NCOA7 (nuclear receptor coactivator 7)

Gene

• Entrez ID: 135112
• Gene name: Nuclear receptor coactivator 7
• Gene symbol: NCOA7
• Synonyms: ERAP140, ESNA1, NCOA7-AS, Nbla00052, Nbla10993, TLDC4, dJ187J11.3
• Chromosome: 6
• Chromosome location: 6q22.31-q22.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020066	hsa-miR-375	Microarray	20215506
MIRT543954	hsa-miR-543	PAR-CLIP	21572407
MIRT543953	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT543952	hsa-miR-181a-5p	PAR-CLIP	21572407
MIRT543951	hsa-miR-181b-5p	PAR-CLIP	21572407
MIRT543950	hsa-miR-181c-5p	PAR-CLIP	21572407
MIRT543949	hsa-miR-181d-5p	PAR-CLIP	21572407
MIRT543948	hsa-miR-4262	PAR-CLIP	21572407
MIRT543947	hsa-miR-5680	PAR-CLIP	21572407
MIRT543946	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT543945	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT543944	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT543943	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT543942	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT543941	hsa-let-7f-2-3p	PAR-CLIP	21572407
MIRT543940	hsa-miR-1185-1-3p	PAR-CLIP	21572407
MIRT543939	hsa-miR-1185-2-3p	PAR-CLIP	21572407
MIRT543954	hsa-miR-543	PAR-CLIP	21572407
MIRT543953	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT543952	hsa-miR-181a-5p	PAR-CLIP	21572407
MIRT543951	hsa-miR-181b-5p	PAR-CLIP	21572407
MIRT543950	hsa-miR-181c-5p	PAR-CLIP	21572407
MIRT543949	hsa-miR-181d-5p	PAR-CLIP	21572407
MIRT543948	hsa-miR-4262	PAR-CLIP	21572407
MIRT543947	hsa-miR-5680	PAR-CLIP	21572407
MIRT543946	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT543945	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT543944	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT543943	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT543942	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT543941	hsa-let-7f-2-3p	PAR-CLIP	21572407
MIRT543940	hsa-miR-1185-1-3p	PAR-CLIP	21572407
MIRT543939	hsa-miR-1185-2-3p	PAR-CLIP	21572407
MIRT1177354	hsa-miR-124	CLIP-seq
MIRT1177355	hsa-miR-128	CLIP-seq
MIRT1177356	hsa-miR-200b	CLIP-seq
MIRT1177357	hsa-miR-200c	CLIP-seq
MIRT1177358	hsa-miR-204	CLIP-seq
MIRT1177359	hsa-miR-208a	CLIP-seq
MIRT1177360	hsa-miR-208b	CLIP-seq
MIRT1177361	hsa-miR-211	CLIP-seq
MIRT1177362	hsa-miR-2681	CLIP-seq
MIRT1177363	hsa-miR-27a	CLIP-seq
MIRT1177364	hsa-miR-27b	CLIP-seq
MIRT1177365	hsa-miR-298	CLIP-seq
MIRT1177366	hsa-miR-300	CLIP-seq
MIRT1177367	hsa-miR-3123	CLIP-seq
MIRT1177368	hsa-miR-3133	CLIP-seq
MIRT1177369	hsa-miR-3148	CLIP-seq
MIRT1177370	hsa-miR-3186-5p	CLIP-seq
MIRT1177371	hsa-miR-3617	CLIP-seq
MIRT1177372	hsa-miR-3658	CLIP-seq
MIRT1177373	hsa-miR-376c	CLIP-seq
