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CCR8 (C-C motif chemokine receptor 8)
Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1237
Gene nameGene Name - the full gene name approved by the HGNC.
C-C motif chemokine receptor 8
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CCR8
SynonymsGene synonyms aliases
CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1
ChromosomeChromosome number
3
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p22.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT1959112 hsa-miR-421 CLIP-seq
MIRT2677610 hsa-miR-129-5p CLIP-seq
MIRT2677611 hsa-miR-205 CLIP-seq
MIRT2677612 hsa-miR-3978 CLIP-seq
MIRT2677613 hsa-miR-4539 CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0004950 Function Chemokine receptor activity TAS 9417093
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane TAS 8816377
GO:0006935 Process Chemotaxis TAS 10910894
GO:0006955 Process Immune response IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P51685
Protein name C-C chemokine receptor type 8 (C-C CKR-8) (CC-CKR-8) (CCR-8) (CC chemokine receptor CHEMR1) (CMKBRL2) (Chemokine receptor-like 1) (CKR-L1) (GPR-CY6) (GPRCY6) (TER1) (CD antigen CDw198)
Protein function Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:9207005, ECO:0000269|PubMed:94694
PDB 8KFX , 8KFY , 8KFZ , 8TLM , 8U1U , 8XML
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1
52 → 300
7 transmembrane receptor (rhodopsin family)
 Family
Sequence
Sequence length 355
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Kaposi sarcoma-associated herpesvirus infection
Viral carcinogenesis 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
Associated diseases
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Grand mal status epilepticus Grand Mal Status Epilepticus 17181556
Nonconvulsive status epilepticus Non-Convulsive Status Epilepticus 17181556
Petit mal status Petit mal status 17181556
Status epilepticus Status Epilepticus, Complex Partial Status Epilepticus, Status Epilepticus, Subclinical 17181556

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