CPB2 (carboxypeptidase B2)

Gene

• Entrez ID: 1361
• Gene name: Carboxypeptidase B2
• Gene symbol: CPB2
• Synonyms: CPU, PCPB, TAFI
• Chromosome: 13
• Chromosome location: 13q14.13
• Summary: Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cl

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029527	hsa-miR-26b-5p	Microarray	19088304
MIRT905703	hsa-miR-3647-3p	CLIP-seq
MIRT905704	hsa-miR-3682-5p	CLIP-seq
MIRT905705	hsa-miR-4256	CLIP-seq
MIRT905706	hsa-miR-4282	CLIP-seq
MIRT905707	hsa-miR-4468	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003331	Process	Positive regulation of extracellular matrix constituent secretion	IEA
GO:0004181	Function	Metallocarboxypeptidase activity	IBA	21873635
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006508	Process	Proteolysis	IBA	21873635
GO:0007596	Process	Blood coagulation	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009408	Process	Response to heat	IEA
GO:0010757	Process	Negative regulation of plasminogen activation	IEA
GO:0030449	Process	Regulation of complement activation	TAS
GO:0042493	Process	Response to drug	IEA
GO:0042730	Process	Fibrinolysis	IBA	21873635
GO:0051918	Process	Negative regulation of fibrinolysis	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0071333	Process	Cellular response to glucose stimulus	IEA
GO:0097421	Process	Liver regeneration	IEA
GO:2000346	Process	Negative regulation of hepatocyte proliferation	IEA

Other IDs

• MIM: 603101
• HGNC: 2300
• e!Ensembl: ENSG00000080618

Protein

• UniProt ID: Q96IY4
• Protein name: Carboxypeptidase B2 (EC 3.4.17.20) (Carboxypeptidase U) (CPU) (Plasma carboxypeptidase B) (pCPB) (Thrombin-activable fibrinolysis inhibitor) (TAFI)
• Protein function: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fib
• PDB: 3D66, 3D67, 3D68, 3LMS, 4P10, 5HVF, 5HVG, 5HVH, 7NEE, 7NEU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02244	Propep_M14	30 → 105	Carboxypeptidase activation peptide	Domain
  PF00246	Peptidase_M14	129 → 411	Zinc carboxypeptidase	Domain

• Sequence:

  MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
  LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
  EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
  HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
  NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
  NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
  TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
  RNV

• Sequence length: 423

Pathways

KEGG:

Complement and coagulation cascades
Pancreatic secretion
Protein digestion and absorption

Reactome:

Metabolism of Angiotensinogen to Angiotensins
Regulation of Complement cascade

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	16959692