CLU (clusterin)

Gene

• Entrez ID: 1191
• Gene name: Clusterin
• Gene symbol: CLU
• Synonyms: AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2
• Chromosome: 8
• Chromosome location: 8p21.1
• Summary: The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegen

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT040971	hsa-miR-18a-3p	CLASH	23622248
MIRT039321	hsa-miR-425-5p	CLASH	23622248
MIRT437882	hsa-miR-17-5p	Immunohistochemistry, qRT-PCR, Western blot	23436804
MIRT438224	hsa-miR-21-5p	Luciferase reporter assay	24327270
MIRT438224	hsa-miR-21-5p	Luciferase reporter assay	24327270
MIRT732481	hsa-miR-217	Luciferase reporter assay, qRT-PCR, Western blotting	33993322
MIRT898248	hsa-miR-15a	CLIP-seq
MIRT898249	hsa-miR-15b	CLIP-seq
MIRT898250	hsa-miR-16	CLIP-seq
MIRT898251	hsa-miR-195	CLIP-seq
MIRT898252	hsa-miR-2053	CLIP-seq
MIRT898253	hsa-miR-2116	CLIP-seq
MIRT898254	hsa-miR-3123	CLIP-seq
MIRT898255	hsa-miR-361-5p	CLIP-seq
MIRT898256	hsa-miR-3919	CLIP-seq
MIRT898257	hsa-miR-424	CLIP-seq
MIRT898258	hsa-miR-4468	CLIP-seq
MIRT898259	hsa-miR-4652-3p	CLIP-seq
MIRT898260	hsa-miR-4677-5p	CLIP-seq
MIRT898261	hsa-miR-4756-3p	CLIP-seq
MIRT898262	hsa-miR-4778-5p	CLIP-seq
MIRT898263	hsa-miR-497	CLIP-seq
MIRT898264	hsa-miR-569	CLIP-seq
MIRT898265	hsa-miR-1184	CLIP-seq
MIRT898266	hsa-miR-1301	CLIP-seq
MIRT898248	hsa-miR-15a	CLIP-seq
MIRT898249	hsa-miR-15b	CLIP-seq
MIRT898250	hsa-miR-16	CLIP-seq
MIRT898251	hsa-miR-195	CLIP-seq
MIRT898252	hsa-miR-2053	CLIP-seq
MIRT898253	hsa-miR-2116	CLIP-seq
MIRT898254	hsa-miR-3123	CLIP-seq
MIRT898255	hsa-miR-361-5p	CLIP-seq
MIRT898256	hsa-miR-3919	CLIP-seq
MIRT898267	hsa-miR-409-5p	CLIP-seq
MIRT898257	hsa-miR-424	CLIP-seq
MIRT898268	hsa-miR-4418	CLIP-seq
MIRT898258	hsa-miR-4468	CLIP-seq
MIRT898259	hsa-miR-4652-3p	CLIP-seq
MIRT898269	hsa-miR-4660	CLIP-seq
MIRT898270	hsa-miR-4667-5p	CLIP-seq
MIRT898260	hsa-miR-4677-5p	CLIP-seq
MIRT898271	hsa-miR-4690-3p	CLIP-seq
MIRT898272	hsa-miR-4700-5p	CLIP-seq
MIRT898261	hsa-miR-4756-3p	CLIP-seq
MIRT898262	hsa-miR-4778-5p	CLIP-seq
MIRT898263	hsa-miR-497	CLIP-seq
MIRT898273	hsa-miR-5047	CLIP-seq
MIRT898274	hsa-miR-509-3-5p	CLIP-seq
MIRT898275	hsa-miR-509-5p	CLIP-seq
MIRT898264	hsa-miR-569	CLIP-seq
MIRT898276	hsa-miR-637	CLIP-seq
MIRT898265	hsa-miR-1184	CLIP-seq
MIRT898266	hsa-miR-1301	CLIP-seq
MIRT898248	hsa-miR-15a	CLIP-seq
MIRT898249	hsa-miR-15b	CLIP-seq
MIRT898250	hsa-miR-16	CLIP-seq
MIRT898251	hsa-miR-195	CLIP-seq
MIRT898253	hsa-miR-2116	CLIP-seq
MIRT898267	hsa-miR-409-5p	CLIP-seq
MIRT898257	hsa-miR-424	CLIP-seq
MIRT898258	hsa-miR-4468	CLIP-seq
MIRT898259	hsa-miR-4652-3p	CLIP-seq
MIRT898269	hsa-miR-4660	CLIP-seq
MIRT898270	hsa-miR-4667-5p	CLIP-seq
MIRT898260	hsa-miR-4677-5p	CLIP-seq
MIRT898272	hsa-miR-4700-5p	CLIP-seq
MIRT1966363	hsa-miR-4701-5p	CLIP-seq
MIRT898262	hsa-miR-4778-5p	CLIP-seq
MIRT898263	hsa-miR-497	CLIP-seq
MIRT898273	hsa-miR-5047	CLIP-seq
MIRT1966364	hsa-miR-588	CLIP-seq
MIRT898276	hsa-miR-637	CLIP-seq
MIRT2202226	hsa-miR-1245b-3p	CLIP-seq
MIRT898248	hsa-miR-15a	CLIP-seq
MIRT898249	hsa-miR-15b	CLIP-seq
MIRT898250	hsa-miR-16	CLIP-seq
MIRT898251	hsa-miR-195	CLIP-seq
MIRT898257	hsa-miR-424	CLIP-seq
MIRT2202227	hsa-miR-4330	CLIP-seq
MIRT2202228	hsa-miR-4452	CLIP-seq
MIRT898263	hsa-miR-497	CLIP-seq
MIRT898248	hsa-miR-15a	CLIP-seq
MIRT898249	hsa-miR-15b	CLIP-seq
MIRT898250	hsa-miR-16	CLIP-seq
MIRT898251	hsa-miR-195	CLIP-seq
MIRT898253	hsa-miR-2116	CLIP-seq
MIRT898267	hsa-miR-409-5p	CLIP-seq
MIRT898257	hsa-miR-424	CLIP-seq
MIRT2505118	hsa-miR-4328	CLIP-seq
MIRT2202228	hsa-miR-4452	CLIP-seq
MIRT898258	hsa-miR-4468	CLIP-seq
MIRT898259	hsa-miR-4652-3p	CLIP-seq
MIRT898260	hsa-miR-4677-5p	CLIP-seq
MIRT898262	hsa-miR-4778-5p	CLIP-seq
MIRT898263	hsa-miR-497	CLIP-seq
MIRT2505119	hsa-miR-520d-5p	CLIP-seq
MIRT2505120	hsa-miR-524-5p	CLIP-seq
MIRT2505121	hsa-miR-548a-3p	CLIP-seq
MIRT2505122	hsa-miR-548e	CLIP-seq
MIRT2505123	hsa-miR-548f	CLIP-seq
MIRT2505124	hsa-miR-600	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
FOS	Repression	10406964
FOSL1	Unknown	10406964
FOSL2	Unknown	10406964
JUNB	Unknown	10406964
JUND	Unknown	10406964
MYCN	Repression	23362253

