GNPDA2 (glucosamine-6-phosphate deaminase 2)

Gene

• Entrez ID: 132789
• Gene name: Glucosamine-6-phosphate deaminase 2
• Gene symbol: GNPDA2
• Synonyms: GNP2, SB52
• Chromosome: 4
• Chromosome location: 4p12
• Summary: The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing bod

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002816	hsa-miR-1-3p	Microarray	15685193
MIRT020422	hsa-miR-106b-5p	Microarray	17242205
MIRT023359	hsa-miR-122-5p	Microarray	17612493
MIRT002816	hsa-miR-1-3p	Microarray	18668037
MIRT002816	hsa-miR-1-3p	Microarray	15685193
MIRT440547	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT440547	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT1025170	hsa-miR-1236	CLIP-seq
MIRT1025171	hsa-miR-1279	CLIP-seq
MIRT1025172	hsa-miR-153	CLIP-seq
MIRT1025173	hsa-miR-2052	CLIP-seq
MIRT1025174	hsa-miR-25	CLIP-seq
MIRT1025175	hsa-miR-3162-5p	CLIP-seq
MIRT1025176	hsa-miR-32	CLIP-seq
MIRT1025177	hsa-miR-320a	CLIP-seq
MIRT1025178	hsa-miR-320b	CLIP-seq
MIRT1025179	hsa-miR-320c	CLIP-seq
MIRT1025180	hsa-miR-320d	CLIP-seq
MIRT1025181	hsa-miR-3622a-5p	CLIP-seq
MIRT1025182	hsa-miR-363	CLIP-seq
MIRT1025183	hsa-miR-367	CLIP-seq
MIRT1025184	hsa-miR-3671	CLIP-seq
MIRT1025185	hsa-miR-4423-3p	CLIP-seq
MIRT1025186	hsa-miR-4429	CLIP-seq
MIRT1025187	hsa-miR-448	CLIP-seq
MIRT1025188	hsa-miR-513a-3p	CLIP-seq
MIRT1025189	hsa-miR-568	CLIP-seq
MIRT1025190	hsa-miR-607	CLIP-seq
MIRT1025191	hsa-miR-656	CLIP-seq
MIRT1025192	hsa-miR-92a	CLIP-seq
MIRT1025193	hsa-miR-92b	CLIP-seq
MIRT2004004	hsa-miR-3613-3p	CLIP-seq
MIRT2236780	hsa-miR-101	CLIP-seq
MIRT2236781	hsa-miR-144	CLIP-seq
MIRT2236782	hsa-miR-4703-3p	CLIP-seq
MIRT2236783	hsa-miR-582-5p	CLIP-seq
MIRT2540672	hsa-miR-106a	CLIP-seq
MIRT2540673	hsa-miR-106b	CLIP-seq
MIRT2540674	hsa-miR-1206	CLIP-seq
MIRT1025170	hsa-miR-1236	CLIP-seq
MIRT2540675	hsa-miR-124	CLIP-seq
MIRT2540676	hsa-miR-1265	CLIP-seq
MIRT1025171	hsa-miR-1279	CLIP-seq
MIRT2540677	hsa-miR-1298	CLIP-seq
MIRT1025172	hsa-miR-153	CLIP-seq
MIRT2540678	hsa-miR-17	CLIP-seq
MIRT1025173	hsa-miR-2052	CLIP-seq
MIRT2540679	hsa-miR-20a	CLIP-seq
MIRT2540680	hsa-miR-20b	CLIP-seq
MIRT2540681	hsa-miR-2355-5p	CLIP-seq
MIRT1025174	hsa-miR-25	CLIP-seq
MIRT2540682	hsa-miR-2964a-5p	CLIP-seq
MIRT2540683	hsa-miR-298	CLIP-seq
MIRT2540684	hsa-miR-302a	CLIP-seq
MIRT2540685	hsa-miR-302b	CLIP-seq
MIRT2540686	hsa-miR-302c	CLIP-seq
MIRT2540687	hsa-miR-302d	CLIP-seq
MIRT2540688	hsa-miR-302e	CLIP-seq
MIRT2540689	hsa-miR-30a	CLIP-seq
MIRT2540690	hsa-miR-30b	CLIP-seq
MIRT2540691	hsa-miR-30c	CLIP-seq
MIRT2540692	hsa-miR-30d	CLIP-seq
MIRT2540693	hsa-miR-30e	CLIP-seq
MIRT2540694	hsa-miR-3194-3p	CLIP-seq
