CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit)

Gene

• Entrez ID: 1138
• Gene name: Cholinergic receptor nicotinic alpha 5 subunit
• Gene symbol: CHRNA5
• Synonyms: LNCR2
• Chromosome: 15
• Chromosome location: 15q25.1
• Summary: The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of sepa

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs16969968	G>A	Risk-factor, drug-response	Intron variant, missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021766	hsa-miR-132-3p	Microarray	17612493
MIRT047593	hsa-miR-10a-5p	CLASH	23622248
MIRT039616	hsa-miR-615-3p	CLASH	23622248
MIRT891788	hsa-miR-1184	CLIP-seq
MIRT891789	hsa-miR-122	CLIP-seq
MIRT891790	hsa-miR-1224-3p	CLIP-seq
MIRT891791	hsa-miR-125a-3p	CLIP-seq
MIRT891792	hsa-miR-1307	CLIP-seq
MIRT891793	hsa-miR-130a	CLIP-seq
MIRT891794	hsa-miR-130b	CLIP-seq
MIRT891795	hsa-miR-140-3p	CLIP-seq
MIRT891796	hsa-miR-150	CLIP-seq
MIRT891797	hsa-miR-15a	CLIP-seq
MIRT891798	hsa-miR-15b	CLIP-seq
MIRT891799	hsa-miR-16	CLIP-seq
MIRT891800	hsa-miR-1911	CLIP-seq
MIRT891801	hsa-miR-1915	CLIP-seq
MIRT891802	hsa-miR-195	CLIP-seq
MIRT891803	hsa-miR-196a	CLIP-seq
MIRT891804	hsa-miR-196b	CLIP-seq
MIRT891805	hsa-miR-1976	CLIP-seq
MIRT891806	hsa-miR-23a	CLIP-seq
MIRT891807	hsa-miR-23b	CLIP-seq
MIRT891808	hsa-miR-23c	CLIP-seq
MIRT891809	hsa-miR-301a	CLIP-seq
MIRT891810	hsa-miR-301b	CLIP-seq
MIRT891811	hsa-miR-3074-3p	CLIP-seq
MIRT891812	hsa-miR-3135b	CLIP-seq
MIRT891813	hsa-miR-3146	CLIP-seq
MIRT891814	hsa-miR-3148	CLIP-seq
MIRT891815	hsa-miR-3155	CLIP-seq
MIRT891816	hsa-miR-3155b	CLIP-seq
MIRT891817	hsa-miR-3171	CLIP-seq
MIRT891818	hsa-miR-3201	CLIP-seq
MIRT891819	hsa-miR-340	CLIP-seq
MIRT891820	hsa-miR-3620	CLIP-seq
MIRT891821	hsa-miR-3652	CLIP-seq
MIRT891822	hsa-miR-3663-5p	CLIP-seq
MIRT891823	hsa-miR-3666	CLIP-seq
MIRT891824	hsa-miR-3672	CLIP-seq
MIRT891825	hsa-miR-3688-3p	CLIP-seq
MIRT891826	hsa-miR-3691-5p	CLIP-seq
MIRT891827	hsa-miR-3927	CLIP-seq
MIRT891828	hsa-miR-3934	CLIP-seq
MIRT891829	hsa-miR-424	CLIP-seq
MIRT891830	hsa-miR-4270	CLIP-seq
MIRT891831	hsa-miR-4279	CLIP-seq
MIRT891832	hsa-miR-4284	CLIP-seq
MIRT891833	hsa-miR-4295	CLIP-seq
MIRT891834	hsa-miR-4307	CLIP-seq
MIRT891835	hsa-miR-4318	CLIP-seq
MIRT891836	hsa-miR-4418	CLIP-seq
MIRT891837	hsa-miR-4423-5p	CLIP-seq
MIRT891838	hsa-miR-4426	CLIP-seq
MIRT891839	hsa-miR-4430	CLIP-seq
MIRT891840	hsa-miR-4441	CLIP-seq
MIRT891841	hsa-miR-4477b	CLIP-seq
MIRT891842	hsa-miR-4499	CLIP-seq
MIRT891843	hsa-miR-4520a-5p	CLIP-seq
MIRT891844	hsa-miR-4520b-5p	CLIP-seq
MIRT891845	hsa-miR-454	CLIP-seq