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000902	Process	Cell morphogenesis	IDA	15857407
GO:0001540	Function	Amyloid-beta binding	IDA	22179788
GO:0001540	Function	Amyloid-beta binding	IPI	9228033, 23106396
GO:0001774	Process	Microglial cell activation	IDA	15857407
GO:0001836	Process	Release of cytochrome c from mitochondria	IC	16113678
GO:0002434	Process	Immune complex clearance	ISS
GO:0002576	Process	Platelet degranulation	TAS
GO:0005102	Function	Signaling receptor binding	IPI	27477018
GO:0005515	Function	Protein binding	IPI	8555189, 16113678, 17043677, 17170699, 17567961, 20195357, 22179788, 22528093, 22689054, 25051234, 25451228, 26496610, 28887769, 31270237, 31413325, 32814053
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005576	Component	Extracellular region	TAS	23164821
GO:0005615	Component	Extracellular space	HDA	16502470, 20551380
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	11123922, 16113678, 17567961, 19996109
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	19137541, 25051234
GO:0005737	Component	Cytoplasm	IDA	9560017, 17689225, 22689054, 25051234
GO:0005737	Component	Cytoplasm	TAS	23164821
GO:0005739	Component	Mitochondrion	IDA	16113678, 22689054
GO:0005743	Component	Mitochondrial inner membrane	IDA	17689225
GO:0005794	Component	Golgi apparatus	ISS
GO:0005829	Component	Cytosol	IDA	22689054
GO:0005856	Component	Cytoskeleton	IDA	25051234
GO:0006629	Process	Lipid metabolic process	NAS	2387851
GO:0006956	Process	Complement activation	TAS	1585460
GO:0006958	Process	Complement activation, classical pathway	IEA
GO:0009615	Process	Response to virus	IEP	16548883
GO:0009986	Component	Cell surface	IDA	17567961
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0016020	Component	Membrane	IDA	25051234
GO:0016887	Function	ATPase activity	IDA	11123922
GO:0017038	Process	Protein import	IDA	24446231
GO:0019730	Process	Antimicrobial humoral response	TAS
GO:0030449	Process	Regulation of complement activation	TAS
GO:0031093	Component	Platelet alpha granule lumen	TAS
GO:0031333	Process	Negative regulation of protein-containing complex assembly	IDA	22179788, 23106396
GO:0031333	Process	Negative regulation of protein-containing complex assembly	IMP	16113678
GO:0031334	Process	Positive regulation of protein-containing complex assembly	IDA	22179788
GO:0031625	Function	Ubiquitin protein ligase binding	IDA	20068069
GO:0032286	Process	Central nervous system myelin maintenance	IMP	21543606
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	20068069
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IDA	15857407
GO:0032991	Component	Protein-containing complex	IDA	9228033, 17567961
GO:0034366	Component	Spherical high-density lipoprotein particle	IDA	16682745
GO:0042127	Process	Regulation of cell population proliferation	IMP	19137541
GO:0042583	Component	Chromaffin granule	IEA
GO:0042981	Process	Regulation of apoptotic process	IBA	21873635
GO:0043065	Process	Positive regulation of apoptotic process	ISS
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA	22689054
GO:0043691	Process	Reverse cholesterol transport	TAS	16682745
GO:0044877	Function	Protein-containing complex binding	IPI	22179788, 23106396
GO:0045087	Process	Innate immune response	IEA
GO:0045202	Component	Synapse	IEA
GO:0045429	Process	Positive regulation of nitric oxide biosynthetic process	IDA	15857407
GO:0048156	Function	Tau protein binding	IPI	25051234
GO:0048260	Process	Positive regulation of receptor-mediated endocytosis	IGI	9228033
GO:0048260	Process	Positive regulation of receptor-mediated endocytosis	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	20068069
GO:0050750	Function	Low-density lipoprotein particle receptor binding	IPI	9228033
GO:0050821	Process	Protein stabilization	IDA	11123922, 12176985
GO:0051082	Function	Unfolded protein binding	IMP	25402950
GO:0051087	Function	Chaperone binding	ISS
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IMP	20068069
GO:0051131	Process	Chaperone-mediated protein complex assembly	IDA	17412999
GO:0051787	Function	Misfolded protein binding	IBA	21873635
GO:0051787	Function	Misfolded protein binding	IDA	11123922
GO:0051787	Function	Misfolded protein binding	IPI	19996109
GO:0051788	Process	Response to misfolded protein	IDA	19996109
GO:0060548	Process	Negative regulation of cell death	IMP	21803450
GO:0060548	Process	Negative regulation of cell death	TAS	23164821
GO:0061077	Process	Chaperone-mediated protein folding	IDA	11123922
GO:0061518	Process	Microglial cell proliferation	IDA	15857407
GO:0061740	Process	Protein targeting to lysosome involved in chaperone-mediated autophagy	IC	9228033
GO:0061741	Process	Chaperone-mediated protein transport involved in chaperone-mediated autophagy	IC	9228033
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	23658023, 27559042
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	20551380
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145
GO:0071944	Component	Cell periphery	IDA	21803450
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0090201	Process	Negative regulation of release of cytochrome c from mitochondria	TAS	21803450
GO:0097418	Component	Neurofibrillary tangle	IDA	9560017, 15897157
GO:0097440	Component	Apical dendrite	IDA	9560017
GO:0099020	Component	Perinuclear endoplasmic reticulum lumen	IDA	22689054
GO:1900221	Process	Regulation of amyloid-beta clearance	IDA	24446231
GO:1901214	Process	Regulation of neuron death	IDA	17412999
GO:1901214	Process	Regulation of neuron death	IMP	9560017
GO:1901216	Process	Positive regulation of neuron death	IDA	15857407
GO:1901216	Process	Positive regulation of neuron death	IMP	15897157
GO:1901216	Process	Positive regulation of neuron death	ISS
GO:1902004	Process	Positive regulation of amyloid-beta formation	ISS
GO:1902230	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP	16113678
GO:1902430	Process	Negative regulation of amyloid-beta formation	IDA	12047389, 17412999
GO:1902847	Process	Regulation of neuronal signal transduction	IMP	21397462
GO:1902949	Process	Positive regulation of tau-protein kinase activity	IMP	15897157
GO:1902998	Process	Positive regulation of neurofibrillary tangle assembly	IMP	15897157
GO:1903573	Process	Negative regulation of response to endoplasmic reticulum stress	IMP	21803450
GO:1905892	Process	Negative regulation of cellular response to thapsigargin	IMP	21803450
GO:1905895	Process	Negative regulation of cellular response to tunicamycin	IMP	21803450
GO:1905907	Process	Negative regulation of amyloid fibril formation	IDA	22179788
GO:1905907	Process	Negative regulation of amyloid fibril formation	TAS	9228033, 23106396
GO:1905908	Process	Positive regulation of amyloid fibril formation	TAS	20005821
GO:2000060	Process	Positive regulation of ubiquitin-dependent protein catabolic process	IMP	20068069

