CCR6 (C-C motif chemokine receptor 6)

Gene

• Entrez ID: 1235
• Gene name: C-C motif chemokine receptor 6
• Gene symbol: CCR6
• Synonyms: BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22
• Chromosome: 6
• Chromosome location: 6q27
• Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligan

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029835	hsa-miR-26b-5p	Microarray	19088304
MIRT054540	hsa-miR-518a-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR	24559209
MIRT054540	hsa-miR-518a-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR	24559209
MIRT054540	hsa-miR-518a-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR	24559209
MIRT054540	hsa-miR-518a-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR	24559209
MIRT438120	hsa-miR-150-5p	ELISA, Immunohistochemistry, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	24385540
MIRT438120	hsa-miR-150-5p	ELISA, Immunohistochemistry, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	24385540
MIRT438120	hsa-miR-150-5p	ELISA, Immunohistochemistry, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	24385540
MIRT438120	hsa-miR-150-5p	ELISA, Immunohistochemistry, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	24385540
MIRT675085	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT675084	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT675083	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT675082	hsa-miR-4770	HITS-CLIP	23824327
MIRT675081	hsa-miR-6088	HITS-CLIP	23824327
MIRT675080	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT675079	hsa-miR-1273f	HITS-CLIP	23824327
MIRT675078	hsa-miR-4534	HITS-CLIP	23824327
MIRT675077	hsa-miR-8082	HITS-CLIP	23824327
MIRT675076	hsa-miR-1289	HITS-CLIP	23824327
MIRT675075	hsa-miR-4294	HITS-CLIP	23824327
MIRT675074	hsa-miR-3198	HITS-CLIP	23824327
MIRT675073	hsa-miR-4309	HITS-CLIP	23824327
MIRT675072	hsa-miR-8055	HITS-CLIP	23824327
MIRT675071	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT663559	hsa-miR-1245a	HITS-CLIP	23824327
MIRT663560	hsa-miR-8079	HITS-CLIP	23824327
MIRT663558	hsa-miR-5579-3p	HITS-CLIP	23824327
MIRT663557	hsa-miR-640	HITS-CLIP	23824327
MIRT663556	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT663555	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT663554	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT663552	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT663553	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT663551	hsa-miR-3666	HITS-CLIP	23824327
MIRT663550	hsa-miR-4295	HITS-CLIP	23824327
MIRT663549	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT663548	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT663547	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT663546	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT663545	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT663544	hsa-miR-3135b	HITS-CLIP	23824327
MIRT663543	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT663542	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT663541	hsa-miR-564	HITS-CLIP	23824327
MIRT663540	hsa-miR-3652	HITS-CLIP	23824327
MIRT663539	hsa-miR-4430	HITS-CLIP	23824327
MIRT663538	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT663537	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT497572	hsa-miR-4539	PAR-CLIP	22291592
MIRT497571	hsa-miR-4635	PAR-CLIP	22291592
MIRT497570	hsa-miR-3928-5p	PAR-CLIP	22291592
MIRT497569	hsa-miR-6806-3p	PAR-CLIP	22291592
MIRT497568	hsa-miR-4749-3p	PAR-CLIP	22291592
MIRT497567	hsa-miR-7843-3p	PAR-CLIP	22291592
MIRT497566	hsa-miR-127-5p	PAR-CLIP	22291592
MIRT731937	hsa-miR-150-3p	Western blot	27935859
