CISH (cytokine inducible SH2 containing protein)

Gene

• Entrez ID: 1154
• Gene name: Cytokine inducible SH2 containing protein
• Gene symbol: CISH
• Synonyms: BACTS2, CIS, CIS-1, G18, SOCS
• Chromosome: 3
• Chromosome location: 3p21.2
• Summary: The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029522	hsa-miR-26b-5p	Microarray	19088304
MIRT054146	hsa-miR-92a-1-5p	Microarray, qRT-PCR	22660396
MIRT437917	hsa-miR-150-5p	Luciferase reporter assay, Western blot	23723424
MIRT437917	hsa-miR-150-5p	Luciferase reporter assay, Western blotting, qRT-PCR	34027272
MIRT893792	hsa-miR-125a-3p	CLIP-seq
MIRT893793	hsa-miR-1266	CLIP-seq
MIRT893794	hsa-miR-1276	CLIP-seq
MIRT893795	hsa-miR-135a	CLIP-seq
MIRT893796	hsa-miR-135b	CLIP-seq
MIRT893797	hsa-miR-181a	CLIP-seq
MIRT893798	hsa-miR-181b	CLIP-seq
MIRT893799	hsa-miR-181c	CLIP-seq
MIRT893800	hsa-miR-181d	CLIP-seq
MIRT893801	hsa-miR-2392	CLIP-seq
MIRT893802	hsa-miR-2467-5p	CLIP-seq
MIRT893803	hsa-miR-27a	CLIP-seq
MIRT893804	hsa-miR-27b	CLIP-seq
MIRT893805	hsa-miR-296-5p	CLIP-seq
MIRT893806	hsa-miR-298	CLIP-seq
MIRT893807	hsa-miR-3138	CLIP-seq
MIRT893808	hsa-miR-3144-5p	CLIP-seq
MIRT893809	hsa-miR-3155	CLIP-seq
MIRT893810	hsa-miR-3155b	CLIP-seq
MIRT893811	hsa-miR-3188	CLIP-seq
MIRT893812	hsa-miR-3191	CLIP-seq
MIRT893813	hsa-miR-3194-3p	CLIP-seq
MIRT893814	hsa-miR-3199	CLIP-seq
MIRT893815	hsa-miR-338-3p	CLIP-seq
MIRT893816	hsa-miR-3652	CLIP-seq
MIRT893817	hsa-miR-3664-3p	CLIP-seq
MIRT893818	hsa-miR-3692	CLIP-seq
MIRT893819	hsa-miR-3975	CLIP-seq
MIRT893820	hsa-miR-4262	CLIP-seq
MIRT893821	hsa-miR-4311	CLIP-seq
MIRT893822	hsa-miR-4312	CLIP-seq
MIRT893823	hsa-miR-4430	CLIP-seq
MIRT893824	hsa-miR-4438	CLIP-seq
MIRT893825	hsa-miR-4488	CLIP-seq
MIRT893826	hsa-miR-4505	CLIP-seq
MIRT893827	hsa-miR-4518	CLIP-seq
MIRT893828	hsa-miR-451b	CLIP-seq
MIRT893829	hsa-miR-4530	CLIP-seq
MIRT893830	hsa-miR-4649-3p	CLIP-seq
MIRT893831	hsa-miR-4652-5p	CLIP-seq
MIRT893832	hsa-miR-4667-5p	CLIP-seq
MIRT893833	hsa-miR-4690-3p	CLIP-seq
MIRT893834	hsa-miR-4693-3p	CLIP-seq
MIRT893835	hsa-miR-4697-5p	CLIP-seq
MIRT893836	hsa-miR-4700-5p	CLIP-seq
MIRT893837	hsa-miR-4731-5p	CLIP-seq
MIRT893838	hsa-miR-4740-5p	CLIP-seq
MIRT893839	hsa-miR-483-5p	CLIP-seq
MIRT893840	hsa-miR-484	CLIP-seq
MIRT893841	hsa-miR-485-5p	CLIP-seq
MIRT893842	hsa-miR-486-3p	CLIP-seq
MIRT893843	hsa-miR-513a-5p	CLIP-seq
MIRT893844	hsa-miR-548b-3p	CLIP-seq
MIRT893845	hsa-miR-548m	CLIP-seq
MIRT893846	hsa-miR-552	CLIP-seq
MIRT893847	hsa-miR-583	CLIP-seq
MIRT893848	hsa-miR-624	CLIP-seq
