Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
122953 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Jun dimerization protein 2 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
JDP2 |
SynonymsGene synonyms aliases
|
JUNDM2 |
ChromosomeChromosome number
|
14 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
14q24.3 |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000122 |
Process |
Negative regulation of transcription by RNA polymerase II |
IDA |
18671972 |
GO:0000785 |
Component |
Chromatin |
ISA |
|
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IBA |
21873635 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
IBA |
21873635 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ISA |
|
GO:0001227 |
Function |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
IDA |
18671972 |
GO:0003682 |
Function |
Chromatin binding |
IEA |
|
GO:0005515 |
Function |
Protein binding |
IPI |
18671972, 32296183 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0006357 |
Process |
Regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0031065 |
Process |
Positive regulation of histone deacetylation |
IEA |
|
GO:0044877 |
Function |
Protein-containing complex binding |
IEA |
|
GO:0045599 |
Process |
Negative regulation of fat cell differentiation |
IEA |
|
GO:1990837 |
Function |
Sequence-specific double-stranded DNA binding |
IDA |
28473536 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q8WYK2 |
Protein name |
Jun dimerization protein 2 |
Protein function |
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorig |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00170 |
bZIP_1 |
70 → 133 |
bZIP transcription factor |
Coiled-coil |
|
Sequence |
|
Sequence length |
163 |
Interactions |
View interactions |
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Basal cell neoplasm |
Basal Cell Neoplasm, Basal Cell Cancer |
rs587776578, rs587776579, rs2117956624, rs2118419579, rs2118365442, rs2118041703, rs2136689212, rs2118336503, rs1587692888, rs267606984, rs878853849, rs1554695110, rs1064793921, rs1588605348, rs1588568813 |
31174203 |
Carcinoma |
Basal cell carcinoma |
rs121912654, rs555607708, rs786202962, rs1564055259 |
31174203 |
Leukemia |
Leukemia, Myelocytic, Acute |
rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 |
27903959 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Liver carcinoma |
Liver carcinoma |
|
20214788 |
|