MIRT731937	hsa-miR-150-3p	Western blot	27935859
MIRT675079	hsa-miR-1273f	HITS-CLIP	27418678
MIRT675079	hsa-miR-1273f	HITS-CLIP	27418678
MIRT675076	hsa-miR-1289	HITS-CLIP	27418678
MIRT675076	hsa-miR-1289	HITS-CLIP	27418678
MIRT675071	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT675071	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT675083	hsa-miR-143-3p	HITS-CLIP	27418678
MIRT675083	hsa-miR-143-3p	HITS-CLIP	27418678
MIRT675074	hsa-miR-3198	HITS-CLIP	27418678
MIRT675074	hsa-miR-3198	HITS-CLIP	27418678
MIRT675075	hsa-miR-4294	HITS-CLIP	27418678
MIRT675075	hsa-miR-4294	HITS-CLIP	27418678
MIRT675073	hsa-miR-4309	HITS-CLIP	27418678
MIRT675073	hsa-miR-4309	HITS-CLIP	27418678
MIRT675078	hsa-miR-4534	HITS-CLIP	27418678
MIRT675078	hsa-miR-4534	HITS-CLIP	27418678
MIRT675080	hsa-miR-4708-5p	HITS-CLIP	27418678
MIRT675080	hsa-miR-4708-5p	HITS-CLIP	27418678
MIRT675082	hsa-miR-4770	HITS-CLIP	27418678
MIRT675082	hsa-miR-4770	HITS-CLIP	27418678
MIRT675081	hsa-miR-6088	HITS-CLIP	27418678
MIRT675081	hsa-miR-6088	HITS-CLIP	27418678
MIRT675085	hsa-miR-6514-5p	HITS-CLIP	27418678
MIRT675085	hsa-miR-6514-5p	HITS-CLIP	27418678
MIRT663538	hsa-miR-6879-3p	HITS-CLIP	27418678
MIRT675072	hsa-miR-8055	HITS-CLIP	27418678
MIRT675072	hsa-miR-8055	HITS-CLIP	27418678
MIRT675077	hsa-miR-8082	HITS-CLIP	27418678
MIRT675077	hsa-miR-8082	HITS-CLIP	27418678
MIRT735791	hsa-miR-518a-5p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR, Flow cytometry	32600091
MIRT675085	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT675084	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT675083	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT675082	hsa-miR-4770	HITS-CLIP	23824327
MIRT675081	hsa-miR-6088	HITS-CLIP	23824327
MIRT675080	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT675079	hsa-miR-1273f	HITS-CLIP	23824327
MIRT675078	hsa-miR-4534	HITS-CLIP	23824327
MIRT675077	hsa-miR-8082	HITS-CLIP	23824327
MIRT675076	hsa-miR-1289	HITS-CLIP	23824327
MIRT675075	hsa-miR-4294	HITS-CLIP	23824327
MIRT675074	hsa-miR-3198	HITS-CLIP	23824327
MIRT675073	hsa-miR-4309	HITS-CLIP	23824327
MIRT675072	hsa-miR-8055	HITS-CLIP	23824327
MIRT675071	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT663559	hsa-miR-1245a	HITS-CLIP	23824327
MIRT663560	hsa-miR-8079	HITS-CLIP	23824327
MIRT663558	hsa-miR-5579-3p	HITS-CLIP	23824327
MIRT663557	hsa-miR-640	HITS-CLIP	23824327
MIRT663556	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT663555	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT663554	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT663552	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT663553	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT663551	hsa-miR-3666	HITS-CLIP	23824327
MIRT663550	hsa-miR-4295	HITS-CLIP	23824327
MIRT663549	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT663548	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT663547	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT663546	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT663545	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT663544	hsa-miR-3135b	HITS-CLIP	23824327
MIRT663543	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT663542	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT663541	hsa-miR-564	HITS-CLIP	23824327
MIRT663540	hsa-miR-3652	HITS-CLIP	23824327
MIRT663539	hsa-miR-4430	HITS-CLIP	23824327
MIRT663538	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT663537	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT497572	hsa-miR-4539	PAR-CLIP	22291592
MIRT497571	hsa-miR-4635	PAR-CLIP	22291592
MIRT497570	hsa-miR-3928-5p	PAR-CLIP	22291592