MIRT893849	hsa-miR-637	CLIP-seq
MIRT893850	hsa-miR-642b	CLIP-seq
MIRT893851	hsa-miR-659	CLIP-seq
MIRT893852	hsa-miR-665	CLIP-seq
MIRT893853	hsa-miR-760	CLIP-seq
MIRT1964976	hsa-miR-1236	CLIP-seq
MIRT1964977	hsa-miR-1254	CLIP-seq
MIRT893793	hsa-miR-1266	CLIP-seq
MIRT893794	hsa-miR-1276	CLIP-seq
MIRT1964978	hsa-miR-1343	CLIP-seq
MIRT893795	hsa-miR-135a	CLIP-seq
MIRT893796	hsa-miR-135b	CLIP-seq
MIRT1964979	hsa-miR-149	CLIP-seq
MIRT1964980	hsa-miR-150	CLIP-seq
MIRT893797	hsa-miR-181a	CLIP-seq
MIRT893798	hsa-miR-181b	CLIP-seq
MIRT893799	hsa-miR-181c	CLIP-seq
MIRT893800	hsa-miR-181d	CLIP-seq
MIRT1964981	hsa-miR-202	CLIP-seq
MIRT1964982	hsa-miR-22	CLIP-seq
MIRT893802	hsa-miR-2467-5p	CLIP-seq
MIRT893803	hsa-miR-27a	CLIP-seq
MIRT893804	hsa-miR-27b	CLIP-seq
MIRT893806	hsa-miR-298	CLIP-seq
MIRT1964983	hsa-miR-3116	CLIP-seq
MIRT1964984	hsa-miR-3126-5p	CLIP-seq
MIRT893807	hsa-miR-3138	CLIP-seq
MIRT1964985	hsa-miR-3163	CLIP-seq
MIRT1964986	hsa-miR-3170	CLIP-seq
MIRT893811	hsa-miR-3188	CLIP-seq
MIRT1964987	hsa-miR-361-5p	CLIP-seq
MIRT893816	hsa-miR-3652	CLIP-seq
MIRT893819	hsa-miR-3975	CLIP-seq
MIRT1964988	hsa-miR-3976	CLIP-seq
MIRT1964989	hsa-miR-4254	CLIP-seq
MIRT1964990	hsa-miR-4257	CLIP-seq
MIRT1964991	hsa-miR-4259	CLIP-seq
MIRT893820	hsa-miR-4262	CLIP-seq
MIRT1964992	hsa-miR-4267	CLIP-seq
MIRT1964993	hsa-miR-4269	CLIP-seq
MIRT893821	hsa-miR-4311	CLIP-seq
MIRT893822	hsa-miR-4312	CLIP-seq
MIRT893823	hsa-miR-4430	CLIP-seq
MIRT1964994	hsa-miR-4436b-3p	CLIP-seq
MIRT893825	hsa-miR-4488	CLIP-seq
MIRT893826	hsa-miR-4505	CLIP-seq
MIRT893827	hsa-miR-4518	CLIP-seq
MIRT1964995	hsa-miR-4685-5p	CLIP-seq
MIRT893834	hsa-miR-4693-3p	CLIP-seq
MIRT893835	hsa-miR-4697-5p	CLIP-seq
MIRT1964996	hsa-miR-4713-5p	CLIP-seq
MIRT893837	hsa-miR-4731-5p	CLIP-seq
MIRT1964997	hsa-miR-4733-3p	CLIP-seq
MIRT1964998	hsa-miR-4779	CLIP-seq
MIRT1964999	hsa-miR-4786-3p	CLIP-seq
MIRT1965000	hsa-miR-4795-3p	CLIP-seq
MIRT893839	hsa-miR-483-5p	CLIP-seq
MIRT893841	hsa-miR-485-5p	CLIP-seq
MIRT893842	hsa-miR-486-3p	CLIP-seq
MIRT893843	hsa-miR-513a-5p	CLIP-seq
MIRT1965001	hsa-miR-532-3p	CLIP-seq
MIRT1965002	hsa-miR-532-5p	CLIP-seq
MIRT893845	hsa-miR-548m	CLIP-seq
MIRT1965003	hsa-miR-571	CLIP-seq
MIRT893847	hsa-miR-583	CLIP-seq
MIRT1965004	hsa-miR-615-5p	CLIP-seq
MIRT893849	hsa-miR-637	CLIP-seq
MIRT893850	hsa-miR-642b	CLIP-seq
MIRT1965005	hsa-miR-661	CLIP-seq
MIRT893853	hsa-miR-760	CLIP-seq
MIRT1965006	hsa-miR-765	CLIP-seq
MIRT2201004	hsa-miR-1200	CLIP-seq
MIRT2201005	hsa-miR-1234	CLIP-seq
MIRT1964976	hsa-miR-1236	CLIP-seq
