COX5B (cytochrome c oxidase subunit 5B)

Gene

• Entrez ID: 1329
• Gene name: Cytochrome c oxidase subunit 5B
• Gene symbol: COX5B
• Synonyms: COXVB
• Chromosome: 2
• Chromosome location: 2q11.2
• Summary: Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradien

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT564388	hsa-miR-3120-3p	PAR-CLIP	20371350
MIRT564387	hsa-miR-6869-5p	PAR-CLIP	20371350
MIRT564386	hsa-miR-8081	PAR-CLIP	20371350
MIRT207609	hsa-miR-8055	PAR-CLIP	20371350
MIRT564388	hsa-miR-3120-3p	PAR-CLIP	20371350
MIRT564387	hsa-miR-6869-5p	PAR-CLIP	20371350
MIRT564386	hsa-miR-8081	PAR-CLIP	20371350
MIRT207609	hsa-miR-8055	PAR-CLIP	20371350
MIRT905399	hsa-miR-1243	CLIP-seq
MIRT905400	hsa-miR-130a	CLIP-seq
MIRT905401	hsa-miR-130b	CLIP-seq
MIRT905402	hsa-miR-301a	CLIP-seq
MIRT905403	hsa-miR-301b	CLIP-seq
MIRT905404	hsa-miR-3591-5p	CLIP-seq
MIRT905405	hsa-miR-3654	CLIP-seq
MIRT905406	hsa-miR-3666	CLIP-seq
MIRT905407	hsa-miR-3978	CLIP-seq
MIRT905408	hsa-miR-4295	CLIP-seq
MIRT905409	hsa-miR-4434	CLIP-seq
MIRT905410	hsa-miR-4473	CLIP-seq
MIRT905411	hsa-miR-4516	CLIP-seq
MIRT905412	hsa-miR-454	CLIP-seq
MIRT905413	hsa-miR-4671-3p	CLIP-seq
MIRT905414	hsa-miR-875-3p	CLIP-seq
MIRT905399	hsa-miR-1243	CLIP-seq
MIRT905400	hsa-miR-130a	CLIP-seq
MIRT905401	hsa-miR-130b	CLIP-seq
MIRT905402	hsa-miR-301a	CLIP-seq
MIRT905403	hsa-miR-301b	CLIP-seq
MIRT905404	hsa-miR-3591-5p	CLIP-seq
MIRT905405	hsa-miR-3654	CLIP-seq
MIRT905406	hsa-miR-3666	CLIP-seq
MIRT905407	hsa-miR-3978	CLIP-seq
MIRT905408	hsa-miR-4295	CLIP-seq
MIRT905409	hsa-miR-4434	CLIP-seq
MIRT905410	hsa-miR-4473	CLIP-seq
MIRT905411	hsa-miR-4516	CLIP-seq
MIRT905412	hsa-miR-454	CLIP-seq
MIRT905413	hsa-miR-4671-3p	CLIP-seq
MIRT905414	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004129	Function	Cytochrome-c oxidase activity	IEA
GO:0005515	Function	Protein binding	IPI	17500595, 21516116, 25416956, 31170524, 31515488, 32296183, 32814053
GO:0005739	Component	Mitochondrion	IDA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006123	Process	Mitochondrial electron transport, cytochrome c to oxygen	IBA	21873635
GO:0006123	Process	Mitochondrial electron transport, cytochrome c to oxygen	TAS
GO:0007585	Process	Respiratory gaseous exchange by respiratory system	TAS	1646156
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 123866
• HGNC: 2269
• e!Ensembl: ENSG00000135940

Protein

• UniProt ID: P10606
• Protein name: Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb)
• Protein function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiqu
• PDB: 5Z62
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01215	COX5B	8 → 128	Cytochrome c oxidase subunit Vb	Domain

• Sequence:

  MASRLLRGAGTLAAQALRARGPSGAAAMRSMASGGGVPTDEEQATGLEREIMLAAKKGLD
  PYNVLAPKGASGTREDPNLVPSISNKRIVGCICEEDNTSVVWFWLHKGEAQRCPRCGAHY
  KLVPQQLAH

• Sequence length: 129

Pathways

KEGG:

Oxidative phosphorylation
Metabolic pathways
Cardiac muscle contraction
Thermogenesis
Non-alcoholic fatty liver disease
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy

Reactome:

TP53 Regulates Metabolic Genes
Respiratory electron transport

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Myocardial ischemia	Myocardial Ischemia		16214533