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TIRAP (TIR domain containing adaptor protein)

Gene

114609

TIR domain containing adaptor protein

TIRAP

BACTS1, Mal, MyD88-2, wyatt

11q24.2

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleuk

Show/Hide all(256)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004748	hsa-miR-145-5p	Immunoprecipitaion, Western blot, Communoprecipitaion	19898489
MIRT674506	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT674505	hsa-miR-764	HITS-CLIP	23824327
MIRT674504	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT674503	hsa-miR-4635	HITS-CLIP	23824327
MIRT674502	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT674501	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT674500	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT674499	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT674498	hsa-miR-8086	HITS-CLIP	23824327
MIRT674497	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT674496	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT674495	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT674494	hsa-miR-640	HITS-CLIP	23824327
MIRT674493	hsa-miR-548s	HITS-CLIP	23824327
MIRT674491	hsa-miR-588	HITS-CLIP	23824327
MIRT674490	hsa-miR-4435	HITS-CLIP	23824327
MIRT674489	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT674488	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT674487	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT674506	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT674505	hsa-miR-764	HITS-CLIP	23824327
MIRT674504	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT674503	hsa-miR-4635	HITS-CLIP	23824327
MIRT674502	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT674501	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT674500	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT674499	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT674498	hsa-miR-8086	HITS-CLIP	23824327
MIRT674497	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT674496	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT674495	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT674494	hsa-miR-640	HITS-CLIP	23824327
MIRT674493	hsa-miR-548s	HITS-CLIP	23824327
MIRT674492	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT674491	hsa-miR-588	HITS-CLIP	23824327
MIRT674490	hsa-miR-4435	HITS-CLIP	23824327
MIRT674489	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT674488	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT674487	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT674506	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT674505	hsa-miR-764	HITS-CLIP	23824327
MIRT674504	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT674503	hsa-miR-4635	HITS-CLIP	23824327
MIRT674502	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT674501	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT674500	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT674499	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT674498	hsa-miR-8086	HITS-CLIP	23824327
MIRT674497	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT674496	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT674495	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT674494	hsa-miR-640	HITS-CLIP	23824327
MIRT674493	hsa-miR-548s	HITS-CLIP	23824327
MIRT674491	hsa-miR-588	HITS-CLIP	23824327
MIRT674490	hsa-miR-4435	HITS-CLIP	23824327
MIRT674489	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT674488	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT674487	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT674506	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT674505	hsa-miR-764	HITS-CLIP	23824327