MIRT893793	hsa-miR-1266	CLIP-seq
MIRT2201006	hsa-miR-1285	CLIP-seq
MIRT1964978	hsa-miR-1343	CLIP-seq
MIRT893795	hsa-miR-135a	CLIP-seq
MIRT893796	hsa-miR-135b	CLIP-seq
MIRT1964979	hsa-miR-149	CLIP-seq
MIRT1964980	hsa-miR-150	CLIP-seq
MIRT893797	hsa-miR-181a	CLIP-seq
MIRT893798	hsa-miR-181b	CLIP-seq
MIRT893799	hsa-miR-181c	CLIP-seq
MIRT893800	hsa-miR-181d	CLIP-seq
MIRT1964982	hsa-miR-22	CLIP-seq
MIRT2201007	hsa-miR-2277-3p	CLIP-seq
MIRT893801	hsa-miR-2392	CLIP-seq
MIRT2201008	hsa-miR-24	CLIP-seq
MIRT893802	hsa-miR-2467-5p	CLIP-seq
MIRT893803	hsa-miR-27a	CLIP-seq
MIRT893804	hsa-miR-27b	CLIP-seq
MIRT893806	hsa-miR-298	CLIP-seq
MIRT2201009	hsa-miR-3065-3p	CLIP-seq
MIRT2201010	hsa-miR-3127-5p	CLIP-seq
MIRT893807	hsa-miR-3138	CLIP-seq
MIRT893808	hsa-miR-3144-5p	CLIP-seq
MIRT1964986	hsa-miR-3170	CLIP-seq
MIRT2201011	hsa-miR-3183	CLIP-seq
MIRT2201012	hsa-miR-3187-5p	CLIP-seq
MIRT893811	hsa-miR-3188	CLIP-seq
MIRT2201013	hsa-miR-3190	CLIP-seq
MIRT893812	hsa-miR-3191	CLIP-seq
MIRT893814	hsa-miR-3199	CLIP-seq
MIRT2201014	hsa-miR-326	CLIP-seq
MIRT2201015	hsa-miR-330-5p	CLIP-seq
MIRT893815	hsa-miR-338-3p	CLIP-seq
MIRT2201016	hsa-miR-3607-5p	CLIP-seq
MIRT1964987	hsa-miR-361-5p	CLIP-seq
MIRT893816	hsa-miR-3652	CLIP-seq
MIRT2201017	hsa-miR-3660	CLIP-seq
MIRT893817	hsa-miR-3664-3p	CLIP-seq
MIRT2201018	hsa-miR-3667-3p	CLIP-seq
MIRT893818	hsa-miR-3692	CLIP-seq
MIRT2201019	hsa-miR-378	CLIP-seq
MIRT2201020	hsa-miR-378b	CLIP-seq
MIRT2201021	hsa-miR-378c	CLIP-seq
MIRT2201022	hsa-miR-378d	CLIP-seq
MIRT2201023	hsa-miR-378e	CLIP-seq
MIRT2201024	hsa-miR-378f	CLIP-seq
MIRT2201025	hsa-miR-378h	CLIP-seq
MIRT2201026	hsa-miR-378i	CLIP-seq
MIRT2201027	hsa-miR-3918	CLIP-seq
MIRT2201028	hsa-miR-3945	CLIP-seq
MIRT893819	hsa-miR-3975	CLIP-seq
MIRT2201029	hsa-miR-422a	CLIP-seq
MIRT1964991	hsa-miR-4259	CLIP-seq
MIRT893820	hsa-miR-4262	CLIP-seq
MIRT2201030	hsa-miR-4264	CLIP-seq
MIRT1964993	hsa-miR-4269	CLIP-seq
MIRT2201031	hsa-miR-4277	CLIP-seq
MIRT2201032	hsa-miR-4279	CLIP-seq
MIRT2201033	hsa-miR-4284	CLIP-seq
MIRT893822	hsa-miR-4312	CLIP-seq
MIRT2201034	hsa-miR-4326	CLIP-seq
MIRT2201035	hsa-miR-4428	CLIP-seq
MIRT893823	hsa-miR-4430	CLIP-seq
MIRT2201036	hsa-miR-4436a	CLIP-seq
MIRT1964994	hsa-miR-4436b-3p	CLIP-seq
MIRT2201037	hsa-miR-4437	CLIP-seq
MIRT893825	hsa-miR-4488	CLIP-seq
MIRT893826	hsa-miR-4505	CLIP-seq
MIRT893827	hsa-miR-4518	CLIP-seq
MIRT893828	hsa-miR-451b	CLIP-seq
MIRT2201038	hsa-miR-4526	CLIP-seq
MIRT893829	hsa-miR-4530	CLIP-seq
MIRT2201039	hsa-miR-4638-3p	CLIP-seq
