CLDN3 (claudin 3)

Gene

• Entrez ID: 1365
• Gene name: Claudin 3
• Gene symbol: CLDN3
• Synonyms: C7orf1, CPE-R2, CPETR2, HRVP1, RVP1
• Chromosome: 7
• Chromosome location: 7q11.23
• Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT895355	hsa-miR-1193	CLIP-seq
MIRT895356	hsa-miR-128	CLIP-seq
MIRT895357	hsa-miR-1287	CLIP-seq
MIRT895358	hsa-miR-1293	CLIP-seq
MIRT895359	hsa-miR-1294	CLIP-seq
MIRT895360	hsa-miR-1297	CLIP-seq
MIRT895361	hsa-miR-133a	CLIP-seq
MIRT895362	hsa-miR-133b	CLIP-seq
MIRT895363	hsa-miR-26a	CLIP-seq
MIRT895364	hsa-miR-26b	CLIP-seq
MIRT895365	hsa-miR-27a	CLIP-seq
MIRT895366	hsa-miR-27b	CLIP-seq
MIRT895367	hsa-miR-296-5p	CLIP-seq
MIRT895368	hsa-miR-3119	CLIP-seq
MIRT895369	hsa-miR-3127-3p	CLIP-seq
MIRT895370	hsa-miR-3154	CLIP-seq
MIRT895371	hsa-miR-3193	CLIP-seq
MIRT895372	hsa-miR-323-5p	CLIP-seq
MIRT895373	hsa-miR-3665	CLIP-seq
MIRT895374	hsa-miR-3675-5p	CLIP-seq
MIRT895375	hsa-miR-371b-3p	CLIP-seq
MIRT895376	hsa-miR-4267	CLIP-seq
MIRT895377	hsa-miR-4281	CLIP-seq
MIRT895378	hsa-miR-4283	CLIP-seq
MIRT895379	hsa-miR-4287	CLIP-seq
MIRT895380	hsa-miR-4292	CLIP-seq
MIRT895381	hsa-miR-4308	CLIP-seq
MIRT895382	hsa-miR-4446-3p	CLIP-seq
MIRT895383	hsa-miR-4465	CLIP-seq
MIRT895384	hsa-miR-4466	CLIP-seq
MIRT895385	hsa-miR-4469	CLIP-seq
MIRT895386	hsa-miR-4483	CLIP-seq
MIRT895387	hsa-miR-4488	CLIP-seq
MIRT895388	hsa-miR-4489	CLIP-seq
MIRT895389	hsa-miR-455-3p	CLIP-seq
MIRT895390	hsa-miR-4651	CLIP-seq
MIRT895391	hsa-miR-4685-3p	CLIP-seq
MIRT895392	hsa-miR-4685-5p	CLIP-seq
MIRT895393	hsa-miR-4694-5p	CLIP-seq
MIRT895394	hsa-miR-4697-5p	CLIP-seq
MIRT895395	hsa-miR-4708-3p	CLIP-seq
MIRT895396	hsa-miR-4710	CLIP-seq
MIRT895397	hsa-miR-4730	CLIP-seq
MIRT895398	hsa-miR-4738-5p	CLIP-seq
MIRT895399	hsa-miR-4746-5p	CLIP-seq
MIRT895400	hsa-miR-4749-3p	CLIP-seq
MIRT895401	hsa-miR-4783-5p	CLIP-seq
MIRT895402	hsa-miR-486-3p	CLIP-seq
MIRT895403	hsa-miR-513a-5p	CLIP-seq
MIRT895404	hsa-miR-541	CLIP-seq
MIRT895405	hsa-miR-548ad	CLIP-seq
MIRT895406	hsa-miR-548q	CLIP-seq
MIRT895407	hsa-miR-608	CLIP-seq
MIRT895408	hsa-miR-615-5p	CLIP-seq
MIRT895409	hsa-miR-654-5p	CLIP-seq
MIRT895410	hsa-miR-657	CLIP-seq
MIRT895411	hsa-miR-675	CLIP-seq
MIRT895412	hsa-miR-766	CLIP-seq
MIRT895413	hsa-miR-876-3p	CLIP-seq
MIRT895414	hsa-miR-885-3p	CLIP-seq
MIRT895372	hsa-miR-323-5p	CLIP-seq
MIRT895355	hsa-miR-1193	CLIP-seq
MIRT895356	hsa-miR-128	CLIP-seq
MIRT895357	hsa-miR-1287	CLIP-seq
MIRT895358	hsa-miR-1293	CLIP-seq
MIRT895359	hsa-miR-1294	CLIP-seq
MIRT895360	hsa-miR-1297	CLIP-seq
MIRT895361	hsa-miR-133a	CLIP-seq
MIRT895362	hsa-miR-133b	CLIP-seq
MIRT1965487	hsa-miR-2110	CLIP-seq
MIRT895363	hsa-miR-26a	CLIP-seq
MIRT895364	hsa-miR-26b	CLIP-seq
MIRT895365	hsa-miR-27a	CLIP-seq
MIRT895366	hsa-miR-27b	CLIP-seq
MIRT895367	hsa-miR-296-5p	CLIP-seq
MIRT895369	hsa-miR-3127-3p	CLIP-seq
MIRT895370	hsa-miR-3154	CLIP-seq
MIRT895371	hsa-miR-3193	CLIP-seq
MIRT895372	hsa-miR-323-5p	CLIP-seq
