AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1)

Gene

• Entrez ID: 116987
• Gene name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
• Gene symbol: AGAP1
• Synonyms: AGAP-1, CENTG2, GGAP1, cnt-g2
• Chromosome: 2
• Chromosome location: 2q37.2
• Summary: This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024193	hsa-miR-221-3p	Sequencing	20371350
MIRT043133	hsa-miR-324-5p	CLASH	23622248
MIRT036541	hsa-miR-1225-3p	CLASH	23622248
MIRT689071	hsa-miR-181d-3p	HITS-CLIP	23313552
MIRT689070	hsa-miR-5193	HITS-CLIP	23313552
MIRT689069	hsa-miR-4638-5p	HITS-CLIP	23313552
MIRT689068	hsa-miR-6869-3p	HITS-CLIP	23313552
MIRT689067	hsa-miR-3648	HITS-CLIP	23313552
MIRT648246	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT648245	hsa-miR-4643	HITS-CLIP	23824327
MIRT648244	hsa-miR-3941	HITS-CLIP	23824327
MIRT648243	hsa-miR-4672	HITS-CLIP	23824327
MIRT648242	hsa-miR-466	HITS-CLIP	23824327
MIRT648241	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT648240	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT648239	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT648238	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT513155	hsa-miR-498	PAR-CLIP	23446348
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22291592
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22291592
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22291592
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22291592
MIRT442217	hsa-miR-6080	PAR-CLIP	22291592
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22291592
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22291592
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22291592
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22291592
MIRT442217	hsa-miR-6080	PAR-CLIP	22291592
MIRT442222	hsa-miR-21-3p	PAR-CLIP	23708386
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	23708386
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	23708386
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	23708386
MIRT442217	hsa-miR-6080	PAR-CLIP	23708386
MIRT459543	hsa-miR-4798-3p	PAR-CLIP	23592263
MIRT459541	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT459542	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT459540	hsa-miR-6077	PAR-CLIP	23592263
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22100165
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22100165
MIRT442217	hsa-miR-6080	PAR-CLIP	22100165
MIRT443587	hsa-miR-8078	PAR-CLIP	22100165
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22100165
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22100165
MIRT442217	hsa-miR-6080	PAR-CLIP	22100165
MIRT459542	hsa-miR-4733-3p	PAR-CLIP	26701625
MIRT459542	hsa-miR-4733-3p	PAR-CLIP	26701625
MIRT689071	hsa-miR-181d-3p	HITS-CLIP	23313552
MIRT689070	hsa-miR-5193	HITS-CLIP	23313552
MIRT689069	hsa-miR-4638-5p	HITS-CLIP	23313552
MIRT689068	hsa-miR-6869-3p	HITS-CLIP	23313552
MIRT689067	hsa-miR-3648	HITS-CLIP	23313552
MIRT648246	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT648245	hsa-miR-4643	HITS-CLIP	23824327
MIRT648244	hsa-miR-3941	HITS-CLIP	23824327
MIRT648243	hsa-miR-4672	HITS-CLIP	23824327
MIRT648242	hsa-miR-466	HITS-CLIP	23824327
MIRT648241	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT648240	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT648239	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT648238	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT513155	hsa-miR-498	PAR-CLIP	23446348
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22291592
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22291592
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22291592
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22291592
MIRT442217	hsa-miR-6080	PAR-CLIP	22291592
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22291592
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22291592
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22291592
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22291592
MIRT442217	hsa-miR-6080	PAR-CLIP	22291592
MIRT442222	hsa-miR-21-3p	PAR-CLIP	23708386
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	23708386
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	23708386
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	23708386
MIRT442217	hsa-miR-6080	PAR-CLIP	23708386
MIRT459543	hsa-miR-4798-3p	PAR-CLIP	23592263
MIRT459541	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT459542	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT459540	hsa-miR-6077	PAR-CLIP	23592263
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22100165
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22100165
MIRT442217	hsa-miR-6080	PAR-CLIP	22100165
