TAGAP (T cell activation RhoGTPase activating protein)

Gene

• Entrez ID: 117289
• Gene name: T cell activation RhoGTPase activating protein
• Gene symbol: TAGAP
• Synonyms: ARHGAP47, FKSG15, IDDM21, TAGAP1
• Chromosome: 6
• Chromosome location: 6q25.3
• Summary: This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disea

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT439486	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT439486	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT1410049	hsa-miR-106a	CLIP-seq
MIRT1410050	hsa-miR-106b	CLIP-seq
MIRT1410051	hsa-miR-139-5p	CLIP-seq
MIRT1410052	hsa-miR-17	CLIP-seq
MIRT1410053	hsa-miR-20a	CLIP-seq
MIRT1410054	hsa-miR-20b	CLIP-seq
MIRT1410055	hsa-miR-2682	CLIP-seq
MIRT1410056	hsa-miR-3189-5p	CLIP-seq
MIRT1410057	hsa-miR-371b-3p	CLIP-seq
MIRT1410058	hsa-miR-4438	CLIP-seq
MIRT1410059	hsa-miR-449c	CLIP-seq
MIRT1410060	hsa-miR-4514	CLIP-seq
MIRT1410061	hsa-miR-4692	CLIP-seq
MIRT1410062	hsa-miR-4758-3p	CLIP-seq
MIRT1410063	hsa-miR-5095	CLIP-seq
MIRT1410064	hsa-miR-519d	CLIP-seq
MIRT1410065	hsa-miR-548ac	CLIP-seq
MIRT1410066	hsa-miR-548ae	CLIP-seq
MIRT1410067	hsa-miR-548aj	CLIP-seq
MIRT1410068	hsa-miR-548am	CLIP-seq
MIRT1410069	hsa-miR-548d-3p	CLIP-seq
MIRT1410070	hsa-miR-548t	CLIP-seq
MIRT1410071	hsa-miR-548x	CLIP-seq
MIRT1410072	hsa-miR-548z	CLIP-seq
MIRT1410073	hsa-miR-93	CLIP-seq
MIRT1410051	hsa-miR-139-5p	CLIP-seq
MIRT1410055	hsa-miR-2682	CLIP-seq
MIRT1410074	hsa-miR-374c	CLIP-seq
MIRT1410075	hsa-miR-4277	CLIP-seq
MIRT1410058	hsa-miR-4438	CLIP-seq
MIRT1410059	hsa-miR-449c	CLIP-seq
MIRT1410060	hsa-miR-4514	CLIP-seq
MIRT1410061	hsa-miR-4692	CLIP-seq
MIRT1410063	hsa-miR-5095	CLIP-seq
MIRT1410076	hsa-miR-655	CLIP-seq
MIRT2122887	hsa-miR-21	CLIP-seq
MIRT2122888	hsa-miR-28-5p	CLIP-seq
MIRT2122889	hsa-miR-3139	CLIP-seq
MIRT2122890	hsa-miR-4272	CLIP-seq
MIRT2122891	hsa-miR-513c	CLIP-seq
MIRT2122892	hsa-miR-514b-5p	CLIP-seq
MIRT2122893	hsa-miR-590-5p	CLIP-seq
MIRT2122894	hsa-miR-708	CLIP-seq
MIRT2461117	hsa-miR-1323	CLIP-seq
MIRT2461118	hsa-miR-2276	CLIP-seq
MIRT2461119	hsa-miR-4420	CLIP-seq
MIRT2461120	hsa-miR-548o	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: 609667
• HGNC: 15669
• e!Ensembl: ENSG00000164691

Protein

• UniProt ID: Q8N103
• Protein name: T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein)
• Protein function: May function as a GTPase-activating protein and may play important roles during T-cell activation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00620	RhoGAP	101 → 250	RhoGAP domain	Domain

• Sequence:

  MKLRSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDSICQLIEVKKRKKVLSW
  PFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQDILTILCLKGPSTEG
  IFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMG
  ALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPN
  MLTLENDQSLSFEAQKDLNNKVKTLVEFLIDNCFEIFGENIPVHSSITSDDSLEHTDSSD
  VSTLQNDSAYDSNDPDVESNSSSGISSPSRQPQVPMATAAGLDSAGPQDAREVSPEPIVS
  TVARLKSSLAQPDRRYSEPSMPSSQECLESRVTNQTLTKSEGDFPVPRVGSRLESEEAED
  PFPEEVFPAVQGKTKRPVDLKIKNLAPGSVLPRALVLKAFSSSSLDASSDSSPVASPSSP
  KRNFFSRHQSFTTKTEKGKPSREIKKHSMSFTFAPHKKVLTKNLSAGSGKSQDFTRDHVP
  RGVRKESQLAGRIVQENGCETHNQTARGFCLRPHALSVDDVFQGADWERPGSPPSYEEAM
  QGPAARLVASESQTVGSMTVGSMRARMLEAHCLLPPLPPAHHVEDSRHRGSKEPLPGHGL
  SPLPERWKQSRTVHASGDSLGHVSGPGRPELLPLRTVSESVQRNKRDCLVRRCSQPVFEA
  DQFQYAKESYI

• Sequence length: 731

Pathways

Reactome:

Rho GTPase cycle

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	21150878
Autoimmune diseases	Autoimmune Diseases	rs41285370, rs869025224	21383967
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	21833088, 22190364
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	23143594
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	20453842, 23143596

Unknown
Disease name	Disease term	dbSNP ID	References
Celiac disease	Celiac Disease	rs2305764, rs35218876	20190752, 24999842, 18311140
Crohn disease	Crohn Disease, Regional enteritis	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	21102463
Crohn`s disease of large bowel	Crohn`s disease of large bowel		21102463
Crohn`s disease of the ileum	Crohn`s disease of the ileum		21102463
Ileocolitis	IIeocolitis		21102463
Immune system diseases	Immune System Diseases		21383967
Palmoplantar pustules	Pustulosis of Palms and Soles		23143594