ARAP1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1)

Gene

• Entrez ID: 116985
• Gene name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
• Gene symbol: ARAP1
• Synonyms: CENTD2, cnt-d2
• Chromosome: 11
• Chromosome location: 11q13.4
• Summary: The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activit

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT042346	hsa-miR-484	CLASH	23622248
MIRT040872	hsa-miR-18a-3p	CLASH	23622248
MIRT646433	hsa-miR-4323	HITS-CLIP	23824327
MIRT646432	hsa-miR-4267	HITS-CLIP	23824327
MIRT646431	hsa-miR-938	HITS-CLIP	23824327
MIRT646430	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT646428	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT646429	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT738040	hsa-miR-4641	HITS-CLIP	33718276
MIRT738036	hsa-miR-4457	HITS-CLIP	33718276
MIRT738037	hsa-miR-4758-3p	HITS-CLIP	33718276
MIRT646433	hsa-miR-4323	HITS-CLIP	33718276
MIRT738038	hsa-miR-766	HITS-CLIP	33718276
MIRT738039	hsa-miR-3925-3p	HITS-CLIP	33718276
MIRT738040	hsa-miR-4641	HITS-CLIP	33718276
MIRT646433	hsa-miR-4323	HITS-CLIP	23824327
MIRT646432	hsa-miR-4267	HITS-CLIP	23824327
MIRT646431	hsa-miR-938	HITS-CLIP	23824327
MIRT646430	hsa-miR-6886-3p	HITS-CLIP	23824327
MIRT646428	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT646429	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT2173659	hsa-miR-1245b-5p	CLIP-seq
MIRT2173660	hsa-miR-1972	CLIP-seq
MIRT2173661	hsa-miR-3142	CLIP-seq
MIRT2173662	hsa-miR-3936	CLIP-seq
MIRT2173663	hsa-miR-432	CLIP-seq
MIRT2173664	hsa-miR-4650-5p	CLIP-seq
MIRT2477247	hsa-miR-1224-3p	CLIP-seq
MIRT2173659	hsa-miR-1245b-5p	CLIP-seq
MIRT2477248	hsa-miR-1260	CLIP-seq
MIRT2477249	hsa-miR-1260b	CLIP-seq
MIRT2477250	hsa-miR-1265	CLIP-seq
MIRT2477251	hsa-miR-1280	CLIP-seq
MIRT2477252	hsa-miR-149	CLIP-seq
MIRT2173660	hsa-miR-1972	CLIP-seq
MIRT2477253	hsa-miR-2392	CLIP-seq
MIRT2477254	hsa-miR-24	CLIP-seq
MIRT2477255	hsa-miR-299-3p	CLIP-seq
MIRT2173661	hsa-miR-3142	CLIP-seq
MIRT2477256	hsa-miR-3151	CLIP-seq
MIRT2477257	hsa-miR-342-5p	CLIP-seq
MIRT2477258	hsa-miR-3605-5p	CLIP-seq
MIRT2477259	hsa-miR-370	CLIP-seq
MIRT2477260	hsa-miR-3940-5p	CLIP-seq
MIRT2477261	hsa-miR-4265	CLIP-seq
MIRT2477262	hsa-miR-4284	CLIP-seq
MIRT2477263	hsa-miR-4296	CLIP-seq
MIRT2173663	hsa-miR-432	CLIP-seq
MIRT2477264	hsa-miR-4322	CLIP-seq
MIRT2477265	hsa-miR-4447	CLIP-seq
MIRT2477266	hsa-miR-4472	CLIP-seq
MIRT2477267	hsa-miR-4507	CLIP-seq
MIRT2477268	hsa-miR-4534	CLIP-seq
MIRT2173664	hsa-miR-4650-5p	CLIP-seq
MIRT2477269	hsa-miR-4651	CLIP-seq
MIRT2477270	hsa-miR-4664-5p	CLIP-seq
MIRT2477271	hsa-miR-4764-5p	CLIP-seq
MIRT2477272	hsa-miR-4802-5p	CLIP-seq
MIRT2477273	hsa-miR-491-5p	CLIP-seq
MIRT2477274	hsa-miR-501-3p	CLIP-seq
MIRT2477275	hsa-miR-502-3p	CLIP-seq
MIRT2477276	hsa-miR-532-3p	CLIP-seq
MIRT2477277	hsa-miR-608	CLIP-seq
MIRT2477278	hsa-miR-765	CLIP-seq
MIRT2477247	hsa-miR-1224-3p	CLIP-seq
MIRT2173659	hsa-miR-1245b-5p	CLIP-seq
MIRT2477248	hsa-miR-1260	CLIP-seq
MIRT2477249	hsa-miR-1260b	CLIP-seq
MIRT2477250	hsa-miR-1265	CLIP-seq
MIRT2477251	hsa-miR-1280	CLIP-seq
MIRT2477252	hsa-miR-149	CLIP-seq
MIRT2173660	hsa-miR-1972	CLIP-seq
MIRT2477253	hsa-miR-2392	CLIP-seq
MIRT2477254	hsa-miR-24	CLIP-seq
MIRT2477255	hsa-miR-299-3p	CLIP-seq
MIRT2173661	hsa-miR-3142	CLIP-seq
MIRT2477256	hsa-miR-3151	CLIP-seq
MIRT2477257	hsa-miR-342-5p	CLIP-seq
MIRT2477258	hsa-miR-3605-5p	CLIP-seq
MIRT2477259	hsa-miR-370	CLIP-seq
MIRT2477260	hsa-miR-3940-5p	CLIP-seq
MIRT2477261	hsa-miR-4265	CLIP-seq
MIRT2477262	hsa-miR-4284	CLIP-seq
MIRT2477263	hsa-miR-4296	CLIP-seq
MIRT2173663	hsa-miR-432	CLIP-seq
MIRT2477264	hsa-miR-4322	CLIP-seq
MIRT2477265	hsa-miR-4447	CLIP-seq
MIRT2477266	hsa-miR-4472	CLIP-seq
MIRT2477267	hsa-miR-4507	CLIP-seq
MIRT2477268	hsa-miR-4534	CLIP-seq
MIRT2173664	hsa-miR-4650-5p	CLIP-seq
MIRT2477269	hsa-miR-4651	CLIP-seq
MIRT2477270	hsa-miR-4664-5p	CLIP-seq
MIRT2477271	hsa-miR-4764-5p	CLIP-seq
MIRT2477272	hsa-miR-4802-5p	CLIP-seq
MIRT2477273	hsa-miR-491-5p	CLIP-seq
MIRT2477274	hsa-miR-501-3p	CLIP-seq
MIRT2477275	hsa-miR-502-3p	CLIP-seq
MIRT2477276	hsa-miR-532-3p	CLIP-seq
MIRT2477277	hsa-miR-608	CLIP-seq
MIRT2477278	hsa-miR-765	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001921	Process	Positive regulation of receptor recycling	IEA
GO:0005096	Function	GTPase activator activity	IDA	11804590
GO:0005515	Function	Protein binding	IPI	15607035, 16169070, 18165900
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	11804589
GO:0005654	Component	Nucleoplasm	IDA
GO:0005794	Component	Golgi apparatus	IDA	11804590
GO:0005802	Component	Trans-Golgi network	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0007165	Process	Signal transduction	IEA
GO:0008360	Process	Regulation of cell shape	IMP	11804590
GO:0030037	Process	Actin filament reorganization involved in cell cycle	TAS	11804590
GO:0031410	Component	Cytoplasmic vesicle	IBA	21873635
GO:0031702	Function	Type 1 angiotensin receptor binding	IEA
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043547	Process	Positive regulation of GTPase activity	IDA	11804590
GO:0045742	Process	Positive regulation of epidermal growth factor receptor signaling pathway	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051270	Process	Regulation of cellular component movement	IMP	11804590
GO:0051491	Process	Positive regulation of filopodium assembly	IMP	11804590
GO:0051497	Process	Negative regulation of stress fiber assembly	IMP	11804590

