CNN3 (calponin 3)

Gene

• Entrez ID: 1266
• Gene name: Calponin 3
• Gene symbol: CNN3
• Synonyms: -
• Chromosome: 1
• Chromosome location: 1p21.3
• Summary: This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associ

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003526	hsa-miR-1-3p	Luciferase reporter assay	20144220
MIRT004059	hsa-miR-7-5p	Microarray	19073608
MIRT019744	hsa-miR-375	Microarray	20215506
MIRT022443	hsa-miR-124-3p	Microarray	18668037
MIRT023223	hsa-miR-122-5p	Proteomics	21750653
MIRT003526	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT004059	hsa-miR-7-5p	Microarray;Other	19073608
MIRT051326	hsa-miR-15a-5p	CLASH	23622248
MIRT051220	hsa-miR-16-5p	CLASH	23622248
MIRT050000	hsa-miR-28-5p	CLASH	23622248
MIRT039532	hsa-miR-652-3p	CLASH	23622248
MIRT039532	hsa-miR-652-3p	CLASH	23622248
MIRT437699	hsa-miR-27a-3p	Microarray, qRT-PCR	22815788
MIRT437708	hsa-miR-27b-3p	Microarray, qRT-PCR	22815788
MIRT628309	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT628308	hsa-miR-337-3p	HITS-CLIP	23824327
MIRT628307	hsa-miR-202-5p	HITS-CLIP	23824327
MIRT628306	hsa-miR-3685	HITS-CLIP	23824327
MIRT628305	hsa-miR-384	HITS-CLIP	23824327
MIRT628304	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT004059	hsa-miR-7-5p	PAR-CLIP	21572407
MIRT548769	hsa-miR-142-3p	PAR-CLIP	21572407
MIRT548768	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT548767	hsa-miR-100-3p	PAR-CLIP	21572407
MIRT548766	hsa-miR-888-5p	PAR-CLIP	21572407
MIRT548765	hsa-miR-577	PAR-CLIP	21572407
MIRT548764	hsa-miR-4476	PAR-CLIP	21572407
MIRT548763	hsa-miR-6876-5p	PAR-CLIP	21572407
MIRT548762	hsa-miR-4255	PAR-CLIP	21572407
MIRT548761	hsa-miR-633	PAR-CLIP	21572407
MIRT548760	hsa-miR-651-5p	PAR-CLIP	21572407
MIRT628309	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT628308	hsa-miR-337-3p	HITS-CLIP	23824327
MIRT628307	hsa-miR-202-5p	HITS-CLIP	23824327
MIRT628306	hsa-miR-3685	HITS-CLIP	23824327
MIRT628305	hsa-miR-384	HITS-CLIP	23824327
MIRT628304	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT004059	hsa-miR-7-5p	PAR-CLIP	21572407
MIRT548769	hsa-miR-142-3p	PAR-CLIP	21572407
MIRT548768	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT548767	hsa-miR-100-3p	PAR-CLIP	21572407
MIRT548766	hsa-miR-888-5p	PAR-CLIP	21572407
MIRT548765	hsa-miR-577	PAR-CLIP	21572407
MIRT548764	hsa-miR-4476	PAR-CLIP	21572407
MIRT548763	hsa-miR-6876-5p	PAR-CLIP	21572407
MIRT548762	hsa-miR-4255	PAR-CLIP	21572407
MIRT548761	hsa-miR-633	PAR-CLIP	21572407
MIRT548760	hsa-miR-651-5p	PAR-CLIP	21572407
MIRT899897	hsa-miR-128	CLIP-seq
MIRT899898	hsa-miR-144	CLIP-seq
MIRT899899	hsa-miR-182	CLIP-seq
MIRT899900	hsa-miR-1827	CLIP-seq
MIRT899901	hsa-miR-27a	CLIP-seq
MIRT899902	hsa-miR-27b	CLIP-seq
MIRT899903	hsa-miR-3126-5p	CLIP-seq
MIRT899904	hsa-miR-3127-3p	CLIP-seq
MIRT899905	hsa-miR-3922-5p	CLIP-seq
MIRT899906	hsa-miR-4259	CLIP-seq
MIRT899907	hsa-miR-4419a	CLIP-seq
MIRT899908	hsa-miR-4470	CLIP-seq
MIRT899909	hsa-miR-4510	CLIP-seq
MIRT899910	hsa-miR-4666-3p	CLIP-seq
MIRT899911	hsa-miR-4715-5p	CLIP-seq
MIRT899912	hsa-miR-4766-3p	CLIP-seq
MIRT899913	hsa-miR-513a-5p	CLIP-seq
MIRT899914	hsa-miR-888	CLIP-seq
MIRT1546532	hsa-miR-338-5p	CLIP-seq
MIRT1546533	hsa-miR-3942-5p	CLIP-seq
MIRT1546534	hsa-miR-4703-5p	CLIP-seq
MIRT1546535	hsa-miR-651	CLIP-seq
MIRT1546536	hsa-miR-7	CLIP-seq
MIRT1546533	hsa-miR-3942-5p	CLIP-seq
MIRT1546534	hsa-miR-4703-5p	CLIP-seq
MIRT899897	hsa-miR-128	CLIP-seq
MIRT899898	hsa-miR-144	CLIP-seq
MIRT2202673	hsa-miR-1911	CLIP-seq
MIRT899901	hsa-miR-27a	CLIP-seq