MIRT1177374	hsa-miR-381	CLIP-seq
MIRT1177375	hsa-miR-3925-5p	CLIP-seq
MIRT1177376	hsa-miR-3976	CLIP-seq
MIRT1177377	hsa-miR-3978	CLIP-seq
MIRT1177378	hsa-miR-4271	CLIP-seq
MIRT1177379	hsa-miR-429	CLIP-seq
MIRT1177380	hsa-miR-4427	CLIP-seq
MIRT1177381	hsa-miR-4453	CLIP-seq
MIRT1177382	hsa-miR-4464	CLIP-seq
MIRT1177383	hsa-miR-4495	CLIP-seq
MIRT1177384	hsa-miR-452	CLIP-seq
MIRT1177385	hsa-miR-4538	CLIP-seq
MIRT1177386	hsa-miR-4666-3p	CLIP-seq
MIRT1177387	hsa-miR-4676-3p	CLIP-seq
MIRT1177388	hsa-miR-4680-3p	CLIP-seq
MIRT1177389	hsa-miR-4708-3p	CLIP-seq
MIRT1177390	hsa-miR-4725-3p	CLIP-seq
MIRT1177391	hsa-miR-4748	CLIP-seq
MIRT1177392	hsa-miR-4762-3p	CLIP-seq
MIRT1177393	hsa-miR-4790-3p	CLIP-seq
MIRT1177394	hsa-miR-499-5p	CLIP-seq
MIRT1177395	hsa-miR-506	CLIP-seq
MIRT1177396	hsa-miR-5096	CLIP-seq
MIRT1177397	hsa-miR-513a-5p	CLIP-seq
MIRT1177398	hsa-miR-520d-5p	CLIP-seq
MIRT1177399	hsa-miR-524-5p	CLIP-seq
MIRT1177400	hsa-miR-548c-3p	CLIP-seq
MIRT1177401	hsa-miR-569	CLIP-seq
MIRT1177402	hsa-miR-583	CLIP-seq
MIRT1177403	hsa-miR-641	CLIP-seq
MIRT1177404	hsa-miR-873	CLIP-seq
MIRT1177405	hsa-miR-935	CLIP-seq
MIRT1177406	hsa-miR-1273f	CLIP-seq
MIRT1177355	hsa-miR-128	CLIP-seq
MIRT1177407	hsa-miR-23a	CLIP-seq
MIRT1177408	hsa-miR-23b	CLIP-seq
MIRT1177409	hsa-miR-23c	CLIP-seq
MIRT1177363	hsa-miR-27a	CLIP-seq
MIRT1177364	hsa-miR-27b	CLIP-seq
MIRT1177410	hsa-miR-3132	CLIP-seq
MIRT1177411	hsa-miR-3170	CLIP-seq
MIRT1177370	hsa-miR-3186-5p	CLIP-seq
MIRT1177412	hsa-miR-3652	CLIP-seq
MIRT1177413	hsa-miR-411	CLIP-seq
MIRT1177414	hsa-miR-4430	CLIP-seq
MIRT1177382	hsa-miR-4464	CLIP-seq
MIRT1177415	hsa-miR-4470	CLIP-seq
MIRT1177416	hsa-miR-4505	CLIP-seq
MIRT1177417	hsa-miR-4717-3p	CLIP-seq
MIRT1177418	hsa-miR-4718	CLIP-seq
MIRT1177391	hsa-miR-4748	CLIP-seq
MIRT1177396	hsa-miR-5096	CLIP-seq
MIRT1177400	hsa-miR-548c-3p	CLIP-seq
MIRT1177404	hsa-miR-873	CLIP-seq
MIRT1177354	hsa-miR-124	CLIP-seq
MIRT2051331	hsa-miR-1264	CLIP-seq
MIRT2051332	hsa-miR-3647-3p	CLIP-seq
MIRT1177395	hsa-miR-506	CLIP-seq
MIRT2051333	hsa-miR-9	CLIP-seq
MIRT2051334	hsa-miR-1283	CLIP-seq
MIRT2051335	hsa-miR-1324	CLIP-seq
MIRT1177356	hsa-miR-200b	CLIP-seq
MIRT1177357	hsa-miR-200c	CLIP-seq
MIRT1177407	hsa-miR-23a	CLIP-seq
MIRT1177408	hsa-miR-23b	CLIP-seq
MIRT1177409	hsa-miR-23c	CLIP-seq
MIRT2051336	hsa-miR-24	CLIP-seq
MIRT1177410	hsa-miR-3132	CLIP-seq
MIRT1177370	hsa-miR-3186-5p	CLIP-seq
MIRT2051337	hsa-miR-338-5p	CLIP-seq
MIRT1177412	hsa-miR-3652	CLIP-seq
MIRT2051338	hsa-miR-374a	CLIP-seq
MIRT2051339	hsa-miR-374b	CLIP-seq
MIRT2051340	hsa-miR-377	CLIP-seq
MIRT2051341	hsa-miR-3942-3p	CLIP-seq
MIRT2051342	hsa-miR-4284	CLIP-seq
