FCRL3 (Fc receptor like 3)

Gene

• Entrez ID: 115352
• Gene name: Fc receptor like 3
• Gene symbol: FCRL3
• Synonyms: CD307c, FCRH3, IFGP3, IRTA3, MAIA, SPAP2
• Chromosome: 1
• Chromosome location: 1q23.1
• Summary: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT994140	hsa-miR-1270	CLIP-seq
MIRT994141	hsa-miR-1273g	CLIP-seq
MIRT994142	hsa-miR-185	CLIP-seq
MIRT994143	hsa-miR-3925-5p	CLIP-seq
MIRT994144	hsa-miR-4306	CLIP-seq
MIRT994145	hsa-miR-4531	CLIP-seq
MIRT994146	hsa-miR-4644	CLIP-seq
MIRT994147	hsa-miR-4773	CLIP-seq
MIRT994148	hsa-miR-522	CLIP-seq
MIRT994149	hsa-miR-620	CLIP-seq
MIRT1994800	hsa-miR-1178	CLIP-seq
MIRT1994801	hsa-miR-1343	CLIP-seq
MIRT1994802	hsa-miR-2110	CLIP-seq
MIRT1994803	hsa-miR-3166	CLIP-seq
MIRT1994804	hsa-miR-4269	CLIP-seq
MIRT1994805	hsa-miR-4271	CLIP-seq
MIRT1994806	hsa-miR-4514	CLIP-seq
MIRT1994807	hsa-miR-4667-5p	CLIP-seq
MIRT1994808	hsa-miR-4692	CLIP-seq
MIRT1994809	hsa-miR-4700-5p	CLIP-seq
MIRT1994810	hsa-miR-4725-3p	CLIP-seq
MIRT1994811	hsa-miR-4742-5p	CLIP-seq
MIRT1994812	hsa-miR-4771	CLIP-seq
MIRT1994813	hsa-miR-4772-5p	CLIP-seq
MIRT2228939	hsa-miR-4789-5p	CLIP-seq
MIRT2449602	hsa-miR-4273	CLIP-seq
MIRT2449603	hsa-miR-4677-5p	CLIP-seq
MIRT2449604	hsa-miR-578	CLIP-seq
MIRT2449602	hsa-miR-4273	CLIP-seq
MIRT2449603	hsa-miR-4677-5p	CLIP-seq
MIRT2449604	hsa-miR-578	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002638	Process	Negative regulation of immunoglobulin production	IDA	23857366
GO:0004888	Function	Transmembrane signaling receptor activity	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007166	Process	Cell surface receptor signaling pathway	IBA	21873635
GO:0009986	Component	Cell surface	IDA	16849395
GO:0019900	Function	Kinase binding	IPI	19843936
GO:0019902	Function	Phosphatase binding	IPI	19843936
GO:0019903	Function	Protein phosphatase binding	IPI	12051764
GO:0030890	Process	Positive regulation of B cell proliferation	IDA	23857366
GO:0034163	Process	Regulation of toll-like receptor 9 signaling pathway	IDA	23857366
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	23857366
GO:0045577	Process	Regulation of B cell differentiation	IDA	23857366
GO:0050859	Process	Negative regulation of B cell receptor signaling pathway	IDA	19843936
GO:0050864	Process	Regulation of B cell activation	IDA	23857366
GO:0090279	Process	Regulation of calcium ion import	IDA	19843936
GO:1905184	Process	Positive regulation of protein serine/threonine phosphatase activity	IDA	12051764
GO:1990782	Function	Protein tyrosine kinase binding	IPI	12051764

Other IDs

• MIM: 606510
• HGNC: 18506
• e!Ensembl: ENSG00000160856

Protein

• UniProt ID: Q96P31
• Protein name: Fc receptor-like protein 3 (FcR-like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation-associated protein 3) (MAIA) (SH2 domain-containing phosphatase anchor protein 2) (CD antigen CD307c)
• Protein function: Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:238
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13895	Ig_2	101 → 185	Immunoglobulin domain	Domain
  PF13895	Ig_2	191 → 280	Immunoglobulin domain	Domain
  PF00047	ig	292 → 370	Immunoglobulin domain	Domain
  PF13895	Ig_2	382 → 471	Immunoglobulin domain	Domain
  PF13895	Ig_2	475 → 562	Immunoglobulin domain	Domain

• Sequence:

  MLLWLLLLILTPGREQSGVAPKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYH
  DEKLLKIKHDKIQITEPGNYQCKTRGSSLSDAVHVEFSPDWLILQALHPVFEGDNVILRC
  QGKDNKNTHQKVYYKDGKQLPNSYNLEKITVNSVSRDNSKYHCTAYRKFYILDIEVTSKP
  LNIQVQELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLGLGWS
  RSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPTGGQLI
  EGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGRYYCAA
  DNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILYRFYHE
  DVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGVSLRVTVPVSRPVLTL
  RAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSGGGASFNLSLTTEHSG
  NYSCEADNGLGAQHSKVVTLNVTGTSRNRTGLTAAGITGLVLSILVLAAAAALLHYARAR
  RKPGGLSATGTSSHSPSECQEPSSSRPSRIDPQEPTHSKPLAPMELEPMYSNVNPGDSNP
  IYSQIWSIQHTKENSANCPMMHQEHEELTVLYSELKKTHPDDSAGEASSRGRAHEEDDEE
  NYENVPRVLLASDH

• Sequence length: 734

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Immunoglobulin a deficiency	Immunoglobulin A deficiency (disorder)	rs72553883, rs72553882, rs144718007	27723758
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	26920376
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	24532676

Unknown
Disease name	Disease term	dbSNP ID	References
Autoimmune thyroiditis	Autoimmune thyroiditis		17952073
Graves disease	Graves Disease		21841780
Selective immunoglobulin a deficiency	Selective immunoglobulin A deficiency		27723758