MIRT443587	hsa-miR-8078	PAR-CLIP	22100165
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22100165
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22100165
MIRT442217	hsa-miR-6080	PAR-CLIP	22100165
MIRT771569	hsa-miR-1227	CLIP-seq
MIRT771570	hsa-miR-1231	CLIP-seq
MIRT771571	hsa-miR-1238	CLIP-seq
MIRT771572	hsa-miR-1269	CLIP-seq
MIRT771573	hsa-miR-1269b	CLIP-seq
MIRT771574	hsa-miR-1272	CLIP-seq
MIRT771575	hsa-miR-1288	CLIP-seq
MIRT771576	hsa-miR-1303	CLIP-seq
MIRT771577	hsa-miR-188-5p	CLIP-seq
MIRT771578	hsa-miR-2113	CLIP-seq
MIRT771579	hsa-miR-3133	CLIP-seq
MIRT771580	hsa-miR-3148	CLIP-seq
MIRT771581	hsa-miR-3158-3p	CLIP-seq
MIRT771582	hsa-miR-3183	CLIP-seq
MIRT771583	hsa-miR-3192	CLIP-seq
MIRT771584	hsa-miR-3646	CLIP-seq
MIRT771585	hsa-miR-3675-3p	CLIP-seq
MIRT771586	hsa-miR-3907	CLIP-seq
MIRT771587	hsa-miR-4314	CLIP-seq
MIRT771588	hsa-miR-4436a	CLIP-seq
MIRT771589	hsa-miR-4515	CLIP-seq
MIRT771590	hsa-miR-4517	CLIP-seq
MIRT771591	hsa-miR-4520b-3p	CLIP-seq
MIRT771592	hsa-miR-4529-3p	CLIP-seq
MIRT771593	hsa-miR-4645-3p	CLIP-seq
MIRT771594	hsa-miR-4646-5p	CLIP-seq
MIRT771595	hsa-miR-4715-3p	CLIP-seq
MIRT771596	hsa-miR-4716-5p	CLIP-seq
MIRT771597	hsa-miR-4721	CLIP-seq
MIRT771598	hsa-miR-4723-3p	CLIP-seq
MIRT771599	hsa-miR-4731-5p	CLIP-seq
MIRT771600	hsa-miR-4740-5p	CLIP-seq
MIRT771601	hsa-miR-4753-3p	CLIP-seq
MIRT771602	hsa-miR-4780	CLIP-seq
MIRT771603	hsa-miR-488	CLIP-seq
MIRT771604	hsa-miR-582-5p	CLIP-seq
MIRT771605	hsa-miR-587	CLIP-seq
MIRT771606	hsa-miR-599	CLIP-seq
MIRT771607	hsa-miR-600	CLIP-seq
MIRT771608	hsa-miR-623	CLIP-seq
MIRT771609	hsa-miR-654-3p	CLIP-seq
MIRT771610	hsa-miR-9	CLIP-seq
MIRT771571	hsa-miR-1238	CLIP-seq
MIRT771572	hsa-miR-1269	CLIP-seq
MIRT771573	hsa-miR-1269b	CLIP-seq
MIRT771575	hsa-miR-1288	CLIP-seq
MIRT771582	hsa-miR-3183	CLIP-seq
MIRT771584	hsa-miR-3646	CLIP-seq
MIRT771589	hsa-miR-4515	CLIP-seq
MIRT771591	hsa-miR-4520b-3p	CLIP-seq
MIRT771592	hsa-miR-4529-3p	CLIP-seq
MIRT771598	hsa-miR-4723-3p	CLIP-seq
MIRT771600	hsa-miR-4740-5p	CLIP-seq
MIRT771601	hsa-miR-4753-3p	CLIP-seq
MIRT771610	hsa-miR-9	CLIP-seq
MIRT1545180	hsa-miR-1915	CLIP-seq
MIRT1545181	hsa-miR-4285	CLIP-seq
MIRT1545182	hsa-miR-4726-3p	CLIP-seq
MIRT1545183	hsa-miR-485-5p	CLIP-seq
MIRT1545184	hsa-miR-764	CLIP-seq
MIRT1927667	hsa-miR-1184	CLIP-seq
MIRT1927668	hsa-miR-1205	CLIP-seq
MIRT1927669	hsa-miR-1253	CLIP-seq
MIRT771574	hsa-miR-1272	CLIP-seq
MIRT1927670	hsa-miR-1273f	CLIP-seq
MIRT1927671	hsa-miR-1307	CLIP-seq
MIRT1927672	hsa-miR-134	CLIP-seq
MIRT1927673	hsa-miR-1468	CLIP-seq
MIRT1927674	hsa-miR-3118	CLIP-seq
MIRT771580	hsa-miR-3148	CLIP-seq
MIRT1927675	hsa-miR-3158-5p	CLIP-seq
MIRT1927676	hsa-miR-3160-5p	CLIP-seq
MIRT1927677	hsa-miR-3164	CLIP-seq
MIRT1927678	hsa-miR-34b	CLIP-seq
MIRT1927679	hsa-miR-3529	CLIP-seq
MIRT771584	hsa-miR-3646	CLIP-seq
MIRT1927680	hsa-miR-3671	CLIP-seq
MIRT771585	hsa-miR-3675-3p	CLIP-seq
MIRT1927681	hsa-miR-3690	CLIP-seq
MIRT1927682	hsa-miR-3691-3p	CLIP-seq
MIRT1927683	hsa-miR-379	CLIP-seq
MIRT1927684	hsa-miR-3913-3p	CLIP-seq
MIRT1927685	hsa-miR-3919	CLIP-seq
MIRT1927686	hsa-miR-4255	CLIP-seq
MIRT1927687	hsa-miR-4268	CLIP-seq
MIRT1545181	hsa-miR-4285	CLIP-seq
MIRT1927688	hsa-miR-4287	CLIP-seq
MIRT1927689	hsa-miR-4292	CLIP-seq
MIRT1927690	hsa-miR-4308	CLIP-seq
MIRT1927691	hsa-miR-4451	CLIP-seq
MIRT1927692	hsa-miR-4469	CLIP-seq
MIRT771590	hsa-miR-4517	CLIP-seq
MIRT1927693	hsa-miR-4520a-3p	CLIP-seq
MIRT1927694	hsa-miR-455-5p	CLIP-seq
MIRT1927695	hsa-miR-4638-3p	CLIP-seq
MIRT771593	hsa-miR-4645-3p	CLIP-seq
MIRT1927696	hsa-miR-4650-3p	CLIP-seq
MIRT1927697	hsa-miR-4659a-3p	CLIP-seq
MIRT1927698	hsa-miR-4659b-3p	CLIP-seq
MIRT1927699	hsa-miR-4676-5p	CLIP-seq
MIRT1927700	hsa-miR-4685-3p	CLIP-seq
MIRT1927701	hsa-miR-4713-5p	CLIP-seq
MIRT1927702	hsa-miR-4756-3p	CLIP-seq
MIRT1927703	hsa-miR-4762-3p	CLIP-seq
MIRT1927704	hsa-miR-4786-3p	CLIP-seq
MIRT1927705	hsa-miR-544	CLIP-seq
MIRT1927706	hsa-miR-575	CLIP-seq
MIRT771604	hsa-miR-582-5p	CLIP-seq
MIRT771607	hsa-miR-600	CLIP-seq
MIRT1927707	hsa-miR-630	CLIP-seq
MIRT1927708	hsa-miR-942	CLIP-seq
MIRT1927678	hsa-miR-34b	CLIP-seq
MIRT2168486	hsa-miR-3664-5p	CLIP-seq
MIRT1927680	hsa-miR-3671	CLIP-seq
MIRT1927684	hsa-miR-3913-3p	CLIP-seq
MIRT771590	hsa-miR-4517	CLIP-seq
MIRT1927699	hsa-miR-4676-5p	CLIP-seq
MIRT1927704	hsa-miR-4786-3p	CLIP-seq
MIRT1927706	hsa-miR-575	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	IEA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005525	Function	GTP binding	IEA
GO:0005543	Function	Phospholipid binding	IDA	18954304
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IEA
GO:0015031	Process	Protein transport	IEA
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 608651
• HGNC: 16922
• e!Ensembl: ENSG00000157985

