ZPBP2 (zona pellucida binding protein 2)

Gene

• Entrez ID: 124626
• Gene name: Zona pellucida binding protein 2
• Gene symbol: ZPBP2
• Synonyms: ZPBPL
• Chromosome: 17
• Chromosome location: 17q21.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017875	hsa-miR-335-5p	Microarray	18185580
MIRT1543373	hsa-miR-185	CLIP-seq
MIRT1543374	hsa-miR-4306	CLIP-seq
MIRT1543375	hsa-miR-4644	CLIP-seq
MIRT1543376	hsa-miR-4802-5p	CLIP-seq
MIRT2163954	hsa-miR-1323	CLIP-seq
MIRT2163955	hsa-miR-3148	CLIP-seq
MIRT2163956	hsa-miR-3978	CLIP-seq
MIRT2163957	hsa-miR-548a-3p	CLIP-seq
MIRT2163958	hsa-miR-548an	CLIP-seq
MIRT2163959	hsa-miR-548e	CLIP-seq
MIRT2163960	hsa-miR-548f	CLIP-seq
MIRT2163961	hsa-miR-548g	CLIP-seq
MIRT2163962	hsa-miR-548o	CLIP-seq
MIRT2383119	hsa-miR-3120-3p	CLIP-seq
MIRT2383120	hsa-miR-331-5p	CLIP-seq
MIRT2383121	hsa-miR-3617	CLIP-seq
MIRT2383122	hsa-miR-3914	CLIP-seq
MIRT2383123	hsa-miR-3928	CLIP-seq
MIRT2383124	hsa-miR-4672	CLIP-seq
MIRT2383125	hsa-miR-4802-3p	CLIP-seq
MIRT1543376	hsa-miR-4802-5p	CLIP-seq
MIRT2383126	hsa-miR-641	CLIP-seq
MIRT2383127	hsa-miR-765	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001669	Component	Acrosomal vesicle	IBA	21873635
GO:0001675	Process	Acrosome assembly	IBA	21873635
GO:0002199	Component	Zona pellucida receptor complex	IBA	21873635
GO:0002638	Process	Negative regulation of immunoglobulin production	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005634	Component	Nucleus	HDA	21630459
GO:0006665	Process	Sphingolipid metabolic process	IEA
GO:0007339	Process	Binding of sperm to zona pellucida	IBA	21873635
GO:0032922	Process	Circadian regulation of gene expression	IEA
GO:0044297	Component	Cell body	IEA
GO:0046466	Process	Membrane lipid catabolic process	IEA

Other IDs

• MIM: 608499
• HGNC: 20678
• e!Ensembl: ENSG00000186075

Protein

• UniProt ID: Q6X784
• Protein name: Zona pellucida-binding protein 2 (ZPBP-like protein)
• Protein function: Is implicated in sperm-oocyte interaction during fertilization.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07354	Sp38	150 → 327	Zona-pellucida-binding protein (Sp38)	Family

• Sequence:

  MMRTCVLLSAVLWCLTGVQCPRFTLFNKKGFIYGKTGQPDKIYVELHQNSPVLICMDFKL
  SKKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCTLSYKTVKAET
  QEEKTVKKRYDFMVFAYREPDYSYQMAVRFTTRSCIGRYNDVFFRVLKKILDSLISDLSC
  HVIEPSYKCHSVEIPEHGLIHELFIAFQVNPFAPGWKGACNGSVDCEDTTNHNILQARDR
  IEDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVVRLDSCRPGFGKNERLHSNCASCCVVCS
  PATFSPDVNVTCQTCVSVLTYGAKSCPQTSNKNQQYED

• Sequence length: 338

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	21804549, 27182965, 20860503, 17611496
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557, rs587777558, rs587777559, rs587777560, rs886037778, rs769405762, rs770372675	29892015, 30061737
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26974007
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	30423114

Unknown
Disease name	Disease term	dbSNP ID	References
Allergic rhinitis	Allergic rhinitis (disorder)		30013184
Ankylosing spondylitis	Ankylosing spondylitis		26974007
Cholangitis	Cholangitis, Sclerosing		26974007
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	26974007
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	rs199865688, rs397515994, rs757096307	29892015
Biliary cirrhosis	Primary biliary cirrhosis		22936693, 22961000
Ulcerative colitis	Ulcerative Colitis		26974007