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FMNL2 (formin like 2)

Gene

Formin like 2

FMNL2

FHOD2

2

2q23.3

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length natu

Show/Hide all(227)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001547	hsa-miR-155-5p	pSILAC	18668040
MIRT001547	hsa-miR-155-5p	Proteomics;Other	18668040
MIRT022700	hsa-miR-124-3p	Microarray	18668037
MIRT023863	hsa-miR-1-3p	Proteomics	18668040
MIRT027997	hsa-miR-93-5p	Sequencing	20371350
MIRT036331	hsa-miR-1229-3p	CLASH	23622248
MIRT437385	hsa-miR-137	Luciferase reporter assay	23201162
MIRT719160	hsa-miR-1277-5p	HITS-CLIP	19536157
MIRT719159	hsa-miR-944	HITS-CLIP	19536157
MIRT719158	hsa-miR-5580-3p	HITS-CLIP	19536157
MIRT719157	hsa-miR-4310	HITS-CLIP	19536157
MIRT719156	hsa-miR-7157-5p	HITS-CLIP	19536157
MIRT719155	hsa-miR-889-3p	HITS-CLIP	19536157
MIRT711350	hsa-miR-96-3p	HITS-CLIP	19536157
MIRT711349	hsa-miR-4501	HITS-CLIP	19536157
MIRT711348	hsa-miR-3607-5p	HITS-CLIP	19536157
MIRT711347	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT711346	hsa-miR-1248	HITS-CLIP	19536157
MIRT711345	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT711344	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT711343	hsa-miR-134-5p	HITS-CLIP	19536157
MIRT711342	hsa-miR-3118	HITS-CLIP	19536157
MIRT711341	hsa-miR-3164	HITS-CLIP	19536157
MIRT711340	hsa-miR-6820-3p	HITS-CLIP	19536157
MIRT711338	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT711339	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT085790	hsa-miR-3609	PAR-CLIP	21572407
MIRT085792	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT551751	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT551750	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT551749	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT551748	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT551747	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT551746	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT551745	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT027997	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT551744	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT551743	hsa-miR-4704-5p	PAR-CLIP	21572407
MIRT085787	hsa-miR-203a-3p	PAR-CLIP	21572407
MIRT085795	hsa-miR-4536-5p	PAR-CLIP	21572407
MIRT736979	hsa-miR-466	Luciferase reporter assay, Western blotting, qRT-PCR	34257650
MIRT719160	hsa-miR-1277-5p	HITS-CLIP	19536157
MIRT719159	hsa-miR-944	HITS-CLIP	19536157
MIRT719158	hsa-miR-5580-3p	HITS-CLIP	19536157
MIRT719157	hsa-miR-4310	HITS-CLIP	19536157
MIRT719156	hsa-miR-7157-5p	HITS-CLIP	19536157
MIRT719155	hsa-miR-889-3p	HITS-CLIP	19536157
MIRT711350	hsa-miR-96-3p	HITS-CLIP	19536157
MIRT711349	hsa-miR-4501	HITS-CLIP	19536157
MIRT711348	hsa-miR-3607-5p	HITS-CLIP	19536157
MIRT711347	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT711346	hsa-miR-1248	HITS-CLIP	19536157
MIRT711345	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT711344	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT711343	hsa-miR-134-5p	HITS-CLIP	19536157
MIRT711342	hsa-miR-3118	HITS-CLIP	19536157
MIRT711341	hsa-miR-3164	HITS-CLIP	19536157
MIRT711340	hsa-miR-6820-3p	HITS-CLIP	19536157