MIRT674504	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT674503	hsa-miR-4635	HITS-CLIP	23824327
MIRT674502	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT674501	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT674500	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT674499	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT674498	hsa-miR-8086	HITS-CLIP	23824327
MIRT674497	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT674496	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT674495	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT674494	hsa-miR-640	HITS-CLIP	23824327
MIRT674493	hsa-miR-548s	HITS-CLIP	23824327
MIRT674492	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT674491	hsa-miR-588	HITS-CLIP	23824327
MIRT674490	hsa-miR-4435	HITS-CLIP	23824327
MIRT674489	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT674488	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT674487	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT1425640	hsa-miR-106a	CLIP-seq
MIRT1425641	hsa-miR-106b	CLIP-seq
MIRT1425642	hsa-miR-1180	CLIP-seq
MIRT1425643	hsa-miR-1234	CLIP-seq
MIRT1425644	hsa-miR-1275	CLIP-seq
MIRT1425645	hsa-miR-1289	CLIP-seq
MIRT1425646	hsa-miR-1343	CLIP-seq
MIRT1425647	hsa-miR-135a	CLIP-seq
MIRT1425648	hsa-miR-135b	CLIP-seq
MIRT1425649	hsa-miR-143	CLIP-seq
MIRT1425650	hsa-miR-145	CLIP-seq
MIRT1425651	hsa-miR-1470	CLIP-seq
MIRT1425652	hsa-miR-150	CLIP-seq
MIRT1425653	hsa-miR-17	CLIP-seq
MIRT1425654	hsa-miR-183	CLIP-seq
MIRT1425655	hsa-miR-198	CLIP-seq
MIRT1425656	hsa-miR-20a	CLIP-seq
MIRT1425657	hsa-miR-20b	CLIP-seq
MIRT1425658	hsa-miR-2355-5p	CLIP-seq
MIRT1425659	hsa-miR-2682	CLIP-seq
MIRT1425660	hsa-miR-302a	CLIP-seq
MIRT1425661	hsa-miR-302b	CLIP-seq
MIRT1425662	hsa-miR-302c	CLIP-seq
MIRT1425663	hsa-miR-302d	CLIP-seq
MIRT1425664	hsa-miR-302e	CLIP-seq
MIRT1425665	hsa-miR-3119	CLIP-seq
MIRT1425666	hsa-miR-3124-3p	CLIP-seq
MIRT1425667	hsa-miR-3145-5p	CLIP-seq
MIRT1425668	hsa-miR-3545-3p	CLIP-seq
MIRT1425669	hsa-miR-3667-3p	CLIP-seq
MIRT1425670	hsa-miR-3685	CLIP-seq
MIRT1425671	hsa-miR-372	CLIP-seq
MIRT1425672	hsa-miR-373	CLIP-seq
MIRT1425673	hsa-miR-383	CLIP-seq
MIRT1425674	hsa-miR-384	CLIP-seq
MIRT1425675	hsa-miR-3934	CLIP-seq
MIRT1425676	hsa-miR-410	CLIP-seq
MIRT1425677	hsa-miR-4278	CLIP-seq
MIRT1425678	hsa-miR-4297	CLIP-seq
MIRT1425679	hsa-miR-4316	CLIP-seq
MIRT1425680	hsa-miR-4421	CLIP-seq
MIRT1425681	hsa-miR-4423-3p	CLIP-seq
MIRT1425682	hsa-miR-4469	CLIP-seq
MIRT1425683	hsa-miR-4476	CLIP-seq
MIRT1425684	hsa-miR-4497	CLIP-seq
MIRT1425685	hsa-miR-449c	CLIP-seq
MIRT1425686	hsa-miR-4525	CLIP-seq
MIRT1425687	hsa-miR-4663	CLIP-seq
MIRT1425688	hsa-miR-4664-3p	CLIP-seq
MIRT1425689	hsa-miR-4665-5p	CLIP-seq
MIRT1425690	hsa-miR-4667-3p	CLIP-seq
MIRT1425691	hsa-miR-4704-3p	CLIP-seq
MIRT1425692	hsa-miR-4710	CLIP-seq
MIRT1425693	hsa-miR-4711-3p	CLIP-seq
MIRT1425694	hsa-miR-4716-3p	CLIP-seq
MIRT1425695	hsa-miR-4722-5p	CLIP-seq
MIRT1425696	hsa-miR-4723-5p	CLIP-seq
MIRT1425697	hsa-miR-4742-5p	CLIP-seq
MIRT1425698	hsa-miR-4768-3p	CLIP-seq
MIRT1425699	hsa-miR-4770	CLIP-seq
MIRT1425700	hsa-miR-4772-5p	CLIP-seq
MIRT1425701	hsa-miR-4792	CLIP-seq
MIRT1425702	hsa-miR-483-3p	CLIP-seq
MIRT1425703	hsa-miR-511	CLIP-seq
MIRT1425704	hsa-miR-512-3p	CLIP-seq
MIRT1425705	hsa-miR-516a-3p	CLIP-seq
MIRT1425706	hsa-miR-519d	CLIP-seq
MIRT1425707	hsa-miR-520a-3p	CLIP-seq
MIRT1425708	hsa-miR-520b	CLIP-seq
MIRT1425709	hsa-miR-520c-3p	CLIP-seq
MIRT1425710	hsa-miR-520d-3p	CLIP-seq
MIRT1425711	hsa-miR-520e	CLIP-seq
MIRT1425712	hsa-miR-520g	CLIP-seq