Other IDs

• MIM: 606646
• HGNC: 16925
• e!Ensembl: ENSG00000186635

Protein

• UniProt ID: Q96P48
• Protein name: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)
• Protein function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (PubMed:11804590, PubMed:19666464). Activated by phosphatidylinositol 3,4,5-trisph
• PDB: 4X1V
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00536	SAM_1	7 → 68	SAM domain (Sterile alpha motif)	Domain
  PF00169	PH	328 → 419	PH domain	Domain
  PF01412	ArfGap	535 → 653	Putative GTPase activating protein for Arf	Domain
  PF00169	PH	744 → 849	PH domain	Domain
  PF00620	RhoGAP	971 → 1123	RhoGAP domain	Domain
  PF00788	RA	1172 → 1261	Ras association (RalGDS/AF-6) domain	Domain
  PF00169	PH	1275 → 1396	PH domain	Domain

• Sequence:

  MAEAGDAALSVAEWLRALHLEQYTGLFEQHGLVWATECQGLSDTRLMDMGMLLPGHRRRI
  LAGLLRAHTSPAPAPRPTPRPVPMKRHIFRSPPVPATPPEPLPTTTEDEGLPAAPPIPPR
  RSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTGPPRLLVSLPTKEEESLL
  PSLSSPPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRLFPEFDDSDYDEVPEEGPG
  APARVMTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSS
  LSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYF
  DSNKDAYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAE
  QRARARLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGI
  TFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAER
  IWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTET
  LIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQE
  ELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNR
  TTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGV
  LSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHE
  WVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPC
  EEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTL
  SEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEG
  EQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRA
  TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFS
  VDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAE
  ELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQ
  AMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQ
  RPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDT
  QMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFT
  ADPLSLLRNV

• Sequence length: 1450

Pathways

KEGG:

Endocytosis

Reactome:

Rho GTPase cycle
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Anemia	Anemia, Sickle Cell	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505	25670933
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	30054458, 29632382, 20581827, 22885922, 24509480, 30595370, 28869590, 30718926, 21647700

Unknown
Disease name	Disease term	dbSNP ID	References
Alloimmunisation	Alloimmunisation		25670933