MIRT891846	hsa-miR-4638-5p	CLIP-seq
MIRT891847	hsa-miR-4647	CLIP-seq
MIRT891848	hsa-miR-4662b	CLIP-seq
MIRT891849	hsa-miR-4668-3p	CLIP-seq
MIRT891850	hsa-miR-4682	CLIP-seq
MIRT891851	hsa-miR-4693-5p	CLIP-seq
MIRT891852	hsa-miR-4695-3p	CLIP-seq
MIRT891853	hsa-miR-4700-3p	CLIP-seq
MIRT891854	hsa-miR-4722-3p	CLIP-seq
MIRT891855	hsa-miR-4726-3p	CLIP-seq
MIRT891856	hsa-miR-4752	CLIP-seq
MIRT891857	hsa-miR-4772-5p	CLIP-seq
MIRT891858	hsa-miR-4791	CLIP-seq
MIRT891859	hsa-miR-4795-3p	CLIP-seq
MIRT891860	hsa-miR-4797-5p	CLIP-seq
MIRT891861	hsa-miR-484	CLIP-seq
MIRT891862	hsa-miR-497	CLIP-seq
MIRT891863	hsa-miR-498	CLIP-seq
MIRT891864	hsa-miR-509-3-5p	CLIP-seq
MIRT891865	hsa-miR-5095	CLIP-seq
MIRT891866	hsa-miR-509-5p	CLIP-seq
MIRT891867	hsa-miR-548ag	CLIP-seq
MIRT891868	hsa-miR-548ai	CLIP-seq
MIRT891869	hsa-miR-552	CLIP-seq
MIRT891870	hsa-miR-561	CLIP-seq
MIRT891871	hsa-miR-622	CLIP-seq
MIRT891872	hsa-miR-652	CLIP-seq
MIRT891873	hsa-miR-764	CLIP-seq
MIRT891874	hsa-miR-767-5p	CLIP-seq
MIRT891875	hsa-miR-892a	CLIP-seq
MIRT891876	hsa-miR-944	CLIP-seq
MIRT891788	hsa-miR-1184	CLIP-seq
MIRT1964302	hsa-miR-1202	CLIP-seq
MIRT891789	hsa-miR-122	CLIP-seq
MIRT891792	hsa-miR-1307	CLIP-seq
MIRT891793	hsa-miR-130a	CLIP-seq
MIRT891794	hsa-miR-130b	CLIP-seq
MIRT891801	hsa-miR-1915	CLIP-seq
MIRT1964303	hsa-miR-197	CLIP-seq
MIRT891805	hsa-miR-1976	CLIP-seq
MIRT891809	hsa-miR-301a	CLIP-seq
MIRT891810	hsa-miR-301b	CLIP-seq
MIRT891812	hsa-miR-3135b	CLIP-seq
MIRT1964304	hsa-miR-3199	CLIP-seq
MIRT891819	hsa-miR-340	CLIP-seq
MIRT1964305	hsa-miR-3618	CLIP-seq
MIRT891821	hsa-miR-3652	CLIP-seq
MIRT891823	hsa-miR-3666	CLIP-seq
MIRT1964306	hsa-miR-3671	CLIP-seq
MIRT891826	hsa-miR-3691-5p	CLIP-seq
MIRT1964307	hsa-miR-3972	CLIP-seq
MIRT1964308	hsa-miR-411	CLIP-seq
MIRT1964309	hsa-miR-412	CLIP-seq
MIRT891831	hsa-miR-4279	CLIP-seq
MIRT891832	hsa-miR-4284	CLIP-seq
MIRT891833	hsa-miR-4295	CLIP-seq
MIRT891835	hsa-miR-4318	CLIP-seq
MIRT891836	hsa-miR-4418	CLIP-seq
MIRT891837	hsa-miR-4423-5p	CLIP-seq
MIRT891839	hsa-miR-4430	CLIP-seq
MIRT1964310	hsa-miR-4433	CLIP-seq
MIRT1964311	hsa-miR-4438	CLIP-seq
MIRT1964312	hsa-miR-4508	CLIP-seq
MIRT891845	hsa-miR-454	CLIP-seq
MIRT891846	hsa-miR-4638-5p	CLIP-seq
MIRT891851	hsa-miR-4693-5p	CLIP-seq
MIRT891852	hsa-miR-4695-3p	CLIP-seq
MIRT1964313	hsa-miR-4716-5p	CLIP-seq
MIRT891854	hsa-miR-4722-3p	CLIP-seq
MIRT891855	hsa-miR-4726-3p	CLIP-seq
MIRT891856	hsa-miR-4752	CLIP-seq
MIRT1964314	hsa-miR-4755-3p	CLIP-seq
MIRT1964315	hsa-miR-4775	CLIP-seq
MIRT1964316	hsa-miR-4781-3p	CLIP-seq
MIRT1964317	hsa-miR-483-5p	CLIP-seq