MIRT895373	hsa-miR-3665	CLIP-seq
MIRT895374	hsa-miR-3675-5p	CLIP-seq
MIRT895375	hsa-miR-371b-3p	CLIP-seq
MIRT895376	hsa-miR-4267	CLIP-seq
MIRT1965488	hsa-miR-4271	CLIP-seq
MIRT895377	hsa-miR-4281	CLIP-seq
MIRT895378	hsa-miR-4283	CLIP-seq
MIRT895379	hsa-miR-4287	CLIP-seq
MIRT895380	hsa-miR-4292	CLIP-seq
MIRT895381	hsa-miR-4308	CLIP-seq
MIRT895382	hsa-miR-4446-3p	CLIP-seq
MIRT895383	hsa-miR-4465	CLIP-seq
MIRT895384	hsa-miR-4466	CLIP-seq
MIRT895385	hsa-miR-4469	CLIP-seq
MIRT895386	hsa-miR-4483	CLIP-seq
MIRT895387	hsa-miR-4488	CLIP-seq
MIRT895388	hsa-miR-4489	CLIP-seq
MIRT895389	hsa-miR-455-3p	CLIP-seq
MIRT895390	hsa-miR-4651	CLIP-seq
MIRT1965489	hsa-miR-4667-5p	CLIP-seq
MIRT895391	hsa-miR-4685-3p	CLIP-seq
MIRT895392	hsa-miR-4685-5p	CLIP-seq
MIRT895393	hsa-miR-4694-5p	CLIP-seq
MIRT895394	hsa-miR-4697-5p	CLIP-seq
MIRT1965490	hsa-miR-4700-5p	CLIP-seq
MIRT895396	hsa-miR-4710	CLIP-seq
MIRT1965491	hsa-miR-4725-3p	CLIP-seq
MIRT1965492	hsa-miR-4731-5p	CLIP-seq
MIRT895398	hsa-miR-4738-5p	CLIP-seq
MIRT895399	hsa-miR-4746-5p	CLIP-seq
MIRT895400	hsa-miR-4749-3p	CLIP-seq
MIRT895401	hsa-miR-4783-5p	CLIP-seq
MIRT895402	hsa-miR-486-3p	CLIP-seq
MIRT895403	hsa-miR-513a-5p	CLIP-seq
MIRT895406	hsa-miR-548q	CLIP-seq
MIRT1965493	hsa-miR-604	CLIP-seq
MIRT895407	hsa-miR-608	CLIP-seq
MIRT895408	hsa-miR-615-5p	CLIP-seq
MIRT1965494	hsa-miR-647	CLIP-seq
MIRT895410	hsa-miR-657	CLIP-seq
MIRT895411	hsa-miR-675	CLIP-seq
MIRT895412	hsa-miR-766	CLIP-seq
MIRT895413	hsa-miR-876-3p	CLIP-seq
MIRT895414	hsa-miR-885-3p	CLIP-seq
MIRT895356	hsa-miR-128	CLIP-seq
MIRT895359	hsa-miR-1294	CLIP-seq
MIRT895360	hsa-miR-1297	CLIP-seq
MIRT895361	hsa-miR-133a	CLIP-seq
MIRT895362	hsa-miR-133b	CLIP-seq
MIRT2201437	hsa-miR-1343	CLIP-seq
MIRT2201438	hsa-miR-1587	CLIP-seq
MIRT895363	hsa-miR-26a	CLIP-seq
MIRT895364	hsa-miR-26b	CLIP-seq
MIRT895365	hsa-miR-27a	CLIP-seq
MIRT895366	hsa-miR-27b	CLIP-seq
MIRT895367	hsa-miR-296-5p	CLIP-seq
MIRT895370	hsa-miR-3154	CLIP-seq
MIRT895373	hsa-miR-3665	CLIP-seq
MIRT895377	hsa-miR-4281	CLIP-seq
MIRT895380	hsa-miR-4292	CLIP-seq
MIRT895381	hsa-miR-4308	CLIP-seq
MIRT2201439	hsa-miR-4314	CLIP-seq
MIRT2201440	hsa-miR-4417	CLIP-seq
MIRT895383	hsa-miR-4465	CLIP-seq
MIRT2201441	hsa-miR-4492	CLIP-seq
MIRT2201442	hsa-miR-4498	CLIP-seq
MIRT895389	hsa-miR-455-3p	CLIP-seq
MIRT895390	hsa-miR-4651	CLIP-seq
MIRT2201443	hsa-miR-4656	CLIP-seq
MIRT1965489	hsa-miR-4667-5p	CLIP-seq
MIRT2201444	hsa-miR-4675	CLIP-seq
MIRT1965490	hsa-miR-4700-5p	CLIP-seq
MIRT895396	hsa-miR-4710	CLIP-seq
MIRT895397	hsa-miR-4730	CLIP-seq
MIRT2201445	hsa-miR-4741	CLIP-seq
MIRT895403	hsa-miR-513a-5p	CLIP-seq
MIRT2201446	hsa-miR-516a-3p	CLIP-seq
MIRT895404	hsa-miR-541	CLIP-seq
MIRT895407	hsa-miR-608	CLIP-seq
MIRT2201447	hsa-miR-637	CLIP-seq
MIRT895409	hsa-miR-654-5p	CLIP-seq
MIRT895410	hsa-miR-657	CLIP-seq
MIRT2201448	hsa-miR-762	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SNAI1	Repression	19874710
SP1	Activation	17986852

