CLTB (clathrin light chain B)

Gene

• Entrez ID: 1212
• Gene name: Clathrin light chain B
• Gene symbol: CLTB
• Synonyms: LCB
• Chromosome: 5
• Chromosome location: 5q35.2
• Summary: Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytos

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025306	hsa-miR-34a-5p	Proteomics	21566225
MIRT495214	hsa-miR-330-3p	PAR-CLIP	23708386
MIRT495213	hsa-miR-329-3p	PAR-CLIP	23708386
MIRT495212	hsa-miR-362-3p	PAR-CLIP	23708386
MIRT495211	hsa-miR-4503	PAR-CLIP	23708386
MIRT495214	hsa-miR-330-3p	PAR-CLIP	23708386
MIRT495213	hsa-miR-329-3p	PAR-CLIP	23708386
MIRT495212	hsa-miR-362-3p	PAR-CLIP	23708386
MIRT495211	hsa-miR-4503	PAR-CLIP	23708386
MIRT898053	hsa-miR-1254	CLIP-seq
MIRT898054	hsa-miR-1270	CLIP-seq
MIRT898055	hsa-miR-1273f	CLIP-seq
MIRT898056	hsa-miR-296-5p	CLIP-seq
MIRT898057	hsa-miR-3116	CLIP-seq
MIRT898058	hsa-miR-3150a-3p	CLIP-seq
MIRT898059	hsa-miR-3175	CLIP-seq
MIRT898060	hsa-miR-342-5p	CLIP-seq
MIRT898061	hsa-miR-3616-3p	CLIP-seq
MIRT898062	hsa-miR-4254	CLIP-seq
MIRT898063	hsa-miR-4419a	CLIP-seq
MIRT898064	hsa-miR-4459	CLIP-seq
MIRT898065	hsa-miR-4510	CLIP-seq
MIRT898066	hsa-miR-4651	CLIP-seq
MIRT898067	hsa-miR-4664-5p	CLIP-seq
MIRT898068	hsa-miR-4683	CLIP-seq
MIRT898069	hsa-miR-4710	CLIP-seq
MIRT898070	hsa-miR-4721	CLIP-seq
MIRT898071	hsa-miR-4738-5p	CLIP-seq
MIRT898072	hsa-miR-4779	CLIP-seq
MIRT898073	hsa-miR-608	CLIP-seq
MIRT898074	hsa-miR-620	CLIP-seq
MIRT898075	hsa-miR-765	CLIP-seq
MIRT898076	hsa-miR-939	CLIP-seq
MIRT898064	hsa-miR-4459	CLIP-seq
MIRT898064	hsa-miR-4459	CLIP-seq
MIRT898053	hsa-miR-1254	CLIP-seq
MIRT898054	hsa-miR-1270	CLIP-seq
MIRT2505093	hsa-miR-151-3p	CLIP-seq
MIRT898056	hsa-miR-296-5p	CLIP-seq
MIRT898057	hsa-miR-3116	CLIP-seq
MIRT2505094	hsa-miR-3184	CLIP-seq
MIRT898060	hsa-miR-342-5p	CLIP-seq
MIRT898061	hsa-miR-3616-3p	CLIP-seq
MIRT2505095	hsa-miR-3619-3p	CLIP-seq
MIRT2505096	hsa-miR-3652	CLIP-seq
MIRT2505097	hsa-miR-411	CLIP-seq
MIRT2505098	hsa-miR-423-5p	CLIP-seq
MIRT898062	hsa-miR-4254	CLIP-seq
MIRT898063	hsa-miR-4419a	CLIP-seq
MIRT2505099	hsa-miR-4430	CLIP-seq
MIRT898064	hsa-miR-4459	CLIP-seq
MIRT2505100	hsa-miR-4463	CLIP-seq
MIRT2505101	hsa-miR-4492	CLIP-seq
MIRT2505102	hsa-miR-4498	CLIP-seq
MIRT2505103	hsa-miR-4499	CLIP-seq
MIRT898065	hsa-miR-4510	CLIP-seq
MIRT2505104	hsa-miR-4640-5p	CLIP-seq
MIRT898066	hsa-miR-4651	CLIP-seq
MIRT898067	hsa-miR-4664-5p	CLIP-seq
MIRT898068	hsa-miR-4683	CLIP-seq
MIRT2505105	hsa-miR-4695-5p	CLIP-seq
MIRT898069	hsa-miR-4710	CLIP-seq
MIRT898070	hsa-miR-4721	CLIP-seq
MIRT2505106	hsa-miR-4726-5p	CLIP-seq
MIRT898071	hsa-miR-4738-5p	CLIP-seq
MIRT2505107	hsa-miR-4776-5p	CLIP-seq
MIRT898072	hsa-miR-4779	CLIP-seq
MIRT898073	hsa-miR-608	CLIP-seq
MIRT898074	hsa-miR-620	CLIP-seq
MIRT2505108	hsa-miR-665	CLIP-seq
MIRT2505109	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005198	Function	Structural molecule activity	IEA
GO:0005515	Function	Protein binding	IPI	11889126
GO:0005802	Component	Trans-Golgi network	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0030118	Component	Clathrin coat	ISS
GO:0030118	Component	Clathrin coat	NAS	3267234
GO:0030125	Component	Clathrin vesicle coat	IBA	21873635
GO:0030130	Component	Clathrin coat of trans-Golgi network vesicle	IEA
GO:0030132	Component	Clathrin coat of coated pit	IEA
GO:0030672	Component	Synaptic vesicle membrane	IBA	21873635
GO:0032050	Function	Clathrin heavy chain binding	IBA	21873635
GO:0042277	Function	Peptide binding	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0045334	Component	Clathrin-coated endocytic vesicle	NAS	25898166
GO:0048268	Process	Clathrin coat assembly	IBA	21873635
GO:0060170	Component	Ciliary membrane	IEA
GO:0061024	Process	Membrane organization	TAS
GO:0072583	Process	Clathrin-dependent endocytosis	IBA	21873635
GO:0098835	Component	Presynaptic endocytic zone membrane	IEA
GO:0099631	Component	Postsynaptic endocytic zone cytoplasmic component	IBA	21873635

Other IDs

• MIM: 118970
• HGNC: 2091
• e!Ensembl: ENSG00000175416

Protein

• UniProt ID: P09497
• Protein name: Clathrin light chain B (Lcb)
• Protein function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01086	Clathrin_lg_ch	1 → 228	Clathrin light chain	Family

• Sequence:

  MADDFGFFSSSESGAPEAAEEDPAAAFLAQQESEIAGIENDEGFGAPAGSHAAPAQPGPT
  SGAGSEDMGTTVNGDVFQEANGPADGYAAIAQADRLTQEPESIRKWREEQRKRLQELDAA
  SKVTEQEWREKAKKDLEEWNQRQSEQVEKNKINNRIADKAFYQQPDADIIGYVASEEAFV
  KESKEETPGTEWEKVAQLCDFNPKSSKQCKDVSRLRSVLMSLKQTPLSR

• Sequence length: 229

Pathways

KEGG:

Lysosome
Endocytosis
Synaptic vesicle cycle
Endocrine and other factor-regulated calcium reabsorption
Huntington disease
Bacterial invasion of epithelial cells

Reactome:

Gap junction degradation
Formation of annular gap junctions
EPH-ephrin mediated repulsion of cells
Lysosome Vesicle Biogenesis
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	27935865

Unknown
Disease name	Disease term	dbSNP ID	References
Lung neoplasms	Lung Neoplasms		27935865