MIRT891863	hsa-miR-498	CLIP-seq
MIRT891864	hsa-miR-509-3-5p	CLIP-seq
MIRT891865	hsa-miR-5095	CLIP-seq
MIRT891866	hsa-miR-509-5p	CLIP-seq
MIRT1964318	hsa-miR-515-5p	CLIP-seq
MIRT1964319	hsa-miR-526b	CLIP-seq
MIRT1964320	hsa-miR-590-3p	CLIP-seq
MIRT1964321	hsa-miR-607	CLIP-seq
MIRT891872	hsa-miR-652	CLIP-seq
MIRT891875	hsa-miR-892a	CLIP-seq
MIRT1964322	hsa-miR-934	CLIP-seq
MIRT2200418	hsa-miR-106a	CLIP-seq
MIRT2200419	hsa-miR-106b	CLIP-seq
MIRT891788	hsa-miR-1184	CLIP-seq
MIRT1964302	hsa-miR-1202	CLIP-seq
MIRT891789	hsa-miR-122	CLIP-seq
MIRT891790	hsa-miR-1224-3p	CLIP-seq
MIRT891791	hsa-miR-125a-3p	CLIP-seq
MIRT891792	hsa-miR-1307	CLIP-seq
MIRT891793	hsa-miR-130a	CLIP-seq
MIRT891794	hsa-miR-130b	CLIP-seq
MIRT891796	hsa-miR-150	CLIP-seq
MIRT2200420	hsa-miR-17	CLIP-seq
MIRT2200421	hsa-miR-186	CLIP-seq
MIRT891801	hsa-miR-1915	CLIP-seq
MIRT1964303	hsa-miR-197	CLIP-seq
MIRT891805	hsa-miR-1976	CLIP-seq
MIRT2200422	hsa-miR-20a	CLIP-seq
MIRT2200423	hsa-miR-20b	CLIP-seq
MIRT891809	hsa-miR-301a	CLIP-seq
MIRT891810	hsa-miR-301b	CLIP-seq
MIRT2200424	hsa-miR-302a	CLIP-seq
MIRT2200425	hsa-miR-302b	CLIP-seq
MIRT2200426	hsa-miR-302c	CLIP-seq
MIRT2200427	hsa-miR-302d	CLIP-seq
MIRT2200428	hsa-miR-302e	CLIP-seq
MIRT2200429	hsa-miR-3133	CLIP-seq
MIRT891812	hsa-miR-3135b	CLIP-seq
MIRT891815	hsa-miR-3155	CLIP-seq
MIRT891816	hsa-miR-3155b	CLIP-seq
MIRT1964304	hsa-miR-3199	CLIP-seq
MIRT2200430	hsa-miR-338-3p	CLIP-seq
MIRT891820	hsa-miR-3620	CLIP-seq
MIRT891821	hsa-miR-3652	CLIP-seq
MIRT891822	hsa-miR-3663-5p	CLIP-seq
MIRT891823	hsa-miR-3666	CLIP-seq
MIRT891826	hsa-miR-3691-5p	CLIP-seq
MIRT2200431	hsa-miR-372	CLIP-seq
MIRT2200432	hsa-miR-373	CLIP-seq
MIRT891828	hsa-miR-3934	CLIP-seq
MIRT1964307	hsa-miR-3972	CLIP-seq
MIRT1964308	hsa-miR-411	CLIP-seq
MIRT1964309	hsa-miR-412	CLIP-seq
MIRT891831	hsa-miR-4279	CLIP-seq
MIRT891832	hsa-miR-4284	CLIP-seq
MIRT891833	hsa-miR-4295	CLIP-seq
MIRT891835	hsa-miR-4318	CLIP-seq
MIRT891836	hsa-miR-4418	CLIP-seq
MIRT891837	hsa-miR-4423-5p	CLIP-seq
MIRT891839	hsa-miR-4430	CLIP-seq
MIRT1964311	hsa-miR-4438	CLIP-seq
MIRT2200433	hsa-miR-4474-5p	CLIP-seq
MIRT2200434	hsa-miR-4503	CLIP-seq
MIRT2200435	hsa-miR-4509	CLIP-seq
MIRT2200436	hsa-miR-4530	CLIP-seq
MIRT891845	hsa-miR-454	CLIP-seq
MIRT891846	hsa-miR-4638-5p	CLIP-seq
MIRT891850	hsa-miR-4682	CLIP-seq
MIRT891851	hsa-miR-4693-5p	CLIP-seq
MIRT1964313	hsa-miR-4716-5p	CLIP-seq
MIRT891854	hsa-miR-4722-3p	CLIP-seq
MIRT891855	hsa-miR-4726-3p	CLIP-seq
MIRT2200437	hsa-miR-4731-5p	CLIP-seq
MIRT2200438	hsa-miR-4744	CLIP-seq
MIRT891856	hsa-miR-4752	CLIP-seq