MIRT1425713	hsa-miR-520h	CLIP-seq
MIRT1425714	hsa-miR-592	CLIP-seq
MIRT1425715	hsa-miR-599	CLIP-seq
MIRT1425716	hsa-miR-615-5p	CLIP-seq
MIRT1425717	hsa-miR-625	CLIP-seq
MIRT1425718	hsa-miR-628-5p	CLIP-seq
MIRT1425719	hsa-miR-637	CLIP-seq
MIRT1425720	hsa-miR-645	CLIP-seq
MIRT1425721	hsa-miR-7	CLIP-seq
MIRT1425722	hsa-miR-93	CLIP-seq
MIRT1425723	hsa-miR-940	CLIP-seq
MIRT1425640	hsa-miR-106a	CLIP-seq
MIRT1425641	hsa-miR-106b	CLIP-seq
MIRT1425643	hsa-miR-1234	CLIP-seq
MIRT2127534	hsa-miR-134	CLIP-seq
MIRT1425652	hsa-miR-150	CLIP-seq
MIRT1425653	hsa-miR-17	CLIP-seq
MIRT1425656	hsa-miR-20a	CLIP-seq
MIRT1425657	hsa-miR-20b	CLIP-seq
MIRT1425660	hsa-miR-302a	CLIP-seq
MIRT1425661	hsa-miR-302b	CLIP-seq
MIRT1425662	hsa-miR-302c	CLIP-seq
MIRT1425663	hsa-miR-302d	CLIP-seq
MIRT1425664	hsa-miR-302e	CLIP-seq
MIRT2127535	hsa-miR-3065-5p	CLIP-seq
MIRT2127536	hsa-miR-3118	CLIP-seq
MIRT2127537	hsa-miR-3144-3p	CLIP-seq
MIRT2127538	hsa-miR-3164	CLIP-seq
MIRT1425668	hsa-miR-3545-3p	CLIP-seq
MIRT2127539	hsa-miR-3655	CLIP-seq
MIRT2127540	hsa-miR-3680	CLIP-seq
MIRT1425671	hsa-miR-372	CLIP-seq
MIRT1425672	hsa-miR-373	CLIP-seq
MIRT1425675	hsa-miR-3934	CLIP-seq
MIRT2127541	hsa-miR-421	CLIP-seq
MIRT2127542	hsa-miR-4277	CLIP-seq
MIRT2127543	hsa-miR-4695-3p	CLIP-seq
MIRT2127544	hsa-miR-4727-5p	CLIP-seq
MIRT2127545	hsa-miR-4760-3p	CLIP-seq
MIRT2127546	hsa-miR-4769-3p	CLIP-seq
MIRT1425702	hsa-miR-483-3p	CLIP-seq
MIRT2127547	hsa-miR-495	CLIP-seq
MIRT1425704	hsa-miR-512-3p	CLIP-seq
MIRT1425706	hsa-miR-519d	CLIP-seq
MIRT1425707	hsa-miR-520a-3p	CLIP-seq
MIRT1425708	hsa-miR-520b	CLIP-seq
MIRT1425709	hsa-miR-520c-3p	CLIP-seq
MIRT1425710	hsa-miR-520d-3p	CLIP-seq
MIRT1425711	hsa-miR-520e	CLIP-seq
MIRT1425712	hsa-miR-520g	CLIP-seq
MIRT1425713	hsa-miR-520h	CLIP-seq
MIRT2127548	hsa-miR-579	CLIP-seq
MIRT2127549	hsa-miR-664	CLIP-seq
MIRT2127550	hsa-miR-875-5p	CLIP-seq
MIRT1425722	hsa-miR-93	CLIP-seq
MIRT1425640	hsa-miR-106a	CLIP-seq
MIRT1425641	hsa-miR-106b	CLIP-seq
MIRT1425643	hsa-miR-1234	CLIP-seq
MIRT2349289	hsa-miR-1236	CLIP-seq
MIRT1425647	hsa-miR-135a	CLIP-seq
MIRT1425648	hsa-miR-135b	CLIP-seq
MIRT1425651	hsa-miR-1470	CLIP-seq
MIRT1425652	hsa-miR-150	CLIP-seq
MIRT1425653	hsa-miR-17	CLIP-seq
MIRT1425656	hsa-miR-20a	CLIP-seq
MIRT1425657	hsa-miR-20b	CLIP-seq
MIRT1425658	hsa-miR-2355-5p	CLIP-seq
MIRT1425660	hsa-miR-302a	CLIP-seq
MIRT1425661	hsa-miR-302b	CLIP-seq
MIRT1425662	hsa-miR-302c	CLIP-seq
MIRT1425663	hsa-miR-302d	CLIP-seq
MIRT1425664	hsa-miR-302e	CLIP-seq
MIRT1425667	hsa-miR-3145-5p	CLIP-seq
MIRT1425668	hsa-miR-3545-3p	CLIP-seq
MIRT2349290	hsa-miR-3614-5p	CLIP-seq
MIRT1425671	hsa-miR-372	CLIP-seq
MIRT1425672	hsa-miR-373	CLIP-seq
MIRT1425675	hsa-miR-3934	CLIP-seq
MIRT2349291	hsa-miR-412	CLIP-seq
MIRT1425682	hsa-miR-4469	CLIP-seq
MIRT2349292	hsa-miR-4645-5p	CLIP-seq
MIRT2349293	hsa-miR-4652-3p	CLIP-seq
MIRT1425687	hsa-miR-4663	CLIP-seq
MIRT1425690	hsa-miR-4667-3p	CLIP-seq
MIRT2349294	hsa-miR-4673	CLIP-seq
MIRT1425697	hsa-miR-4742-5p	CLIP-seq
MIRT1425702	hsa-miR-483-3p	CLIP-seq
MIRT1425704	hsa-miR-512-3p	CLIP-seq
MIRT1425706	hsa-miR-519d	CLIP-seq
MIRT1425707	hsa-miR-520a-3p	CLIP-seq
MIRT1425708	hsa-miR-520b	CLIP-seq
MIRT1425709	hsa-miR-520c-3p	CLIP-seq
MIRT1425710	hsa-miR-520d-3p	CLIP-seq
MIRT1425711	hsa-miR-520e	CLIP-seq
MIRT1425712	hsa-miR-520g	CLIP-seq
MIRT1425713	hsa-miR-520h	CLIP-seq
MIRT1425722	hsa-miR-93	CLIP-seq
MIRT2642659	hsa-miR-23a	CLIP-seq
MIRT2642660	hsa-miR-23b	CLIP-seq
MIRT2642661	hsa-miR-23c	CLIP-seq
MIRT2127537	hsa-miR-3144-3p	CLIP-seq
MIRT2127539	hsa-miR-3655	CLIP-seq
MIRT1425702	hsa-miR-483-3p	CLIP-seq
MIRT2127550	hsa-miR-875-5p	CLIP-seq