MIRT1025176	hsa-miR-32	CLIP-seq
MIRT1025181	hsa-miR-3622a-5p	CLIP-seq
MIRT1025182	hsa-miR-363	CLIP-seq
MIRT2540695	hsa-miR-3647-3p	CLIP-seq
MIRT1025183	hsa-miR-367	CLIP-seq
MIRT1025184	hsa-miR-3671	CLIP-seq
MIRT2540696	hsa-miR-3714	CLIP-seq
MIRT2540697	hsa-miR-372	CLIP-seq
MIRT2540698	hsa-miR-373	CLIP-seq
MIRT2540699	hsa-miR-3907	CLIP-seq
MIRT2540700	hsa-miR-3910	CLIP-seq
MIRT2540701	hsa-miR-3941	CLIP-seq
MIRT2540702	hsa-miR-4307	CLIP-seq
MIRT1025185	hsa-miR-4423-3p	CLIP-seq
MIRT2540703	hsa-miR-4476	CLIP-seq
MIRT1025187	hsa-miR-448	CLIP-seq
MIRT2540704	hsa-miR-4495	CLIP-seq
MIRT2540705	hsa-miR-4643	CLIP-seq
MIRT2540706	hsa-miR-466	CLIP-seq
MIRT2540707	hsa-miR-4672	CLIP-seq
MIRT2540708	hsa-miR-4698	CLIP-seq
MIRT2540709	hsa-miR-4716-5p	CLIP-seq
MIRT2540710	hsa-miR-4718	CLIP-seq
MIRT2540711	hsa-miR-4760-3p	CLIP-seq
MIRT2540712	hsa-miR-4777-5p	CLIP-seq
MIRT2540713	hsa-miR-4789-3p	CLIP-seq
MIRT2540714	hsa-miR-506	CLIP-seq
MIRT1025188	hsa-miR-513a-3p	CLIP-seq
MIRT2540715	hsa-miR-519d	CLIP-seq
MIRT2540716	hsa-miR-520a-3p	CLIP-seq
MIRT2540717	hsa-miR-520b	CLIP-seq
MIRT2540718	hsa-miR-520c-3p	CLIP-seq
MIRT2540719	hsa-miR-520d-3p	CLIP-seq
MIRT2540720	hsa-miR-520e	CLIP-seq
MIRT2540721	hsa-miR-548g	CLIP-seq
MIRT2540722	hsa-miR-548t	CLIP-seq
MIRT1025190	hsa-miR-607	CLIP-seq
MIRT1025192	hsa-miR-92a	CLIP-seq
MIRT1025193	hsa-miR-92b	CLIP-seq
MIRT2540723	hsa-miR-93	CLIP-seq
MIRT2540672	hsa-miR-106a	CLIP-seq
MIRT2540673	hsa-miR-106b	CLIP-seq
MIRT1025170	hsa-miR-1236	CLIP-seq
MIRT2540675	hsa-miR-124	CLIP-seq
MIRT2540676	hsa-miR-1265	CLIP-seq
MIRT1025171	hsa-miR-1279	CLIP-seq
MIRT1025172	hsa-miR-153	CLIP-seq
MIRT2540678	hsa-miR-17	CLIP-seq
MIRT1025173	hsa-miR-2052	CLIP-seq
MIRT2540679	hsa-miR-20a	CLIP-seq
MIRT2540680	hsa-miR-20b	CLIP-seq
MIRT2540681	hsa-miR-2355-5p	CLIP-seq
MIRT1025174	hsa-miR-25	CLIP-seq
MIRT2540682	hsa-miR-2964a-5p	CLIP-seq
MIRT2540683	hsa-miR-298	CLIP-seq
MIRT2540684	hsa-miR-302a	CLIP-seq
MIRT2540685	hsa-miR-302b	CLIP-seq
MIRT2540686	hsa-miR-302c	CLIP-seq
MIRT2540687	hsa-miR-302d	CLIP-seq
MIRT2540688	hsa-miR-302e	CLIP-seq
MIRT2540689	hsa-miR-30a	CLIP-seq
MIRT2540690	hsa-miR-30b	CLIP-seq
MIRT2540691	hsa-miR-30c	CLIP-seq
MIRT2540692	hsa-miR-30d	CLIP-seq
MIRT2540693	hsa-miR-30e	CLIP-seq
MIRT2540694	hsa-miR-3194-3p	CLIP-seq
MIRT1025176	hsa-miR-32	CLIP-seq
MIRT1025181	hsa-miR-3622a-5p	CLIP-seq
MIRT1025182	hsa-miR-363	CLIP-seq
MIRT2540695	hsa-miR-3647-3p	CLIP-seq
MIRT1025183	hsa-miR-367	CLIP-seq
MIRT1025184	hsa-miR-3671	CLIP-seq
MIRT2540696	hsa-miR-3714	CLIP-seq
MIRT2540697	hsa-miR-372	CLIP-seq
MIRT2540698	hsa-miR-373	CLIP-seq
MIRT2540699	hsa-miR-3907	CLIP-seq
MIRT2540700	hsa-miR-3910	CLIP-seq
