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ACMSD (aminocarboxymuconate semialdehyde decarboxylase)
Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
130013
Gene nameGene Name - the full gene name approved by the HGNC.
Aminocarboxymuconate semialdehyde decarboxylase
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ACMSD
SynonymsGene synonyms aliases
-
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q21.3
SummarySummary of gene provided in NCBI Entrez Gene.
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-mucon
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT1924863 hsa-miR-520d-5p CLIP-seq
MIRT1924864 hsa-miR-524-5p CLIP-seq
MIRT1924865 hsa-miR-570 CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0001760 Function Aminocarboxymuconate-semialdehyde decarboxylase activity IDA 12140278, 25392945
GO:0005515 Function Protein binding IPI 25416956
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005829 Component Cytosol IBA 21873635
GO:0005829 Component Cytosol IDA 12140278
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q8TDX5
Protein name 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase)
Protein function Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal c
PDB 2WM1 , 4IGM , 4IGN , 4IH3 , 4OFC , 7PWY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04909 Amidohydro_2
3 → 330
Amidohydrolase
 Domain
Sequence
Sequence length 336
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
  Tryptophan metabolism
Metabolic pathways 		 
Associated diseases
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Asthma Asthma rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 25918132

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