GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A)

Gene

• Entrez ID: 116443
• Gene name: Glutamate ionotropic receptor NMDA type subunit 3A
• Gene symbol: GRIN3A
• Synonyms: GluN3A, NMDAR-L, NMDAR3A, NR3A
• Chromosome: 9
• Chromosome location: 9q31.1
• Summary: This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows great

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006066	hsa-miR-542-5p	Microarray, qRT-PCR	21310526
MIRT006066	hsa-miR-542-5p	Microarray, qRT-PCR	21310526
MIRT006066	hsa-miR-542-5p	Microarray, qRT-PCR	21310526
MIRT1034491	hsa-miR-1185	CLIP-seq
MIRT1034492	hsa-miR-1262	CLIP-seq
MIRT1034493	hsa-miR-1275	CLIP-seq
MIRT1034494	hsa-miR-1294	CLIP-seq
MIRT1034495	hsa-miR-134	CLIP-seq
MIRT1034496	hsa-miR-141	CLIP-seq
MIRT1034497	hsa-miR-199a-5p	CLIP-seq
MIRT1034498	hsa-miR-199b-5p	CLIP-seq
MIRT1034499	hsa-miR-200a	CLIP-seq
MIRT1034500	hsa-miR-2052	CLIP-seq
MIRT1034501	hsa-miR-2117	CLIP-seq
MIRT1034502	hsa-miR-2392	CLIP-seq
MIRT1034503	hsa-miR-28-3p	CLIP-seq
MIRT1034504	hsa-miR-29a	CLIP-seq
MIRT1034505	hsa-miR-29b	CLIP-seq
MIRT1034506	hsa-miR-29c	CLIP-seq
MIRT1034507	hsa-miR-3065-3p	CLIP-seq
MIRT1034508	hsa-miR-3118	CLIP-seq
MIRT1034509	hsa-miR-3187-3p	CLIP-seq
MIRT1034510	hsa-miR-3200-5p	CLIP-seq
MIRT1034511	hsa-miR-324-5p	CLIP-seq
MIRT1034512	hsa-miR-3605-5p	CLIP-seq
MIRT1034513	hsa-miR-3675-3p	CLIP-seq
MIRT1034514	hsa-miR-3679-5p	CLIP-seq
MIRT1034515	hsa-miR-376c	CLIP-seq
MIRT1034516	hsa-miR-3908	CLIP-seq
MIRT1034517	hsa-miR-409-3p	CLIP-seq
MIRT1034518	hsa-miR-4251	CLIP-seq
MIRT1034519	hsa-miR-4267	CLIP-seq
MIRT1034520	hsa-miR-4282	CLIP-seq
MIRT1034521	hsa-miR-4303	CLIP-seq
MIRT1034522	hsa-miR-4316	CLIP-seq
MIRT1034523	hsa-miR-4435	CLIP-seq
MIRT1034524	hsa-miR-4450	CLIP-seq
MIRT1034525	hsa-miR-4455	CLIP-seq
MIRT1034526	hsa-miR-4477a	CLIP-seq
MIRT1034527	hsa-miR-4481	CLIP-seq
MIRT1034528	hsa-miR-4522	CLIP-seq
MIRT1034529	hsa-miR-4525	CLIP-seq
MIRT1034530	hsa-miR-4665-5p	CLIP-seq
MIRT1034531	hsa-miR-4684-5p	CLIP-seq
MIRT1034532	hsa-miR-4701-3p	CLIP-seq
MIRT1034533	hsa-miR-4701-5p	CLIP-seq
MIRT1034534	hsa-miR-4723-5p	CLIP-seq
MIRT1034535	hsa-miR-4745-5p	CLIP-seq
MIRT1034536	hsa-miR-4758-5p	CLIP-seq
MIRT1034537	hsa-miR-4766-5p	CLIP-seq
MIRT1034538	hsa-miR-4793-5p	CLIP-seq
MIRT1034539	hsa-miR-498	CLIP-seq
MIRT1034540	hsa-miR-548p	CLIP-seq
MIRT1034541	hsa-miR-548s	CLIP-seq
MIRT1034542	hsa-miR-588	CLIP-seq
MIRT1034543	hsa-miR-590-3p	CLIP-seq
MIRT1034544	hsa-miR-609	CLIP-seq
MIRT1034545	hsa-miR-625	CLIP-seq
MIRT1034546	hsa-miR-944	CLIP-seq
MIRT1034496	hsa-miR-141	CLIP-seq
MIRT2006812	hsa-miR-146a	CLIP-seq
MIRT2006813	hsa-miR-146b-5p	CLIP-seq
MIRT1034499	hsa-miR-200a	CLIP-seq
MIRT2006814	hsa-miR-342-5p	CLIP-seq
MIRT2006815	hsa-miR-3671	CLIP-seq
MIRT1034513	hsa-miR-3675-3p	CLIP-seq
MIRT2006816	hsa-miR-4651	CLIP-seq
MIRT2006817	hsa-miR-4664-5p	CLIP-seq
MIRT2006818	hsa-miR-580	CLIP-seq
MIRT2006819	hsa-miR-589	CLIP-seq
MIRT1034543	hsa-miR-590-3p	CLIP-seq
MIRT2006820	hsa-miR-607	CLIP-seq
MIRT2006821	hsa-miR-608	CLIP-seq
MIRT1034493	hsa-miR-1275	CLIP-seq
MIRT2006812	hsa-miR-146a	CLIP-seq
MIRT2006813	hsa-miR-146b-5p	CLIP-seq
MIRT2239278	hsa-miR-3140-3p	CLIP-seq
MIRT2006815	hsa-miR-3671	CLIP-seq
MIRT2239279	hsa-miR-375	CLIP-seq
MIRT2239280	hsa-miR-3919	CLIP-seq
MIRT2239281	hsa-miR-4254	CLIP-seq
MIRT2239282	hsa-miR-4273	CLIP-seq
MIRT2239283	hsa-miR-4422	CLIP-seq
MIRT1034524	hsa-miR-4450	CLIP-seq
MIRT1034530	hsa-miR-4665-5p	CLIP-seq
MIRT2239284	hsa-miR-4677-5p	CLIP-seq
MIRT1034537	hsa-miR-4766-5p	CLIP-seq
MIRT2006818	hsa-miR-580	CLIP-seq
MIRT2006819	hsa-miR-589	CLIP-seq
MIRT2006820	hsa-miR-607	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004972	Function	NMDA glutamate receptor activity	IDA	17502428
