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ANKRD13B (ankyrin repeat domain 13B)

Gene

124930

Ankyrin repeat domain 13B

ANKRD13B

17q11.2

Show/Hide all(99)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003948	hsa-miR-373-3p	Microarray	15685193
MIRT040994	hsa-miR-505-3p	CLASH	23622248
MIRT145377	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT145378	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT145379	hsa-miR-92a-2-5p	PAR-CLIP	20371350
MIRT145379	hsa-miR-92a-2-5p	PAR-CLIP	26701625
MIRT145382	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT145386	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT145392	hsa-miR-608	PAR-CLIP	20371350
MIRT145392	hsa-miR-608	PAR-CLIP	26701625
MIRT145404	hsa-miR-1275	PAR-CLIP	23592263
MIRT145404	hsa-miR-1275	PAR-CLIP	20371350
MIRT145404	hsa-miR-1275	PAR-CLIP	26701625
MIRT145411	hsa-miR-4447	PAR-CLIP	20371350
MIRT145411	hsa-miR-4447	PAR-CLIP	26701625
MIRT145413	hsa-miR-4472	PAR-CLIP	20371350
MIRT145413	hsa-miR-4472	PAR-CLIP	26701625
MIRT145419	hsa-miR-4651	PAR-CLIP	20371350
MIRT145419	hsa-miR-4651	PAR-CLIP	26701625
MIRT145421	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT145421	hsa-miR-4665-5p	PAR-CLIP	20371350
MIRT145421	hsa-miR-4665-5p	PAR-CLIP	26701625
MIRT145433	hsa-miR-6756-5p	PAR-CLIP	20371350
MIRT145433	hsa-miR-6756-5p	PAR-CLIP	26701625
MIRT145434	hsa-miR-6766-5p	PAR-CLIP	20371350
MIRT145434	hsa-miR-6766-5p	PAR-CLIP	26701625
MIRT494778	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT494778	hsa-miR-6858-5p	PAR-CLIP	20371350
MIRT494778	hsa-miR-6858-5p	PAR-CLIP	26701625
MIRT494779	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT494779	hsa-miR-6779-5p	PAR-CLIP	20371350
MIRT494779	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT494780	hsa-miR-6089	PAR-CLIP	23592263
MIRT494780	hsa-miR-6089	PAR-CLIP	20371350
MIRT494780	hsa-miR-6089	PAR-CLIP	26701625
MIRT494781	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT494781	hsa-miR-5010-5p	PAR-CLIP	20371350
MIRT494781	hsa-miR-5010-5p	PAR-CLIP	26701625
MIRT494782	hsa-miR-4525	PAR-CLIP	23592263
MIRT494782	hsa-miR-4525	PAR-CLIP	20371350
MIRT494782	hsa-miR-4525	PAR-CLIP	26701625
MIRT494783	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT494783	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT494783	hsa-miR-7111-5p	PAR-CLIP	26701625
MIRT494784	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT494784	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT494784	hsa-miR-6870-5p	PAR-CLIP	26701625
MIRT494785	hsa-miR-5698	PAR-CLIP	23592263
MIRT494785	hsa-miR-5698	PAR-CLIP	20371350
MIRT494785	hsa-miR-5698	PAR-CLIP	26701625
MIRT494786	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT494786	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT494786	hsa-miR-4723-5p	PAR-CLIP	26701625
MIRT494787	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT494787	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT494787	hsa-miR-625-5p	PAR-CLIP	26701625
MIRT494788	hsa-miR-185-3p	PAR-CLIP	23592263
MIRT494788	hsa-miR-185-3p	PAR-CLIP	20371350
MIRT494788	hsa-miR-185-3p	PAR-CLIP	26701625
MIRT494789	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT494789	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT494789	hsa-miR-6825-5p	PAR-CLIP	26701625
MIRT494790	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT494790	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT494790	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT494791	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT494791	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT494791	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT494792	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT494792	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT494792	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT494793	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT494793	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT494793	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT494794	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT494794	hsa-miR-423-5p	PAR-CLIP	20371350
MIRT494794	hsa-miR-423-5p	PAR-CLIP	26701625
MIRT494795	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT494795	hsa-miR-3184-5p	PAR-CLIP	20371350
MIRT494795	hsa-miR-3184-5p	PAR-CLIP	26701625
MIRT494796	hsa-miR-6813-5p	PAR-CLIP	23592263
MIRT494796	hsa-miR-6813-5p	PAR-CLIP	20371350
MIRT494796	hsa-miR-6813-5p	PAR-CLIP	26701625
MIRT494797	hsa-miR-6085	PAR-CLIP	23592263
MIRT494797	hsa-miR-6085	PAR-CLIP	20371350
MIRT494797	hsa-miR-6085	PAR-CLIP	26701625
MIRT494798	hsa-miR-203a-3p	PAR-CLIP	23592263
MIRT494798	hsa-miR-203a-3p	PAR-CLIP	20371350
MIRT494798	hsa-miR-203a-3p	PAR-CLIP	26701625
MIRT570741	hsa-miR-762	PAR-CLIP	20371350
MIRT570741	hsa-miR-762	PAR-CLIP	26701625
MIRT570742	hsa-miR-5001-5p	PAR-CLIP	20371350
MIRT570742	hsa-miR-5001-5p	PAR-CLIP	26701625
MIRT570743	hsa-miR-4498	PAR-CLIP	20371350
MIRT570743	hsa-miR-4498	PAR-CLIP	26701625
MIRT570744	hsa-miR-4492	PAR-CLIP	20371350
MIRT570744	hsa-miR-4492	PAR-CLIP	26701625
MIRT745504	hsa-miR-4505	PAR-CLIP	26701625
MIRT751454	hsa-miR-5787	PAR-CLIP	26701625

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002091	Process	Negative regulation of receptor internalization	IMP	22298428
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	22298428
GO:0005769	Component	Early endosome	IDA	22298428
GO:0005770	Component	Late endosome	IDA	22298428
GO:0005886	Component	Plasma membrane	IDA	22298428
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	22298428
GO:0140036	Function	Ubiquitin-dependent protein binding	IDA	22298428
GO:0140036	Function	Ubiquitin-dependent protein binding	IPI	22298428

MIM	HGNC	e!Ensembl
615124	26363	ENSG00000198720

Protein

UniProt ID

Q86YJ7

Protein name

Ankyrin repeat domain-containing protein 13B

Protein function

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12796	Ank_2	18 → 110	Ankyrin repeats (3 copies)	Repeat
PF11904	GPCR_chapero_1	163 → 490	GPCR-chaperone	Domain

Sequence

MIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGH
LECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLL
EKLRKAQDFYVEMKWEFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGN
RSFVFRGQDTSAVVMEIDHDRRVVYTETLALAGQDRELLLAAAQPTEEQVLSRLTAPVVT
TQLDTKNISFERNKTGILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKV
KGCKTPLQSFLGIAEQHGGPQNGTLITQTLSQANPTAITAEEYFNPNFELGNRDMGRPME
LTTKTQKFKAKLWLCEEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIE
IPIFHILNARITFGNLNGCDEPVPSVRGSPSSETPSPGSDSSSVSSSSSTTSCRGCEISP
ALFEAPRGYSMMGGQREAATRDDDDDLLQFAIQQSLLEAGSEYDQVTIWEALTNSKPGTH
PMSYEGRRQDRSAPPTPQRQPAPPASVPSPRPSSGPGSGGHVFRSYDEQLRLAMELSAQE
QEERRRRARQEEEELERILRLSLTEQ

Sequence length

626

Interactions

View interactions

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	29212778

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