Other IDs

• MIM: 185430
• HGNC: 2095
• e!Ensembl: ENSG00000120885

Protein

• UniProt ID: P10909
• Protein name: Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate me
• Protein function: [Isoform 1]: Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed:11123922, PubMed:19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed:11123922, PubMed:12176985, PubMed:1726097
• PDB: 7ZET, 7ZEU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01093	Clusterin	30 → 447	Clusterin	Family

• Sequence:

  MMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLI
  EKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQT
  CMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHF
  SRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNF
  HAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKD
  QCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLE
  QLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTVP
  VEVSRKNPKFMETVAEKALQEYRKKHREE

• Sequence length: 449

Pathways

KEGG:

Complement and coagulation cascades

Reactome:

Platelet degranulation
Terminal pathway of complement
Antimicrobial peptides
Regulation of Complement cascade

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	19734903, 21460841, 19734902, 21460841, 19734903, 19734902, 19734902, 30617256, 31473137, 30805717, 21460841, 24162737, 19734903, 29777097, 25778476, 19734902, 21460841, 19734903
Amyotrophic lateral sclerosis	Amyotrophic Lateral Sclerosis, Familial	rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733, rs80356731, rs80356726, rs267606928, rs267606929, rs1885090126, rs121434591, rs121912431, rs121912432, rs121912433, rs121912434, rs121912435, rs121912440, rs121912436, rs121912437, rs121912438, rs121912439, rs74315452, rs121912442, rs121912443, rs121912444, rs121912446, rs121912447, rs1197141604, rs121912448, rs121912449, rs121912450, rs121912451, rs121912452, rs121912453, rs121912454, rs369600566, rs121912455, rs121912456, rs121912457, rs121912458, rs1555836889, rs121909667, rs121909668, rs121909669, rs121909671, rs121909535, rs121909537, rs121909538, rs121909539, rs121909540, rs121909542, rs121909544, rs80356734, rs367543041, rs80356740, rs80356719, rs80356721, rs80356723, rs80356725, rs387906627, rs387906628, rs387906709, rs387906710, rs387906711, rs387906829, rs387907264, rs387907265, rs387907266, rs312262739, rs312262709, rs312262749, rs200793464, rs147713329, rs312262788, rs397514262, rs63751180, rs587777132, rs730880025, rs730880026, rs730880027, rs368743618, rs730880029, rs730882255, rs730882256, rs786205611, rs121912441, rs199947197, rs780136067, rs772731615, rs879253926, rs879254294, rs764717219, rs886041390, rs750159428, rs753207473, rs267607087, rs767350733, rs778305085, rs1554707680, rs1554707622, rs1393363759, rs750959420, rs1555509569, rs1554716504, rs11556620, rs1247392012, rs142083484, rs140385286, rs749428135, rs371575563, rs1402429085, rs1218712729, rs1555179091, rs1555179087, rs746971952, rs1555836950, rs368276916, rs140376902, rs747220413, rs76731700, rs770684782, rs1200906022, rs1804449, rs1482760341, rs769898852, rs140599944, rs757972700, rs1555451521, rs1592362719, rs1555836803, rs763455928, rs1378590183, rs1583695322, rs1362178149, rs1197928094, rs368751524, rs1555509609, rs1574787779, rs1601157750, rs1301635320, rs1341055534, rs1402092579, rs1568809172, rs1555836170, rs1315541036, rs1339283341, rs1643659556, rs1644506661, rs1435710212, rs1553122918, rs1689580631, rs374047961, rs775935265, rs2076486420, rs1820836522, rs757260058, rs1844420892, rs1833371664, rs1833438306, rs1833451208, rs2083790483, rs1303294230, rs1226110412, rs2053207945, rs2053208751, rs2053501632, rs2053539304, rs1567479067, rs544088874, rs1228194239, rs1568807400, rs1169198442, rs2049594204, rs2049594311, rs1568810641, rs1568811372, rs2049618449, rs1476760624, rs2079347087	11796754
