VSIG4 (V-set and immunoglobulin domain containing 4)

Gene

• Entrez ID: 11326
• Gene name: V-set and immunoglobulin domain containing 4
• Gene symbol: VSIG4
• Synonyms: CRIg, Z39IG
• Chromosome: X
• Chromosome location: Xq12
• Summary: This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for th

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1487833	hsa-miR-1273f	CLIP-seq
MIRT1487834	hsa-miR-143	CLIP-seq
MIRT1487835	hsa-miR-3126-3p	CLIP-seq
MIRT1487836	hsa-miR-3128	CLIP-seq
MIRT1487837	hsa-miR-4470	CLIP-seq
MIRT1487838	hsa-miR-4708-5p	CLIP-seq
MIRT1487839	hsa-miR-4720-5p	CLIP-seq
MIRT1487840	hsa-miR-4770	CLIP-seq
MIRT1487841	hsa-miR-4799-3p	CLIP-seq
MIRT1487842	hsa-miR-185	CLIP-seq
MIRT1487843	hsa-miR-193a-5p	CLIP-seq
MIRT1487844	hsa-miR-29a	CLIP-seq
MIRT1487845	hsa-miR-29b	CLIP-seq
MIRT1487846	hsa-miR-29c	CLIP-seq
MIRT1487847	hsa-miR-31	CLIP-seq
MIRT1487848	hsa-miR-3182	CLIP-seq
MIRT1487849	hsa-miR-3663-3p	CLIP-seq
MIRT1487850	hsa-miR-3688-5p	CLIP-seq
MIRT1487851	hsa-miR-4299	CLIP-seq
MIRT1487852	hsa-miR-4306	CLIP-seq
MIRT1487853	hsa-miR-4456	CLIP-seq
MIRT1487854	hsa-miR-4644	CLIP-seq
MIRT1487855	hsa-miR-4733-3p	CLIP-seq
MIRT1487856	hsa-miR-4768-3p	CLIP-seq
MIRT1487857	hsa-miR-548q	CLIP-seq
MIRT1487858	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001851	Function	Complement component C3b binding	IBA	21873635
GO:0001851	Function	Complement component C3b binding	IPI	17051150
GO:0005515	Function	Protein binding	IPI	32296183
GO:0006957	Process	Complement activation, alternative pathway	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0032703	Process	Negative regulation of interleukin-2 production	IBA	21873635
GO:0032991	Component	Protein-containing complex	IPI	17051150
GO:0042130	Process	Negative regulation of T cell proliferation	IBA	21873635
GO:0043031	Process	Negative regulation of macrophage activation	IEA
GO:0045957	Process	Negative regulation of complement activation, alternative pathway	IBA	21873635
GO:0045957	Process	Negative regulation of complement activation, alternative pathway	IPI	17051150

Other IDs

• MIM: 300353
• HGNC: 17032
• e!Ensembl: ENSG00000155659

Protein

• UniProt ID: Q9Y279
• Protein name: V-set and immunoglobulin domain-containing protein 4 (Protein Z39Ig)
• Protein function: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.
• PDB: 2ICC, 2ICE, 2ICF, 5IMK, 5IML, 8TE5, 8TE6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	24 → 136	Immunoglobulin V-set domain	Domain
  PF13927	Ig_3	142 → 214		Domain

• Sequence:

  MGILLGLLLLGHLTVDTYGRPILEVPESVTGPWKGDVNLPCTYDPLQGYTQVLVKWLVQR
  GSDPVTIFLRDSSGDHIQQAKYQGRLHVSHKVPGDVSLQLSTLEMDDRSHYTCEVTWQTP
  DGNQVVRDKITELRVQKLSVSKPTVTTGSGYGFTVPQGMRISLQCQARGSPPISYIWYKQ
  QTNNQEPIKVATLSTLLFKPAVIADSGSYFCTAKGQVGSEQHSDIVKFVVKDSSKLLKTK
  TEAPTTMTYPLKATSTVKQSWDWTTDMDGYLGETSAGPGKSLPVFAIILIISLCCMVVFT
  MAYIMLCRKTSQQEHVYEAARAHAREANDSGETMRVAIFASGCSSDEPTSQNLGNNYSDE
  PCIGQEYQIIAQINGNYARLLDTVPLDYEFLATEGKSVC

• Sequence length: 399

Pathways

KEGG:

Complement and coagulation cascades

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Glomerulonephritis	IGA Glomerulonephritis	rs778043831	25133636
Leukemia	Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2)	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	18206229

Unknown
Disease name	Disease term	dbSNP ID	References
Alopecia	Alopecia		28196072
Liver carcinoma	Liver carcinoma		28284560
Myeloid leukemia	Acute Myeloid Leukemia, M1		18206229