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MTERF4 (mitochondrial transcription termination factor 4)
Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
130916
Gene nameGene Name - the full gene name approved by the HGNC.
Mitochondrial transcription termination factor 4
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
MTERF4
SynonymsGene synonyms aliases
MTERFD2
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q37.3
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT445184 hsa-miR-1253 PAR-CLIP 22100165
MIRT445183 hsa-miR-6770-5p PAR-CLIP 22100165
MIRT445182 hsa-miR-580-3p PAR-CLIP 22100165
MIRT755273 hsa-miR-1253 PAR-CLIP 22100165
MIRT755274 hsa-miR-6770-5p PAR-CLIP 22100165
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0003690 Function Double-stranded DNA binding IEA
GO:0005515 Function Protein binding IPI 21531335, 22949673, 23022348, 32296183
GO:0005739 Component Mitochondrion IDA
GO:0005759 Component Mitochondrial matrix TAS
GO:0005762 Component Mitochondrial large ribosomal subunit IDA 21531335
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q7Z6M4
Protein name Transcription termination factor 4, mitochondrial (Mitochondrial transcription termination factor 4) (mTERF domain-containing protein 2) [Cleaved into: mTERF domain-containing protein 2 processed]
Protein function Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).
PDB 4FP9 , 4FZV , 7O9K , 7O9M , 7ODR , 7ODS , 7ODT , 7OF0 , 7OF3 , 7OF5 , 7OF7 , 7OIC , 7PD3 , 8PK0 , 8QSJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02536 mTERF
55 → 302
mTERF
 Family
Sequence
Sequence length 381
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
 
Reactome
    rRNA modification in the mitochondrion
Associated diseases
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 25944848
Unknown
Disease name Disease term dbSNP ID References
Bipolar disorder Bipolar Disorder 25944848
Mental depression Unipolar Depression, Major Depressive Disorder rs587778876, rs587778877 25944848

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