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CCR5 (C-C motif chemokine receptor 5)

Gene

1234

C-C motif chemokine receptor 5

CCR5

CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22

3p21.31

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-recep

Show/Hide all(287)

miRTarBase ID	miRNA	Experiments	Reference
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT641338	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT641337	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT641338	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT641337	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620770	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT641338	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT641337	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT641338	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT641337	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT620771	hsa-miR-5193	HITS-CLIP	23824327
MIRT620770	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT620769	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT620768	hsa-miR-1248	HITS-CLIP	23824327
MIRT620767	hsa-miR-6889-3p	HITS-CLIP	23824327
MIRT620766	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT620765	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT620764	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT620763	hsa-miR-3182	HITS-CLIP	23824327
MIRT620762	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT620761	hsa-miR-548ac	HITS-CLIP	23824327
MIRT620760	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT620759	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT620758	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT620757	hsa-miR-548z	HITS-CLIP	23824327
MIRT620756	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT620755	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT620754	hsa-miR-3183	HITS-CLIP	23824327
MIRT620753	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT620752	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT620751	hsa-miR-4469	HITS-CLIP	23824327
MIRT620750	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT620749	hsa-miR-4287	HITS-CLIP	23824327
MIRT620748	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT620747	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT620746	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620745	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620744	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT620743	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT620742	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620741	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873225	hsa-miR-345	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT873229	hsa-miR-451b	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT873232	hsa-miR-4696	CLIP-seq
MIRT873233	hsa-miR-4714-5p	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq
MIRT873236	hsa-miR-1279	CLIP-seq
MIRT873237	hsa-miR-2113	CLIP-seq
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT873238	hsa-miR-3929	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT873239	hsa-miR-4251	CLIP-seq
MIRT873240	hsa-miR-4257	CLIP-seq
MIRT873241	hsa-miR-4265	CLIP-seq
MIRT873242	hsa-miR-4296	CLIP-seq
MIRT873243	hsa-miR-4322	CLIP-seq
MIRT873244	hsa-miR-4419b	CLIP-seq
MIRT873245	hsa-miR-4478	CLIP-seq
MIRT873246	hsa-miR-4490	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT873247	hsa-miR-485-5p	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT873248	hsa-miR-539	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq
MIRT873249	hsa-miR-629	CLIP-seq
MIRT1959090	hsa-miR-1321	CLIP-seq
MIRT1959091	hsa-miR-185	CLIP-seq
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT1959092	hsa-miR-4306	CLIP-seq
MIRT1959093	hsa-miR-4419a	CLIP-seq
MIRT1959094	hsa-miR-4510	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT1959095	hsa-miR-4644	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT1959096	hsa-miR-4728-5p	CLIP-seq
MIRT1959097	hsa-miR-4739	CLIP-seq
MIRT1959098	hsa-miR-4756-5p	CLIP-seq
MIRT1959099	hsa-miR-511	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT1959100	hsa-miR-579	CLIP-seq
MIRT1959101	hsa-miR-607	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq
MIRT1959102	hsa-miR-664	CLIP-seq
MIRT2196029	hsa-miR-150	CLIP-seq
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873225	hsa-miR-345	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT2196030	hsa-miR-376a	CLIP-seq
MIRT2196031	hsa-miR-376b	CLIP-seq
MIRT873238	hsa-miR-3929	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT873239	hsa-miR-4251	CLIP-seq
MIRT2196032	hsa-miR-4277	CLIP-seq
MIRT873244	hsa-miR-4419b	CLIP-seq
MIRT873245	hsa-miR-4478	CLIP-seq
MIRT2196033	hsa-miR-4522	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT873247	hsa-miR-485-5p	CLIP-seq
MIRT2196034	hsa-miR-498	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT873248	hsa-miR-539	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq
MIRT873222	hsa-miR-2115	CLIP-seq
MIRT873223	hsa-miR-2277-3p	CLIP-seq
MIRT873224	hsa-miR-3074-5p	CLIP-seq
MIRT873226	hsa-miR-3660	CLIP-seq
MIRT873227	hsa-miR-370	CLIP-seq
MIRT2385724	hsa-miR-3921	CLIP-seq
MIRT873228	hsa-miR-3977	CLIP-seq
MIRT873230	hsa-miR-4526	CLIP-seq
MIRT2385725	hsa-miR-4653-5p	CLIP-seq
MIRT873231	hsa-miR-4691-3p	CLIP-seq
MIRT873247	hsa-miR-485-5p	CLIP-seq
MIRT873234	hsa-miR-516a-3p	CLIP-seq
MIRT873235	hsa-miR-628-5p	CLIP-seq

