ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide)

Gene

• Entrez ID: 127
• Gene name: Alcohol dehydrogenase 4 (class II), pi polypeptide
• Gene symbol: ADH4
• Synonyms: ADH-2, HEL-S-4
• Chromosome: 4
• Chromosome location: 4q23
• Summary: This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxystero

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT549913	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT549912	hsa-miR-1265	PAR-CLIP	21572407
MIRT549911	hsa-miR-6841-5p	PAR-CLIP	21572407
MIRT549910	hsa-miR-4464	PAR-CLIP	21572407
MIRT549909	hsa-miR-4748	PAR-CLIP	21572407
MIRT549908	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT549907	hsa-miR-1286	PAR-CLIP	21572407
MIRT549906	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT549905	hsa-miR-3665	PAR-CLIP	21572407
MIRT549904	hsa-miR-657	PAR-CLIP	21572407
MIRT549903	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT549902	hsa-miR-5087	PAR-CLIP	21572407
MIRT549901	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT549900	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT549899	hsa-miR-8068	PAR-CLIP	21572407
MIRT549898	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT549913	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT549912	hsa-miR-1265	PAR-CLIP	21572407
MIRT549911	hsa-miR-6841-5p	PAR-CLIP	21572407
MIRT549910	hsa-miR-4464	PAR-CLIP	21572407
MIRT549909	hsa-miR-4748	PAR-CLIP	21572407
MIRT549908	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT549907	hsa-miR-1286	PAR-CLIP	21572407
MIRT549906	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT549905	hsa-miR-3665	PAR-CLIP	21572407
MIRT549904	hsa-miR-657	PAR-CLIP	21572407
MIRT549903	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT549902	hsa-miR-5087	PAR-CLIP	21572407
MIRT549901	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT549900	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT549899	hsa-miR-8068	PAR-CLIP	21572407
MIRT549898	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT768622	hsa-miR-30a	CLIP-seq
MIRT768623	hsa-miR-30b	CLIP-seq
MIRT768624	hsa-miR-30c	CLIP-seq
MIRT768625	hsa-miR-30d	CLIP-seq
MIRT768626	hsa-miR-30e	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT768628	hsa-miR-3907	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT2167643	hsa-miR-1236	CLIP-seq
MIRT2167644	hsa-miR-1298	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT768622	hsa-miR-30a	CLIP-seq
MIRT768623	hsa-miR-30b	CLIP-seq
MIRT768624	hsa-miR-30c	CLIP-seq
MIRT768625	hsa-miR-30d	CLIP-seq
MIRT768626	hsa-miR-30e	CLIP-seq
MIRT2167646	hsa-miR-338-3p	CLIP-seq
MIRT2167647	hsa-miR-3675-3p	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT2167648	hsa-miR-4286	CLIP-seq
MIRT2167649	hsa-miR-4786-3p	CLIP-seq
MIRT2167650	hsa-miR-885-5p	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2470329	hsa-miR-4282	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2470330	hsa-miR-513a-3p	CLIP-seq
MIRT2470331	hsa-miR-548c-3p	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2470329	hsa-miR-4282	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2470330	hsa-miR-513a-3p	CLIP-seq
MIRT2470331	hsa-miR-548c-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	IDA	15369820
GO:0003960	Function	NADPH:quinone reductase activity	ISS
GO:0004022	Function	Alcohol dehydrogenase (NAD+) activity	IDA	3466164, 16787387
GO:0004024	Function	Alcohol dehydrogenase activity, zinc-dependent	IBA	21873635
GO:0004024	Function	Alcohol dehydrogenase activity, zinc-dependent	IDA	10407146
GO:0004032	Function	Alditol:NADP+ 1-oxidoreductase activity	IEA
GO:0004745	Function	Retinol dehydrogenase activity	IDA	10514444, 15369820, 16787387, 17279314
GO:0005503	Function	All-trans retinal binding	IDA	15369820
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006066	Process	Alcohol metabolic process	IDA	3466164
GO:0006069	Process	Ethanol oxidation	IDA	16787387
GO:0006069	Process	Ethanol oxidation	TAS
GO:0006081	Process	Cellular aldehyde metabolic process	IDA	3466164
GO:0008270	Function	Zinc ion binding	IBA	21873635
GO:0008270	Function	Zinc ion binding	IDA	10407146
GO:0010430	Process	Fatty acid omega-oxidation	IDA	16081420
GO:0016620	Function	Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IDA	3466164
GO:0019115	Function	Benzaldehyde dehydrogenase [NAD(P)+] activity	IDA	3466164
GO:0019841	Function	Retinol binding	IDA	10407146
GO:0035276	Function	Ethanol binding	IEA
GO:0042572	Process	Retinol metabolic process	IDA	16787387, 17279314
GO:0046164	Process	Alcohol catabolic process	ISS
GO:0046294	Process	Formaldehyde catabolic process	IBA	21873635
GO:0051287	Function	NAD binding	IDA	10407146
GO:0051903	Function	S-(hydroxymethyl)glutathione dehydrogenase activity	IBA	21873635
GO:1901661	Process	Quinone metabolic process	ISS

Other IDs

• MIM: 103740
• HGNC: 252
• e!Ensembl: ENSG00000198099

Protein

• UniProt ID: P08319
• Protein name: All-trans-retinol dehydrogenase [NAD(+)] ADH4 (EC 1.1.1.105) (Alcohol dehydrogenase 2) (Alcohol dehydrogenase 4) (Alcohol dehydrogenase class II pi chain)
• Protein function: Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end p
• PDB: 3COS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08240	ADH_N	34 → 166	Alcohol dehydrogenase GroES-like domain	Domain
  PF00107	ADH_zinc_N	208 → 340	Zinc-binding dehydrogenase	Family

• Sequence:

  MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEG
  LAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLK
  SPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGC
  GFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKA
  LGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGV
  AAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDK
  ISEAFDLMNQGKSVRTILIF

• Sequence length: 380

Pathways

KEGG:

Glycolysis / Gluconeogenesis
Fatty acid degradation
Tyrosine metabolism
Pyruvate metabolism
Retinol metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Metabolic pathways
Alcoholic liver disease

Reactome:

RA biosynthesis pathway
Ethanol oxidation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Esophagus neoplasm	Esophageal Neoplasms	rs28934578, rs121918714, rs1567556006, rs1575166666	20833657, 22960999
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560
Non-alcoholic fatty liver disease	Non-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis		29718361