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CNTF (ciliary neurotrophic factor)

Gene

1270

Ciliary neurotrophic factor

CNTF

HCNTF

11q12.1

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival fact

Show/Hide all(132)

miRTarBase ID	miRNA	Experiments	Reference
MIRT608879	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT608878	hsa-miR-8068	HITS-CLIP	21572407
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	21572407
MIRT608875	hsa-miR-147a	HITS-CLIP	21572407
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	21572407
MIRT608873	hsa-miR-4455	HITS-CLIP	21572407
MIRT608872	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT528928	hsa-miR-8485	HITS-CLIP	23313552
MIRT528928	hsa-miR-8485	HITS-CLIP	23313552
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528927	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT608879	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT608878	hsa-miR-8068	HITS-CLIP	23824327
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT608875	hsa-miR-147a	HITS-CLIP	23824327
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	23824327
MIRT608873	hsa-miR-4455	HITS-CLIP	23824327
MIRT608872	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT608879	hsa-miR-511-3p	HITS-CLIP	24906430
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608878	hsa-miR-8068	HITS-CLIP	24906430
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	24906430
MIRT608875	hsa-miR-147a	HITS-CLIP	24906430
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	24906430
MIRT608873	hsa-miR-4455	HITS-CLIP	24906430
MIRT608872	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT528928	hsa-miR-8485	HITS-CLIP	24906430
MIRT528928	hsa-miR-8485	HITS-CLIP	24906430
MIRT528928	hsa-miR-8485	PAR-CLIP	22012620
MIRT528927	hsa-miR-377-3p	PAR-CLIP	22012620
MIRT608875	hsa-miR-147a	HITS-CLIP	27418678
MIRT608875	hsa-miR-147a	HITS-CLIP	27418678
MIRT528927	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT528927	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT528927	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608873	hsa-miR-4455	HITS-CLIP	27418678
MIRT608873	hsa-miR-4455	HITS-CLIP	27418678
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608872	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608872	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608878	hsa-miR-8068	HITS-CLIP	27418678
MIRT608878	hsa-miR-8068	HITS-CLIP	27418678
MIRT528928	hsa-miR-8485	HITS-CLIP	27418678
MIRT528928	hsa-miR-8485	HITS-CLIP	27418678
MIRT528928	hsa-miR-8485	HITS-CLIP	27418678
MIRT528928	hsa-miR-8485	HITS-CLIP	27418678
MIRT528928	hsa-miR-8485	HITS-CLIP	27418678
MIRT528928	hsa-miR-8485	HITS-CLIP	27418678
MIRT733687	hsa-let-7a-5p	ELISA, Luciferase reporter assay, qRT-PCR, Western blotting	31925656
MIRT608879	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT608878	hsa-miR-8068	HITS-CLIP	21572407
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	21572407
MIRT608875	hsa-miR-147a	HITS-CLIP	21572407
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	21572407
MIRT608873	hsa-miR-4455	HITS-CLIP	21572407
MIRT608872	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT528928	hsa-miR-8485	HITS-CLIP	23313552
MIRT528928	hsa-miR-8485	HITS-CLIP	23313552
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528927	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT608879	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT608877	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT608878	hsa-miR-8068	HITS-CLIP	23824327
MIRT608876	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT608875	hsa-miR-147a	HITS-CLIP	23824327
MIRT608874	hsa-miR-5010-3p	HITS-CLIP	23824327
MIRT608873	hsa-miR-4455	HITS-CLIP	23824327
MIRT608872	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	HITS-CLIP	23824327
MIRT528928	hsa-miR-8485	PAR-CLIP	22012620
MIRT528927	hsa-miR-377-3p	PAR-CLIP	22012620
MIRT901519	hsa-miR-216b	CLIP-seq
MIRT901520	hsa-miR-34c-3p	CLIP-seq
MIRT901521	hsa-miR-3609	CLIP-seq
MIRT901522	hsa-miR-4677-3p	CLIP-seq
MIRT901523	hsa-miR-4679	CLIP-seq
MIRT901524	hsa-miR-4711-5p	CLIP-seq
MIRT901525	hsa-miR-4762-5p	CLIP-seq
MIRT901526	hsa-miR-4763-5p	CLIP-seq
MIRT901527	hsa-miR-548ah	CLIP-seq
MIRT901528	hsa-miR-548n	CLIP-seq
MIRT901529	hsa-miR-548t	CLIP-seq
MIRT1967445	hsa-miR-2115	CLIP-seq
MIRT1967446	hsa-miR-4694-3p	CLIP-seq
MIRT1967447	hsa-miR-4698	CLIP-seq
MIRT2506140	hsa-miR-1178	CLIP-seq
MIRT2506141	hsa-miR-3200-3p	CLIP-seq
MIRT2506142	hsa-miR-3591-3p	CLIP-seq
MIRT2506143	hsa-miR-4457	CLIP-seq
MIRT2506144	hsa-miR-513b	CLIP-seq
MIRT2506145	hsa-miR-624	CLIP-seq
MIRT2506140	hsa-miR-1178	CLIP-seq
MIRT2506141	hsa-miR-3200-3p	CLIP-seq
MIRT2506142	hsa-miR-3591-3p	CLIP-seq
MIRT2506143	hsa-miR-4457	CLIP-seq
MIRT2506144	hsa-miR-513b	CLIP-seq
MIRT2506145	hsa-miR-624	CLIP-seq