Transcription factors

Show/Hide all(5)

Transcription factor	Regulation	Reference
KLF2	Activation	22988032
NFKB1	Unknown	12745546;19469019;9840284
NR3C2	Activation	11751947
RELA	Unknown	12745546;19469019;9840284
YY1	Repression	12571248;15737629

Show/Hide all(43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEP	12032188
GO:0001618	Function	Virus receptor activity	IEA
GO:0002407	Process	Dendritic cell chemotaxis	TAS	16621978
GO:0003779	Function	Actin binding	IDA	12421915
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	TAS	8663314
GO:0004950	Function	Chemokine receptor activity	TAS	10201901
GO:0005515	Function	Protein binding	IPI	10816381, 12421915, 15001559, 15660419, 18230715, 18632580, 23235831, 23480650, 23597562, 24405750, 28381538, 30542158, 32296183
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005768	Component	Endosome	IDA	10679098
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	10393923
GO:0006816	Process	Calcium ion transport	IDA	8699119
GO:0006935	Process	Chemotaxis	TAS	10741397
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0006955	Process	Immune response	IBA	21873635
GO:0006968	Process	Cellular defense response	TAS	10201901
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	8639485
GO:0007186	Process	G protein-coupled receptor signaling pathway	IMP	19523456
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0007267	Process	Cell-cell signaling	IDA	10679098
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0009897	Component	External side of plasma membrane	IDA	10383387, 10679098, 11278962, 19523456
GO:0009986	Component	Cell surface	IDA	10521508
GO:0014808	Process	Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA	19523456
GO:0015026	Function	Coreceptor activity	TAS	10469138
GO:0016493	Function	C-C chemokine receptor activity	IBA	21873635
GO:0016493	Function	C-C chemokine receptor activity	IDA	10383387, 11278962
GO:0016493	Function	C-C chemokine receptor activity	NAS	8639485
GO:0019064	Process	Fusion of virus membrane with host plasma membrane	TAS
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019722	Process	Calcium-mediated signaling	IBA	21873635
GO:0019722	Process	Calcium-mediated signaling	IDA	10679098, 19523456
GO:0019957	Function	C-C chemokine binding	IBA	21873635
GO:0019957	Function	C-C chemokine binding	IPI	8699119, 10383387, 10679098
GO:0023052	Process	Signaling	IEP	12032188
GO:0042802	Function	Identical protein binding	IPI	18230715, 18632580, 23121557
GO:0060326	Process	Cell chemotaxis	IBA	21873635
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA
GO:0070723	Process	Response to cholesterol	IMP	19523456
GO:0071222	Process	Cellular response to lipopolysaccharide	IEP	10679098
GO:0071791	Function	Chemokine (C-C motif) ligand 5 binding	IBA	21873635
GO:0071791	Function	Chemokine (C-C motif) ligand 5 binding	IPI	8699119

MIM	HGNC	e!Ensembl
601373	1606	ENSG00000160791

Protein

UniProt ID

P51681

Protein name

C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)

Protein function

Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lin

PDB

2L87 , 2MZX , 2RLL , 2RRS , 4MBS , 5UIW , 5YD3 , 5YD4 , 5YD5 , 5YY4 , 6FGP , 6MEO , 6MET , 7F1Q , 7F1R , 7F1S , 7NJZ , 7NW3 , 7O7F , 8AS2 , 8AS3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	47 → 297	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL

Sequence length

352

Interactions

View interactions

	KEGG		Reactome
	Viral life cycle - HIV-1 Virion - Human immunodeficiency virus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Endocytosis Toxoplasmosis Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Viral carcinogenesis		Binding and entry of HIV virion Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling

Associated diseases

Show/Hide Causal Diseases (3)

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Dermatitis, Atopic	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	18249437
Diabetes mellitus	DIABETES MELLITUS, INSULIN-DEPENDENT, 22 (disorder)	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	16513874

Show/Hide Unknown Diseases (4)

Unknown
Disease name	Disease term	dbSNP ID	References
Eczema	Eczema, Infantile		18249437
Kidney failure	Kidney Failure, Acute		26055553
Nephritis	Nephritis		26055553
Acute kidney insufficiency	Acute Kidney Insufficiency		26055553

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