CPT1B (carnitine palmitoyltransferase 1B)

Gene

• Entrez ID: 1375
• Gene name: Carnitine palmitoyltransferase 1B
• Gene symbol: CPT1B
• Synonyms: CPT1-M, CPT1M, CPTI, CPTI-M, M-CPT1, MCCPT1, MCPT1
• Chromosome: 22
• Chromosome location: 22q13.33
• Summary: The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017237	hsa-miR-335-5p	Microarray	18185580
MIRT036268	hsa-miR-1229-3p	CLASH	23622248
MIRT646357	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT646356	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT646355	hsa-miR-3938	HITS-CLIP	23824327
MIRT646353	hsa-miR-8063	HITS-CLIP	23824327
MIRT646354	hsa-miR-4698	HITS-CLIP	23824327
MIRT646352	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT646351	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT646350	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT646349	hsa-miR-623	HITS-CLIP	23824327
MIRT646348	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT646347	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT646346	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT646345	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT646344	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT646343	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT646357	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT646356	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT646355	hsa-miR-3938	HITS-CLIP	23824327
MIRT646353	hsa-miR-8063	HITS-CLIP	23824327
MIRT646354	hsa-miR-4698	HITS-CLIP	23824327
MIRT646352	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT646351	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT646350	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT646349	hsa-miR-623	HITS-CLIP	23824327
MIRT646348	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT646347	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT646346	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT646345	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT646344	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT646343	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT1969085	hsa-miR-1224-3p	CLIP-seq
MIRT1969086	hsa-miR-128	CLIP-seq
MIRT1969087	hsa-miR-3144-5p	CLIP-seq
MIRT1969088	hsa-miR-3151	CLIP-seq
MIRT1969089	hsa-miR-3191	CLIP-seq
MIRT1969090	hsa-miR-370	CLIP-seq
MIRT1969091	hsa-miR-4302	CLIP-seq
MIRT1969092	hsa-miR-4447	CLIP-seq
MIRT1969093	hsa-miR-4472	CLIP-seq
MIRT1969094	hsa-miR-4652-5p	CLIP-seq
MIRT1969095	hsa-miR-4691-5p	CLIP-seq
MIRT1969096	hsa-miR-491-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MEF2C	Activation	15356291
PPARG	Activation	15356291
RXRA	Activation	15356291

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004095	Function	Carnitine O-palmitoyltransferase activity	IBA	21873635
GO:0004095	Function	Carnitine O-palmitoyltransferase activity	IMP	9344464
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005739	Component	Mitochondrion	HDA	20833797
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005739	Component	Mitochondrion	IDA	9344464
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0006631	Process	Fatty acid metabolic process	IBA	21873635
GO:0006635	Process	Fatty acid beta-oxidation	IEA
GO:0006853	Process	Carnitine shuttle	TAS
GO:0009437	Process	Carnitine metabolic process	IBA	21873635
GO:0009637	Process	Response to blue light	ISS
GO:0015909	Process	Long-chain fatty acid transport	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA

Other IDs

• MIM: 601987
• HGNC: 2329
• e!Ensembl: ENSG00000205560

Protein

• UniProt ID: Q92523
• Protein name: Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1-M) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (CPT I) (CPTI-M) (Carnitine palmitoyltransferase 1B) (Carnitine palmitoyltransferase I-like protein)
• Protein function: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. {ECO:0000250|UniP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16484	CPT_N	1 → 47	Carnitine O-palmitoyltransferase N-terminus	Domain
  PF00755	Carn_acyltransf	173 → 762	Choline/Carnitine o-acyltransferase	Family

• Sequence:

  MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPT
  SWLVVIMATVGSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTG
  IFFFRQTLKLLLCYHGWMFEMHGKTSNLTRIWAMCIRLLSSRHPMLYSFQTSLPKLPVPR
  VSATIQRYLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEE
  YIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGNIIHAMIMYRRKLDREEIKPVMALG
  IVPMCSYQMERMFNTTRIPGKDTDVLQHLSDSRHVAVYHKGRFFKLWLYEGARLLKPQDL
  EMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVA
  LDEESYSYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNAEHAWADAPI
  IGHLWEFVLGTDSFHLGYTETGHCLGKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKAL
  ADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREG
  RTETVRSCTSESTAFVQAMMEGSHTKADLRDLFQKAAKKHQNMYRLAMTGAGIDRHLFCL
  YLVSKYLGVSSPFLAEVLSEPWRLSTSQIPQSQIRMFDPEQHPNHLGAGGGFGPVADDGY
  GVSYMIAGENTIFFHISSKFSSSETNAQRFGNHIRKALLDIADLFQVPKAYS

• Sequence length: 772

Pathways

KEGG:

Fatty acid degradation
Fatty acid metabolism
PPAR signaling pathway
Efferocytosis
AMPK signaling pathway
Thermogenesis
Adipocytokine signaling pathway
Glucagon signaling pathway
Insulin resistance
Alcoholic liver disease
Diabetic cardiomyopathy

Reactome:

Carnitine metabolism
Signaling by Retinoic Acid

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Narcolepsy	Narcolepsy	rs104894574, rs387906655	18820697

Unknown
Disease name	Disease term	dbSNP ID	References
Liver neoplasms	Liver neoplasms		25058030
Liver cancer	Malignant neoplasm of liver		25058030
Myocardial ischemia	Myocardial Ischemia		16214533
Narcolepsy-cataplexy syndrome	Narcolepsy-Cataplexy Syndrome		18820697