MIRT1964314	hsa-miR-4755-3p	CLIP-seq
MIRT1964316	hsa-miR-4781-3p	CLIP-seq
MIRT1964317	hsa-miR-483-5p	CLIP-seq
MIRT891861	hsa-miR-484	CLIP-seq
MIRT891863	hsa-miR-498	CLIP-seq
MIRT891864	hsa-miR-509-3-5p	CLIP-seq
MIRT891865	hsa-miR-5095	CLIP-seq
MIRT891866	hsa-miR-509-5p	CLIP-seq
MIRT2200439	hsa-miR-512-3p	CLIP-seq
MIRT1964318	hsa-miR-515-5p	CLIP-seq
MIRT2200440	hsa-miR-519d	CLIP-seq
MIRT2200441	hsa-miR-520a-3p	CLIP-seq
MIRT2200442	hsa-miR-520b	CLIP-seq
MIRT2200443	hsa-miR-520c-3p	CLIP-seq
MIRT2200444	hsa-miR-520d-3p	CLIP-seq
MIRT2200445	hsa-miR-520e	CLIP-seq
MIRT2200446	hsa-miR-520g	CLIP-seq
MIRT2200447	hsa-miR-520h	CLIP-seq
MIRT1964319	hsa-miR-526b	CLIP-seq
MIRT2200448	hsa-miR-548v	CLIP-seq
MIRT891869	hsa-miR-552	CLIP-seq
MIRT2200449	hsa-miR-566	CLIP-seq
MIRT891872	hsa-miR-652	CLIP-seq
MIRT891873	hsa-miR-764	CLIP-seq
MIRT891874	hsa-miR-767-5p	CLIP-seq
MIRT891875	hsa-miR-892a	CLIP-seq
MIRT2200450	hsa-miR-93	CLIP-seq
MIRT2200418	hsa-miR-106a	CLIP-seq
MIRT2200419	hsa-miR-106b	CLIP-seq
MIRT891788	hsa-miR-1184	CLIP-seq
MIRT891789	hsa-miR-122	CLIP-seq
MIRT891792	hsa-miR-1307	CLIP-seq
MIRT891793	hsa-miR-130a	CLIP-seq
MIRT891794	hsa-miR-130b	CLIP-seq
MIRT891796	hsa-miR-150	CLIP-seq
MIRT2200420	hsa-miR-17	CLIP-seq
MIRT891801	hsa-miR-1915	CLIP-seq
MIRT2200422	hsa-miR-20a	CLIP-seq
MIRT2200423	hsa-miR-20b	CLIP-seq
MIRT891809	hsa-miR-301a	CLIP-seq
MIRT891810	hsa-miR-301b	CLIP-seq
MIRT2200424	hsa-miR-302a	CLIP-seq
MIRT2200425	hsa-miR-302b	CLIP-seq
MIRT2200426	hsa-miR-302c	CLIP-seq
MIRT2200427	hsa-miR-302d	CLIP-seq
MIRT2200428	hsa-miR-302e	CLIP-seq
MIRT891812	hsa-miR-3135b	CLIP-seq
MIRT891821	hsa-miR-3652	CLIP-seq
MIRT891823	hsa-miR-3666	CLIP-seq
MIRT2200431	hsa-miR-372	CLIP-seq
MIRT2200432	hsa-miR-373	CLIP-seq
MIRT891832	hsa-miR-4284	CLIP-seq
MIRT891833	hsa-miR-4295	CLIP-seq
MIRT891836	hsa-miR-4418	CLIP-seq
MIRT891837	hsa-miR-4423-5p	CLIP-seq
MIRT891839	hsa-miR-4430	CLIP-seq
MIRT891845	hsa-miR-454	CLIP-seq
MIRT891846	hsa-miR-4638-5p	CLIP-seq
MIRT891852	hsa-miR-4695-3p	CLIP-seq
MIRT891855	hsa-miR-4726-3p	CLIP-seq
MIRT891864	hsa-miR-509-3-5p	CLIP-seq
MIRT891866	hsa-miR-509-5p	CLIP-seq
MIRT2200440	hsa-miR-519d	CLIP-seq
MIRT2200441	hsa-miR-520a-3p	CLIP-seq
MIRT2200442	hsa-miR-520b	CLIP-seq
MIRT2200443	hsa-miR-520c-3p	CLIP-seq
MIRT2200444	hsa-miR-520d-3p	CLIP-seq
MIRT2200445	hsa-miR-520e	CLIP-seq
MIRT2200446	hsa-miR-520g	CLIP-seq
MIRT2200447	hsa-miR-520h	CLIP-seq
MIRT2386066	hsa-miR-576-3p	CLIP-seq
MIRT891872	hsa-miR-652	CLIP-seq
MIRT2200450	hsa-miR-93	CLIP-seq
MIRT891788	hsa-miR-1184	CLIP-seq
MIRT891792	hsa-miR-1307	CLIP-seq