MIRT711338	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT711339	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT085790	hsa-miR-3609	PAR-CLIP	21572407
MIRT085792	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT551751	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT551750	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT551749	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT551748	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT551747	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT551746	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT551745	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT027997	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT551744	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT551743	hsa-miR-4704-5p	PAR-CLIP	21572407
MIRT085787	hsa-miR-203a-3p	PAR-CLIP	21572407
MIRT085795	hsa-miR-4536-5p	PAR-CLIP	21572407
MIRT999525	hsa-miR-106a	CLIP-seq
MIRT999526	hsa-miR-106b	CLIP-seq
MIRT999527	hsa-miR-1227	CLIP-seq
MIRT999528	hsa-miR-1273f	CLIP-seq
MIRT999529	hsa-miR-143	CLIP-seq
MIRT999530	hsa-miR-155	CLIP-seq
MIRT999531	hsa-miR-17	CLIP-seq
MIRT999532	hsa-miR-1912	CLIP-seq
MIRT999533	hsa-miR-197	CLIP-seq
MIRT999534	hsa-miR-203	CLIP-seq
MIRT999535	hsa-miR-2053	CLIP-seq
MIRT999536	hsa-miR-20a	CLIP-seq
MIRT999537	hsa-miR-20b	CLIP-seq
MIRT999538	hsa-miR-2113	CLIP-seq
MIRT999539	hsa-miR-219-2-3p	CLIP-seq
MIRT999540	hsa-miR-23a	CLIP-seq
MIRT999541	hsa-miR-23b	CLIP-seq
MIRT999542	hsa-miR-23c	CLIP-seq
MIRT999543	hsa-miR-2964a-3p	CLIP-seq
MIRT999544	hsa-miR-302f	CLIP-seq
MIRT999545	hsa-miR-3121-3p	CLIP-seq
MIRT999546	hsa-miR-3130-5p	CLIP-seq
MIRT999547	hsa-miR-3140-3p	CLIP-seq
MIRT999548	hsa-miR-3163	CLIP-seq
MIRT999549	hsa-miR-3188	CLIP-seq
MIRT999550	hsa-miR-324-5p	CLIP-seq
MIRT999551	hsa-miR-338-5p	CLIP-seq
MIRT999552	hsa-miR-340	CLIP-seq
MIRT999553	hsa-miR-34a	CLIP-seq
MIRT999554	hsa-miR-34c-5p	CLIP-seq
MIRT999555	hsa-miR-3607-3p	CLIP-seq
MIRT999556	hsa-miR-3649	CLIP-seq
MIRT999557	hsa-miR-3653	CLIP-seq
MIRT999558	hsa-miR-3686	CLIP-seq
MIRT999559	hsa-miR-3936	CLIP-seq
MIRT999560	hsa-miR-410	CLIP-seq
MIRT999561	hsa-miR-412	CLIP-seq
MIRT999562	hsa-miR-4252	CLIP-seq
MIRT999563	hsa-miR-4418	CLIP-seq
MIRT999564	hsa-miR-4475	CLIP-seq
MIRT999565	hsa-miR-4482	CLIP-seq
MIRT999566	hsa-miR-4496	CLIP-seq
MIRT999567	hsa-miR-449a	CLIP-seq
MIRT999568	hsa-miR-449b	CLIP-seq
MIRT999569	hsa-miR-4536	CLIP-seq
MIRT999570	hsa-miR-4639-5p	CLIP-seq
MIRT999571	hsa-miR-4643	CLIP-seq
MIRT999572	hsa-miR-4652-3p	CLIP-seq
MIRT999573	hsa-miR-4690-5p	CLIP-seq
MIRT999574	hsa-miR-4699-3p	CLIP-seq
MIRT999575	hsa-miR-4708-5p	CLIP-seq
MIRT999576	hsa-miR-4770	CLIP-seq
MIRT999577	hsa-miR-4775	CLIP-seq
MIRT999578	hsa-miR-4789-3p	CLIP-seq
MIRT999579	hsa-miR-509-3-5p	CLIP-seq
MIRT999580	hsa-miR-509-5p	CLIP-seq
MIRT999581	hsa-miR-519d	CLIP-seq
MIRT999582	hsa-miR-543	CLIP-seq
MIRT999583	hsa-miR-548ah	CLIP-seq
MIRT999584	hsa-miR-556-3p	CLIP-seq
MIRT999585	hsa-miR-569	CLIP-seq
MIRT999586	hsa-miR-576-5p	CLIP-seq
MIRT999587	hsa-miR-590-3p	CLIP-seq
MIRT999588	hsa-miR-606	CLIP-seq
MIRT999589	hsa-miR-633	CLIP-seq
MIRT999590	hsa-miR-873	CLIP-seq
MIRT999591	hsa-miR-93	CLIP-seq
MIRT1996272	hsa-miR-1284	CLIP-seq
MIRT999535	hsa-miR-2053	CLIP-seq
MIRT1996273	hsa-miR-300	CLIP-seq
MIRT1996274	hsa-miR-381	CLIP-seq
MIRT999569	hsa-miR-4536	CLIP-seq
MIRT999572	hsa-miR-4652-3p	CLIP-seq