Protein

• UniProt ID: Q9UPQ3
• Protein name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1)
• Protein function: GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.
• PDB: 7EB6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	73 → 231	Ras family	Domain
  PF01412	ArfGap	609 → 725	Putative GTPase activating protein for Arf	Domain
  PF12796	Ank_2	736 → 830	Ankyrin repeats (3 copies)	Repeat

• Sequence:

  MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNS
  QEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLL
  LIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQD
  AISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSI
  GPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPT
  ANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKS
  LNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPI
  SSPKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQ
  WSEATVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKA
  DGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNK
  SRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSR
  VRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKL
  FLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKG
  NVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLS
  RRNNNRNNSSGRVPTII

• Sequence length: 857

Pathways

KEGG:

Endocytosis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	15892143
Hypertension	Hypertensive disease	rs13306026, rs13333226	26516778
Parkinson disease	Parkinson Disease	rs116074753, rs118203903, rs118203904, rs115735611, rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs74315361, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121917767, rs121918104, rs1589451049, rs104893877, rs104893878, rs283413, rs112176450, rs111290936, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs387906942, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106	28892059
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	19571809, 22688191

Unknown
Disease name	Disease term	dbSNP ID	References
Cardiovascular diseases	Cardiovascular Diseases		26516778
Goldenhar syndrome	Goldenhar Syndrome		26853712
Knee osteoarthritis	Osteoarthritis, Knee		29559693