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THEM4 (thioesterase superfamily member 4)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
117145
Gene nameGene Name - the full gene name approved by the HGNC.
Thioesterase superfamily member 4
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
THEM4
SynonymsGene synonyms aliases
CTMP
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.3
SummarySummary of gene provided in NCBI Entrez Gene.
Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory doma
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005171 hsa-miR-30a-5p pSILAC 18668040
MIRT005171 hsa-miR-30a-5p Proteomics;Other 18668040
MIRT031745 hsa-miR-16-5p Proteomics 18668040
MIRT693161 hsa-miR-3609 HITS-CLIP 23313552
MIRT693162 hsa-miR-548ah-5p HITS-CLIP 23313552
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19541650, 22309289, 24670654, 32814053
GO:0005739 Component Mitochondrion IDA 19604401
GO:0005743 Component Mitochondrial inner membrane IEA
GO:0005758 Component Mitochondrial intermembrane space IEA
GO:0005759 Component Mitochondrial matrix TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q5T1C6
Protein name Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4)
Protein function Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1
PDB 4AE8 , 4GAH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03061 4HBT
148 223
Thioesterase superfamily
Domain
Sequence
MLRSCAARLRTLGALCLPPVGRRLPGSEPRPELRSFSSEEVILKDCSVPNPSWNKDLRLL
FDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLFTRSFDDGLG
FEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMMAGGIVMTANL
NINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLY
SEATSLFIKLNPAKSLT
Sequence length 240
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Fatty acid elongation
Metabolic pathways
PI3K-Akt signaling pathway
  PIP3 activates AKT signaling
Activation of AKT2
Negative regulation of the PI3K/AKT network
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
Mitochondrial Fatty Acid Beta-Oxidation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Kidney disease Chronic Kidney Diseases rs74315342, rs749740335, rs757649673, rs112417755, rs35138315 29545352
Unknown
Disease name Disease term dbSNP ID References
Kidney failure Kidney Failure, Chronic 29545352
Liver carcinoma Liver carcinoma 23392203

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