MIRT497569	hsa-miR-6806-3p	PAR-CLIP	22291592
MIRT497568	hsa-miR-4749-3p	PAR-CLIP	22291592
MIRT497567	hsa-miR-7843-3p	PAR-CLIP	22291592
MIRT497566	hsa-miR-127-5p	PAR-CLIP	22291592
MIRT873250	hsa-miR-122	CLIP-seq
MIRT873251	hsa-miR-1245	CLIP-seq
MIRT873252	hsa-miR-1307	CLIP-seq
MIRT873253	hsa-miR-130a	CLIP-seq
MIRT873254	hsa-miR-130b	CLIP-seq
MIRT873255	hsa-miR-183	CLIP-seq
MIRT873256	hsa-miR-301a	CLIP-seq
MIRT873257	hsa-miR-301b	CLIP-seq
MIRT873258	hsa-miR-3149	CLIP-seq
MIRT873259	hsa-miR-371-5p	CLIP-seq
MIRT873260	hsa-miR-371b-5p	CLIP-seq
MIRT873261	hsa-miR-411	CLIP-seq
MIRT873262	hsa-miR-454	CLIP-seq
MIRT873263	hsa-miR-4729	CLIP-seq
MIRT873264	hsa-miR-548l	CLIP-seq
MIRT873265	hsa-miR-548n	CLIP-seq
MIRT873266	hsa-miR-720	CLIP-seq
MIRT873250	hsa-miR-122	CLIP-seq
MIRT873253	hsa-miR-130a	CLIP-seq
MIRT873254	hsa-miR-130b	CLIP-seq
MIRT873267	hsa-miR-150	CLIP-seq
MIRT873255	hsa-miR-183	CLIP-seq
MIRT873256	hsa-miR-301a	CLIP-seq
MIRT873257	hsa-miR-301b	CLIP-seq
MIRT873268	hsa-miR-3128	CLIP-seq
MIRT873269	hsa-miR-4258	CLIP-seq
MIRT873270	hsa-miR-4269	CLIP-seq
MIRT873271	hsa-miR-4438	CLIP-seq
MIRT873262	hsa-miR-454	CLIP-seq
MIRT873272	hsa-miR-5095	CLIP-seq
MIRT873273	hsa-miR-562	CLIP-seq
MIRT1959103	hsa-miR-3187-3p	CLIP-seq
MIRT1959104	hsa-miR-4435	CLIP-seq
MIRT1959105	hsa-miR-4701-5p	CLIP-seq
MIRT1959106	hsa-miR-4755-3p	CLIP-seq
MIRT1959107	hsa-miR-548s	CLIP-seq
MIRT1959108	hsa-miR-588	CLIP-seq
MIRT873250	hsa-miR-122	CLIP-seq
MIRT873252	hsa-miR-1307	CLIP-seq
MIRT873253	hsa-miR-130a	CLIP-seq
MIRT873254	hsa-miR-130b	CLIP-seq
MIRT1959109	hsa-miR-1343	CLIP-seq
MIRT873255	hsa-miR-183	CLIP-seq
MIRT873256	hsa-miR-301a	CLIP-seq
MIRT873257	hsa-miR-301b	CLIP-seq
MIRT1959110	hsa-miR-4284	CLIP-seq
MIRT873262	hsa-miR-454	CLIP-seq
MIRT1959111	hsa-miR-498	CLIP-seq
MIRT873250	hsa-miR-122	CLIP-seq
MIRT873252	hsa-miR-1307	CLIP-seq
MIRT873253	hsa-miR-130a	CLIP-seq
MIRT873254	hsa-miR-130b	CLIP-seq
MIRT1959109	hsa-miR-1343	CLIP-seq
MIRT873267	hsa-miR-150	CLIP-seq
MIRT873255	hsa-miR-183	CLIP-seq
MIRT873256	hsa-miR-301a	CLIP-seq
MIRT873257	hsa-miR-301b	CLIP-seq
MIRT2196035	hsa-miR-3152-5p	CLIP-seq
MIRT2196036	hsa-miR-377	CLIP-seq
MIRT1959110	hsa-miR-4284	CLIP-seq
MIRT873262	hsa-miR-454	CLIP-seq
MIRT2196037	hsa-miR-4641	CLIP-seq
MIRT2196038	hsa-miR-4690-3p	CLIP-seq
MIRT2196039	hsa-miR-4709-3p	CLIP-seq
MIRT2196040	hsa-miR-4731-5p	CLIP-seq
MIRT2196041	hsa-miR-4753-3p	CLIP-seq
MIRT2196042	hsa-miR-4772-3p	CLIP-seq
MIRT1959111	hsa-miR-498	CLIP-seq
MIRT873250	hsa-miR-122	CLIP-seq
MIRT873253	hsa-miR-130a	CLIP-seq
MIRT873254	hsa-miR-130b	CLIP-seq
MIRT2446537	hsa-miR-143	CLIP-seq
MIRT873256	hsa-miR-301a	CLIP-seq
MIRT873257	hsa-miR-301b	CLIP-seq
MIRT873262	hsa-miR-454	CLIP-seq
MIRT873266	hsa-miR-720	CLIP-seq
MIRT873250	hsa-miR-122	CLIP-seq
MIRT873252	hsa-miR-1307	CLIP-seq
MIRT873253	hsa-miR-130a	CLIP-seq
MIRT873254	hsa-miR-130b	CLIP-seq
MIRT1959109	hsa-miR-1343	CLIP-seq
MIRT873255	hsa-miR-183	CLIP-seq
MIRT873256	hsa-miR-301a	CLIP-seq
MIRT873257	hsa-miR-301b	CLIP-seq
MIRT2196035	hsa-miR-3152-5p	CLIP-seq
MIRT1959110	hsa-miR-4284	CLIP-seq
MIRT873262	hsa-miR-454	CLIP-seq
MIRT2196041	hsa-miR-4753-3p	CLIP-seq
MIRT2196042	hsa-miR-4772-3p	CLIP-seq
MIRT1959111	hsa-miR-498	CLIP-seq
MIRT873252	hsa-miR-1307	CLIP-seq
MIRT1959109	hsa-miR-1343	CLIP-seq
MIRT873267	hsa-miR-150	CLIP-seq
MIRT2196035	hsa-miR-3152-5p	CLIP-seq
MIRT1959110	hsa-miR-4284	CLIP-seq
MIRT873271	hsa-miR-4438	CLIP-seq
MIRT2196041	hsa-miR-4753-3p	CLIP-seq
MIRT1959111	hsa-miR-498	CLIP-seq
MIRT873272	hsa-miR-5095	CLIP-seq
MIRT873273	hsa-miR-562	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
NR3C2	Activation	11751947