MIRT1177379	hsa-miR-429	CLIP-seq
MIRT1177380	hsa-miR-4427	CLIP-seq
MIRT1177414	hsa-miR-4430	CLIP-seq
MIRT1177416	hsa-miR-4505	CLIP-seq
MIRT1177388	hsa-miR-4680-3p	CLIP-seq
MIRT1177417	hsa-miR-4717-3p	CLIP-seq
MIRT2051343	hsa-miR-4740-3p	CLIP-seq
MIRT1177392	hsa-miR-4762-3p	CLIP-seq
MIRT1177393	hsa-miR-4790-3p	CLIP-seq
MIRT2051344	hsa-miR-564	CLIP-seq
MIRT2051345	hsa-miR-642b	CLIP-seq
MIRT1177355	hsa-miR-128	CLIP-seq
MIRT1177363	hsa-miR-27a	CLIP-seq
MIRT1177364	hsa-miR-27b	CLIP-seq
MIRT1177396	hsa-miR-5096	CLIP-seq
MIRT2280459	hsa-miR-1275	CLIP-seq
MIRT2280460	hsa-miR-146a	CLIP-seq
MIRT2280461	hsa-miR-146b-5p	CLIP-seq
MIRT1177407	hsa-miR-23a	CLIP-seq
MIRT1177408	hsa-miR-23b	CLIP-seq
MIRT1177409	hsa-miR-23c	CLIP-seq
MIRT2051336	hsa-miR-24	CLIP-seq
MIRT1177362	hsa-miR-2681	CLIP-seq
MIRT1177365	hsa-miR-298	CLIP-seq
MIRT1177410	hsa-miR-3132	CLIP-seq
MIRT1177370	hsa-miR-3186-5p	CLIP-seq
MIRT1177412	hsa-miR-3652	CLIP-seq
MIRT2051342	hsa-miR-4284	CLIP-seq
MIRT1177414	hsa-miR-4430	CLIP-seq
MIRT1177416	hsa-miR-4505	CLIP-seq
MIRT2280462	hsa-miR-4525	CLIP-seq
MIRT2280463	hsa-miR-4665-5p	CLIP-seq
MIRT1177417	hsa-miR-4717-3p	CLIP-seq
MIRT2280464	hsa-miR-4723-5p	CLIP-seq
MIRT2280465	hsa-miR-4773	CLIP-seq
MIRT2280466	hsa-miR-589	CLIP-seq
MIRT2280467	hsa-miR-625	CLIP-seq
MIRT2280459	hsa-miR-1275	CLIP-seq
MIRT2280460	hsa-miR-146a	CLIP-seq
MIRT2280461	hsa-miR-146b-5p	CLIP-seq
MIRT2454960	hsa-miR-2115	CLIP-seq
MIRT1177362	hsa-miR-2681	CLIP-seq
MIRT2280462	hsa-miR-4525	CLIP-seq
MIRT2280463	hsa-miR-4665-5p	CLIP-seq
MIRT2280464	hsa-miR-4723-5p	CLIP-seq
MIRT2280465	hsa-miR-4773	CLIP-seq
MIRT2280466	hsa-miR-589	CLIP-seq
MIRT2280467	hsa-miR-625	CLIP-seq
MIRT2051333	hsa-miR-9	CLIP-seq
MIRT2051345	hsa-miR-642b	CLIP-seq
MIRT2051333	hsa-miR-9	CLIP-seq
MIRT2578894	hsa-miR-4728-3p	CLIP-seq
MIRT2051333	hsa-miR-9	CLIP-seq
MIRT2685936	hsa-miR-1179	CLIP-seq
MIRT2685937	hsa-miR-1228	CLIP-seq
MIRT2051331	hsa-miR-1264	CLIP-seq
MIRT2685938	hsa-miR-1278	CLIP-seq
MIRT2685939	hsa-miR-18a	CLIP-seq
MIRT2685940	hsa-miR-18b	CLIP-seq
MIRT2685941	hsa-miR-190	CLIP-seq
MIRT2685942	hsa-miR-190b	CLIP-seq
MIRT2685943	hsa-miR-203	CLIP-seq
MIRT1177358	hsa-miR-204	CLIP-seq
MIRT1177359	hsa-miR-208a	CLIP-seq
MIRT1177360	hsa-miR-208b	CLIP-seq
MIRT1177361	hsa-miR-211	CLIP-seq
MIRT2685944	hsa-miR-2114	CLIP-seq
MIRT2454960	hsa-miR-2115	CLIP-seq
MIRT2685945	hsa-miR-2117	CLIP-seq
MIRT2051336	hsa-miR-24	CLIP-seq
MIRT2685946	hsa-miR-2964a-3p	CLIP-seq
MIRT2685947	hsa-miR-302f	CLIP-seq
MIRT2685948	hsa-miR-3119	CLIP-seq
MIRT2685949	hsa-miR-3121-3p	CLIP-seq
MIRT2685950	hsa-miR-3140-3p	CLIP-seq
MIRT2685951	hsa-miR-3173-3p	CLIP-seq
MIRT2685952	hsa-miR-335	CLIP-seq
