SLITRK1 (SLIT and NTRK like family member 1)

Gene

• Entrez ID: 114798
• Gene name: SLIT and NTRK like family member 1
• Gene symbol: SLITRK1
• Synonyms: LRRC12, TTM
• Chromosome: 13
• Chromosome location: 13q31.1
• Summary: This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin re

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs191284403	C>A,T	Pathogenic	3 prime UTR variant
rs193302861	G>-	Pathogenic	Coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005653	hsa-miR-24-1-5p	GFP reporter assay, In situ hybridization, Luciferase reporter assay	16224024
MIRT018680	hsa-miR-335-5p	Microarray	18185580
MIRT1369719	hsa-miR-15a	CLIP-seq
MIRT1369720	hsa-miR-15b	CLIP-seq
MIRT1369721	hsa-miR-16	CLIP-seq
MIRT1369722	hsa-miR-181a	CLIP-seq
MIRT1369723	hsa-miR-181b	CLIP-seq
MIRT1369724	hsa-miR-181c	CLIP-seq
MIRT1369725	hsa-miR-181d	CLIP-seq
MIRT1369726	hsa-miR-195	CLIP-seq
MIRT1369727	hsa-miR-28-5p	CLIP-seq
MIRT1369728	hsa-miR-29a	CLIP-seq
MIRT1369729	hsa-miR-29b	CLIP-seq
MIRT1369730	hsa-miR-29c	CLIP-seq
MIRT1369731	hsa-miR-3065-5p	CLIP-seq
MIRT1369732	hsa-miR-3139	CLIP-seq
MIRT1369733	hsa-miR-338-5p	CLIP-seq
MIRT1369734	hsa-miR-3973	CLIP-seq
MIRT1369735	hsa-miR-424	CLIP-seq
MIRT1369736	hsa-miR-4262	CLIP-seq
MIRT1369737	hsa-miR-4633-3p	CLIP-seq
MIRT1369738	hsa-miR-4649-5p	CLIP-seq
MIRT1369739	hsa-miR-4699-3p	CLIP-seq
MIRT1369740	hsa-miR-497	CLIP-seq
MIRT1369741	hsa-miR-520g	CLIP-seq
MIRT1369742	hsa-miR-520h	CLIP-seq
MIRT1369743	hsa-miR-708	CLIP-seq
MIRT1369744	hsa-miR-922	CLIP-seq
MIRT2109757	hsa-miR-103a	CLIP-seq
MIRT2109758	hsa-miR-107	CLIP-seq
MIRT2109759	hsa-miR-128	CLIP-seq
MIRT1369719	hsa-miR-15a	CLIP-seq
MIRT1369720	hsa-miR-15b	CLIP-seq
MIRT1369721	hsa-miR-16	CLIP-seq
MIRT1369726	hsa-miR-195	CLIP-seq
MIRT2109760	hsa-miR-27a	CLIP-seq
MIRT2109761	hsa-miR-27b	CLIP-seq
MIRT2109762	hsa-miR-3685	CLIP-seq
MIRT2109763	hsa-miR-384	CLIP-seq
MIRT1369735	hsa-miR-424	CLIP-seq
MIRT1369740	hsa-miR-497	CLIP-seq
MIRT2109764	hsa-miR-5096	CLIP-seq
MIRT2109765	hsa-miR-513a-5p	CLIP-seq
MIRT2109759	hsa-miR-128	CLIP-seq
MIRT2109760	hsa-miR-27a	CLIP-seq
MIRT2109761	hsa-miR-27b	CLIP-seq
MIRT1369733	hsa-miR-338-5p	CLIP-seq
MIRT1369734	hsa-miR-3973	CLIP-seq
MIRT1369739	hsa-miR-4699-3p	CLIP-seq
MIRT2109764	hsa-miR-5096	CLIP-seq
MIRT2109765	hsa-miR-513a-5p	CLIP-seq
MIRT1369741	hsa-miR-520g	CLIP-seq
MIRT1369742	hsa-miR-520h	CLIP-seq
MIRT2627402	hsa-miR-185	CLIP-seq
MIRT2627403	hsa-miR-4306	CLIP-seq
MIRT2627404	hsa-miR-4644	CLIP-seq
MIRT2627405	hsa-miR-498	CLIP-seq
MIRT2627406	hsa-miR-622	CLIP-seq
MIRT2627407	hsa-miR-651	CLIP-seq
MIRT2627408	hsa-miR-767-3p	CLIP-seq
MIRT2627402	hsa-miR-185	CLIP-seq
MIRT2627403	hsa-miR-4306	CLIP-seq
MIRT2627404	hsa-miR-4644	CLIP-seq
MIRT2627405	hsa-miR-498	CLIP-seq
MIRT2627406	hsa-miR-622	CLIP-seq
MIRT2627407	hsa-miR-651	CLIP-seq
MIRT2627408	hsa-miR-767-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19640509, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007409	Process	Axonogenesis	IBA	21873635
GO:0007416	Process	Synapse assembly	IMP	27273464
GO:0030534	Process	Adult behavior	IEA
GO:0035264	Process	Multicellular organism growth	IEA
GO:0042592	Process	Homeostatic process	IEA
GO:0045202	Component	Synapse	ISS
GO:0050772	Process	Positive regulation of axonogenesis	IMP	23990902
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0098978	Component	Glutamatergic synapse	IDA	23345436
GO:0098978	Component	Glutamatergic synapse	IMP	23345436
GO:0098982	Component	GABA-ergic synapse	IDA	23345436
GO:0098982	Component	GABA-ergic synapse	IMP	23345436
GO:0099061	Component	Integral component of postsynaptic density membrane	IEA
GO:0099560	Process	Synaptic membrane adhesion	IDA	23345436
GO:0099560	Process	Synaptic membrane adhesion	IMP	23345436
GO:1905606	Process	Regulation of presynapse assembly	IDA	23345436
GO:1905606	Process	Regulation of presynapse assembly	IMP	23345436

Other IDs

• MIM: 609678
• HGNC: 20297
• e!Ensembl: ENSG00000178235

Protein

• UniProt ID: Q96PX8
• Protein name: SLIT and NTRK-like protein 1 (Leucine-rich repeat-containing protein 12)
• Protein function: It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Enhances neuronal dendrite outgrowth (PubMed:16224024, PubMed:19640509). {ECO:0000269|PubMed:16224024, ECO:0000269|PubMed:196405
• PDB: 4RCA, 4RCW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	83 → 142	Leucine rich repeat	Repeat
  PF13855	LRR_8	138 → 189	Leucine rich repeat	Repeat

• Sequence:

  MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQF
  YHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKS
  FRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPIT
  HLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVV
  CEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQEDHAT
  PGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKPLANSLPCPGGCSCDHIPGSGLKMNCN
  NRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFK
  NLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNN
  NLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPF
  KQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARISPTLTSHSKNSTGLA
  ETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASE
  INSLQTVCDSSYWHNGPYNADGAHRVYDCGSHSLSD

• Sequence length: 696

Pathways

KEGG:

Cell adhesion molecules

Reactome:

Receptor-type tyrosine-protein phosphatases

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder	rs120074176, rs786205019
Tourette syndrome	Gilles de la Tourette syndrome, NON RARE IN EUROPE: Tourette syndrome	rs193302861, rs191284403, rs267606861
Trichotillomania	Trichotillomania	rs193302861	17003809, 27812321, 16224024

Unknown
Disease name	Disease term	dbSNP ID	References
Alopecia	Alopecia
Dyssomnia	Dyssomnias
Obsessive-compulsive disorder	Obsessive compulsive behavior
Sleep disorders	Sleep Disorders