CCR4 (C-C motif chemokine receptor 4)

Gene

• Entrez ID: 1233
• Gene name: C-C motif chemokine receptor 4
• Gene symbol: CCR4
• Synonyms: CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5
• Chromosome: 3
• Chromosome location: 3p22.3
• Summary: The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell traff

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018019	hsa-miR-335-5p	Microarray	18185580
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677124	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT677123	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT677122	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677121	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677124	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT677123	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT677122	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635501	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677121	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635501	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT571161	hsa-miR-4695-5p	PAR-CLIP	20371350
MIRT571162	hsa-miR-4459	PAR-CLIP	20371350
MIRT571160	hsa-miR-665	PAR-CLIP	20371350
MIRT571159	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT571158	hsa-miR-6087	PAR-CLIP	20371350
MIRT571157	hsa-miR-6499-3p	PAR-CLIP	20371350
MIRT571156	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT571155	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT571154	hsa-miR-455-3p	PAR-CLIP	20371350
MIRT571153	hsa-miR-6516-5p	PAR-CLIP	20371350
MIRT571152	hsa-miR-1273e	PAR-CLIP	20371350
MIRT571152	hsa-miR-1273e	PAR-CLIP	27292025
MIRT571156	hsa-miR-25-5p	PAR-CLIP	27292025
MIRT571162	hsa-miR-4459	PAR-CLIP	27292025
MIRT571154	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT571161	hsa-miR-4695-5p	PAR-CLIP	27292025
MIRT571158	hsa-miR-6087	PAR-CLIP	27292025
MIRT571157	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT571153	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT571160	hsa-miR-665	PAR-CLIP	27292025
MIRT571155	hsa-miR-6807-5p	PAR-CLIP	27292025
MIRT571159	hsa-miR-6840-3p	PAR-CLIP	27292025
MIRT735368	hsa-miR-6089	Luciferase reporter assay, Western blotting, qRT-PCR	32552050
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677124	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT677123	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT677122	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677121	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677124	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT677123	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT677122	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635501	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677121	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT635508	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT635507	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT635506	hsa-miR-764	HITS-CLIP	23824327
MIRT635505	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT635504	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT635503	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT635502	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT635501	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635500	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT635499	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT635498	hsa-miR-4454	HITS-CLIP	23824327
MIRT635497	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635496	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT635495	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT635494	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT635493	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT571161	hsa-miR-4695-5p	PAR-CLIP	20371350
MIRT571162	hsa-miR-4459	PAR-CLIP	20371350
MIRT571160	hsa-miR-665	PAR-CLIP	20371350
MIRT571159	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT571158	hsa-miR-6087	PAR-CLIP	20371350
MIRT571157	hsa-miR-6499-3p	PAR-CLIP	20371350
MIRT571156	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT571155	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT571154	hsa-miR-455-3p	PAR-CLIP	20371350
MIRT571153	hsa-miR-6516-5p	PAR-CLIP	20371350
MIRT571152	hsa-miR-1273e	PAR-CLIP	20371350
MIRT873216	hsa-miR-1205	CLIP-seq
MIRT873217	hsa-miR-345	CLIP-seq
MIRT873218	hsa-miR-4690-3p	CLIP-seq
MIRT873219	hsa-miR-4726-3p	CLIP-seq
MIRT873220	hsa-miR-4742-5p	CLIP-seq
MIRT873221	hsa-miR-4763-5p	CLIP-seq
MIRT1959082	hsa-miR-3124-3p	CLIP-seq
MIRT1959083	hsa-miR-3692	CLIP-seq
MIRT1959084	hsa-miR-4318	CLIP-seq
MIRT1959085	hsa-miR-4436b-5p	CLIP-seq
MIRT1959086	hsa-miR-4455	CLIP-seq
MIRT1959087	hsa-miR-511	CLIP-seq
MIRT1959088	hsa-miR-609	CLIP-seq
MIRT1959089	hsa-miR-626	CLIP-seq
MIRT873216	hsa-miR-1205	CLIP-seq
MIRT873221	hsa-miR-4763-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
FOSL2	Activation	22493372
FOXP3	Activation	21036387
JUND	Activation	22493372
TBX21	Repression	14500650

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001764	Process	Neuron migration	IEA
GO:0002507	Process	Tolerance induction	IEA
GO:0004950	Function	Chemokine receptor activity	TAS	7642634
GO:0005515	Function	Protein binding	IPI	28381538, 32296183
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	7642634
GO:0006935	Process	Chemotaxis	TAS	7642634
GO:0006954	Process	Inflammatory response	IEA
GO:0006955	Process	Immune response	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0009314	Process	Response to radiation	IEA
GO:0009617	Process	Response to bacterium	IEA
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0016493	Function	C-C chemokine receptor activity	IBA	21873635
GO:0019722	Process	Calcium-mediated signaling	IBA	21873635
GO:0019957	Function	C-C chemokine binding	IBA	21873635
GO:0043025	Component	Neuronal cell body	IEA
GO:0046677	Process	Response to antibiotic	IEA
GO:0048872	Process	Homeostasis of number of cells	IEA
GO:0050927	Process	Positive regulation of positive chemotaxis	IEA
GO:0060326	Process	Cell chemotaxis	IBA	21873635
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA

Other IDs

• MIM: 604836
• HGNC: 1605
• e!Ensembl: ENSG00000183813

Protein

• UniProt ID: P51679
• Protein name: C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)
• Protein function: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	56 → 304	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
  VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
  FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
  ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
  VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
  PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  

• Sequence length: 360

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Kaposi sarcoma-associated herpesvirus infection
Viral carcinogenesis

Reactome:

Chemokine receptors bind chemokines
G alpha (i) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Glioma	Glioma, mixed gliomas, Malignant Glioma	rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499, rs1060500122, rs781647403, rs1060500126, rs1554897889, rs1114167629, rs1114167656, rs587782603, rs1554893824, rs1554900615, rs1564568660, rs786204900, rs762518389, rs1339631701	17522861
Sezary syndrome	Sezary Syndrome	rs587776632	26551670

Unknown
Disease name	Disease term	dbSNP ID	References
Celiac disease	Celiac Disease	rs2305764, rs35218876	20190752
Cerebral ischemia	Brain Ischemia		15829914
Liver neoplasms	Liver neoplasms		19233941
Liver cancer	Malignant neoplasm of liver		19233941
T-cell lymphoma/leukemia	Adult T-Cell Lymphoma/Leukemia		26437031