MIRT2447011	hsa-miR-1910	CLIP-seq
MIRT891801	hsa-miR-1915	CLIP-seq
MIRT891805	hsa-miR-1976	CLIP-seq
MIRT2447012	hsa-miR-2114	CLIP-seq
MIRT2447013	hsa-miR-3129-3p	CLIP-seq
MIRT891821	hsa-miR-3652	CLIP-seq
MIRT891831	hsa-miR-4279	CLIP-seq
MIRT891832	hsa-miR-4284	CLIP-seq
MIRT891836	hsa-miR-4418	CLIP-seq
MIRT891837	hsa-miR-4423-5p	CLIP-seq
MIRT891839	hsa-miR-4430	CLIP-seq
MIRT2447014	hsa-miR-455-3p	CLIP-seq
MIRT891846	hsa-miR-4638-5p	CLIP-seq
MIRT891854	hsa-miR-4722-3p	CLIP-seq
MIRT891855	hsa-miR-4726-3p	CLIP-seq
MIRT2447015	hsa-miR-4780	CLIP-seq
MIRT891863	hsa-miR-498	CLIP-seq
MIRT891864	hsa-miR-509-3-5p	CLIP-seq
MIRT891866	hsa-miR-509-5p	CLIP-seq
MIRT2447016	hsa-miR-623	CLIP-seq
MIRT891789	hsa-miR-122	CLIP-seq
MIRT891793	hsa-miR-130a	CLIP-seq
MIRT891794	hsa-miR-130b	CLIP-seq
MIRT891801	hsa-miR-1915	CLIP-seq
MIRT891805	hsa-miR-1976	CLIP-seq
MIRT891809	hsa-miR-301a	CLIP-seq
MIRT891810	hsa-miR-301b	CLIP-seq
MIRT891812	hsa-miR-3135b	CLIP-seq
MIRT891821	hsa-miR-3652	CLIP-seq
MIRT891823	hsa-miR-3666	CLIP-seq
MIRT891824	hsa-miR-3672	CLIP-seq
MIRT891831	hsa-miR-4279	CLIP-seq
MIRT891833	hsa-miR-4295	CLIP-seq
MIRT891837	hsa-miR-4423-5p	CLIP-seq
MIRT891839	hsa-miR-4430	CLIP-seq
MIRT891842	hsa-miR-4499	CLIP-seq
MIRT891845	hsa-miR-454	CLIP-seq
MIRT891850	hsa-miR-4682	CLIP-seq
MIRT891852	hsa-miR-4695-3p	CLIP-seq
MIRT891854	hsa-miR-4722-3p	CLIP-seq
MIRT891855	hsa-miR-4726-3p	CLIP-seq
MIRT891863	hsa-miR-498	CLIP-seq
MIRT1964319	hsa-miR-526b	CLIP-seq
MIRT891788	hsa-miR-1184	CLIP-seq
MIRT891789	hsa-miR-122	CLIP-seq
MIRT891792	hsa-miR-1307	CLIP-seq
MIRT891793	hsa-miR-130a	CLIP-seq
MIRT891794	hsa-miR-130b	CLIP-seq
MIRT891801	hsa-miR-1915	CLIP-seq
MIRT891805	hsa-miR-1976	CLIP-seq
MIRT891809	hsa-miR-301a	CLIP-seq
MIRT891810	hsa-miR-301b	CLIP-seq
MIRT891812	hsa-miR-3135b	CLIP-seq
MIRT891821	hsa-miR-3652	CLIP-seq
MIRT891823	hsa-miR-3666	CLIP-seq
MIRT891824	hsa-miR-3672	CLIP-seq
MIRT891831	hsa-miR-4279	CLIP-seq
MIRT891832	hsa-miR-4284	CLIP-seq
MIRT891833	hsa-miR-4295	CLIP-seq
MIRT891836	hsa-miR-4418	CLIP-seq
MIRT891837	hsa-miR-4423-5p	CLIP-seq
MIRT891839	hsa-miR-4430	CLIP-seq
MIRT891842	hsa-miR-4499	CLIP-seq
MIRT891845	hsa-miR-454	CLIP-seq
MIRT891846	hsa-miR-4638-5p	CLIP-seq
MIRT891850	hsa-miR-4682	CLIP-seq
MIRT891852	hsa-miR-4695-3p	CLIP-seq
MIRT891854	hsa-miR-4722-3p	CLIP-seq
MIRT891855	hsa-miR-4726-3p	CLIP-seq
MIRT891863	hsa-miR-498	CLIP-seq
MIRT891864	hsa-miR-509-3-5p	CLIP-seq
MIRT891866	hsa-miR-509-5p	CLIP-seq
MIRT1964319	hsa-miR-526b	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ASCL1	Unknown	20124469

