CHRM5 (cholinergic receptor muscarinic 5)

Gene

• Entrez ID: 1133
• Gene name: Cholinergic receptor muscarinic 5
• Gene symbol: CHRM5
• Synonyms: HM5
• Chromosome: 15
• Chromosome location: 15q14
• Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, pho

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT891660	hsa-miR-3662	CLIP-seq
MIRT891661	hsa-miR-371b-5p	CLIP-seq
MIRT891662	hsa-miR-4698	CLIP-seq
MIRT891663	hsa-miR-548c-3p	CLIP-seq
MIRT891664	hsa-miR-888	CLIP-seq
MIRT1964267	hsa-miR-1178	CLIP-seq
MIRT1964268	hsa-miR-4257	CLIP-seq
MIRT1964269	hsa-miR-4793-5p	CLIP-seq
MIRT2200380	hsa-miR-520d-5p	CLIP-seq
MIRT2200381	hsa-miR-524-5p	CLIP-seq
MIRT2386054	hsa-miR-1206	CLIP-seq
MIRT2386055	hsa-miR-1208	CLIP-seq
MIRT2386056	hsa-miR-125a-5p	CLIP-seq
MIRT2386057	hsa-miR-125b	CLIP-seq
MIRT2386058	hsa-miR-4289	CLIP-seq
MIRT2386059	hsa-miR-4319	CLIP-seq
MIRT2386060	hsa-miR-4732-3p	CLIP-seq
MIRT2386061	hsa-miR-670	CLIP-seq
MIRT2447002	hsa-miR-300	CLIP-seq
MIRT2447003	hsa-miR-381	CLIP-seq
MIRT2447004	hsa-miR-4666-3p	CLIP-seq
MIRT2503222	hsa-miR-1184	CLIP-seq
MIRT2503223	hsa-miR-1301	CLIP-seq
MIRT2503224	hsa-miR-302f	CLIP-seq
MIRT2503225	hsa-miR-4660	CLIP-seq
MIRT2503226	hsa-miR-5047	CLIP-seq
MIRT2503227	hsa-miR-545	CLIP-seq
MIRT2503222	hsa-miR-1184	CLIP-seq
MIRT2503223	hsa-miR-1301	CLIP-seq
MIRT2503224	hsa-miR-302f	CLIP-seq
MIRT2503225	hsa-miR-4660	CLIP-seq
MIRT2503226	hsa-miR-5047	CLIP-seq
MIRT2503227	hsa-miR-545	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001696	Process	Gastric acid secretion	IEA
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	TAS	1905013
GO:0004993	Function	G protein-coupled serotonin receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	20398705
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	21873635
GO:0007197	Process	Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA	21873635
GO:0007213	Process	G protein-coupled acetylcholine receptor signaling pathway	TAS	3272174
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0015872	Process	Dopamine transport	IEA
GO:0016907	Function	G protein-coupled acetylcholine receptor activity	IBA	21873635
GO:0019226	Process	Transmission of nerve impulse	IEA
GO:0030425	Component	Dendrite	IBA	21873635
GO:0030594	Function	Neurotransmitter receptor activity	IBA	21873635
GO:0045202	Component	Synapse	IBA	21873635
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0060304	Process	Regulation of phosphatidylinositol dephosphorylation	IEA
GO:0098664	Process	G protein-coupled serotonin receptor signaling pathway	IEA

Other IDs

• MIM: 118496
• HGNC: 1954
• e!Ensembl: ENSG00000184984

Protein

• UniProt ID: P08912
• Protein name: Muscarinic acetylcholine receptor M5
• Protein function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effec
• PDB: 6OL9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	47 → 495	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ
  LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN
  LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL
  DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE
  KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL
  TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN
  YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP
  NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG
  YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP

• Sequence length: 532

Pathways

KEGG:

Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
Alzheimer disease
Pathways of neurodegeneration - multiple diseases

Reactome:

Muscarinic acetylcholine receptors
G alpha (q) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	15292665

Unknown
Disease name	Disease term	dbSNP ID	References
Scleroderma	Systemic Scleroderma		23740937