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ACVR1C (activin A receptor type 1C)

Gene

130399

Activin A receptor type 1C

ACVR1C

ACVRLK7, ALK7

2q24.1

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in

Show/Hide all(118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005775	hsa-miR-376c-3p	Luciferase reporter assay, Western blot	21224400
MIRT005775	hsa-miR-376c-3p	Luciferase reporter assay, Western blot	21224400
MIRT005775	hsa-miR-376c-3p	Luciferase reporter assay, Western blot	21224400
MIRT005775	hsa-miR-376c-3p	Luciferase reporter assay, Western blot	21224400
MIRT005776	hsa-miR-376a-3p	Luciferase reporter assay	21224400
MIRT005777	hsa-miR-376a-5p	Luciferase reporter assay	21224400
MIRT005778	hsa-miR-376b-3p	Luciferase reporter assay	21224400
MIRT005779	hsa-miR-22-3p	Luciferase reporter assay, Western blot	21224400
MIRT005775	hsa-miR-376c-3p	Luciferase reporter assay	21224400
MIRT005780	hsa-miR-412-3p	Luciferase reporter assay	21224400
MIRT005781	hsa-miR-147a	Luciferase reporter assay	21224400
MIRT005781	hsa-miR-147a	Luciferase reporter assay	21224400
MIRT005782	hsa-miR-122-5p	Luciferase reporter assay	21224400
MIRT005780	hsa-miR-412-3p	Reporter assay	21224400
MIRT005778	hsa-miR-376b-3p	Reporter assay;Western blot	21224400
MIRT005776	hsa-miR-376a-3p	Reporter assay;Western blot	21224400
MIRT005777	hsa-miR-376a-5p	Reporter assay;Western blot	21224400
MIRT005775	hsa-miR-376c-3p	Reporter assay;Western blot;qRT-PCR	21224400
MIRT005782	hsa-miR-122-5p	Reporter assay	21224400
MIRT005781	hsa-miR-147a	Reporter assay	21224400
MIRT005779	hsa-miR-22-3p	Reporter assay;Western blot	21224400
MIRT005775	hsa-miR-376c-3p	Luciferase reporter assay, qRT-PCR, Western blot	23424236
MIRT005775	hsa-miR-376c-3p	Luciferase reporter assay, qRT-PCR, Western blot	23424236
MIRT539489	hsa-miR-323a-3p	PAR-CLIP	22012620
MIRT539488	hsa-miR-4699-3p	PAR-CLIP	22012620
MIRT539487	hsa-miR-8063	PAR-CLIP	22012620
MIRT539486	hsa-miR-4698	PAR-CLIP	22012620
MIRT539485	hsa-miR-4639-3p	PAR-CLIP	22012620
MIRT539484	hsa-miR-676-5p	PAR-CLIP	22012620
MIRT539483	hsa-miR-6837-3p	PAR-CLIP	22012620
MIRT539482	hsa-miR-3682-5p	PAR-CLIP	22012620
MIRT539481	hsa-miR-6794-3p	PAR-CLIP	22012620
MIRT735689	hsa-miR-548c-3p	Western blotting, Immunofluorescence, qRT-PCR	33114016
MIRT539489	hsa-miR-323a-3p	PAR-CLIP	22012620
MIRT539488	hsa-miR-4699-3p	PAR-CLIP	22012620
MIRT539487	hsa-miR-8063	PAR-CLIP	22012620
MIRT539486	hsa-miR-4698	PAR-CLIP	22012620
MIRT539485	hsa-miR-4639-3p	PAR-CLIP	22012620
MIRT539484	hsa-miR-676-5p	PAR-CLIP	22012620
MIRT539483	hsa-miR-6837-3p	PAR-CLIP	22012620
MIRT539482	hsa-miR-3682-5p	PAR-CLIP	22012620
MIRT539481	hsa-miR-6794-3p	PAR-CLIP	22012620
MIRT765043	hsa-let-7a	CLIP-seq
MIRT765044	hsa-let-7b	CLIP-seq
MIRT765045	hsa-let-7c	CLIP-seq
MIRT765046	hsa-let-7d	CLIP-seq
MIRT765047	hsa-let-7e	CLIP-seq
MIRT765048	hsa-let-7f	CLIP-seq
MIRT765049	hsa-let-7g	CLIP-seq
MIRT765050	hsa-let-7i	CLIP-seq
MIRT765051	hsa-miR-1179	CLIP-seq
MIRT765052	hsa-miR-1245b-3p	CLIP-seq
MIRT765053	hsa-miR-1283	CLIP-seq
MIRT765054	hsa-miR-1290	CLIP-seq
MIRT765055	hsa-miR-1304	CLIP-seq
MIRT765056	hsa-miR-137	CLIP-seq
MIRT765057	hsa-miR-202	CLIP-seq
MIRT765058	hsa-miR-217	CLIP-seq
MIRT765059	hsa-miR-218	CLIP-seq
MIRT765060	hsa-miR-3129-3p	CLIP-seq
MIRT765061	hsa-miR-3148	CLIP-seq
MIRT765062	hsa-miR-3167	CLIP-seq
MIRT765063	hsa-miR-3184	CLIP-seq
MIRT765064	hsa-miR-3185	CLIP-seq
MIRT765065	hsa-miR-337-3p	CLIP-seq
MIRT765066	hsa-miR-3613-3p	CLIP-seq
MIRT765067	hsa-miR-376c	CLIP-seq
MIRT765068	hsa-miR-3927	CLIP-seq
MIRT765069	hsa-miR-3940-3p	CLIP-seq
MIRT765070	hsa-miR-3942-3p	CLIP-seq
MIRT765071	hsa-miR-423-5p	CLIP-seq
MIRT765072	hsa-miR-4263	CLIP-seq
MIRT765073	hsa-miR-4418	CLIP-seq
MIRT765074	hsa-miR-4458	CLIP-seq
MIRT765075	hsa-miR-4500	CLIP-seq
MIRT765076	hsa-miR-452	CLIP-seq
MIRT765077	hsa-miR-4521	CLIP-seq
MIRT765078	hsa-miR-4650-3p	CLIP-seq
MIRT765079	hsa-miR-4653-3p	CLIP-seq
MIRT765080	hsa-miR-4668-5p	CLIP-seq
MIRT765081	hsa-miR-4676-3p	CLIP-seq
MIRT765082	hsa-miR-4693-5p	CLIP-seq
MIRT765083	hsa-miR-4735-5p	CLIP-seq
MIRT765084	hsa-miR-4738-3p	CLIP-seq
