequence length: 953

Pathways

KEGG:

Axon guidance

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28672053
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Neuropathy	Neuropathy, NEUROPATHY, CONGENITAL HYPOMYELINATING, 2, NEUROPATHY, CONGENITAL HYPOMYELINATING, 3	rs121913593, rs121913595, rs751050956, rs878853221, rs768554986, rs1553259568, rs1567973091, rs1560046845, rs1567969825, rs1567973088, rs756896276	28672053

Unknown
Disease name	Disease term	dbSNP ID	References
Diabetic foot	Diabetic Foot		28672053
Hereditary and idiopathic neuropathy	Hereditary and idiopathic neuropathy, unspecified		28672053