Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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1306 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Collagen type XV alpha 1 chain |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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COL15A1 |
SynonymsGene synonyms aliases
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- |
ChromosomeChromosome number
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9 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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9q22.33 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement memb |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P39059 |
Protein name |
Collagen alpha-1(XV) chain [Cleaved into: Restin (Endostatin-XV) (Related to endostatin) (Restin-I); Restin-2 (Restin-II); Restin-3 (Restin-III); Restin-4 (Restin-IV)] |
Protein function |
Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. ; Restin potently inhibits angiogenesis. |
PDB |
3N3F
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF13385 |
Laminin_G_3 |
76 → 235 |
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Domain |
PF01391 |
Collagen |
617 → 681 |
Collagen triple helix repeat (20 copies) |
Repeat |
PF01391 |
Collagen |
673 → 735 |
Collagen triple helix repeat (20 copies) |
Repeat |
PF01391 |
Collagen |
820 → 868 |
Collagen triple helix repeat (20 copies) |
Repeat |
PF01391 |
Collagen |
877 → 929 |
Collagen triple helix repeat (20 copies) |
Repeat |
PF06482 |
Endostatin |
1133 → 1200 |
Collagenase NC10 and Endostatin |
Domain |
PF06482 |
Endostatin |
1192 → 1383 |
Collagenase NC10 and Endostatin |
Domain |
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Sequence |
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Sequence length |
1388 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Leukemia |
Leukemia, Myelocytic, Acute |
rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 |
27903959 |
Ovarian cancer |
Epithelial ovarian cancer |
rs34424986, rs137853060, rs28934575, rs79658334, rs121913021, rs62625308, rs80356898, rs80357579, rs41293497, rs80356904, rs80357471, rs80357522, rs80357234, rs80357912, rs80357828, rs80357208, rs55770810, rs80358165, rs80358010, rs587780226, rs536907995, rs139414606, rs371638537, rs574552037, rs730881647, rs747993448, rs786202125, rs786202962, rs121913321, rs189261858, rs869320800, rs753023295, rs779466229, rs752411477, rs80357438, rs191486604, rs760874290, rs752780954, rs760782298, rs1555591361, rs1555578360, rs1555588460, rs1555587401, rs747427602, rs112675807, rs80357393 |
25134534 |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
29610475 |
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Eczema |
Eczema |
|
30595370 |
Liver carcinoma |
Liver carcinoma |
|
28284560 |
Prostatic neoplasms |
Prostatic Neoplasms |
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29610475 |
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