GO:0004972	Function	NMDA glutamate receptor activity	ISS
GO:0005262	Function	Calcium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	17658481, 17997397
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0006816	Process	Calcium ion transport	ISS
GO:0014069	Component	Postsynaptic density	IEA
GO:0015276	Function	Ligand-gated ion channel activity	IBA	21873635
GO:0016020	Component	Membrane	IDA	17997397
GO:0016021	Component	Integral component of membrane	NAS	11880201
GO:0016358	Process	Dendrite development	IEA
GO:0016594	Function	Glycine binding	IDA	17320117
GO:0017146	Component	NMDA selective glutamate receptor complex	IDA	17997397
GO:0035235	Process	Ionotropic glutamate receptor signaling pathway	IBA	21873635
GO:0038023	Function	Signaling receptor activity	IBA	21873635
GO:0042802	Function	Identical protein binding	IPI	17997397
GO:0043005	Component	Neuron projection	IDA	17658481
GO:0043025	Component	Neuronal cell body	IDA	17658481
GO:0045202	Component	Synapse	IDA	17658481
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045471	Process	Response to ethanol	IDA	17502428, 18445116
GO:0051721	Function	Protein phosphatase 2A binding	ISS
GO:0060078	Process	Regulation of postsynaptic membrane potential	IEA
GO:0060134	Process	Prepulse inhibition	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1904315	Function	Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	IEA
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IEA

Other IDs

• MIM: 606650
• HGNC: 16767
• e!Ensembl: ENSG00000198785

Protein

• UniProt ID: Q8TCU5
• Protein name: Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L)
• Protein function: Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+) (By similarity). During the de
• PDB: 8USW, 8USX, 8UUE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10613	Lig_chan-Glu_bd	557 → 661	Ligated ion channel L-glutamate- and glycine-binding site	Domain
  PF00060	Lig_chan	674 → 942	Ligand-gated ion channel	Family

• Sequence:

  MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTT
  APRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAE
  ALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSF
  LQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQL
  SLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITAN
  LPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQ
  NVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCM
  EVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTR
  LGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAG
  QLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIV
  GDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTR
  DTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSAL
  NICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGI
  HDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLD
  AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFM
  DMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLL
  PRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLS
  HDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELS
  ELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES

• Sequence length: 1115

Pathways

KEGG:

Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse
Spinocerebellar ataxia
Prion disease
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism

Reactome:

Assembly and cell surface presentation of NMDA receptors

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	23237318, 15474907, 19665356

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		15474907
Erectile dysfunction	Erectile dysfunction		19295509