AGAP2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2)

Gene

• Entrez ID: 116986
• Gene name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
• Gene symbol: AGAP2
• Synonyms: CENTG1, GGAP2, PIKE
• Chromosome: 12
• Chromosome location: 12q14.1
• Summary: The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT771611	hsa-miR-1183	CLIP-seq
MIRT771612	hsa-miR-1324	CLIP-seq
MIRT771613	hsa-miR-1471	CLIP-seq
MIRT771614	hsa-miR-3156-3p	CLIP-seq
MIRT771615	hsa-miR-3162-3p	CLIP-seq
MIRT771616	hsa-miR-342-5p	CLIP-seq
MIRT771617	hsa-miR-4301	CLIP-seq
MIRT771618	hsa-miR-4313	CLIP-seq
MIRT771619	hsa-miR-4664-5p	CLIP-seq
MIRT771620	hsa-miR-615-5p	CLIP-seq
MIRT771621	hsa-miR-642b	CLIP-seq
MIRT1927709	hsa-miR-4447	CLIP-seq
MIRT1927710	hsa-miR-4472	CLIP-seq
MIRT1927711	hsa-miR-4492	CLIP-seq
MIRT1927712	hsa-miR-4498	CLIP-seq
MIRT1927713	hsa-miR-4505	CLIP-seq
MIRT1927714	hsa-miR-762	CLIP-seq
MIRT1927715	hsa-miR-1207-5p	CLIP-seq
MIRT1927716	hsa-miR-1321	CLIP-seq
MIRT771612	hsa-miR-1324	CLIP-seq
MIRT1927717	hsa-miR-1827	CLIP-seq
MIRT1927718	hsa-miR-3126-5p	CLIP-seq
MIRT1927719	hsa-miR-3612	CLIP-seq
MIRT1927720	hsa-miR-3940-5p	CLIP-seq
MIRT1927721	hsa-miR-4419a	CLIP-seq
MIRT1927722	hsa-miR-4446-3p	CLIP-seq
MIRT1927711	hsa-miR-4492	CLIP-seq
MIRT1927712	hsa-miR-4498	CLIP-seq
MIRT1927713	hsa-miR-4505	CLIP-seq
MIRT1927723	hsa-miR-4507	CLIP-seq
MIRT1927724	hsa-miR-4510	CLIP-seq
MIRT1927725	hsa-miR-4640-5p	CLIP-seq
MIRT1927726	hsa-miR-4690-3p	CLIP-seq
MIRT1927727	hsa-miR-4726-5p	CLIP-seq
MIRT1927728	hsa-miR-4739	CLIP-seq
MIRT1927729	hsa-miR-4756-5p	CLIP-seq
MIRT1927730	hsa-miR-4763-3p	CLIP-seq
MIRT1927731	hsa-miR-647	CLIP-seq
MIRT1927732	hsa-miR-650	CLIP-seq
MIRT1927714	hsa-miR-762	CLIP-seq
MIRT1927733	hsa-miR-940	CLIP-seq
MIRT1927715	hsa-miR-1207-5p	CLIP-seq
MIRT2168487	hsa-miR-1273f	CLIP-seq
MIRT2168488	hsa-miR-1285	CLIP-seq
MIRT2168489	hsa-miR-143	CLIP-seq
MIRT2168490	hsa-miR-2110	CLIP-seq
MIRT1927718	hsa-miR-3126-5p	CLIP-seq
MIRT2168491	hsa-miR-3127-3p	CLIP-seq
MIRT2168492	hsa-miR-3155	CLIP-seq
MIRT2168493	hsa-miR-3155b	CLIP-seq
MIRT2168494	hsa-miR-3187-5p	CLIP-seq
MIRT2168495	hsa-miR-34a	CLIP-seq
MIRT2168496	hsa-miR-34c-5p	CLIP-seq
MIRT2168497	hsa-miR-3689a-3p	CLIP-seq
MIRT2168498	hsa-miR-3689c	CLIP-seq
MIRT2168499	hsa-miR-4271	CLIP-seq
MIRT2168500	hsa-miR-4420	CLIP-seq
MIRT1927711	hsa-miR-4492	CLIP-seq
MIRT1927712	hsa-miR-4498	CLIP-seq
MIRT2168501	hsa-miR-449a	CLIP-seq
MIRT2168502	hsa-miR-449b	CLIP-seq
MIRT1927713	hsa-miR-4505	CLIP-seq
MIRT2168503	hsa-miR-4708-5p	CLIP-seq
MIRT2168504	hsa-miR-4725-3p	CLIP-seq
MIRT2168505	hsa-miR-4728-5p	CLIP-seq
MIRT1927730	hsa-miR-4763-3p	CLIP-seq
MIRT2168506	hsa-miR-4770	CLIP-seq
MIRT2168507	hsa-miR-484	CLIP-seq
MIRT2168508	hsa-miR-612	CLIP-seq
MIRT2168509	hsa-miR-711	CLIP-seq
MIRT1927714	hsa-miR-762	CLIP-seq
MIRT2443300	hsa-miR-3922-5p	CLIP-seq
MIRT2443301	hsa-miR-4687-5p	CLIP-seq
MIRT2443302	hsa-miR-624	CLIP-seq
MIRT2471072	hsa-miR-1275	CLIP-seq
MIRT2471073	hsa-miR-186	CLIP-seq
MIRT2471074	hsa-miR-1913	CLIP-seq
MIRT2471075	hsa-miR-324-3p	CLIP-seq
MIRT2443300	hsa-miR-3922-5p	CLIP-seq
MIRT2471076	hsa-miR-4506	CLIP-seq
MIRT2471077	hsa-miR-4525	CLIP-seq
MIRT2471078	hsa-miR-4665-5p	CLIP-seq
MIRT2443301	hsa-miR-4687-5p	CLIP-seq
MIRT2471079	hsa-miR-4722-3p	CLIP-seq
MIRT2471080	hsa-miR-4723-5p	CLIP-seq
MIRT2168505	hsa-miR-4728-5p	CLIP-seq
MIRT2471081	hsa-miR-4749-3p	CLIP-seq
MIRT771620	hsa-miR-615-5p	CLIP-seq
MIRT2443302	hsa-miR-624	CLIP-seq
MIRT2471082	hsa-miR-625	CLIP-seq
MIRT2471083	hsa-miR-639	CLIP-seq
MIRT2471084	hsa-miR-720	CLIP-seq
MIRT2471085	hsa-miR-938	CLIP-seq
MIRT2443300	hsa-miR-3922-5p	CLIP-seq
MIRT2443301	hsa-miR-4687-5p	CLIP-seq
MIRT2443302	hsa-miR-624	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	IDA	11136977, 12640130
GO:0003924	Function	GTPase activity	TAS	18374643
GO:0005096	Function	GTPase activator activity	IDA	1238857
GO:0005515	Function	Protein binding	IPI	21720388
GO:0005524	Function	ATP binding	IDA	11136977
GO:0005525	Function	GTP binding	IDA	11136977, 12640130
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	14761976
GO:0005634	Component	Nucleus	ISS	11136977
GO:0005634	Component	Nucleus	TAS	18374643
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	14761976
GO:0005737	Component	Cytoplasm	TAS	18374643
GO:0005768	Component	Endosome	IDA	12388557
GO:0005829	Component	Cytosol	IDA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016197	Process	Endosomal transport	IDA	12388557
GO:0019901	Function	Protein kinase binding	IDA	14761976
GO:0030036	Process	Actin cytoskeleton organization	IDA	12388557
GO:0030295	Function	Protein kinase activator activity	IDA	14761976
GO:0032147	Process	Activation of protein kinase activity	IEA
GO:0035014	Function	Phosphatidylinositol 3-kinase regulator activity	IDA	11136977
GO:0042177	Process	Negative regulation of protein catabolic process	IDA	18374643
GO:0043524	Process	Negative regulation of neuron apoptotic process	IGI	18374643
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0045860	Process	Positive regulation of protein kinase activity	IDA	14761976
GO:0046872	Function	Metal ion binding	IEA
GO:0061903	Process	Positive regulation of 1-phosphatidylinositol-3-kinase activity	TAS	18374643
GO:0070062	Component	Extracellular exosome	HDA	18570454
GO:0090543	Component	Flemming body	IDA