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002407	Process	Dendritic cell chemotaxis	TAS	16621978
GO:0002523	Process	Leukocyte migration involved in inflammatory response	ISS
GO:0004950	Function	Chemokine receptor activity	TAS	11001880
GO:0005515	Function	Protein binding	IPI	20068036, 25122636
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	9186513
GO:0006935	Process	Chemotaxis	IDA	20068036
GO:0006935	Process	Chemotaxis	IMP	12081481
GO:0006955	Process	Immune response	IBA	21873635
GO:0006959	Process	Humoral immune response	TAS	11001880
GO:0006968	Process	Cellular defense response	TAS	10521347
GO:0007165	Process	Signal transduction	TAS	9186513
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0009986	Component	Cell surface	IDA	12081481
GO:0010634	Process	Positive regulation of epithelial cell migration	IEA
GO:0016493	Function	C-C chemokine receptor activity	IBA	21873635
GO:0016493	Function	C-C chemokine receptor activity	IDA	20068036
GO:0016493	Function	C-C chemokine receptor activity	IMP	12081481
GO:0019722	Process	Calcium-mediated signaling	IBA	21873635
GO:0019722	Process	Calcium-mediated signaling	IMP	12081481
GO:0019957	Function	C-C chemokine binding	IBA	21873635
GO:0019957	Function	C-C chemokine binding	IDA	20068036
GO:0019957	Function	C-C chemokine binding	IMP	12081481
GO:0036126	Component	Sperm flagellum	IDA	23765988
GO:0038023	Function	Signaling receptor activity	TAS	9186513
GO:0048290	Process	Isotype switching to IgA isotypes	ISS
GO:0060326	Process	Cell chemotaxis	IBA	21873635
GO:0060326	Process	Cell chemotaxis	IDA	23765988
GO:0060474	Process	Positive regulation of flagellated sperm motility involved in capacitation	IDA	23765988
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA
GO:0072676	Process	Lymphocyte migration	ISS
GO:0072678	Process	T cell migration	ISS
GO:0072679	Process	Thymocyte migration	IBA	21873635
GO:0072679	Process	Thymocyte migration	ISS
GO:0097225	Component	Sperm midpiece	IDA	23765988
GO:0097228	Component	Sperm principal piece	IDA	23765988
GO:0097524	Component	Sperm plasma membrane	IDA	23765988
GO:1904155	Process	DN2 thymocyte differentiation	ISS
GO:1904156	Process	DN3 thymocyte differentiation	ISS
GO:2000404	Process	Regulation of T cell migration	ISS
GO:2000510	Process	Positive regulation of dendritic cell chemotaxis	IBA	21873635