MIRT2201040	hsa-miR-4640-3p	CLIP-seq
MIRT2201041	hsa-miR-4640-5p	CLIP-seq
MIRT2201042	hsa-miR-4643	CLIP-seq
MIRT893830	hsa-miR-4649-3p	CLIP-seq
MIRT893831	hsa-miR-4652-5p	CLIP-seq
MIRT893832	hsa-miR-4667-5p	CLIP-seq
MIRT1964995	hsa-miR-4685-5p	CLIP-seq
MIRT893834	hsa-miR-4693-3p	CLIP-seq
MIRT893835	hsa-miR-4697-5p	CLIP-seq
MIRT893836	hsa-miR-4700-5p	CLIP-seq
MIRT1964996	hsa-miR-4713-5p	CLIP-seq
MIRT2201043	hsa-miR-4717-3p	CLIP-seq
MIRT2201044	hsa-miR-4723-3p	CLIP-seq
MIRT2201045	hsa-miR-4726-5p	CLIP-seq
MIRT893837	hsa-miR-4731-5p	CLIP-seq
MIRT893838	hsa-miR-4740-5p	CLIP-seq
MIRT2201046	hsa-miR-4761-3p	CLIP-seq
MIRT2201047	hsa-miR-4768-5p	CLIP-seq
MIRT1964999	hsa-miR-4786-3p	CLIP-seq
MIRT2201048	hsa-miR-4793-5p	CLIP-seq
MIRT2201049	hsa-miR-4797-3p	CLIP-seq
MIRT893839	hsa-miR-483-5p	CLIP-seq
MIRT893841	hsa-miR-485-5p	CLIP-seq
MIRT893842	hsa-miR-486-3p	CLIP-seq
MIRT893843	hsa-miR-513a-5p	CLIP-seq
MIRT1965001	hsa-miR-532-3p	CLIP-seq
MIRT1965002	hsa-miR-532-5p	CLIP-seq
MIRT893844	hsa-miR-548b-3p	CLIP-seq
MIRT2201050	hsa-miR-548c-3p	CLIP-seq
MIRT1965003	hsa-miR-571	CLIP-seq
MIRT2201051	hsa-miR-593	CLIP-seq
MIRT2201052	hsa-miR-612	CLIP-seq
MIRT1965004	hsa-miR-615-5p	CLIP-seq
MIRT2201053	hsa-miR-616	CLIP-seq
MIRT893849	hsa-miR-637	CLIP-seq
MIRT893850	hsa-miR-642b	CLIP-seq
MIRT893851	hsa-miR-659	CLIP-seq
MIRT1965005	hsa-miR-661	CLIP-seq
MIRT893852	hsa-miR-665	CLIP-seq
MIRT2201054	hsa-miR-7	CLIP-seq
MIRT893853	hsa-miR-760	CLIP-seq
MIRT1964978	hsa-miR-1343	CLIP-seq
MIRT1964981	hsa-miR-202	CLIP-seq
MIRT1964982	hsa-miR-22	CLIP-seq
MIRT1964986	hsa-miR-3170	CLIP-seq
MIRT1964990	hsa-miR-4257	CLIP-seq
MIRT1964993	hsa-miR-4269	CLIP-seq
MIRT1964997	hsa-miR-4733-3p	CLIP-seq
MIRT2201013	hsa-miR-3190	CLIP-seq
MIRT2201054	hsa-miR-7	CLIP-seq
MIRT2201005	hsa-miR-1234	CLIP-seq
MIRT1964980	hsa-miR-150	CLIP-seq
MIRT2201008	hsa-miR-24	CLIP-seq
MIRT2201033	hsa-miR-4284	CLIP-seq
MIRT893822	hsa-miR-4312	CLIP-seq
MIRT2201035	hsa-miR-4428	CLIP-seq
MIRT893825	hsa-miR-4488	CLIP-seq
MIRT2201042	hsa-miR-4643	CLIP-seq
MIRT893835	hsa-miR-4697-5p	CLIP-seq
MIRT1964996	hsa-miR-4713-5p	CLIP-seq
MIRT2201043	hsa-miR-4717-3p	CLIP-seq
MIRT2678219	hsa-miR-4777-3p	CLIP-seq
MIRT1964999	hsa-miR-4786-3p	CLIP-seq
MIRT2201049	hsa-miR-4797-3p	CLIP-seq
MIRT1965001	hsa-miR-532-3p	CLIP-seq
MIRT1965002	hsa-miR-532-5p	CLIP-seq
MIRT893849	hsa-miR-637	CLIP-seq
MIRT893850	hsa-miR-642b	CLIP-seq
MIRT1965005	hsa-miR-661	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
STAT3	Activation	14630083
STAT6	Unknown	18342537