MIRT1996275	hsa-miR-4666-3p	CLIP-seq
MIRT1996276	hsa-miR-548g	CLIP-seq
MIRT999585	hsa-miR-569	CLIP-seq
MIRT2230203	hsa-miR-1	CLIP-seq
MIRT999525	hsa-miR-106a	CLIP-seq
MIRT999526	hsa-miR-106b	CLIP-seq
MIRT2230204	hsa-miR-1252	CLIP-seq
MIRT999531	hsa-miR-17	CLIP-seq
MIRT999534	hsa-miR-203	CLIP-seq
MIRT2230205	hsa-miR-206	CLIP-seq
MIRT999536	hsa-miR-20a	CLIP-seq
MIRT999537	hsa-miR-20b	CLIP-seq
MIRT999545	hsa-miR-3121-3p	CLIP-seq
MIRT2230206	hsa-miR-3125	CLIP-seq
MIRT999556	hsa-miR-3649	CLIP-seq
MIRT2230207	hsa-miR-374c	CLIP-seq
MIRT2230208	hsa-miR-3916	CLIP-seq
MIRT999560	hsa-miR-410	CLIP-seq
MIRT999564	hsa-miR-4475	CLIP-seq
MIRT2230209	hsa-miR-4476	CLIP-seq
MIRT2230210	hsa-miR-4533	CLIP-seq
MIRT999569	hsa-miR-4536	CLIP-seq
MIRT999571	hsa-miR-4643	CLIP-seq
MIRT2230211	hsa-miR-4716-5p	CLIP-seq
MIRT999578	hsa-miR-4789-3p	CLIP-seq
MIRT999581	hsa-miR-519d	CLIP-seq
MIRT999583	hsa-miR-548ah	CLIP-seq
MIRT999588	hsa-miR-606	CLIP-seq
MIRT2230212	hsa-miR-613	CLIP-seq
MIRT2230213	hsa-miR-655	CLIP-seq
MIRT999591	hsa-miR-93	CLIP-seq
MIRT999545	hsa-miR-3121-3p	CLIP-seq
MIRT2449826	hsa-miR-298	CLIP-seq
MIRT2449827	hsa-miR-411	CLIP-seq
MIRT2534001	hsa-miR-1202	CLIP-seq
MIRT999527	hsa-miR-1227	CLIP-seq
MIRT2534002	hsa-miR-124	CLIP-seq
MIRT2534003	hsa-miR-1251	CLIP-seq
MIRT2534004	hsa-miR-141	CLIP-seq
MIRT2534005	hsa-miR-200a	CLIP-seq
MIRT999538	hsa-miR-2113	CLIP-seq
MIRT2534006	hsa-miR-2117	CLIP-seq
MIRT2534007	hsa-miR-2861	CLIP-seq
MIRT2449826	hsa-miR-298	CLIP-seq
MIRT999550	hsa-miR-324-5p	CLIP-seq
MIRT2534008	hsa-miR-342-3p	CLIP-seq
MIRT2534009	hsa-miR-3664-5p	CLIP-seq
MIRT2534010	hsa-miR-3918	CLIP-seq
MIRT2534011	hsa-miR-3972	CLIP-seq
MIRT2449827	hsa-miR-411	CLIP-seq
MIRT999562	hsa-miR-4252	CLIP-seq
MIRT2534012	hsa-miR-4261	CLIP-seq
MIRT2534013	hsa-miR-4325	CLIP-seq
MIRT999563	hsa-miR-4418	CLIP-seq
MIRT2534014	hsa-miR-4512	CLIP-seq
MIRT2534015	hsa-miR-4658	CLIP-seq
MIRT2534016	hsa-miR-4684-5p	CLIP-seq
MIRT2534017	hsa-miR-4685-5p	CLIP-seq
MIRT2534018	hsa-miR-4708-3p	CLIP-seq
MIRT2534019	hsa-miR-4714-5p	CLIP-seq
MIRT2534020	hsa-miR-4738-3p	CLIP-seq
MIRT2534021	hsa-miR-4755-3p	CLIP-seq
MIRT2534022	hsa-miR-4758-5p	CLIP-seq
MIRT2534023	hsa-miR-4765	CLIP-seq
MIRT2534024	hsa-miR-4776-3p	CLIP-seq
MIRT2534025	hsa-miR-4793-5p	CLIP-seq
MIRT2534026	hsa-miR-502-5p	CLIP-seq
MIRT2534027	hsa-miR-506	CLIP-seq
MIRT2534028	hsa-miR-507	CLIP-seq
MIRT999579	hsa-miR-509-3-5p	CLIP-seq
MIRT999580	hsa-miR-509-5p	CLIP-seq
MIRT2534029	hsa-miR-557	CLIP-seq
MIRT2534030	hsa-miR-621	CLIP-seq
MIRT2534031	hsa-miR-628-3p	CLIP-seq
MIRT2534032	hsa-miR-653	CLIP-seq
MIRT2534033	hsa-miR-875-3p	CLIP-seq
MIRT2534003	hsa-miR-1251	CLIP-seq
MIRT2534006	hsa-miR-2117	CLIP-seq
MIRT2534008	hsa-miR-342-3p	CLIP-seq
MIRT2534016	hsa-miR-4684-5p	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0007010	Process	Cytoskeleton organization	IMP	21834987
GO:0008360	Process	Regulation of cell shape	IBA	21873635
GO:0016477	Process	Cell migration	IBA	21873635
GO:0022604	Process	Regulation of cell morphogenesis	IMP	21834987
GO:0030866	Process	Cortical actin cytoskeleton organization	IBA	21873635
GO:0030866	Process	Cortical actin cytoskeleton organization	IMP	21834987
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0051015	Function	Actin filament binding	IBA	21873635

