GSTO2 (glutathione S-transferase omega 2)

Gene

• Entrez ID: 119391
• Gene name: Glutathione S-transferase omega 2
• Gene symbol: GSTO2
• Synonyms: GSTO 2-2, bA127L20.1
• Chromosome: 10
• Chromosome location: 10q25.1
• Summary: The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq,

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT681099	hsa-miR-4712-3p	HITS-CLIP	23706177
MIRT681098	hsa-miR-218-2-3p	HITS-CLIP	23706177
MIRT681097	hsa-miR-3158-5p	HITS-CLIP	23706177
MIRT681096	hsa-miR-1184	HITS-CLIP	23706177
MIRT681095	hsa-miR-1205	HITS-CLIP	23706177
MIRT681094	hsa-miR-17-3p	HITS-CLIP	23706177
MIRT681093	hsa-miR-6847-3p	HITS-CLIP	23706177
MIRT681092	hsa-miR-4999-5p	HITS-CLIP	23706177
MIRT681091	hsa-miR-4284	HITS-CLIP	23706177
MIRT681090	hsa-miR-24-3p	HITS-CLIP	23706177
MIRT681089	hsa-miR-182-3p	HITS-CLIP	23706177
MIRT681088	hsa-miR-597-3p	HITS-CLIP	23706177
MIRT681087	hsa-miR-152-5p	HITS-CLIP	23706177
MIRT681086	hsa-miR-6511b-5p	HITS-CLIP	23706177
MIRT681085	hsa-miR-6811-5p	HITS-CLIP	23706177
MIRT681084	hsa-miR-8057	HITS-CLIP	23706177
MIRT681083	hsa-miR-544a	HITS-CLIP	23706177
MIRT657554	hsa-miR-4717-5p	HITS-CLIP	23824327
MIRT657553	hsa-miR-1972	HITS-CLIP	23824327
MIRT657554	hsa-miR-4717-5p	HITS-CLIP	23824327
MIRT657553	hsa-miR-1972	HITS-CLIP	23824327
MIRT657552	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT657551	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT657550	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT657549	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT657548	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT657547	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT657546	hsa-miR-1245b-5p	HITS-CLIP	23824327
MIRT657545	hsa-miR-3142	HITS-CLIP	23824327
MIRT657544	hsa-miR-532-5p	HITS-CLIP	23824327
MIRT657543	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT657542	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT657541	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT657540	hsa-miR-578	HITS-CLIP	23824327
MIRT657539	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT681099	hsa-miR-4712-3p	HITS-CLIP	23706177
MIRT681098	hsa-miR-218-2-3p	HITS-CLIP	23706177
MIRT681097	hsa-miR-3158-5p	HITS-CLIP	23706177
MIRT681096	hsa-miR-1184	HITS-CLIP	23706177
MIRT681095	hsa-miR-1205	HITS-CLIP	23706177
MIRT681094	hsa-miR-17-3p	HITS-CLIP	23706177
MIRT681093	hsa-miR-6847-3p	HITS-CLIP	23706177
MIRT681092	hsa-miR-4999-5p	HITS-CLIP	23706177
MIRT681091	hsa-miR-4284	HITS-CLIP	23706177
MIRT681090	hsa-miR-24-3p	HITS-CLIP	23706177
MIRT681089	hsa-miR-182-3p	HITS-CLIP	23706177
MIRT681088	hsa-miR-597-3p	HITS-CLIP	23706177
MIRT681087	hsa-miR-152-5p	HITS-CLIP	23706177
MIRT681086	hsa-miR-6511b-5p	HITS-CLIP	23706177
MIRT681085	hsa-miR-6811-5p	HITS-CLIP	23706177
MIRT681084	hsa-miR-8057	HITS-CLIP	23706177
MIRT681083	hsa-miR-544a	HITS-CLIP	23706177
MIRT657554	hsa-miR-4717-5p	HITS-CLIP	23824327
MIRT657553	hsa-miR-1972	HITS-CLIP	23824327
MIRT657554	hsa-miR-4717-5p	HITS-CLIP	23824327
MIRT657553	hsa-miR-1972	HITS-CLIP	23824327
MIRT657552	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT657551	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT657550	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT657549	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT657548	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT657547	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT657546	hsa-miR-1245b-5p	HITS-CLIP	23824327
MIRT657545	hsa-miR-3142	HITS-CLIP	23824327
MIRT657544	hsa-miR-532-5p	HITS-CLIP	23824327
MIRT657543	hsa-miR-203a-3p	HITS-CLIP	23824327
MIRT657542	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT657541	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT657540	hsa-miR-578	HITS-CLIP	23824327
MIRT657539	hsa-miR-4446-5p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004364	Function	Glutathione transferase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 31515488, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0006749	Process	Glutathione metabolic process	IEA
GO:0006805	Process	Xenobiotic metabolic process	IDA	15970797
GO:0016491	Function	Oxidoreductase activity	IDA	15970797
GO:0019852	Process	L-ascorbic acid metabolic process	IDA	15970797
GO:0019852	Process	L-ascorbic acid metabolic process	TAS
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0045174	Function	Glutathione dehydrogenase (ascorbate) activity	IBA	21873635
GO:0045174	Function	Glutathione dehydrogenase (ascorbate) activity	IDA	15970797
GO:0050610	Function	Methylarsonate reductase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0071243	Process	Cellular response to arsenic-containing substance	IDA	15970797
GO:0098869	Process	Cellular oxidant detoxification	IEA
GO:1901687	Process	Glutathione derivative biosynthetic process	TAS

Other IDs

• MIM: 612314
• HGNC: 23064
• e!Ensembl: ENSG00000065621

Protein

• UniProt ID: Q9H4Y5
• Protein name: Glutathione S-transferase omega-2 (GSTO-2) (EC 2.5.1.18) (Glutathione S-transferase omega 2-2) (GSTO 2-2) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2)
• Protein function: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsoni
• PDB: 3Q18, 3Q19, 3QAG
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13417	GST_N_3	26 → 101	Glutathione S-transferase, N-terminal domain	Domain
  PF13410	GST_C_2	108 → 206		Domain

• Sequence:

  MSGDATRTLGKGSQPPGPVPEGLIRIYSMRFCPYSHRTRLVLKAKDIRHEVVNINLRNKP
  EWYYTKHPFGHIPVLETSQCQLIYESVIACEYLDDAYPGRKLFPYDPYERARQKMLLELF
  CKVPHLTKECLVALRCGRECTNLKAALRQEFSNLEEILEYQNTTFFGGTCISMIDYLLWP
  WFERLDVYGILDCVSHTPALRLWISAMKWDPTVCALLMDKSIFQGFLNLYFQNNPNAFDF
  GLC

• Sequence length: 243

Pathways

KEGG:

Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Platinum drug resistance
Pathways in cancer
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Hepatocellular carcinoma
Fluid shear stress and atherosclerosis

Reactome:

Glutathione conjugation
Vitamin C (ascorbate) metabolism

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Urinary bladder cancer	Malignant neoplasm of urinary bladder		22306368
Bladder neoplasm	Bladder Neoplasm		22306368