Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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117145 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Thioesterase superfamily member 4 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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THEM4 |
SynonymsGene synonyms aliases
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CTMP |
ChromosomeChromosome number
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1 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1q21.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
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Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory doma |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
Q5T1C6 |
Protein name |
Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4) |
Protein function |
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 |
PDB |
4AE8
,
4GAH
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF03061 |
4HBT |
148 → 223 |
Thioesterase superfamily |
Domain |
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Sequence |
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Sequence length |
240 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Kidney failure |
Kidney Failure, Chronic |
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29545352 |
Liver carcinoma |
Liver carcinoma |
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23392203 |
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