MIRT1177371	hsa-miR-3617	CLIP-seq
MIRT2685953	hsa-miR-3654	CLIP-seq
MIRT1177372	hsa-miR-3658	CLIP-seq
MIRT2685954	hsa-miR-3660	CLIP-seq
MIRT2685955	hsa-miR-3685	CLIP-seq
MIRT2685956	hsa-miR-369-3p	CLIP-seq
MIRT2051338	hsa-miR-374a	CLIP-seq
MIRT2051339	hsa-miR-374b	CLIP-seq
MIRT2685957	hsa-miR-380	CLIP-seq
MIRT2685958	hsa-miR-384	CLIP-seq
MIRT2685959	hsa-miR-4252	CLIP-seq
MIRT2685960	hsa-miR-4263	CLIP-seq
MIRT2685961	hsa-miR-4273	CLIP-seq
MIRT2685962	hsa-miR-4274	CLIP-seq
MIRT2685963	hsa-miR-4282	CLIP-seq
MIRT2051342	hsa-miR-4284	CLIP-seq
MIRT2685964	hsa-miR-4428	CLIP-seq
MIRT2685965	hsa-miR-4459	CLIP-seq
MIRT2685966	hsa-miR-4477b	CLIP-seq
MIRT2685967	hsa-miR-4490	CLIP-seq
MIRT1177383	hsa-miR-4495	CLIP-seq
MIRT2685968	hsa-miR-451b	CLIP-seq
MIRT2685969	hsa-miR-4526	CLIP-seq
MIRT2685970	hsa-miR-4638-3p	CLIP-seq
MIRT2685971	hsa-miR-4654	CLIP-seq
MIRT2685972	hsa-miR-4661-5p	CLIP-seq
MIRT2685973	hsa-miR-4677-5p	CLIP-seq
MIRT2685974	hsa-miR-4695-5p	CLIP-seq
MIRT2685975	hsa-miR-4698	CLIP-seq
MIRT2685976	hsa-miR-4717-5p	CLIP-seq
MIRT2685977	hsa-miR-4719	CLIP-seq
MIRT2578894	hsa-miR-4728-3p	CLIP-seq
MIRT2685978	hsa-miR-4729	CLIP-seq
MIRT2685979	hsa-miR-4735-3p	CLIP-seq
MIRT2685980	hsa-miR-4738-3p	CLIP-seq
MIRT2051343	hsa-miR-4740-3p	CLIP-seq
MIRT2685981	hsa-miR-4753-3p	CLIP-seq
MIRT2685982	hsa-miR-4769-5p	CLIP-seq
MIRT2685983	hsa-miR-4774-5p	CLIP-seq
MIRT2685984	hsa-miR-4795-3p	CLIP-seq
MIRT1177394	hsa-miR-499-5p	CLIP-seq
MIRT2685985	hsa-miR-513a-3p	CLIP-seq
MIRT2685986	hsa-miR-513b	CLIP-seq
MIRT2685987	hsa-miR-548n	CLIP-seq
MIRT2685988	hsa-miR-548t	CLIP-seq
MIRT2685989	hsa-miR-548v	CLIP-seq
MIRT2051344	hsa-miR-564	CLIP-seq
MIRT1177401	hsa-miR-569	CLIP-seq
MIRT2685990	hsa-miR-579	CLIP-seq
MIRT2685991	hsa-miR-590-3p	CLIP-seq
MIRT2685992	hsa-miR-630	CLIP-seq
MIRT1177403	hsa-miR-641	CLIP-seq
MIRT2685993	hsa-miR-653	CLIP-seq
MIRT2685994	hsa-miR-657	CLIP-seq
MIRT2685995	hsa-miR-659	CLIP-seq
MIRT2685996	hsa-miR-664	CLIP-seq
MIRT2051333	hsa-miR-9	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	10395741, 20562859
GO:0005634	Component	Nucleus	IBA	21873635
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006979	Process	Response to oxidative stress	IBA	21873635
GO:0030374	Function	Nuclear receptor coactivator activity	IBA	21873635
GO:0030374	Function	Nuclear receptor coactivator activity	IDA	11971969
GO:0035257	Function	Nuclear hormone receptor binding	IDA	11971969
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	11971969
GO:1900408	Process	Negative regulation of cellular response to oxidative stress	IEA
GO:1902083	Process	Negative regulation of peptidyl-cysteine S-nitrosylation	IEA