Other IDs

• MIM: 605476
• HGNC: 16921
• e!Ensembl: ENSG00000135439

Protein

• UniProt ID: Q99490
• Protein name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE)
• Protein function: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor
• PDB: 2BMJ, 2IWR, 2RLO
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	408 → 568	Ras family	Domain
  PF01412	ArfGap	931 → 1046	Putative GTPase activating protein for Arf	Domain
  PF00023	Ank	1091 → 1122	Ankyrin repeat	Repeat

• Sequence:

  MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAVGAPGARGSEPRDPGSPRGAEE
  PGKKRHERLFHRQDALWISTSSAGAGGAEPPALSPAPASPARPVSPAPGRRLSLWAAPPG
  PPLSGGLSPDSKPGGAPSSSRRPLLSSPSWGGPEPEGRTGGGVPGSSSPHPGTGSRRLKV
  APPPPAPKPCKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASVSAAATA
  AAAGGGGSTASTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHPGPPAGSPPPLTLPPTPS
  PATAVTAASAQPPGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPP
  GSGPLPGPPSLSSGSGSRELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKS
  SLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFS
  LEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMK
  RCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQAS
  NGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEK
  RSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHS
  THGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSP
  SPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTT
  PSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDA
  WVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLN
  LGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAK
  PSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHG
  PLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCA
  DILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV

• Sequence length: 1192

Pathways

KEGG:

FoxO signaling pathway
Endocytosis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	21833088, 19525955