MIM	HGNC	e!Ensembl
616285	18267	ENSG00000157827

Protein

UniProt ID

Protein name

Formin-like protein 2 (Formin homology 2 domain-containing protein 2)

Protein function

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.

PDB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06371	Drf_GBD	23 → 159	Diaphanous GTPase-binding Domain	Family
PF06371	Drf_GBD	202 → 275	Diaphanous GTPase-binding Domain	Family
PF06367	Drf_FH3	278 → 475	Diaphanous FH3 Domain	Family
PF02181	FH2	616 → 982	Formin Homology 2 Domain	Family

Sequence

MGNAGSMDSQQTDFRAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKK
WELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIG
WVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSN
LPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNM
VMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRF
EKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTE
SDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKI
VELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGT
IKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTP
ETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGT
SSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDE
FEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAI
HVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQ
KMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAV
YGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVL
LDVKELQRGMDLTKREYTMHDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGE
NPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHK
SKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITVLKTVPFTARTAKRGSRFFCEPVL
TEEYHY

Sequence length

1086

Interactions

View interactions

	KEGG		Reactome
	Cytoskeleton in muscle cells		RHO GTPases Activate Formins

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Glaucoma	Glaucoma, Glaucoma, Open-Angle	rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328, rs121909193, rs74315330, rs74315329, rs74315332, rs74315334, rs74315336, rs74315338, rs74315341, rs121909194, rs74315331, rs1558603396, rs387907175, rs587778873, rs587778875, rs104894979, rs137854895, rs766425037, rs72549380, rs148542782, rs541217363, rs753021890, rs771076928, rs56010818, rs777678299, rs1446110883, rs1573274915, rs1587545234, rs751768343, rs944452644	30054594, 29891935
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959

Show/Hide Unknown Diseases (2)

Unknown
Disease name	Disease term	dbSNP ID	References
Corneal astigmatism	Regular astigmatism - corneal		30306274
Stroke	Cerebrovascular accident		22384361

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