PLIN2 (perilipin 2)

Gene

• Entrez ID: 123
• Gene name: Perilipin 2
• Gene symbol: PLIN2
• Synonyms: ADFP, ADRP
• Chromosome: 9
• Chromosome location: 9p22.1
• Summary: The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1242782	hsa-miR-1305	CLIP-seq
MIRT1242783	hsa-miR-3135	CLIP-seq
MIRT1242784	hsa-miR-3942-3p	CLIP-seq
MIRT1242785	hsa-miR-421	CLIP-seq
MIRT1242786	hsa-miR-4272	CLIP-seq
MIRT1242787	hsa-miR-4307	CLIP-seq
MIRT1242788	hsa-miR-4422	CLIP-seq
MIRT1242789	hsa-miR-4423-5p	CLIP-seq
MIRT1242790	hsa-miR-4519	CLIP-seq
MIRT1242791	hsa-miR-451b	CLIP-seq
MIRT1242792	hsa-miR-4699-5p	CLIP-seq
MIRT1242793	hsa-miR-4774-3p	CLIP-seq
MIRT1242794	hsa-miR-4775	CLIP-seq
MIRT1242795	hsa-miR-577	CLIP-seq
MIRT2298884	hsa-miR-1228	CLIP-seq
MIRT1242784	hsa-miR-3942-3p	CLIP-seq
MIRT1242795	hsa-miR-577	CLIP-seq
MIRT2595698	hsa-miR-125a-3p	CLIP-seq
MIRT2595699	hsa-miR-146a	CLIP-seq
MIRT2595700	hsa-miR-146b-5p	CLIP-seq
MIRT2595701	hsa-miR-302a	CLIP-seq
MIRT2595702	hsa-miR-302b	CLIP-seq
MIRT2595703	hsa-miR-302c	CLIP-seq
MIRT2595704	hsa-miR-302d	CLIP-seq
MIRT2595705	hsa-miR-302e	CLIP-seq
MIRT2595706	hsa-miR-365	CLIP-seq
MIRT2595707	hsa-miR-372	CLIP-seq
MIRT2595708	hsa-miR-373	CLIP-seq
MIRT2595709	hsa-miR-4452	CLIP-seq
MIRT2595710	hsa-miR-4686	CLIP-seq
MIRT2595711	hsa-miR-4803	CLIP-seq
MIRT2595712	hsa-miR-519a	CLIP-seq
MIRT2595713	hsa-miR-519b-3p	CLIP-seq
MIRT2595714	hsa-miR-519c-3p	CLIP-seq
MIRT2595715	hsa-miR-520a-3p	CLIP-seq
MIRT2595716	hsa-miR-520b	CLIP-seq
MIRT2595717	hsa-miR-520c-3p	CLIP-seq
MIRT2595718	hsa-miR-520d-3p	CLIP-seq
MIRT2595719	hsa-miR-520e	CLIP-seq
MIRT2595720	hsa-miR-589	CLIP-seq
MIRT2595698	hsa-miR-125a-3p	CLIP-seq
MIRT2595706	hsa-miR-365	CLIP-seq
MIRT2595710	hsa-miR-4686	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
PPARA	Repression	17150915
PPARG	Activation	11420178;16403437
PPARG	Unknown	17322100;19571381

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005576	Component	Extracellular region	TAS	9003395
GO:0005634	Component	Nucleus	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	9003395
GO:0005811	Component	Lipid droplet	IBA	21873635
GO:0005811	Component	Lipid droplet	IDA	14741744
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0010890	Process	Positive regulation of sequestering of triglyceride	IBA	21873635
GO:0014070	Process	Response to organic cyclic compound	IEA
GO:0015909	Process	Long-chain fatty acid transport	IEA
GO:0019216	Process	Regulation of lipid metabolic process	TAS
GO:0019915	Process	Lipid storage	IBA	21873635
GO:0042493	Process	Response to drug	IEA

Other IDs

• MIM: 103195
• HGNC: 248
• e!Ensembl: ENSG00000147872

Protein

• UniProt ID: Q99541
• Protein name: Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP)
• Protein function: Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03036	Perilipin	5 → 409	Perilipin family	Family

• Sequence:

  MASVAVDPQPSVVTRVVNLPLVSSTYDLMSSAYLSTKDQYPYLKSVCEMAENGVKTITSV
  AMTSALPIIQKLEPQIAVANTYACKGLDRIEERLPILNQPSTQIVANAKGAVTGAKDAVT
  TTVTGAKDSVASTITGVMDKTKGAVTGSVEKTKSVVSGSINTVLGSRMMQLVSSGVENAL
  TKSELLVEQYLPLTEEELEKEAKKVEGFDLVQKPSYYVRLGSLSTKLHSRAYQQALSRVK
  EAKQKSQQTISQLHSTVHLIEFARKNVYSANQKIQDAQDKLYLSWVEWKRSIGYDDTDES
  HCAEHIESRTLAIARNLTQQLQTTCHTLLSNIQGVPQNIQDQAKHMGVMAGDIYSVFRNA
  ASFKEVSDSLLTSSKGQLQKMKESLDDVMDYLVNNTPLNWLVGPFYPQLTESQNAQDQGA
  EMDKSSQETQRSEHKTH

• Sequence length: 437

Pathways

KEGG:

PPAR signaling pathway

Reactome:

PPARA activates gene expression

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	16367923

Unknown
Disease name	Disease term	dbSNP ID	References
Fatty liver	Fatty Liver, Steatohepatitis		16439473
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		16367923