MIRT765085	hsa-miR-4768-3p	CLIP-seq
MIRT765086	hsa-miR-4773	CLIP-seq
MIRT765087	hsa-miR-4775	CLIP-seq
MIRT765088	hsa-miR-487a	CLIP-seq
MIRT765089	hsa-miR-509-3-5p	CLIP-seq
MIRT765090	hsa-miR-509-5p	CLIP-seq
MIRT765091	hsa-miR-539	CLIP-seq
MIRT765092	hsa-miR-582-5p	CLIP-seq
MIRT765093	hsa-miR-590-3p	CLIP-seq
MIRT765094	hsa-miR-636	CLIP-seq
MIRT765095	hsa-miR-876-5p	CLIP-seq
MIRT765096	hsa-miR-98	CLIP-seq
MIRT765072	hsa-miR-4263	CLIP-seq
MIRT765076	hsa-miR-452	CLIP-seq
MIRT765077	hsa-miR-4521	CLIP-seq
MIRT765079	hsa-miR-4653-3p	CLIP-seq
MIRT765081	hsa-miR-4676-3p	CLIP-seq
MIRT765082	hsa-miR-4693-5p	CLIP-seq
MIRT765086	hsa-miR-4773	CLIP-seq
MIRT1545064	hsa-miR-3609	CLIP-seq
MIRT1545065	hsa-miR-548ah	CLIP-seq
MIRT1545066	hsa-miR-605	CLIP-seq
MIRT1925394	hsa-miR-2052	CLIP-seq
MIRT1925395	hsa-miR-2054	CLIP-seq
MIRT1925396	hsa-miR-4517	CLIP-seq
MIRT1925397	hsa-miR-5096	CLIP-seq
MIRT765086	hsa-miR-4773	CLIP-seq
MIRT2443109	hsa-miR-155	CLIP-seq
MIRT2443110	hsa-miR-2116	CLIP-seq
MIRT765076	hsa-miR-452	CLIP-seq
MIRT765081	hsa-miR-4676-3p	CLIP-seq
MIRT2443111	hsa-miR-4793-5p	CLIP-seq
MIRT1925397	hsa-miR-5096	CLIP-seq
MIRT2443112	hsa-miR-570	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001834	Process	Trophectodermal cell proliferation	IDA	15150278
GO:0002021	Process	Response to dietary excess	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006468	Process	Protein phosphorylation	IBA	21873635
GO:0006468	Process	Protein phosphorylation	IC	12063393
GO:0007399	Process	Nervous system development	IBA	21873635
GO:0009749	Process	Response to glucose	IEA
GO:0016361	Function	Activin receptor activity, type I	IBA	21873635
GO:0016361	Function	Activin receptor activity, type I	IDA	12063393
GO:0019838	Function	Growth factor binding	IPI	21805089
GO:0019915	Process	Lipid storage	IEA
GO:0030154	Process	Cell differentiation	IDA	15531507
GO:0030262	Process	Apoptotic nuclear changes	IDA	15531507
GO:0032868	Process	Response to insulin	IEA
GO:0032924	Process	Activin receptor signaling pathway	IBA	21873635
GO:0038092	Process	Nodal signaling pathway	IMP	15150278
GO:0038100	Function	Nodal binding	IMP	21356369
GO:0043065	Process	Positive regulation of apoptotic process	IDA	15150278
GO:0043235	Component	Receptor complex	IBA	21873635
GO:0043280	Process	Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	15150278
GO:0046676	Process	Negative regulation of insulin secretion	IEA
GO:0046872	Function	Metal ion binding	IC	12063393
GO:0048179	Component	Activin receptor complex	IBA	21873635
GO:0048179	Component	Activin receptor complex	IDA	15531507
GO:0071363	Process	Cellular response to growth factor stimulus	IBA	21873635
GO:1901164	Process	Negative regulation of trophoblast cell migration	IDA	21356369
GO:1901383	Process	Negative regulation of chorionic trophoblast cell proliferation	IMP	15150278

MIM	HGNC	e!Ensembl
608981	18123	ENSG00000123612

Protein

UniProt ID

Q8NER5

Protein name

Activin receptor type-1C (EC 2.7.11.30) (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7)

Protein function

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01064	Activin_recp	26 → 96	Activin types I and II receptor domain	Domain
PF08515	TGF_beta_GS	166 → 193	Transforming growth factor beta type I GS-motif	Family
PF07714	PK_Tyr_Ser-Thr	195 → 482	Protein tyrosine and serine/threonine kinase	Domain

Sequence

MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI
KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITV
PVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSG
SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ
TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA
SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN
PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD
MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK
TISQLCVKEDCKA

Sequence length

493

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells		Signaling by Activin

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Lung carcinoma	Squamous cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193

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