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	8663494, 27344019
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005892	Component	Acetylcholine-gated channel complex	IC	1542648
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0007165	Process	Signal transduction	NAS	9009220
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0007268	Process	Chemical synaptic transmission	TAS	9009220
GO:0007271	Process	Synaptic transmission, cholinergic	IBA	21873635
GO:0015276	Function	Ligand-gated ion channel activity	TAS	20438829
GO:0015464	Function	Acetylcholine receptor activity	IDA	1542648
GO:0022848	Function	Acetylcholine-gated cation-selective channel activity	NAS	1542648
GO:0022848	Function	Acetylcholine-gated cation-selective channel activity	TAS	20438829
GO:0030594	Function	Neurotransmitter receptor activity	IBA	21873635
GO:0034220	Process	Ion transmembrane transport	IBA	21873635
GO:0035094	Process	Response to nicotine	IBA	21873635
GO:0035095	Process	Behavioral response to nicotine	IMP	18227835
GO:0042391	Process	Regulation of membrane potential	IBA	21873635
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0045202	Component	Synapse	IBA	21873635
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050877	Process	Nervous system process	IBA	21873635
GO:0060079	Process	Excitatory postsynaptic potential	IEA
GO:0098691	Component	Dopaminergic synapse	IEA
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IEA

Other IDs

• MIM: 118505
• HGNC: 1959
• e!Ensembl: ENSG00000169684

Protein

• UniProt ID: P30532
• Protein name: Neuronal acetylcholine receptor subunit alpha-5
• Protein function: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02931	Neur_chan_LBD	47 → 250	Neurotransmitter-gated ion-channel ligand binding domain	Family
  PF02932	Neur_chan_memb	257 → 381	Neurotransmitter-gated ion-channel transmembrane region	Family
  PF02932	Neur_chan_memb	368 → 447	Neurotransmitter-gated ion-channel transmembrane region	Family