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001558	Process	Regulation of cell growth	NAS	9465889
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	16273093, 24658140, 31980649, 32814053
GO:0005575	Component	Cellular_component	ND
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005942	Component	Phosphatidylinositol 3-kinase complex	IBA	21873635
GO:0007205	Process	Protein kinase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0035556	Process	Intracellular signal transduction	NAS	10902923
GO:0038111	Process	Interleukin-7-mediated signaling pathway	TAS
GO:0043551	Process	Regulation of phosphatidylinositol 3-kinase activity	IEA
GO:0043687	Process	Post-translational protein modification	TAS
GO:0046854	Process	Phosphatidylinositol phosphorylation	IBA	21873635
GO:0046935	Function	1-phosphatidylinositol-3-kinase regulator activity	IBA	21873635

Other IDs

• MIM: 602441
• HGNC: 1984
• e!Ensembl: ENSG00000114737

Protein

• UniProt ID: Q9NSE2
• Protein name: Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
• Protein function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolact
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00017	SH2	82 → 163	SH2 domain	Domain
  PF07525	SOCS_box	221 → 254	SOCS box	Domain

• Sequence:

  MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKV
  LDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSV
  KTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAP
  TPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDC
  LPLPRRMADYLRQYPFQL

• Sequence length: 258

Pathways

KEGG:

JAK-STAT signaling pathway
Prolactin signaling pathway

Reactome:

Interleukin-7 signaling
Neddylation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Dermatitis, Allergic Contact	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	16033404