Show/Hide all(45)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS	19509286
GO:0005080	Function	Protein kinase C binding	IPI	17161867
GO:0005515	Function	Protein binding	IPI	11544529, 17258210, 17583698, 19509286, 19574958, 19948740, 21334391, 21829704, 21903422, 22155231, 24275656
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	ISS
GO:0005737	Component	Cytoplasm	IDA	19948740
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	19948740
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	ISS
GO:0007250	Process	Activation of NF-kappaB-inducing kinase activity	IMP	24275656
GO:0030099	Process	Myeloid cell differentiation	ISS
GO:0030139	Component	Endocytic vesicle	ISS
GO:0030674	Function	Protein-macromolecule adaptor activity	NAS	19509286
GO:0030890	Process	Positive regulation of B cell proliferation	ISS
GO:0031334	Process	Positive regulation of protein-containing complex assembly	IDA	12062447
GO:0032496	Process	Response to lipopolysaccharide	IDA	11544529
GO:0032587	Component	Ruffle membrane	ISS
GO:0032648	Process	Regulation of interferon-beta production	ISS
GO:0032735	Process	Positive regulation of interleukin-12 production	ISS
GO:0032738	Process	Positive regulation of interleukin-15 production	IDA	18583567
GO:0032755	Process	Positive regulation of interleukin-6 production	IMP	16301656
GO:0032757	Process	Positive regulation of interleukin-8 production	IMP	16301656
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IMP	16301656, 19509286
GO:0034137	Process	Positive regulation of toll-like receptor 2 signaling pathway	IMP	19509286
GO:0034141	Process	Positive regulation of toll-like receptor 3 signaling pathway	ISS
GO:0034145	Process	Positive regulation of toll-like receptor 4 signaling pathway	IMP	19509286
GO:0035662	Function	Toll-like receptor 4 binding	IPI	19509286
GO:0035663	Function	Toll-like receptor 2 binding	IPI	19509286
GO:0035665	Process	TIRAP-dependent toll-like receptor 4 signaling pathway	IDA	11544529
GO:0042802	Function	Identical protein binding	IPI	17258210, 24275656
GO:0042802	Function	Identical protein binding	ISS
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	19509286
GO:0045087	Process	Innate immune response	IEA
GO:0045088	Process	Regulation of innate immune response	IC	19509286
GO:0046330	Process	Positive regulation of JNK cascade	IMP	11544529
GO:0050830	Process	Defense response to Gram-positive bacterium	ISS
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IMP	19509286
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	11544529
GO:0070935	Process	3'-UTR-mediated mRNA stabilization	IDA	15294994
GO:0071221	Process	Cellular response to bacterial lipopeptide	ISS
GO:0071223	Process	Cellular response to lipoteichoic acid	ISS
GO:0090023	Process	Positive regulation of neutrophil chemotaxis	ISS
GO:2000340	Process	Positive regulation of chemokine (C-X-C motif) ligand 1 production	ISS
GO:2000343	Process	Positive regulation of chemokine (C-X-C motif) ligand 2 production	ISS

MIM	HGNC	e!Ensembl
606252	17192	ENSG00000150455

Protein

UniProt ID

P58753

Protein name

Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2)

Protein function

Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response

PDB

2NDH , 2Y92 , 3UB2 , 3UB3 , 3UB4 , 4FZ5 , 4LQD , 5T7Q , 5UZB , 8JZM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13676	TIR_2	88 → 211	TIR domain	Domain

Sequence

MASSTSLPAPGSRPKKPLGKMADWFRQTLLKKPKKRPNSPESTSSDASQPTSQDSPLPPS
LSSVTSPSLPPTHASDSGSSRWSKDYDVCVCHSEEDLVAAQDLVSYLEGSTASLRCFLQL
RDATPGGAIVSELCQALSSSHCRVLLITPGFLQDPWCKYQMLQALTEAPGAEGCTIPLLS
GLSRAAYPPELRFMYYVDGRGPDGGFRQVKEAVMRYLQTLS

Sequence length

221

Interactions

View interactions

	KEGG		Reactome
	NF-kappa B signaling pathway Toll-like receptor signaling pathway Alcoholic liver disease Pathogenic Escherichia coli infection Salmonella infection Pertussis Tuberculosis Hepatitis B PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4)

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	16284379

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		16284379

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