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ADCYAP1R1 (ADCYAP receptor type I)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
117
Gene nameGene Name - the full gene name approved by the HGNC.
ADCYAP receptor type I
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ADCYAP1R1
SynonymsGene synonyms aliases
PAC1, PAC1R, PACAPR, PACAPRI
ChromosomeChromosome number
7
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p14.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT611488 hsa-miR-8485 HITS-CLIP 22927820
MIRT636742 hsa-miR-329-3p HITS-CLIP 22927820
MIRT636741 hsa-miR-362-3p HITS-CLIP 22927820
MIRT636740 hsa-miR-603 HITS-CLIP 22927820
MIRT614418 hsa-miR-4789-3p HITS-CLIP 22927820
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004999 Function Vasoactive intestinal polypeptide receptor activity IEA
GO:0005515 Function Protein binding IPI 17470806
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane TAS 7902709
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P41586
Protein name Pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1 receptor) (PAC1R) (PACAP type I receptor) (PACAP-R-1) (PACAP-R1)
Protein function G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). Binds both PACAP27 and PACAP38 bioactive peptides (
PDB 2JOD , 3N94 , 6LPB , 6M1H , 6M1I , 6P9Y , 7JQD , 8E3X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02793 HRM
51 137
Hormone receptor domain
Family
PF00002 7tm_2
150 396
7 transmembrane receptor (Secretin family)
Family
Sequence
Sequence length 468
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Insulin secretion
Renin secretion
  G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Asthma Asthma rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 21059121
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 17387318

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