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001666	Process	Response to hypoxia	IEP	15174142
GO:0001934	Process	Positive regulation of protein phosphorylation	IMP	27593915
GO:0003382	Process	Epithelial cell morphogenesis	ISS
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	9334247
GO:0005198	Function	Structural molecule activity	IEA
GO:0005515	Function	Protein binding	IPI	25849148
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	TAS	9334247
GO:0005911	Component	Cell-cell junction	IDA	18774778
GO:0005923	Component	Bicellular tight junction	IBA	21873635
GO:0005923	Component	Bicellular tight junction	IDA	25849148
GO:0005923	Component	Bicellular tight junction	ISS
GO:0007155	Process	Cell adhesion	IBA	21873635
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	27593915
GO:0010628	Process	Positive regulation of gene expression	IMP	27593915
GO:0010629	Process	Negative regulation of gene expression	IMP	27593915
GO:0014045	Process	Establishment of endothelial blood-brain barrier	ISS
GO:0016021	Component	Integral component of membrane	TAS	9441748
GO:0016327	Component	Apicolateral plasma membrane	IEA
GO:0016328	Component	Lateral plasma membrane	IEA
GO:0016338	Process	Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	IEA
GO:0022604	Process	Regulation of cell morphogenesis	IMP	16103090
GO:0030335	Process	Positive regulation of cell migration	IMP	16103090
GO:0030336	Process	Negative regulation of cell migration	IMP	27593915
GO:0031532	Process	Actin cytoskeleton reorganization	IMP	27593915
GO:0032991	Component	Protein-containing complex	IDA	25849148
GO:0034331	Process	Cell junction maintenance	ISS
GO:0035633	Process	Maintenance of blood-brain barrier	NAS	30280653
GO:0042802	Function	Identical protein binding	IPI	25849148
GO:0043296	Component	Apical junction complex	IMP	27593915
GO:0045471	Process	Response to ethanol	IEA
GO:0061045	Process	Negative regulation of wound healing	IMP	27593915
GO:0070160	Component	Tight junction	IDA	30734065
GO:0070160	Component	Tight junction	IMP	20655293
GO:0070830	Process	Bicellular tight junction assembly	IBA	21873635
GO:0070830	Process	Bicellular tight junction assembly	IMP	25849148
GO:0090303	Process	Positive regulation of wound healing	IMP	16103090
GO:0090559	Process	Regulation of membrane permeability	IMP	20655293
GO:0150111	Process	Regulation of transepithelial transport	IMP	27593915
GO:1901890	Process	Positive regulation of cell junction assembly	IMP	27593915
GO:1903348	Process	Positive regulation of bicellular tight junction assembly	IMP	20655293
GO:1905050	Process	Positive regulation of metallopeptidase activity	IMP	16103090

Other IDs

• MIM: 602910
• HGNC: 2045
• e!Ensembl: ENSG00000165215

Protein

• UniProt ID: O15551
• Protein name: Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE-R 2) (CPE-receptor 2) (Rat ventral prostate.1 protein homolog) (hRVP1)
• Protein function: Barrier-forming claudin. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00822	PMP22_Claudin	3 → 180	PMP-22/EMP/MP20/Claudin family	Family

• Sequence:

  MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQ
  MQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVA
  GVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALL
  CCSCPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYV

• Sequence length: 220

Pathways

KEGG:

Virion - Hepatitis viruses
Cell adhesion molecules
Tight junction
Leukocyte transendothelial migration
Pathogenic Escherichia coli infection
Hepatitis C

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	16367923
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		16367923