Arthritis	Degenerative polyarthritis, Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	18784066, 17568789, 19565504
Kidney disease	Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	24863737, 21258088, 21593213
Lateral sclerosis	AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic	rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048	11796754
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	15955107
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17148459
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	20738160
Seizure	Complex partial seizures, Generalized seizures, Visual seizure, Tonic - clonic seizures, Single Seizure	rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061, rs121912707, rs118192249, rs118192251, rs118192217, rs118192218, rs118192219, rs118192222, rs118192226, rs118192228, rs118192234, rs118192236, rs118192235, rs118192241, rs118192242, rs118192185, rs118192188, rs118192245, rs118192246, rs118192186, rs118192194, rs118192197, rs118192199, rs118192201, rs118192202, rs118192203, rs118192204, rs118192205, rs118192206, rs118192208, rs118192211, rs118192216, rs118192239, rs387906684, rs387906686, rs387906687, rs1596893185, rs387907126, rs387907281, rs397515405, rs587778771, rs730882067, rs730882073, rs397514579, rs397514582, rs587776976, rs398122394, rs121918784, rs121918751, rs121918735, rs398123588, rs587780450, rs61749751, rs587777620, rs727503974, rs730882124, rs794726710, rs794726697, rs794726799, rs794727444, rs794727740, rs796053166, rs794726825, rs796052676, rs796053219, rs796053220, rs796053228, rs796052653, rs759584387, rs796052650, rs796052641, rs796052626, rs796052623, rs796052663, rs796052615, rs796052802, rs797044999, rs797045047, rs797045942, rs797045941, rs118192212, rs797044938, rs777257591, rs864321712, rs879255652, rs886039268, rs886039517, rs886039529, rs199497486, rs886039496, rs886039903, rs886041300, rs769827124, rs886041339, rs886041591, rs587783092, rs1555850151, rs1057516123, rs1057516121, rs1057516115, rs1057516111, rs1057516106, rs1057516105, rs756921902, rs1057516089, rs1057516087, rs1057516080, rs1057516076, rs1060499544, rs1555850512, rs1057517919, rs118192231, rs1057520413, rs1060503101, rs1064796294, rs1064794981, rs1064794632, rs1064797245, rs1131691830, rs1131692231, rs1131691936, rs1554626549, rs1553579225, rs1553531385, rs121918736, rs1554898088, rs1553579282, rs763353895, rs1553463119, rs1554093891, rs77838305, rs1555408401, rs1554627439, rs1554097873, rs1555850403, rs1064794719, rs1315483224, rs1567134495, rs770187706, rs1057518555, rs1576983339, rs1574192005, rs1459374430, rs1586800133, rs1574641522, rs1572096837, rs1572630269, rs1574554892, rs1574556643, rs1574571769, rs1574641605, rs1574697769, rs1574716524, rs1574746733, rs1574746935, rs1574752700, rs1574754680, rs863225030, rs1601545088, rs1600714727, rs1371059392, rs1600767259, rs1339542565, rs1600785769, rs2065899210, rs1600732174, rs1162306056, rs879255709, rs1900111672, rs2066910297, rs1554122080, rs796052941, rs1600789325, rs2082695884, rs1737677036, rs1737495759, rs868389022, rs1737685202, rs1737672350, rs762737130	23266720

