SORCS1 (sortilin related VPS10 domain containing receptor 1)

Gene

• Entrez ID: 114815
• Gene name: Sortilin related VPS10 domain containing receptor 1
• Gene symbol: SORCS1
• Synonyms: hSorCS
• Chromosome: 10
• Chromosome location: 10q25.1
• Summary: This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many e

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT622145	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT622145	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT1379523	hsa-miR-1253	CLIP-seq
MIRT1379524	hsa-miR-1290	CLIP-seq
MIRT1379525	hsa-miR-1303	CLIP-seq
MIRT1379526	hsa-miR-193a-3p	CLIP-seq
MIRT1379527	hsa-miR-193b	CLIP-seq
MIRT1379528	hsa-miR-194	CLIP-seq
MIRT1379529	hsa-miR-3120-3p	CLIP-seq
MIRT1379530	hsa-miR-3148	CLIP-seq
MIRT1379531	hsa-miR-3173-3p	CLIP-seq
MIRT1379532	hsa-miR-3185	CLIP-seq
MIRT1379533	hsa-miR-361-5p	CLIP-seq
MIRT1379534	hsa-miR-383	CLIP-seq
MIRT1379535	hsa-miR-3919	CLIP-seq
MIRT1379536	hsa-miR-3929	CLIP-seq
MIRT1379537	hsa-miR-3978	CLIP-seq
MIRT1379538	hsa-miR-4257	CLIP-seq
MIRT1379539	hsa-miR-4311	CLIP-seq
MIRT1379540	hsa-miR-4419a	CLIP-seq
MIRT1379541	hsa-miR-4419b	CLIP-seq
MIRT1379542	hsa-miR-4478	CLIP-seq
MIRT1379543	hsa-miR-4510	CLIP-seq
MIRT1379544	hsa-miR-4643	CLIP-seq
MIRT1379545	hsa-miR-4663	CLIP-seq
MIRT1379546	hsa-miR-4691-5p	CLIP-seq
MIRT1379547	hsa-miR-4693-3p	CLIP-seq
MIRT1379548	hsa-miR-4695-5p	CLIP-seq
MIRT1379549	hsa-miR-4756-3p	CLIP-seq
MIRT1379550	hsa-miR-485-5p	CLIP-seq
MIRT1379551	hsa-miR-583	CLIP-seq
MIRT1379552	hsa-miR-892b	CLIP-seq
MIRT1379553	hsa-miR-1468	CLIP-seq
MIRT1379526	hsa-miR-193a-3p	CLIP-seq
MIRT1379527	hsa-miR-193b	CLIP-seq
MIRT1379554	hsa-miR-2052	CLIP-seq
MIRT1379555	hsa-miR-3591-3p	CLIP-seq
MIRT1379556	hsa-miR-4496	CLIP-seq
MIRT1379557	hsa-miR-664	CLIP-seq
MIRT1379552	hsa-miR-892b	CLIP-seq
MIRT2336419	hsa-miR-511	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12482870, 24128306
GO:0005794	Component	Golgi apparatus	IBA	21873635
GO:0006892	Process	Post-Golgi vesicle-mediated transport	IBA	21873635
GO:0007218	Process	Neuropeptide signaling pathway	NAS	11499680
GO:0008188	Function	Neuropeptide receptor activity	NAS	11499680
GO:0016020	Component	Membrane	IDA	12482870
GO:0016021	Component	Integral component of membrane	IBA	21873635

Other IDs

• MIM: 606283
• HGNC: 16697
• e!Ensembl: ENSG00000108018

Protein

• UniProt ID: Q8WY21
• Protein name: VPS10 domain-containing receptor SorCS1 (hSorCS)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15902	Sortilin-Vps10	205 → 635	Sortilin, neurotensin receptor 3,	Domain
  PF15901	Sortilin_C	637 → 792	Sortilin, neurotensin receptor 3, C-terminal	Domain
  PF00801	PKD	803 → 880	PKD domain	Domain

• Sequence:

  MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
  RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
  GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
  SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
  RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
  EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
  PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
  NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
  ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
  IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
  KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
  VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
  CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
  VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
  IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
  TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
  NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
  LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
  VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
  SSLRLQRARHATPPSTPKRGSAGAQYAI

• Sequence length: 1168

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	22843504
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243