Other IDs

• MIM: 601835
• HGNC: 1607
• e!Ensembl: ENSG00000112486

Protein

• UniProt ID: P51684
• Protein name: C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (Chemokine receptor-like 3) (CKR-L3) (DRY6) (G-protein coupled receptor 29) (GPR-CY4) (GPRCY4) (LARC receptor) (CD antigen CD196)
• Protein function: Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a recepto
• PDB: 6WWZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	63 → 316	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFG
  LLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKL
  LKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISS
  STFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKT
  LVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTV
  TEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQT
  SETADNDNASSFTM

• Sequence length: 374

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway

Reactome:

Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Arthritis	Arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	26031901
Autoimmune diseases	Autoimmune Diseases	rs41285370, rs869025224	21383967
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	22190364
Pulmonary arterial hypertension	Pulmonary arterial hypertension, Idiopathic pulmonary arterial hypertension	rs121909288, rs137852741, rs137852742, rs137852743, rs137852744, rs137852745, rs137852746, rs137852748, rs137852749, rs137852750, rs137852751, rs137852753, rs863223423, rs863223426, rs863223424, rs863223408, rs869025366, rs876657748, rs886039506, rs886041324, rs1060502576, rs1060502581, rs1060502584, rs1085307149, rs1085307154, rs1085307157, rs1085307163, rs1085307169, rs1085307177, rs1085307180, rs1085307184, rs1085307188, rs1085307191, rs1085307203, rs1085307222, rs1085307223, rs1085307225, rs1085307229, rs1085307234, rs1085307246, rs1085307261, rs1085307267, rs576091247, rs200948870, rs1085307278, rs1085307282, rs1085307285, rs1085307290, rs1085307301, rs1085307306, rs1085307307, rs1085307308, rs1085307315, rs1085307316, rs1553509997, rs1085307324, rs1085307340, rs1085307349, rs1085307352, rs765887545, rs1085307183, rs1555208696, rs1592224412, rs1574415785, rs1574415799, rs1574462520, rs1085307197, rs1574464060, rs749485755, rs1574464121, rs1574464150, rs1574464160, rs1085307214, rs1574485996, rs1574486497, rs1574486566, rs1574488314, rs1574488346, rs1574488353, rs1574488357, rs1574488412, rs1414031345, rs1574488484, rs1574488490, rs863223419, rs1574489046, rs1574494632, rs1574494655, rs1574500018, rs1574505253, rs1574505321, rs371174955, rs1574506729, rs1574506732, rs1574506781, rs1574506790, rs1574506799, rs1574506914, rs1574506976, rs1574507076, rs1574507124, rs1574507215, rs1574507268, rs1574507272, rs1574507276, rs1574507290, rs1574507331, rs398123042, rs374644720, rs1588573831, rs1592222308, rs1592223392, rs756315327, rs1603248167, rs1397811125, rs1603255267, rs1603255327, rs1603255336, rs1603255339, rs754897911, rs1603256095, rs1085307155, rs1085307156, rs1574464226, rs1085307226, rs1574486038, rs1553508321, rs1574488277, rs1574488501, rs1574493841, rs1574499954
Pulmonary fibrosis	Pulmonary Fibrosis	rs121918666, rs199422300, rs121917737, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs863223336, rs786205702, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899, rs938938578
Renal insufficiency	Renal Insufficiency	rs1596536873
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	23143596, 20453841, 24532676, 24390342, 20453842, 24782177, 22446963, 30423114

Unknown
Disease name	Disease term	dbSNP ID	References
Anhedonia	Anhedonia		24333375
Congestive heart failure	Congestive heart failure	rs2301610, rs3833910, rs12301951, rs201674674, rs186741807, rs150140412, rs786205727, rs757840030, rs552050895, rs759465783, rs201978086, rs572757800, rs1572143354, rs749160569
Crest syndrome	CREST Syndrome		23983073
Diffuse cutaneous systemic sclerosis	Diffuse cutaneous systemic sclerosis
Dysphagia	Deglutition Disorders
Gastroesophageal reflux disease	Gastroesophageal reflux disease
Immune system diseases	Immune System Diseases		21383967
Limited systemic sclerosis	Limited cutaneous systemic sclerosis
Malabsorption syndrome	Malabsorption Syndrome
Scleroderma	Scleroderma, Limited, Diffuse Scleroderma		23983073
Ulcerative colitis	Ulcerative Colitis		16306769
Vitiligo	Vitiligo		20526340