Other IDs

• MIM: 609752
• HGNC: 21081
• e!Ensembl: ENSG00000111912

Protein

• UniProt ID: Q8NI08
• Protein name: Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1)
• Protein function: Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.
• PDB: 7OBP, 8AR6, 8AR9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01476	LysM	116 → 158	LysM domain	Domain
  PF07534	TLD	806 → 942	TLD	Domain

• Sequence:

  MDTKEEKKERKQSYFARLKKKKQAKQNAETASAVATRTHTGKEDNNTVVLEPDKCNIAVE
  EEYMTDEKKKRKSNQLKEIRRTELKRYYSIDDNQNKTHDKKEKKMVVQKPHGTMEYTAGN
  QDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVPDANSPSSTLRLSSSSPGATVSP
  SSSDAEYDKLPDADLARKALKPIERVLSSTSEEDEPGVVKFLKMNCRYFTDGKGVVGGVM
  IVTPNNIMFDPHKSDPLVIENGCEEYGLICPMEEVVSIALYNDISHMKIKDALPSDLPQD
  LCPLYRPGEWEDLASEKDINPFSKFKSINKEKRQQNGEKIMTSDSRPIVPLEKSTGHTPT
  KPSGSSVSEKLKKLDSSRETSHGSPTVTKLSKEPSDTSSAFESTAKENFLGEDDDFVDLE
  ELSSQTGGGMHKKDTLKECLSLDPEERKKAESQINNSAVEMQVQSALAFLGTENDVELKG
  ALDLETCEKQDIMPEVDKQSGSPESRVENTLNIHEDLDKVKLIEYYLTKNKEGPQVSENL
  QKTELSDGKSIEPGGIDITLSSSLSQAGDPITEGNKEPDKTWVKKGEPLPVKLNSSTEAN
  VIKEALDSSLESTLDNSCQGAQMDNKSEVQLWLLKRIQVPIEDILPSKEEKSKTPPMFLC
  IKVGKPMRKSFATHTAAMVQQYGKRRKQPEYWFAVPRERVDHLYTFFVQWSPDVYGKDAK
  EQGFVVVEKEELNMIDNFFSEPTTKSWEIITVEEAKRRKSTCSYYEDEDEEVLPVLRPHS
  ALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDN
  QIFGAYATHPFKFSDHYYGTGETFLYTFSPHFKVFKWSGENSYFINGDISSLELGGGGGR
  FGLWLDADLYHGRSNSCSTFNNDILSKKEDFIVQDLEVWAFD

• Sequence length: 942

Pathways

KEGG:

Lysosome

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29662167

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		29662167