Unknown
Disease name	Disease term	dbSNP ID	References
Clonic seizures	Clonic Seizures		23266720
Cognitive disorder	Mild cognitive disorder		30503753
Hypotonic seizures	Epileptic drop attack		23266720
Impaired cognition	Impaired cognition		30503753
Jacksonian seizure	Jacksonian Seizure		23266720
Juvenile arthritis	Juvenile psoriatic arthritis		19565504
Kidney failure	Kidney Failure, Acute		22005293, 28885000, 20623750, 20118187, 24361871, 23052191
Lupus erythematosus	Lupus Erythematosus, Systemic		15304052
Nonbacterial verrucal endocardiosis	Libman-Sacks Disease		15304052
Osteoarthrosis deformans	Osteoarthrosis Deformans		17568789, 18784066
Seronegative polyarthritis	Polyarthritis, Juvenile, Rheumatoid Factor Negative		19565504
Polyarthritis, rheumatoid factor positive	Polyarthritis, Juvenile, Rheumatoid Factor Positive		19565504
Prostatic neoplasms	Prostatic Neoplasms		17148459
Acute kidney insufficiency	Acute Kidney Insufficiency		20118187, 22005293, 20623750, 24361871, 28885000, 23052191
Senile dementia	Presenile dementia, Acute Confusional Senile Dementia		19734903, 19734902, 21460841, 21460841, 19734903, 19734902
Still disease	Juvenile-Onset Still Disease		19565504