MIRT899902	hsa-miR-27b	CLIP-seq
MIRT2202674	hsa-miR-3123	CLIP-seq
MIRT2202675	hsa-miR-3682-5p	CLIP-seq
MIRT899913	hsa-miR-513a-5p	CLIP-seq
MIRT2202676	hsa-miR-570	CLIP-seq
MIRT2202677	hsa-miR-618	CLIP-seq
MIRT2386291	hsa-miR-105	CLIP-seq
MIRT899897	hsa-miR-128	CLIP-seq
MIRT899898	hsa-miR-144	CLIP-seq
MIRT2202673	hsa-miR-1911	CLIP-seq
MIRT899901	hsa-miR-27a	CLIP-seq
MIRT899902	hsa-miR-27b	CLIP-seq
MIRT2202674	hsa-miR-3123	CLIP-seq
MIRT899904	hsa-miR-3127-3p	CLIP-seq
MIRT2427385	hsa-miR-34b	CLIP-seq
MIRT2202675	hsa-miR-3682-5p	CLIP-seq
MIRT2427386	hsa-miR-4427	CLIP-seq
MIRT2427387	hsa-miR-4643	CLIP-seq
MIRT2427388	hsa-miR-466	CLIP-seq
MIRT2427389	hsa-miR-4719	CLIP-seq
MIRT2427390	hsa-miR-4728-3p	CLIP-seq
MIRT2427391	hsa-miR-4789-3p	CLIP-seq
MIRT899913	hsa-miR-513a-5p	CLIP-seq
MIRT1546535	hsa-miR-651	CLIP-seq
MIRT1546536	hsa-miR-7	CLIP-seq
MIRT2386291	hsa-miR-105	CLIP-seq
MIRT2202673	hsa-miR-1911	CLIP-seq
MIRT2505642	hsa-miR-1972	CLIP-seq
MIRT2202674	hsa-miR-3123	CLIP-seq
MIRT2505643	hsa-miR-3156-5p	CLIP-seq
MIRT2427385	hsa-miR-34b	CLIP-seq
MIRT2505644	hsa-miR-3591-3p	CLIP-seq
MIRT2427387	hsa-miR-4643	CLIP-seq
MIRT2505645	hsa-miR-4650-5p	CLIP-seq
MIRT2427388	hsa-miR-466	CLIP-seq
MIRT2505646	hsa-miR-4711-5p	CLIP-seq
MIRT2505647	hsa-miR-4714-5p	CLIP-seq
MIRT2505648	hsa-miR-4717-5p	CLIP-seq
MIRT2427389	hsa-miR-4719	CLIP-seq
MIRT2505649	hsa-miR-4766-5p	CLIP-seq
MIRT2427391	hsa-miR-4789-3p	CLIP-seq
MIRT2386291	hsa-miR-105	CLIP-seq
MIRT2505642	hsa-miR-1972	CLIP-seq
MIRT2427385	hsa-miR-34b	CLIP-seq
MIRT2505644	hsa-miR-3591-3p	CLIP-seq
MIRT2427387	hsa-miR-4643	CLIP-seq
MIRT2505645	hsa-miR-4650-5p	CLIP-seq
MIRT2427388	hsa-miR-466	CLIP-seq
MIRT2505646	hsa-miR-4711-5p	CLIP-seq
MIRT2505648	hsa-miR-4717-5p	CLIP-seq
MIRT2427389	hsa-miR-4719	CLIP-seq
MIRT899912	hsa-miR-4766-3p	CLIP-seq
MIRT2427391	hsa-miR-4789-3p	CLIP-seq
MIRT2678349	hsa-miR-548p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005912	Component	Adherens junction	HDA	25468996
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0008017	Function	Microtubule binding	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0030855	Process	Epithelial cell differentiation	IEP	21492153
GO:0031032	Process	Actomyosin structure organization	IEA
GO:0032780	Process	Negative regulation of ATPase activity	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0098609	Process	Cell-cell adhesion	IEA
GO:0098641	Function	Cadherin binding involved in cell-cell adhesion	HDA	25468996

Other IDs

• MIM: 602374
• HGNC: 2157
• e!Ensembl: ENSG00000117519

Protein

• UniProt ID: Q15417
• Protein name: Calponin-3 (Calponin, acidic isoform)
• Protein function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00307	CH	26 → 131	Calponin homology (CH) domain	Domain
  PF00402	Calponin	164 → 188	Calponin family repeat	Repeat
  PF00402	Calponin	204 → 228	Calponin family repeat	Repeat
  PF00402	Calponin	243 → 267	Calponin family repeat	Repeat

• Sequence:

  MTHFNKGPSYGLSAEVKNKIASKYDHQAEEDLRNWIEEVTGMSIGPNFQLGLKDGIILCE
  LINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQT
  TLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMT
  AYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDN
  STISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDY
  QAEYPDEYHGEYQDDYPRDYQYSDQGIDY

• Sequence length: 329

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	12376462
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Anaplastic carcinoma	Anaplastic carcinoma		12376462
Prostatic neoplasms	Prostatic Neoplasms		17013881