MIRT2540701	hsa-miR-3941	CLIP-seq
MIRT2540702	hsa-miR-4307	CLIP-seq
MIRT2681756	hsa-miR-4422	CLIP-seq
MIRT1025185	hsa-miR-4423-3p	CLIP-seq
MIRT2540703	hsa-miR-4476	CLIP-seq
MIRT1025187	hsa-miR-448	CLIP-seq
MIRT2540704	hsa-miR-4495	CLIP-seq
MIRT2540705	hsa-miR-4643	CLIP-seq
MIRT2540706	hsa-miR-466	CLIP-seq
MIRT2540707	hsa-miR-4672	CLIP-seq
MIRT2540708	hsa-miR-4698	CLIP-seq
MIRT2540709	hsa-miR-4716-5p	CLIP-seq
MIRT2540710	hsa-miR-4718	CLIP-seq
MIRT2540711	hsa-miR-4760-3p	CLIP-seq
MIRT2540712	hsa-miR-4777-5p	CLIP-seq
MIRT2540713	hsa-miR-4789-3p	CLIP-seq
MIRT2540714	hsa-miR-506	CLIP-seq
MIRT1025188	hsa-miR-513a-3p	CLIP-seq
MIRT2540715	hsa-miR-519d	CLIP-seq
MIRT2540716	hsa-miR-520a-3p	CLIP-seq
MIRT2540717	hsa-miR-520b	CLIP-seq
MIRT2540718	hsa-miR-520c-3p	CLIP-seq
MIRT2540719	hsa-miR-520d-3p	CLIP-seq
MIRT2540720	hsa-miR-520e	CLIP-seq
MIRT2540721	hsa-miR-548g	CLIP-seq
MIRT2540722	hsa-miR-548t	CLIP-seq
MIRT1025190	hsa-miR-607	CLIP-seq
MIRT1025192	hsa-miR-92a	CLIP-seq
MIRT1025193	hsa-miR-92b	CLIP-seq
MIRT2540723	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004342	Function	Glucosamine-6-phosphate deaminase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	25416956, 29892012
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006043	Process	Glucosamine catabolic process	IBA	21873635
GO:0006043	Process	Glucosamine catabolic process	TAS
GO:0006046	Process	N-acetylglucosamine catabolic process	IBA	21873635
GO:0006048	Process	UDP-N-acetylglucosamine biosynthetic process	IBA	21873635
GO:0019262	Process	N-acetylneuraminate catabolic process	IBA	21873635
GO:0042802	Function	Identical protein binding	IBA	21873635

Other IDs

• MIM: 613222
• HGNC: 21526
• e!Ensembl: ENSG00000163281

Protein

• UniProt ID: Q8TDQ7
• Protein name: Glucosamine-6-phosphate deaminase 2 (GlcN6P deaminase 2) (EC 3.5.99.6) (Glucosamine-6-phosphate isomerase 2) (Glucosamine-6-phosphate isomerase SB52)
• Protein function: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) bios
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01182	Glucosamine_iso	7 → 237	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	Domain

• Sequence:

  MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPTGSTPLGCYKKLIEYHKNGH
  LSFKYVKTFNMDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDA
  FENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANAKYFDGDLSK
  VPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD
  EDATLELRVKTVKYFKGLMHVHNKLVDPLFSMKDGN

• Sequence length: 276

Pathways

KEGG:

Amino sugar and nucleotide sugar metabolism
Metabolic pathways

Reactome:

Glycolysis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	19079261