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CNTFR (ciliary neurotrophic factor receptor)

Gene

Ciliary neurotrophic factor receptor

CNTFR

9p13.3

This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and ge

Show/Hide all(87)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029854	hsa-miR-26b-5p	Microarray	19088304
MIRT438715	hsa-miR-708-5p	Luciferase reporter assay, qRT-PCR, Western blot	23970374
MIRT438715	hsa-miR-708-5p	Luciferase reporter assay, qRT-PCR, Western blot	23970374
MIRT901530	hsa-miR-2467-3p	CLIP-seq
MIRT901531	hsa-miR-3154	CLIP-seq
MIRT901532	hsa-miR-3199	CLIP-seq
MIRT901533	hsa-miR-3647-3p	CLIP-seq
MIRT901534	hsa-miR-3660	CLIP-seq
MIRT901535	hsa-miR-3688-5p	CLIP-seq
MIRT901536	hsa-miR-4292	CLIP-seq
MIRT901537	hsa-miR-4436b-3p	CLIP-seq
MIRT901538	hsa-miR-4475	CLIP-seq
MIRT901539	hsa-miR-4494	CLIP-seq
MIRT901540	hsa-miR-4513	CLIP-seq
MIRT901541	hsa-miR-4525	CLIP-seq
MIRT901542	hsa-miR-4526	CLIP-seq
MIRT901543	hsa-miR-4652-5p	CLIP-seq
MIRT901544	hsa-miR-4716-3p	CLIP-seq
MIRT901545	hsa-miR-4723-5p	CLIP-seq
MIRT901546	hsa-miR-4725-5p	CLIP-seq
MIRT901547	hsa-miR-4728-5p	CLIP-seq
MIRT901548	hsa-miR-4731-5p	CLIP-seq
MIRT901549	hsa-miR-4740-5p	CLIP-seq
MIRT901550	hsa-miR-4761-3p	CLIP-seq
MIRT901551	hsa-miR-499a-5p	CLIP-seq
MIRT901552	hsa-miR-504	CLIP-seq
MIRT901553	hsa-miR-637	CLIP-seq
MIRT901554	hsa-miR-1207-5p	CLIP-seq
MIRT901555	hsa-miR-3180	CLIP-seq
MIRT901556	hsa-miR-3180-3p	CLIP-seq
MIRT901557	hsa-miR-3196	CLIP-seq
MIRT901532	hsa-miR-3199	CLIP-seq
MIRT901533	hsa-miR-3647-3p	CLIP-seq
MIRT901558	hsa-miR-4446-3p	CLIP-seq
MIRT901559	hsa-miR-4466	CLIP-seq
MIRT901560	hsa-miR-4488	CLIP-seq
MIRT901561	hsa-miR-4492	CLIP-seq
MIRT901562	hsa-miR-4498	CLIP-seq
MIRT901563	hsa-miR-4505	CLIP-seq
MIRT901543	hsa-miR-4652-5p	CLIP-seq
MIRT901564	hsa-miR-4697-5p	CLIP-seq
MIRT901547	hsa-miR-4728-5p	CLIP-seq
MIRT901548	hsa-miR-4731-5p	CLIP-seq
MIRT901549	hsa-miR-4740-5p	CLIP-seq
MIRT901565	hsa-miR-4763-3p	CLIP-seq
MIRT901553	hsa-miR-637	CLIP-seq
MIRT901566	hsa-miR-675	CLIP-seq
MIRT901567	hsa-miR-762	CLIP-seq
MIRT901530	hsa-miR-2467-3p	CLIP-seq
MIRT901532	hsa-miR-3199	CLIP-seq
MIRT901533	hsa-miR-3647-3p	CLIP-seq
MIRT901543	hsa-miR-4652-5p	CLIP-seq
MIRT901547	hsa-miR-4728-5p	CLIP-seq
MIRT901549	hsa-miR-4740-5p	CLIP-seq
MIRT901531	hsa-miR-3154	CLIP-seq
MIRT901532	hsa-miR-3199	CLIP-seq
MIRT901534	hsa-miR-3660	CLIP-seq
MIRT901538	hsa-miR-4475	CLIP-seq
MIRT901539	hsa-miR-4494	CLIP-seq
MIRT901540	hsa-miR-4513	CLIP-seq
MIRT901542	hsa-miR-4526	CLIP-seq
MIRT901549	hsa-miR-4740-5p	CLIP-seq
MIRT901550	hsa-miR-4761-3p	CLIP-seq
MIRT901551	hsa-miR-499a-5p	CLIP-seq
MIRT1967448	hsa-miR-1184	CLIP-seq
MIRT1967449	hsa-miR-1205	CLIP-seq
MIRT901530	hsa-miR-2467-3p	CLIP-seq
MIRT1967450	hsa-miR-3158-5p	CLIP-seq
MIRT1967451	hsa-miR-3909	CLIP-seq
MIRT901537	hsa-miR-4436b-3p	CLIP-seq
MIRT2203129	hsa-miR-28-5p	CLIP-seq
MIRT2203130	hsa-miR-3139	CLIP-seq
MIRT2203131	hsa-miR-708	CLIP-seq
MIRT901530	hsa-miR-2467-3p	CLIP-seq
MIRT901532	hsa-miR-3199	CLIP-seq
MIRT901533	hsa-miR-3647-3p	CLIP-seq
MIRT901537	hsa-miR-4436b-3p	CLIP-seq
MIRT901543	hsa-miR-4652-5p	CLIP-seq
MIRT901547	hsa-miR-4728-5p	CLIP-seq
MIRT901549	hsa-miR-4740-5p	CLIP-seq
MIRT901530	hsa-miR-2467-3p	CLIP-seq
MIRT901532	hsa-miR-3199	CLIP-seq
MIRT901533	hsa-miR-3647-3p	CLIP-seq
MIRT901537	hsa-miR-4436b-3p	CLIP-seq
MIRT901543	hsa-miR-4652-5p	CLIP-seq
MIRT901547	hsa-miR-4728-5p	CLIP-seq
MIRT901549	hsa-miR-4740-5p	CLIP-seq

