B3GAT2 (beta-1,3-glucuronyltransferase 2)

Gene

• Entrez ID: 135152
• Gene name: Beta-1,3-glucuronyltransferase 2
• Gene symbol: B3GAT2
• Synonyms: GLCATS
• Chromosome: 6
• Chromosome location: 6q13
• Summary: The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4G

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT539000	hsa-miR-4310	PAR-CLIP	22012620
MIRT538999	hsa-miR-7157-5p	PAR-CLIP	22012620
MIRT538998	hsa-miR-4530	PAR-CLIP	22012620
MIRT538997	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT538996	hsa-miR-766-3p	PAR-CLIP	22012620
MIRT538994	hsa-miR-4326	PAR-CLIP	22012620
MIRT538995	hsa-miR-4691-5p	PAR-CLIP	22012620
MIRT538993	hsa-miR-6792-3p	PAR-CLIP	22012620
MIRT538992	hsa-miR-6749-3p	PAR-CLIP	22012620
MIRT539000	hsa-miR-4310	PAR-CLIP	22012620
MIRT538999	hsa-miR-7157-5p	PAR-CLIP	22012620
MIRT538998	hsa-miR-4530	PAR-CLIP	22012620
MIRT538997	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT538996	hsa-miR-766-3p	PAR-CLIP	22012620
MIRT538994	hsa-miR-4326	PAR-CLIP	22012620
MIRT538995	hsa-miR-4691-5p	PAR-CLIP	22012620
MIRT538993	hsa-miR-6792-3p	PAR-CLIP	22012620
MIRT538992	hsa-miR-6749-3p	PAR-CLIP	22012620
MIRT813139	hsa-miR-298	CLIP-seq
MIRT813140	hsa-miR-3123	CLIP-seq
MIRT813141	hsa-miR-3613-5p	CLIP-seq
MIRT813142	hsa-miR-3674	CLIP-seq
MIRT813143	hsa-miR-3925-5p	CLIP-seq
MIRT813144	hsa-miR-4732-5p	CLIP-seq
MIRT813145	hsa-miR-570	CLIP-seq
MIRT2444558	hsa-miR-1245b-3p	CLIP-seq
MIRT2444559	hsa-miR-136	CLIP-seq
MIRT2444560	hsa-miR-2964a-5p	CLIP-seq
MIRT2444561	hsa-miR-4718	CLIP-seq
MIRT2444558	hsa-miR-1245b-3p	CLIP-seq
MIRT2444559	hsa-miR-136	CLIP-seq
MIRT2444560	hsa-miR-2964a-5p	CLIP-seq
MIRT2482860	hsa-miR-3137	CLIP-seq
MIRT2482861	hsa-miR-3140-5p	CLIP-seq
MIRT2482862	hsa-miR-3194-3p	CLIP-seq
MIRT2444561	hsa-miR-4718	CLIP-seq
MIRT2482863	hsa-miR-4724-5p	CLIP-seq
MIRT2482864	hsa-miR-495	CLIP-seq
MIRT2444558	hsa-miR-1245b-3p	CLIP-seq
MIRT2444559	hsa-miR-136	CLIP-seq
MIRT2444560	hsa-miR-2964a-5p	CLIP-seq
MIRT2482860	hsa-miR-3137	CLIP-seq
MIRT2482861	hsa-miR-3140-5p	CLIP-seq
MIRT2482862	hsa-miR-3194-3p	CLIP-seq
MIRT2444561	hsa-miR-4718	CLIP-seq
MIRT2482863	hsa-miR-4724-5p	CLIP-seq
MIRT2482864	hsa-miR-495	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA	21873635
GO:0000139	Component	Golgi membrane	TAS
GO:0005975	Process	Carbohydrate metabolic process	IBA	21873635
GO:0006486	Process	Protein glycosylation	IEA
GO:0015018	Function	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA	21873635
GO:0015018	Function	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	ISS
GO:0016021	Component	Integral component of membrane	IEA
GO:0030203	Process	Glycosaminoglycan metabolic process	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IBA	21873635

Other IDs

• MIM: 607497
• HGNC: 922
• e!Ensembl: ENSG00000112309

Protein

• UniProt ID: Q9NPZ5
• Protein name: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 2) (GlcAT-D) (UDP-glucuronosyltransferase S) (GlcAT-S) (Glucuronosyltransferase S)
• Protein function: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins.
• PDB: 2D0J
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03360	Glyco_transf_43	101 → 304	Glycosyltransferase family 43	Family

• Sequence:

  MKSALFTRFFILLPWILIVIIMLDVDTRRPVPPLTPRPYFSPYAVGRGGARLPLRRGGPA
  HGTQKRNQSRPQPQPEPQLPTIYAITPTYSRPVQKAELTRLANTFRQVAQLHWILVEDAA
  ARSELVSRFLARAGLPSTHLHVPTPRRYKRPGLPRATEQRNAGLAWLRQRHQHQRAQPGV
  LFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRYERPLVENGKVVGWYTGWRADRPF
  AIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESDFLKQITTVEELEPKANNCTKVLVWH
  TRTEKVNLANEPKYHLDTVKIEV

• Sequence length: 323

Pathways

KEGG:

Mannose type O-glycan biosynthesis
Metabolic pathways

Reactome:

A tetrasaccharide linker sequence is required for GAG synthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	20950796