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LACTB (lactamase beta)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
114294
Gene nameGene Name - the full gene name approved by the HGNC.
Lactamase beta
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
LACTB
SynonymsGene synonyms aliases
G24, MRPL56
ChromosomeChromosome number
15
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q22.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004998 hsa-miR-125b-5p Microarray 17891175
MIRT643855 hsa-miR-125a-3p HITS-CLIP 22927820
MIRT643854 hsa-miR-764 HITS-CLIP 22927820
MIRT643853 hsa-miR-3934-5p HITS-CLIP 22927820
MIRT643852 hsa-miR-1224-3p HITS-CLIP 22927820
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005739 Component Mitochondrion HDA 20833797
GO:0005739 Component Mitochondrion IDA 28329758
GO:0005829 Component Cytosol IDA
GO:0006508 Process Proteolysis IDA 28329758
GO:0006629 Process Lipid metabolic process IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P83111
Protein name Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)
Protein function Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (
PDB 7ULW , 7V1Y , 7V1Z , 7V21
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00144 Beta-lactamase
111 253
Beta-lactamase
Domain
PF00144 Beta-lactamase
277 538
Beta-lactamase
Domain
Sequence
Sequence length 547
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Obesity Obesity rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840 18344982

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