Show/Hide all(29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001967	Process	Suckling behavior	IEA
GO:0003360	Process	Brainstem development	IEA
GO:0004896	Function	Cytokine receptor activity	IBA	21873635
GO:0004897	Function	Ciliary neurotrophic factor receptor activity	IBA	21873635
GO:0004897	Function	Ciliary neurotrophic factor receptor activity	IDA	12643274
GO:0005102	Function	Signaling receptor binding	IPI	12707266
GO:0005515	Function	Protein binding	IPI	18775332, 20584990, 26858303
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	NAS	1648265
GO:0007399	Process	Nervous system development	TAS	7585948
GO:0007548	Process	Sex differentiation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0016324	Component	Apical plasma membrane	IDA	21912637
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA	21873635
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019898	Component	Extrinsic component of membrane	TAS	1648265
GO:0019955	Function	Cytokine binding	IBA	21873635
GO:0019955	Function	Cytokine binding	IPI	15272019
GO:0031225	Component	Anchored component of membrane	IEA
GO:0043235	Component	Receptor complex	IBA	21873635
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0060538	Process	Skeletal muscle organ development	IEA
GO:0070110	Component	Ciliary neurotrophic factor receptor complex	IBA	21873635
GO:0070110	Component	Ciliary neurotrophic factor receptor complex	IDA	12643274
GO:0070120	Process	Ciliary neurotrophic factor-mediated signaling pathway	IBA	21873635
GO:0070120	Process	Ciliary neurotrophic factor-mediated signaling pathway	IDA	12643274
GO:0097059	Component	CNTFR-CLCF1 complex	IBA	21873635
GO:0097059	Component	CNTFR-CLCF1 complex	IDA	11285233

MIM	HGNC	e!Ensembl
118946	2170	ENSG00000122756

Protein

UniProt ID

P26992

Protein name

Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)

Protein function

Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303). Acts as a receptor for the neuroprotective peptide humanin as part of a

PDB

1UC6 , 8D74 , 8D7E , 8D7H , 8D7R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00041	fn3	205 → 294	Fibronectin type III domain	Domain

Sequence

MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN
GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT
YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS
ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL
KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT
PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL
AAAAATASSLLI

Sequence length

372

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway		IL-6-type cytokine receptor ligand interactions

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	19503088

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