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CMKLR1 (chemerin chemokine-like receptor 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1240
Gene nameGene Name - the full gene name approved by the HGNC.
Chemerin chemokine-like receptor 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CMKLR1
SynonymsGene synonyms aliases
CHEMERINR, ChemR23, DEZ, ERV1, RVER1
ChromosomeChromosome number
12
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q23.3
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT710975 hsa-miR-3127-3p HITS-CLIP 19536157
MIRT710974 hsa-miR-6756-3p HITS-CLIP 19536157
MIRT710973 hsa-miR-5088-3p HITS-CLIP 19536157
MIRT710972 hsa-miR-3183 HITS-CLIP 19536157
MIRT710971 hsa-miR-4723-3p HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001501 Process Skeletal system development TAS 9144535
GO:0002430 Process Complement receptor mediated signaling pathway IBA 21873635
GO:0004875 Function Complement receptor activity IBA 21873635
GO:0004930 Function G protein-coupled receptor activity IBA 21873635
GO:0004930 Function G protein-coupled receptor activity NAS 9603476
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q99788
Protein name Chemerin-like receptor 1 (Chemokine-like receptor 1) (G-protein coupled receptor ChemR23) (G-protein coupled receptor DEZ)
Protein function Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses
PDB 7YKD , 8SG1 , 8ZJG , 9L3W
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1
57 316
7 transmembrane receptor (rhodopsin family)
Family
Sequence
Sequence length 373
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Class A/1 (Rhodopsin-like receptors)
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Lung carcinoma Non-Small Cell Lung Carcinoma rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 21483023
Unknown
Disease name Disease term dbSNP ID References
Granulosa cell tumor granulosa cell tumor, Granulosa Cell Cancer 29653259
Mental depression Mental Depression, Depressive disorder rs587778876, rs587778877 22796467

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