CLDN7 (claudin 7)

Gene

• Entrez ID: 1366
• Gene name: Claudin 7
• Gene symbol: CLDN7
• Synonyms: CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1
• Chromosome: 17
• Chromosome location: 17p13.1
• Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellula

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017878	hsa-miR-335-5p	Microarray	18185580
MIRT042085	hsa-miR-484	CLASH	23622248
MIRT736372	hsa-miR-1193	Luciferase reporter assay, Western blotting, qRT-PCR	32547067
MIRT895523	hsa-miR-1183	CLIP-seq
MIRT895524	hsa-miR-1289	CLIP-seq
MIRT895525	hsa-miR-223	CLIP-seq
MIRT895526	hsa-miR-3198	CLIP-seq
MIRT895527	hsa-miR-323b-3p	CLIP-seq
MIRT895528	hsa-miR-342-5p	CLIP-seq
MIRT895529	hsa-miR-3545-3p	CLIP-seq
MIRT895530	hsa-miR-4255	CLIP-seq
MIRT895531	hsa-miR-4294	CLIP-seq
MIRT895532	hsa-miR-4309	CLIP-seq
MIRT895533	hsa-miR-4539	CLIP-seq
MIRT895534	hsa-miR-4639-5p	CLIP-seq
MIRT895535	hsa-miR-4651	CLIP-seq
MIRT895536	hsa-miR-4664-5p	CLIP-seq
MIRT895537	hsa-miR-4693-5p	CLIP-seq
MIRT895538	hsa-miR-4697-3p	CLIP-seq
MIRT895539	hsa-miR-556-3p	CLIP-seq
MIRT895540	hsa-miR-595	CLIP-seq
MIRT895541	hsa-miR-608	CLIP-seq
MIRT895523	hsa-miR-1183	CLIP-seq
MIRT895542	hsa-miR-1224-3p	CLIP-seq
MIRT895543	hsa-miR-1260	CLIP-seq
MIRT895544	hsa-miR-1260b	CLIP-seq
MIRT895545	hsa-miR-1280	CLIP-seq
MIRT895546	hsa-miR-150	CLIP-seq
MIRT895547	hsa-miR-2115	CLIP-seq
MIRT895548	hsa-miR-3148	CLIP-seq
MIRT895527	hsa-miR-323b-3p	CLIP-seq
MIRT895549	hsa-miR-3620	CLIP-seq
MIRT895550	hsa-miR-4269	CLIP-seq
MIRT895551	hsa-miR-4287	CLIP-seq
MIRT895552	hsa-miR-4305	CLIP-seq
MIRT895553	hsa-miR-4323	CLIP-seq
MIRT895554	hsa-miR-4469	CLIP-seq
MIRT895555	hsa-miR-4514	CLIP-seq
MIRT895556	hsa-miR-4639-3p	CLIP-seq
MIRT895557	hsa-miR-4668-5p	CLIP-seq
MIRT895558	hsa-miR-4685-3p	CLIP-seq
MIRT895559	hsa-miR-4690-3p	CLIP-seq
MIRT895560	hsa-miR-4692	CLIP-seq
MIRT895537	hsa-miR-4693-5p	CLIP-seq
MIRT895561	hsa-miR-4713-5p	CLIP-seq
MIRT895562	hsa-miR-4742-5p	CLIP-seq
MIRT895563	hsa-miR-516a-3p	CLIP-seq
MIRT895564	hsa-miR-532-3p	CLIP-seq
MIRT895565	hsa-miR-593	CLIP-seq
MIRT895566	hsa-miR-596	CLIP-seq
MIRT895567	hsa-miR-642a	CLIP-seq
MIRT895547	hsa-miR-2115	CLIP-seq
MIRT895548	hsa-miR-3148	CLIP-seq
MIRT1965518	hsa-miR-3179	CLIP-seq
MIRT895527	hsa-miR-323b-3p	CLIP-seq
MIRT895557	hsa-miR-4668-5p	CLIP-seq
MIRT895563	hsa-miR-516a-3p	CLIP-seq
MIRT895539	hsa-miR-556-3p	CLIP-seq
MIRT895566	hsa-miR-596	CLIP-seq
MIRT895535	hsa-miR-4651	CLIP-seq
MIRT895541	hsa-miR-608	CLIP-seq
MIRT895524	hsa-miR-1289	CLIP-seq
MIRT895526	hsa-miR-3198	CLIP-seq
MIRT895528	hsa-miR-342-5p	CLIP-seq
MIRT895530	hsa-miR-4255	CLIP-seq
MIRT895531	hsa-miR-4294	CLIP-seq
MIRT895532	hsa-miR-4309	CLIP-seq
MIRT895534	hsa-miR-4639-5p	CLIP-seq
MIRT895535	hsa-miR-4651	CLIP-seq
MIRT895536	hsa-miR-4664-5p	CLIP-seq
MIRT895538	hsa-miR-4697-3p	CLIP-seq
MIRT895540	hsa-miR-595	CLIP-seq
MIRT895541	hsa-miR-608	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CTBP1	Repression	19277896
ELF3	Unknown	17060315
HDAC1	Activation	19277896
RUNX3	Activation	19706291

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005198	Function	Structural molecule activity	IEA
GO:0005515	Function	Protein binding	IPI	16054130, 20651236, 25416956, 32296183
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	20375010
GO:0005923	Component	Bicellular tight junction	IBA	21873635
GO:0005923	Component	Bicellular tight junction	ISS
GO:0007155	Process	Cell adhesion	IBA	21873635
GO:0007162	Process	Negative regulation of cell adhesion	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016327	Component	Apicolateral plasma membrane	IEA
GO:0016328	Component	Lateral plasma membrane	IEA
GO:0016338	Process	Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISS
GO:0019904	Function	Protein domain specific binding	IEA
GO:0031333	Process	Negative regulation of protein-containing complex assembly	IEA
GO:0042802	Function	Identical protein binding	ISS
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0045471	Process	Response to ethanol	IEA
GO:0050839	Function	Cell adhesion molecule binding	IEA
GO:0070830	Process	Bicellular tight junction assembly	IBA	21873635
GO:2000147	Process	Positive regulation of cell motility	IEA

Other IDs

• MIM: 609131
• HGNC: 2049
• e!Ensembl: ENSG00000181885

Protein

• UniProt ID: O95471
• Protein name: Claudin-7 (CLDN-7)
• Protein function: Plays a major role in tight junction-specific obliteration of the intercellular space.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00822	PMP22_Claudin	4 → 182	PMP-22/EMP/MP20/Claudin family	Family

• Sequence:

  MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
  MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
  GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA
  LLSCSCPGNESKAGYRVPRSYPKSNSSKEYV

• Sequence length: 211

Pathways

KEGG:

Virion - Hepatitis viruses
Cell adhesion molecules
Tight junction
Leukocyte transendothelial migration
Pathogenic Escherichia coli infection
Hepatitis C

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Ovarian epithelial carcinoma	Carcinoma, Ovarian Epithelial		21134740
Prostatic neoplasms	Prostatic Neoplasms		17013881