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IBA	21873635
GO:0005127	Function	Ciliary neurotrophic factor receptor binding	IBA	21873635
GO:0005138	Function	Interleukin-6 receptor binding	IPI	12643274
GO:0005515	Function	Protein binding	IPI	16051226, 18775332, 20584990, 25416956, 32296183, 32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IC	12643274
GO:0005737	Component	Cytoplasm	IEA
GO:0007165	Process	Signal transduction	NAS	1840538
GO:0008083	Function	Growth factor activity	IBA	21873635
GO:0008083	Function	Growth factor activity	IDA	12643274
GO:0008284	Process	Positive regulation of cell population proliferation	IBA	21873635
GO:0010628	Process	Positive regulation of gene expression	IDA	24129709
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0030424	Component	Axon	IBA	21873635
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IBA	21873635
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IDA	12643274, 21912637
GO:0043524	Process	Negative regulation of neuron apoptotic process	IBA	21873635
GO:0043524	Process	Negative regulation of neuron apoptotic process	IDA	10966616
GO:0044877	Function	Protein-containing complex binding	IPI	10966616
GO:0046533	Process	Negative regulation of photoreceptor cell differentiation	IEA
GO:0046668	Process	Regulation of retinal cell programmed cell death	IEA
GO:0048143	Process	Astrocyte activation	IBA	21873635
GO:0048644	Process	Muscle organ morphogenesis	IEA
GO:0048666	Process	Neuron development	IEA
GO:0048680	Process	Positive regulation of axon regeneration	IBA	21873635
GO:0070120	Process	Ciliary neurotrophic factor-mediated signaling pathway	IBA	21873635
GO:0070120	Process	Ciliary neurotrophic factor-mediated signaling pathway	IDA	12643274

MIM	HGNC	e!Ensembl
118945	2169	ENSG00000242689

Protein

UniProt ID

P26441

Protein name

Ciliary neurotrophic factor (CNTF)

Protein function

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

PDB

1CNT , 8D74

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01110	CNTF	1 → 194	Ciliary neurotrophic factor	Domain

Sequence

MAFTEHSPLTPHRRDLCSRSIWLARKIRSDLTALTESYVKHQGLNKNINLDSADGMPVAS
TDQWSELTEAERLQENLQAYRTFHVLLARLLEDQQVHFTPTEGDFHQAIHTLLLQVAAFA
YQIEELMILLEYKIPRNEADGMPINVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRFIS
SHQTGIPARGSHYIANNKKM

Sequence length

200

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway		IL-6-type cytokine receptor ligand interactions

Associated diseases

Show/Hide Causal Diseases (3)

Causal
Disease name	Disease term	dbSNP ID	References
Amyotrophic lateral sclerosis	Amyotrophic Lateral Sclerosis, Familial	rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733, rs80356731, rs80356726, rs267606928, rs267606929, rs1885090126, rs121434591, rs121912431, rs121912432, rs121912433, rs121912434, rs121912435, rs121912440, rs121912436, rs121912437, rs121912438, rs121912439, rs74315452, rs121912442, rs121912443, rs121912444, rs121912446, rs121912447, rs1197141604, rs121912448, rs121912449, rs121912450, rs121912451, rs121912452, rs121912453, rs121912454, rs369600566, rs121912455, rs121912456, rs121912457, rs121912458, rs1555836889, rs121909667, rs121909668, rs121909669, rs121909671, rs121909535, rs121909537, rs121909538, rs121909539, rs121909540, rs121909542, rs121909544, rs80356734, rs367543041, rs80356740, rs80356719, rs80356721, rs80356723, rs80356725, rs387906627, rs387906628, rs387906709, rs387906710, rs387906711, rs387906829, rs387907264, rs387907265, rs387907266, rs312262739, rs312262709, rs312262749, rs200793464, rs147713329, rs312262788, rs397514262, rs63751180, rs587777132, rs730880025, rs730880026, rs730880027, rs368743618, rs730880029, rs730882255, rs730882256, rs786205611, rs121912441, rs199947197, rs780136067, rs772731615, rs879253926, rs879254294, rs764717219, rs886041390, rs750159428, rs753207473, rs267607087, rs767350733, rs778305085, rs1554707680, rs1554707622, rs1393363759, rs750959420, rs1555509569, rs1554716504, rs11556620, rs1247392012, rs142083484, rs140385286, rs749428135, rs371575563, rs1402429085, rs1218712729, rs1555179091, rs1555179087, rs746971952, rs1555836950, rs368276916, rs140376902, rs747220413, rs76731700, rs770684782, rs1200906022, rs1804449, rs1482760341, rs769898852, rs140599944, rs757972700, rs1555451521, rs1592362719, rs1555836803, rs763455928, rs1378590183, rs1583695322, rs1362178149, rs1197928094, rs368751524, rs1555509609, rs1574787779, rs1601157750, rs1301635320, rs1341055534, rs1402092579, rs1568809172, rs1555836170, rs1315541036, rs1339283341, rs1643659556, rs1644506661, rs1435710212, rs1553122918, rs1689580631, rs374047961, rs775935265, rs2076486420, rs1820836522, rs757260058, rs1844420892, rs1833371664, rs1833438306, rs1833451208, rs2083790483, rs1303294230, rs1226110412, rs2053207945, rs2053208751, rs2053501632, rs2053539304, rs1567479067, rs544088874, rs1228194239, rs1568807400, rs1169198442, rs2049594204, rs2049594311, rs1568810641, rs1568811372, rs2049618449, rs1476760624, rs2079347087	11951178
Lateral sclerosis	AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic	rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048	11951178
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	16969278, 18303965, 15474906, 11343865

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	15585112, 16797081, 18603262, 22266927, 22266927, 18603262, 15585112, 16797081

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