• Sequence:

  MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYER
  WVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKV
  IRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFD
  LQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYV
  TYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIE
  EIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTL
  PKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDW
  KFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK

• Sequence length: 468

Pathways

KEGG:

Neuroactive ligand-receptor interaction

Reactome:

Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	29767774, 28166215, 26634245, 25101718
Lung carcinoma	Non-Small Cell Lung Carcinoma, Small cell carcinoma of lung, Carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	31326317, 28604730, 28604730, 27393504
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	19836008, 28604730
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	22899653, 18385738
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	28540026, 23196875, 21418140
Seizure	Complex partial seizures, Generalized seizures, Visual seizure, Tonic - clonic seizures, Single Seizure	rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061, rs121912707, rs118192249, rs118192251, rs118192217, rs118192218, rs118192219, rs118192222, rs118192226, rs118192228, rs118192234, rs118192236, rs118192235, rs118192241, rs118192242, rs118192185, rs118192188, rs118192245, rs118192246, rs118192186, rs118192194, rs118192197, rs118192199, rs118192201, rs118192202, rs118192203, rs118192204, rs118192205, rs118192206, rs118192208, rs118192211, rs118192216, rs118192239, rs387906684, rs387906686, rs387906687, rs1596893185, rs387907126, rs387907281, rs397515405, rs587778771, rs730882067, rs730882073, rs397514579, rs397514582, rs587776976, rs398122394, rs121918784, rs121918751, rs121918735, rs398123588, rs587780450, rs61749751, rs587777620, rs727503974, rs730882124, rs794726710, rs794726697, rs794726799, rs794727444, rs794727740, rs796053166, rs794726825, rs796052676, rs796053219, rs796053220, rs796053228, rs796052653, rs759584387, rs796052650, rs796052641, rs796052626, rs796052623, rs796052663, rs796052615, rs796052802, rs797044999, rs797045047, rs797045942, rs797045941, rs118192212, rs797044938, rs777257591, rs864321712, rs879255652, rs886039268, rs886039517, rs886039529, rs199497486, rs886039496, rs886039903, rs886041300, rs769827124, rs886041339, rs886041591, rs587783092, rs1555850151, rs1057516123, rs1057516121, rs1057516115, rs1057516111, rs1057516106, rs1057516105, rs756921902, rs1057516089, rs1057516087, rs1057516080, rs1057516076, rs1060499544, rs1555850512, rs1057517919, rs118192231, rs1057520413, rs1060503101, rs1064796294, rs1064794981, rs1064794632, rs1064797245, rs1131691830, rs1131692231, rs1131691936, rs1554626549, rs1553579225, rs1553531385, rs121918736, rs1554898088, rs1553579282, rs763353895, rs1553463119, rs1554093891, rs77838305, rs1555408401, rs1554627439, rs1554097873, rs1555850403, rs1064794719, rs1315483224, rs1567134495, rs770187706, rs1057518555, rs1576983339, rs1574192005, rs1459374430, rs1586800133, rs1574641522, rs1572096837, rs1572630269, rs1574554892, rs1574556643, rs1574571769, rs1574641605, rs1574697769, rs1574716524, rs1574746733, rs1574746935, rs1574752700, rs1574754680, rs863225030, rs1601545088, rs1600714727, rs1371059392, rs1600767259, rs1339542565, rs1600785769, rs2065899210, rs1600732174, rs1162306056, rs879255709, rs1900111672, rs2066910297, rs1554122080, rs796052941, rs1600789325, rs2082695884, rs1737677036, rs1737495759, rs868389022, rs1737685202, rs1737672350, rs762737130	14996991, 9495872, 9495872, 14996991

Unknown
Disease name	Disease term	dbSNP ID	References
Anxiety disorder	Anxiety Disorders, Anxiety States, Neurotic		29944862, 19220484
Clonic seizures	Clonic Seizures		9495872, 14996991
Development disorder	Child Development Disorders, Pervasive		28540026
Hypotonic seizures	Epileptic drop attack		9495872, 14996991
Jacksonian seizure	Jacksonian Seizure		14996991, 9495872
Lung neoplasms	Lung Neoplasms		18385738